Annals of Joint最新文献

{"title":"A narrative review of mesenchymal stem cells effect on osteoarthritis.","authors":"Cameron Joseph Shegos, Arooj Fatima Chaudhry","doi":"10.21037/aoj-21-16","DOIUrl":"10.21037/aoj-21-16","url":null,"abstract":"<p><strong>Objective: </strong>To describe and discuss the purposed mechanism of mesenchymal stem cells (MSCs) and their effect as a potential therapeutic in osteoarthritis (OA).</p><p><strong>Background: </strong>OA is a chronic, degenerative joint disease affecting millions worldwide. Traditional management, including physical therapy, anti-inflammatories, intra-articular injections, and surgical procedures are directed towards symptom control rather than disease modification. In light of a better understanding that low-grade inflammation disrupts articular cartilage homeostasis in OA, application of MSCs as a form of regenerative medicine has emerged with the goal to provide symptomatic relief as well as reverse the articular cartilage damage seen in OA.</p><p><strong>Methods: </strong>PubMed was searched using terms 'osteoarthritis', 'mesenchymal stem cell', 'regenerative medicine', 'chondrocyte', and 'articular cartilage' available from 2006 through May 2021.</p><p><strong>Conclusions: </strong>The use of MSC therapy for articular cartilage regeneration through direct tissue growth, differentiation, and inflammation modulations for the treatment of OA is promising. MSCs migrate to injured sites, inhibit pro-inflammatory pathways, and promote tissue repair by releasing paracrine signals and differentiating into specialized chondrocytes. Multiple clinical trials have displayed a significant improvement in both pain and joint function, inflammatory cell reduction within a joint, and articular cartilage growth as well as patient safety. However, high quality evidence supporting the beneficial role of MSCs is lacking due to the limited number of studies, small populations tested, and the use of various derivatives. Although limited, current evidence suggests MSCs are a potential therapeutic in OA and provides a great foundation for further research.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45509000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral meniscus allograft transplantation without bone plugs: technique and outcomes.","authors":"Tommaso Bonanzinga, Gian Luca Doro, Andrea Dorotei, Maurilio Marcacci","doi":"10.21037/aoj-20-108","DOIUrl":"10.21037/aoj-20-108","url":null,"abstract":"<p><p>Once considered a non-fundamental structure, the menisci are now known to provide several functions within the knee, including protection of articular cartilage, load-bearing, shock absorption, joint stability, joint lubrification and joint congruity functions. Meniscal tears are one of the most common lesions in knee orthopedics, and partial or total meniscectomies are commonly performed procedures in orthopedic surgery. Despite meniscectomy is well recognized to lead improvement in clinical outcomes, it has been related to early onset knee osteoarthritis and joint degeneration which are associated with pain and functional limitations. Meniscal allograft transplantation has become a viable option for patients under 55 years old that have undergone total or near total meniscectomy and are in a painful state. This procedure can be performed using bone plugs or without bone plugs. In the bone plugs free technique allograft will be presented as a lateral meniscus with a portion of tibial plateau and is then introduced into the joint through an arthroscopic portal and fixed to the capsule with all-inside stitches. The most important aspect required to obtain good clinical results are graft size, anatomic placement and fixation, because extrusion is the most common complication related to meniscal transplantation. Although a lack of long-term follow-up (FU) studies, it has been demonstrated that lateral meniscus transplantation without bone plugs is a minimal invasive surgical procedure that improves the knee function, increases patient physical activity and reduces pain.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45326505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanics of the lateral meniscus: evidences from narrative review.","authors":"Stefano Di Paolo, Alberto Grassi, Gian Andrea Lucidi, Luca Macchiarola, Giacomo Dal Fabbro, Stefano Zaffagnini","doi":"10.21037/aoj-20-123","DOIUrl":"10.21037/aoj-20-123","url":null,"abstract":"<p><p>Lateral meniscus plays a crucial role in the knee stability and function. Although complex settings are required for lateral meniscus biomechanical assessment, such characteristics have been investigated over time to optimize the daily clinical practice surgical procedure. The aim of the present study was to provide an overview of literature knowledge regarding the biomechanics of lateral meniscus and give further insights about novel experimental analyses. Studies regarding lateral meniscus mobility, effect on knee laxity, and contact mechanics were included in the review. The effect of meniscal lesion, meniscal repair, partial meniscectomy, and meniscus allograft transplantation were retrieved for either <i>in vivo</i>, cadaveric, or in-silico computational settings. Knee laxity was evaluated both in presence of isolated meniscal tears and in anterior cruciate ligament (ACL) deficient knees. Surgical navigation systems and robots were mainly used for the investigations <i>in vivo</i> and in cadaveric studies, while accelerometers emerged as an alternative for ambulatory assessments. Contact mechanics was only assessed in cadaveric and computational studies. Great effort has been put into exploring lateral meniscus biomechanics from multiple perspectives. Strong evidence emerged regarding the importance of lateral meniscus repair: increased knee stability at high degrees of knee flexion and reduction of peak contact pressures on tibial cartilage were the most reported benefits. The meniscus allograft transplantation also emerged as a concrete solution for irreparable tears and further studies are needed to investigate its long-term influence on knee stability.