Trudy Instituta Matematiki i Mekhaniki UrO RAN最新文献_第8页

О существенных значениях показателей колеблемости решений линейной однородной двумерной дифференциальной системы 线性均匀二维微分系统决策的波动值

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-06-01 DOI: 10.21538/0134-4889-2023-29-2-157-171

А. Х. Сташ

引用次数: 0

From the Triangulation Technique to the Use of the Donor Aorta and Vena Cava for Kidney Transplantation: Lessons from the Past and Path to the Future of Xenotransplantation 从三角测量技术到使用供体主动脉和腔静脉进行肾移植:异种移植的过去和未来的经验教训

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-05-26 DOI: 10.3390/uro3020016

D. Nghiem

引用次数: 0

A Decade of Pancreas Transplantation—A Registry Report 十年胰腺移植——一份登记报告

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-05-25 DOI: 10.3390/uro3020015

A. Gruessner

{"title":"A Decade of Pancreas Transplantation—A Registry Report","authors":"A. Gruessner","doi":"10.3390/uro3020015","DOIUrl":"https://doi.org/10.3390/uro3020015","url":null,"abstract":"Since the first pancreas transplant in 1966, over 67,000 pancreas transplants have been performed worldwide and the number is growing. While the number of transplants in the US has changed only slightly over the past decade, many countries outside the US have shown strong growth in transplant numbers. The worldwide growth in numbers is due to the increasing number of patients with type 2 diabetes mellitus receiving a pancreas transplant. Only during the COVID-19 pandemic in 2020 and 2021 did transplant numbers decline, but they started to recover in 2022. The decline was especially noted for solitary transplants. This development over time was due to excellent patient and graft survival after simultaneous pancreas and kidney transplant (SPK). Patient survival at three years was >90% in SPK as well as in solitary transplants. At 3 years post-transplant, SPK pancreas graft survival was over 86% and SPK kidney graft survival over 90%. In pancreas transplants alone (PTA) and in pancreas after kidney transplants, the 3-year graft function reached 75%. The main reasons for advancement in outcome were reductions in technical failures and immunological graft losses. These improvements were due to better patient and donor selection, standardization of surgical techniques, and superior immunosuppressive protocols.","PeriodicalId":44555,"journal":{"name":"Trudy Instituta Matematiki i Mekhaniki UrO RAN","volume":"50 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76378239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Evolving Treatment Options for Metastatic Renal Cell Carcinoma (mRCC) 转移性肾细胞癌(mRCC)治疗方案的演变

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-04-01 DOI: 10.3390/uro3020014

Eun-mi Yu, M. Mudireddy, Ishan Patel, J. Aragon-Ching

{"title":"Evolving Treatment Options for Metastatic Renal Cell Carcinoma (mRCC)","authors":"Eun-mi Yu, M. Mudireddy, Ishan Patel, J. Aragon-Ching","doi":"10.3390/uro3020014","DOIUrl":"https://doi.org/10.3390/uro3020014","url":null,"abstract":"Approximately a third of patients diagnosed with kidney cancer in the United States present with advanced disease and those who present with distant metastases historically had dismal 5-year relative survival. However, over the last several years, advancements have led to improved life expectancy and patient outcomes in those who develop advanced renal cell carcinoma. Metastatic clear cell renal cell carcinoma (mccRCC) treatment has rapidly evolved with multiple drug approvals since 2006. Moreover, multiple combination regimens including a vascular endothelial growth factor tyrosine kinase inhibitor (VEGF-TKI) plus immune checkpoint inhibitor (ICI) and the combination of ipilimumab plus nivolumab have supplanted first-line VEGF-TKI monotherapy. Thus, the insights we gained from prospective randomized controlled trials focusing on systemic therapy beyond first-line therapy in mRCC patients treated in the TKI monotherapy era quickly became less relevant with the adoption of contemporary first-line combination regimens. Herein, we will review contemporary first- and second-line therapies for mccRCC, as well as highly anticipated clinical trials looking into novel regimens beyond first-line therapy in patients who have received combination therapy.","PeriodicalId":44555,"journal":{"name":"Trudy Instituta Matematiki i Mekhaniki UrO RAN","volume":"17 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85170129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Current Knowledge on Radiation-Therapy-Induced Erectile Dysfunction in Prostate-Cancer Patients: A Narrative Review 前列腺癌患者放射治疗引起的勃起功能障碍的现状:一个叙述性的回顾

