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I: Experimental therapeutics – preclinical最新文献

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I22 Cannabinoid receptor in hippocampal hippocampus as a potential therapeutic treatment for the cognitive deficits in Huntington dieases I22海马大麻素受体作为亨廷顿病认知缺陷的潜在治疗方法
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.248
Nadia Di Franco, A. Bortolozzi, L. Campo, Marc Espina Cortes, Laura Lopez, Silvia Ginés Padrós
{"title":"I22 Cannabinoid receptor in hippocampal hippocampus as a potential therapeutic treatment for the cognitive deficits in Huntington dieases","authors":"Nadia Di Franco, A. Bortolozzi, L. Campo, Marc Espina Cortes, Laura Lopez, Silvia Ginés Padrós","doi":"10.1136/jnnp-2022-ehdn.248","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.248","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122036806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I16 LXR signaling in the striatum and neuroprotection in Huntington’s disease [16]纹状体中的LXR信号传导与亨廷顿病的神经保护作用
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.242
C. Mounier, Maxime Brilland, M. Marinozzi, P. Vanhoutte, J. Caboche, S. Betuing
{"title":"I16 LXR signaling in the striatum and neuroprotection in Huntington’s disease","authors":"C. Mounier, Maxime Brilland, M. Marinozzi, P. Vanhoutte, J. Caboche, S. Betuing","doi":"10.1136/jnnp-2022-ehdn.242","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.242","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130914313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I04 Aav5-mihtt gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington disease minipigs up to 4 years aav5 - mitt基因治疗介导亨廷顿病迷你猪脑和脑脊液中亨廷顿蛋白持续突变降低长达4年
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.230
L. V. D. Bent, C. Brouwers, Robin Pocornie, A. Stam, Steffi Jonk, J. Klíma, Š. Juhás, J. Motlík, M. Evers, Zdenka Ellederovaé, A. Vallès
{"title":"I04 Aav5-mihtt gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington disease minipigs up to 4 years","authors":"L. V. D. Bent, C. Brouwers, Robin Pocornie, A. Stam, Steffi Jonk, J. Klíma, Š. Juhás, J. Motlík, M. Evers, Zdenka Ellederovaé, A. Vallès","doi":"10.1136/jnnp-2022-ehdn.230","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.230","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133067114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I03 CAG-targeted brain-permeable protein lowering strategy tested in polyQ mouse models I03 cag靶向脑渗透蛋白降低策略在polyQ小鼠模型中的实验研究
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.229
M. Surdyka, A. Niewiadomska-Cimicka, Żaneta Kalinowska-Pośka, Ewelina Jesion, Elisabeth Singer-Mikosch, Lorraine Fievet, Agnieszka Fiszer, N. Caron, Michael R. Hayden, H. Nguyen, Y. Trottier, M. Figiel
{"title":"I03 CAG-targeted brain-permeable protein lowering strategy tested in polyQ mouse models","authors":"M. Surdyka, A. Niewiadomska-Cimicka, Żaneta Kalinowska-Pośka, Ewelina Jesion, Elisabeth Singer-Mikosch, Lorraine Fievet, Agnieszka Fiszer, N. Caron, Michael R. Hayden, H. Nguyen, Y. Trottier, M. Figiel","doi":"10.1136/jnnp-2022-ehdn.229","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.229","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124730345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I17 Sustained benefits of brain-permeable cholesterol-loaded nanoparticles in zQ175DN mouse model I17在zQ175DN小鼠模型中，脑渗透胆固醇负载纳米颗粒的持续益处
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.243
M. Valenza, Giulia Birolini, I. Ottonelli, F. Talpo, A. Passoni, Monica Favagrossa, L. Colombo, Riccardo Caraffi, C. Caccia, Valerio Leoni, F. Taroni, A. Cappelleri, L. Minoli, S. Paltrinieri, E. Scanziani, B. Ruozi, M. Salmona, G. Biella, G. Tosi, E. Cattaneo
{"title":"I17 Sustained benefits of brain-permeable cholesterol-loaded nanoparticles in zQ175DN mouse model","authors":"M. Valenza, Giulia Birolini, I. Ottonelli, F. Talpo, A. Passoni, Monica Favagrossa, L. Colombo, Riccardo Caraffi, C. Caccia, Valerio Leoni, F. Taroni, A. Cappelleri, L. Minoli, S. Paltrinieri, E. Scanziani, B. Ruozi, M. Salmona, G. Biella, G. Tosi, E. Cattaneo","doi":"10.1136/jnnp-2022-ehdn.243","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.243","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117300519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