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47750942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral collagen meniscus implant (CMI): techniques and outcomes-a narrative review.","authors":"Alberto Grassi, Gian Andrea Lucidi, Piero Agostinone, Stefano di Paolo, Giacomo Dal Fabbro, Stefano Zaffagnini","doi":"10.21037/aoj-21-2","DOIUrl":"10.21037/aoj-21-2","url":null,"abstract":"<p><p>The menisci increase the stability of the tibio-femoral joint, distribute axial load, absorb shock, and provide nutrition and lubrification to the knee articular cartilage. Therefore, is it clear the importance of the meniscus on the overall knee function and the need to preserve it during arthroscopic surgery. However, according to many registry databases, meniscectomy is still the most performed meniscus surgery. In a percentage of patients, knee pain and swelling, as well as bone edema on the tibial plateau, could follow meniscus resection; this constellation of symptoms is known as \"post-meniscectomy syndrome\". If this syndrome is not promptly managed, a rapid worsening of the symptoms and develop of knee osteoarthritis could be expected. While dealing with such condition, the clinician must perform first an accurate clinical examination and a full radiological evaluation. If the patient is candidate for surgery, the replacement of the resected tissue should be performed: a meniscus allograft should be implanted in case of previous total meniscectomy or a meniscus scaffold if the patients has an history of a previous partial resection. The present article represents a comprehensive review of the literature and aims to discuss basic science, preoperative planning and evaluation, indication, surgical technique, and outcomes of the lateral collagen meniscus implant (CMI), a biologic scaffold aimed at replacing partial meniscal defects.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hypermobile and unstable lateral meniscus: a narrative review of the anatomy, biomechanics, diagnosis and treatment options.","authors":"Wouter Beel, Luca Macchiarola, Caroline Mouton, Lior Laver, Romain Seil","doi":"10.21037/aoj-21-9","DOIUrl":"10.21037/aoj-21-9","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this review is to improve the awareness of lateral meniscal hypermobility by describing its relevant anatomy, biomechanics, pathophysiology, imaging and arthroscopic findings as well as the treatment options.</p><p><strong>Background: </strong>The lateral meniscus is less stable than the medial meniscus. Its important posterior stabilizers are the popliteomeniscal fascicles, the posterior capsule, the meniscofemoral ligaments and the posterior meniscotibial ligament, which are divided by a bare area, the popliteal hiatus. Atraumatic insufficiency or rupture of one of these key structures may impact the mobility of the lateral meniscus and can lead to an unstable, hypermobile lateral meniscus. Lateral meniscus hypermobility can cause lateral knee pain and mechanical symptoms as locking. Ruptures of the popliteomeniscal fascicles are frequently associated with anterior cruciate ligament and posterolateral corner injuries. Their repair may be important to fully restore knee stability.</p><p><strong>Methods: </strong>This is a narrative overview of the literature synthesizing current knowledge about the hypermobile lateral meniscus. Anatomy, biomechanics, diagnosis and treatment of this entity was of particular interest for this review. Literature was retrieved from PubMed database, hand searches and cross-reference checking.</p><p><strong>Conclusions: </strong>Diagnosing lateral meniscus hypermobility is challenging since the magnetic resonance imaging are often unspecific and may show no structural alterations of the meniscus and its attachments. The only hint can be the patient's history and clinical symptoms (e.g., locking). Ultimately, the diagnosis is confirmed during knee arthroscopy, when the lateral meniscus can be mobilized over 50% of the lateral tibial plateau or lateral femoral condyle while anterior probing or by using the aspiration function during arthroscopy. Treatment includes stabilizing the posterior lateral meniscus by repairing the injured structures. Therefore, a systematic arthroscopic evaluation of the lateral compartment is important to fully recognize the problem. Repair can be achieved arthroscopically with various suturing techniques used for meniscal repair with satisfactory results and low recurrence rates.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46451947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic surgical treatment using CT-based rigidity analysis <i>vs.