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-04-01 DOI: 10.3390/uro3020013

Connie Labate, A. Panunzio, Francesco De Carlo, F. Zacheo, Sara De Matteis, M. Barba, U. Carbonara, F. Rizzo, S. Leo, S. Forte, P. Ditonno, A. Tafuri, V. Pagliarulo

引用次数: 0

Prostate Cancer: Advances in Genetic Testing and Clinical Implications 前列腺癌:基因检测和临床意义的进展

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-03-24 DOI: 10.3390/uro3020012

A. Abdelrazek, K. Ghoniem, Mohamed E. Ahmed, Vidhu B. Joshi, Ahmed M. Mahmoud, Nader Saeed, N. Khater, M. Elsharkawy, A. Gamal, E. Kwon, A. Kendi

{"title":"Prostate Cancer: Advances in Genetic Testing and Clinical Implications","authors":"A. Abdelrazek, K. Ghoniem, Mohamed E. Ahmed, Vidhu B. Joshi, Ahmed M. Mahmoud, Nader Saeed, N. Khater, M. Elsharkawy, A. Gamal, E. Kwon, A. Kendi","doi":"10.3390/uro3020012","DOIUrl":"https://doi.org/10.3390/uro3020012","url":null,"abstract":"The demand for genetic testing (GT) for prostate cancer (PCa) is expanding, but there is limited knowledge about the genetic counseling (GC) needs of men. A strong-to-moderate inherited genetic predisposition causes approximately 5–20% of prostate cancer (PCa). In men with prostate cancer, germline testing may benefit the patient by informing treatment options, and if a mutation is noticed, it may also guide screening for other cancers and have family implications for cascade genetic testing (testing of close relatives for the same germline mutation). Relatives with the same germline mutations may be eligible for early cancer detection strategies and preventive measures. Cascade family testing can be favorable for family members, but it is currently unutilized, and strategies to overcome obstacles like knowledge deficiency, family communication, lack of access to genetic services, and testing expenses are needed. In this review, we will look at the genetic factors that have been linked to prostate cancer, as well as the role of genetic counseling and testing in the early detection of advanced prostate cancer.","PeriodicalId":44555,"journal":{"name":"Trudy Instituta Matematiki i Mekhaniki UrO RAN","volume":"30 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76074763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Importance of Urodynamic Dysfunctions as Risk Factors for Recurrent Urinary Tract Infections in Patients with Multiple Sclerosis 尿动力功能障碍是多发性硬化症患者复发性尿路感染的危险因素

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-03-14 DOI: 10.3390/uro3010011