I18 Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase (SGPL1), modulates glycosphingolipid metabolism and results therapeutically effective in a mouse model of Huntington’s disease [18]在亨廷顿氏病小鼠模型中，用鞘氨醇-1-磷酸裂解酶(SGPL1)抑制剂THI治疗可调节鞘氨醇脂糖代谢，并取得有效的治疗效果
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.244
G. Pepe, L. Capocci, F. Marracino, N. Realini, P. Scarselli, Clotilde Di Cicco, A. Armirotti, R. Parlato, A. D. Pardo, V. Maglione
{"title":"I18 Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase (SGPL1), modulates glycosphingolipid metabolism and results therapeutically effective in a mouse model of Huntington’s disease","authors":"G. Pepe, L. Capocci, F. Marracino, N. Realini, P. Scarselli, Clotilde Di Cicco, A. Armirotti, R. Parlato, A. D. Pardo, V. Maglione","doi":"10.1136/jnnp-2022-ehdn.244","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.244","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128750503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I11 High throughput screening reveal drugs to rescue polyQ induced toxicity in Huntington’s disease cell and animal models [11]高通量筛选揭示拯救polyQ诱导的亨廷顿舞蹈病细胞和动物模型毒性的药物
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.237
Xuexin Li, Maria Häggblad, Lars Bräutigam, Jordi Carreras-Puigvert, D. Hühn, O. Fernandez-Capetillo
{"title":"I11 High throughput screening reveal drugs to rescue polyQ induced toxicity in Huntington’s disease cell and animal models","authors":"Xuexin Li, Maria Häggblad, Lars Bräutigam, Jordi Carreras-Puigvert, D. Hühn, O. Fernandez-Capetillo","doi":"10.1136/jnnp-2022-ehdn.237","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.237","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126873383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I09 A Huntington’s disease embryonic stem cell phenotypic hts to identify small molecule modulators of mutant huntingtin [09]一种亨廷顿氏病胚胎干细胞表型研究旨在鉴定突变亨廷顿蛋白的小分子调节剂
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.235
D. Todd, Marta Stebbeds, Emma Thatcher, A. Barnard, Jeremy Anton, Arnold R. Sienerth, M. Visser, Philip Mitchell, P. Breccia, David Smith, G. Mcallister, T. Haque, Longbin Liu, C. Dominguez, I. Muñoz-Sanjuán
{"title":"I09 A Huntington’s disease embryonic stem cell phenotypic hts to identify small molecule modulators of mutant huntingtin","authors":"D. Todd, Marta Stebbeds, Emma Thatcher, A. Barnard, Jeremy Anton, Arnold R. Sienerth, M. Visser, Philip Mitchell, P. Breccia, David Smith, G. Mcallister, T. Haque, Longbin Liu, C. Dominguez, I. Muñoz-Sanjuán","doi":"10.1136/jnnp-2022-ehdn.235","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.235","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128137654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I08 Passive immunization, with the anti-huntingtin aggregate antibody EM48, is beneficial in R6/2 mouse model I08被动免疫抗亨廷顿蛋白聚集抗体EM48对R6/2小鼠模型有益
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.234
G. Pepe, L. Capocci, F. Marracino, Clotilde Di Cicco, P. Scarselli, R. Parlato, A. D. Pardo, V. Maglione
{"title":"I08 Passive immunization, with the anti-huntingtin aggregate antibody EM48, is beneficial in R6/2 mouse model","authors":"G. Pepe, L. Capocci, F. Marracino, Clotilde Di Cicco, P. Scarselli, R. Parlato, A. D. Pardo, V. Maglione","doi":"10.1136/jnnp-2022-ehdn.234","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.234","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117162694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I02 Therapeutic effect of antisense oligonucleotide treatment in YAC128 Huntington mice I02反义寡核苷酸对YAC128小鼠的治疗作用
I: Experimental therapeutics – preclinical Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.228
E. Kuijper, M. Overzier, E. Suidgeest, L. Weerd, L. Toonen, W. V. Roon-Mom
{"title":"I02 Therapeutic effect of antisense oligonucleotide treatment in YAC128 Huntington mice","authors":"E. Kuijper, M. Overzier, E. Suidgeest, L. Weerd, L. Toonen, W. V. Roon-Mom","doi":"10.1136/jnnp-2022-ehdn.228","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.228","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129826765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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