</i> after the fact fracture treatment of pathologic femoral lesions.","authors":"Kaitlyn DeHority, Tina Craig, Timothy A Damron","doi":"10.21037/aoj-20-92","DOIUrl":"10.21037/aoj-20-92","url":null,"abstract":"<p><strong>Background: </strong>Accurate comparison of prophylactic surgical treatment (PST) to after fracture treatment (AF) of patients with femoral metastatic disease requires more accurately identifying patients for impending fracture, such as with CT-based structural rigidity analysis (CTRA). This study compares a more accurately defined PST group (of impending fractures defined by CTRA) to AF for metastatic femoral disease.</p><p><strong>Methods: </strong>PST patients were enrolled and treated by the PI in a longitudinal multicenter study of impending pathologic fractures evaluated for accuracy by CTRA. The AF patients were also treated by the senior author and were identified by retrospective chart review. Fifty-five patients were treated surgically for metastatic femoral lesions and were divided into three groups for the purpose of this study: Group I (AF), Group II (PST-high), and Group III (PST-low). Demographic information, comorbidities, and clinical variables of interest were collected by retrospective chart review; cost data was collected by collaboration with our hospital financial personnel (office of the Chief Financial Officer).</p><p><strong>Results: </strong>Survival showed statistically significant differences favoring Group II. Transfusions in Group I were nearly twice those of Groups II and III, but there was no statistically significant (NS) difference between groups. Estimated blood loss (EBL) was generally with NS difference. Similarly, there were NS differences in LOS between groups. Discharge disposition showed statistically significant differences between groups (P=0.012, global). Discharge to home was highest in Group II (76%) and lowest in Group I (27%). Discharge to rehab was lowest in Group II (24%) and highest in Group I (47%). There were no discharges to hospice or morgue in Group II, while both occurred in Group I. Mean direct and total costs were highest in Group I ($18,837 and $31,997, respectively) and lowest in Group II ($16,094 and $27,357) but the differences were NS.</p><p><strong>Conclusions: </strong>This study shows benefits of PST over AF in a group of PST patients more accurately defined to have impending pathologic fractures by CTRA definition.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43409160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cemented-augmented fixation of metastatic humeral lesions without segmental bone loss results in reliable outcomes.","authors":"Joseph A Ippolito, Jennifer E Thomson, Valdis Lelkes, Kamil Amer, Francis R Patterson, Joseph Benevenia, Kathleen S Beebe","doi":"10.21037/aoj-20-114","DOIUrl":"10.21037/aoj-20-114","url":null,"abstract":"<p><strong>Background: </strong>Treatment of metastatic lesions to the humerus is dependent on patient's pain, lesion size and location, and post-operative functional goals. Surgical options include plate or nail fixation [open reduction internal fixation (ORIF)], or endoprosthetic replacement (EPR), with cement augmentation. The objective of this study was to perform a single institution retrospective analysis of outcomes by method of reconstruction, tumor volume, and pathologic diagnosis.</p><p><strong>Methods: </strong>The records of 229 consecutive patients treated surgically for appendicular metastatic disease from 2005-2018 at our musculoskeletal oncology center were retrospectively reviewed following institutional review board (IRB) approval. Indications for surgical treatment at the humerus included patients who presented with impending and displaced pathologic fractures.</p><p><strong>Results: </strong>Sixty patients (34 male, 26 female) with a mean age of 62.9±12.2 were identified who were treated surgically at the proximal (n=21), diaphyseal (n=29), or distal (n=10) humerus. Forty-nine (82%) patients presented with displaced pathologic fractures. The remaining eleven patients had a mean Mirels score of 9.5. There was no difference in overall complication rate between EPR or ORIF [4/36 (11%) versus 2/24 (8%); P=0.725]. Mean Musculoskeletal Tumor Society (MSTS) scores were 83% for both EPR and ORIF, with no differences in subgroup analyses at the proximal, diaphyseal, or distal humerus. Patients with cortical destruction on anterior posterior (AP) and lateral imaging were at increased risk for mechanical failure [2/6 (33%) versus 0/18 (0%), P=0.015].</p><p><strong>Conclusions: </strong>In conclusion, when pathologic pattern permits, cement-augmented fixation allows for stabilization of pathologic bone, while minimizing risk of soft-tissue detachment, while EPR resulted in similar outcomes in patients with more extensive bone destruction. Increased tumor volume was associated with lower MSTS scores.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45561846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular osteoid osteoma at the elbow mimicking arthritis: a case report.","authors":"Ryuichi Fukuda, Masatake Matsuoka, Daisuke Kawamura, Takeshi Endo, Hiromi Kanno-Okada, Atsushi Urita, Yuichiro Matsui, Tomohiro Onodera, Norimasa Iwasaki","doi":"10.21037/aoj-21-27","DOIUrl":"10.21037/aoj-21-27","url":null,"abstract":"<p><p>Osteoid osteomas are benign, typically intracortical lesions most often affecting the diaphysis of long bones. Nocturnal pain and characteristic symptoms that are relieved by administration of non-steroidal anti-inflammatory drugs (NSAIDs) are present and can help in the diagnosis of osteoid osteoma. We report a case of 18-year-old boy with an osteoid osteoma in the olecranon fossa with an atypical clinical