M. Vírseda-Chamorro, J. Salinas‐Casado, J. Matías‐Guiu

{"title":"Importance of Urodynamic Dysfunctions as Risk Factors for Recurrent Urinary Tract Infections in Patients with Multiple Sclerosis","authors":"M. Vírseda-Chamorro, J. Salinas‐Casado, J. Matías‐Guiu","doi":"10.3390/uro3010011","DOIUrl":"https://doi.org/10.3390/uro3010011","url":null,"abstract":"Objective: To analyze the role of urodynamic dysfunctions as risk factors for recurrent urinary tract infections (rUTIs) in patients with multiple sclerosis (MS). Material and methods: We conducted a prospective cohort study of 170 patients with MS who underwent a urodynamic study due to lower urinary tract symptoms. Patients were followed for one year, and 114 (84 women [74%] and 30 men [26%]; mean age 49 years) completed the study. Clinical variables and urodynamic findings (free uroflowmetry, cystometry, and pressure-flow study results) were recorded. Results indicated rUTIs was present in 37 patients (32%). Statistical analysis was performed using Fisher’s exact test, chi-square test, Student’s t-test, and multivariate regression analysis. Results: In univariate analysis, significant differences were observed between patients with and without rUTIs for the following clinical variables: symptom progression time, MS duration, Expanded Disability Status Scale score, and MS type. Regarding urodynamic findings, significant differences were observed in maximum flow rate (Qmax) (lower in patients with rUTIs), voided volume, bladder voiding efficiency, stress urinary incontinence (SUI) (greater rUTI frequency in affected patients), detrusor pressure at maximum flow, and bladder contractility index score. Multivariate analysis identified the urodynamic factors: low Qmax [Odds Ratio (OR) = 0.90 and SUI (OR = 2.95) as the independent predictors of rUTs. Conclusions: Two urodynamic variables: Qmax and SUI, are independent risk factors for rUTIs in MS patients. These two variables might be associated with Pelvic floor dysfunctions.","PeriodicalId":44555,"journal":{"name":"Trudy Instituta Matematiki i Mekhaniki UrO RAN","volume":"21 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72426798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospitalist Co-Management of Urethroplasty Patients in an Academic Center: Implementation of a Standardized Postoperative Care Model 学术中心泌尿道成形术患者的住院医师共同管理:标准化术后护理模式的实施

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-03-02 DOI: 10.3390/uro3010010

Pegah Taheri, A. Tijerina, Sofia Gereta, Safiya-Hana Belbina, E. Osterberg

{"title":"Hospitalist Co-Management of Urethroplasty Patients in an Academic Center: Implementation of a Standardized Postoperative Care Model","authors":"Pegah Taheri, A. Tijerina, Sofia Gereta, Safiya-Hana Belbina, E. Osterberg","doi":"10.3390/uro3010010","DOIUrl":"https://doi.org/10.3390/uro3010010","url":null,"abstract":"Objectives: to evaluate whether hospitalist co-management would lead to improved outcomes and value in patients undergoing urethroplasty (UPL) with a single surgeon for urethral stricture disease (USD). Material: A co-management model with hospitalists was introduced in August 2019 for all patients undergoing UPL for USD with a single surgeon in a United States teaching center. The hospitalist worked closely with the urologic surgeon and the support staff. The hospitalist managed post-operative concerns, such as pain and comorbidities, as well as conducted rounds with the urological team for disposition planning and addressing interdisciplinary needs. Retrospective analysis compared a 42-month period before initiation of co-management (Jan 2016–July 2019) with a 32-month period after initiation (Aug 2019–March 2022). Outcomes assessed were recurrence of stricture, complications, length of stay, readmission, and emergency room visits. Results: A total of 135 patients (71 surgeon-managed, 64 co-managed) underwent urethroplasty from January 2016 to March 2022. Hospitalist co-management did not affect complications, length of stay, readmission, and emergency room visits. Accounting for confounding variables using multivariable analysis, no factors were independently associated with recurrence. There were no demographic, comorbidity, or American Society of Anesthesiologists (ASA) score differences between the two groups. Conclusions: This study suggests that hospitalist care for patients undergoing urethroplasty may be non-inferior to surgeon care, based on similar outcomes between the two groups. There were no significant differences in the total length of stay or blood pressure readings, and the complication rates and hospital readmission rates were also similar.","PeriodicalId":44555,"journal":{"name":"Trudy Instituta Matematiki i Mekhaniki UrO RAN","volume":"16 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77863737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Асимптотика решения задачи оптимального управления с интегральным выпуклым критерием качества, дешевым управлением и возмущением начальных данных 最佳管理问题的渐近线，具有集成质量标准、廉价管理和原始数据扰动。

Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-03-01 DOI: 10.21538/0134-4889-2023-29-1-67-76

А. Р. Данилин, А. А. Шабуров

引用次数: 0

О cинтезе управлений в задаче усиленного уклонения для линейных многошаговых систем 论线性多步系统强化偏差问题中的控制集成

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Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-03-01 DOI: 10.21538/0134-4889-2023-29-1-111-126

Е. К. Костоусова

引用次数: 0