manifestation. The initial manifestation was arthritis-like symptoms such as local heat, motion pain rather than pain at rest, and limited range-of-motion. Notably, NSAIDs were not effective at all for relieving his symptoms. Magnetic resonance imaging showed bone marrow edema around the elbow joint. The symptoms were resistant to conservative treatments, and thus, surgical resection was required. Histopathological examination showed that the lesion consisted of woven bones and osteoid tissues that anastomosed with each other. Combined with a tumor size that was less than 2 cm, clinicopathologically, the tumor was diagnosed as an osteoid osteoma. The pain was immediately relieved after the operation, and range-of-motion recovered at 2 months postoperatively. At 1 year after the surgery, the patient did not exhibit recurrence of the tumor or exacerbation of elbow pain and had a full range of elbow motion. Osteoid osteoma should be considered for the differential diagnosis of arthritis of the elbow in patients who are adolescents and young adults, which is the peak age of onset for osteoid osteoma.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44100102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of lateral meniscus root tears and extrusion: techniques and outcomes.","authors":"Yusuke Nakagawa, Nobutake Ozeki, Hideyuki Koga","doi":"10.21037/aoj-20-112","DOIUrl":"10.21037/aoj-20-112","url":null,"abstract":"<p><strong>Objective: </strong>In this review, we performed a literature search and described the surgical procedure for a lateral meniscus posterior root tears (LMPRT) repair using a pull-out technique and an arthroscopic centralization for lateral meniscus (LM) extrusion.</p><p><strong>Background: </strong>The menisci play a pivotal role in the shock-absorbing and load-dispersing functions of the knee joint. They also contribute to its stability. Meniscal root tears substantially affect meniscal hoop function and accelerate cartilage degeneration. Additionally, LMPRT have been shown to affect anterolateral knee laxity and tibiofemoral contact pressure in knees with anterior cruciate ligament (ACL) injury. Therefore, appropriate management of LMPRT is essential for restoring knee function. Meniscus extrusion has attracted attention due to its association with early osteoarthritis (OA). Recently, an arthroscopic centralization technique has been proposed to reduce meniscal extrusion. During this procedure the capsule attached to the meniscus is sutured to the edge of the tibial plateau using suture anchors.</p><p><strong>Methods: </strong>A narrative review of LMPRT repair and arthroscopic centralization of lateral meniscal extrusion was performed through a PubMed search.</p><p><strong>Conclusions: </strong>Specific magnetic resonance imaging (MRI) signs were useful for the diagnosis of LMPRT. Pull-out techniques can restore knee stability and load distribution function and result in favorable clinical outcomes. Arthroscopic centralization of the extruded LM caused by meniscectomy and lateral discoid meniscus achieved satisfactory clinical outcomes at the 2-year follow-up. Biomechanical studies demonstrated that this procedure reduced meniscus extrusion and had beneficial effects on load distribution and joint stability. In summary, to restore knee function, LMPRT should be repaired as much as possible. The centralization technique is a promising surgical treatment for extruded lateral menisci due to meniscectomy and discoid meniscus. However, due to the lack of high-level evidence studies such as randomized control trials (RCTs) in this field, it remains necessary to accumulate evidence to confirm the efficacy of LMPRT repair and the centralization technique.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45152101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomy of lateral meniscus.","authors":"Simone Perelli, Rodolfo Morales Avalos, Angel Masferrer-Pino, Juan Carlos Monllau","doi":"10.21037/aoj-20-118","DOIUrl":"10.21037/aoj-20-118","url":null,"abstract":"<p><p>The anatomy of the lateral meniscus underlies the understanding of its unique biomechanics. Moreover, the knowledge of its microscopic structure, its vascularization and its ligament insertions can make us understand the rationale for its surgical treatment. It is well known as the respect of the anatomy leads to better results in reconstructive surgery. Knowing the differences in the shape and in the areas of insertion of the meniscal roots can be useful in case of reinserting a root or when performing a meniscal transplant. Learning about the capsular insertions, the anchoring ligaments and the areas of greatest mobility of the lateral meniscus is useful during meniscal repair and replacement surgery. This information can let us choose the most appropriate technique and the best device to face any kind of meniscal lesion. In this article, we will consider both the micro and the macro meniscal structure in order to be able to give a description as complete as possible of this fundamental structure. We will consider the interrelation of the meniscus with the neighboring anatomical structures with which it contributes to the biomechanical control of the joint. It is important to understand the interrelation with both anterior and posterior cruciate ligament (PCL) given that frequently a combined meniscal and ligamentous reconstruction is necessary.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42690026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}