Journal of IMAB最新文献_第3页

EFFECT OF SAHA AND C-JUN N-TERMINAL KINASE INHIBITOR ON THE INDUCIBLE MRNA EXPRESSION OF INTERLEUKIN-17 saha和c-jun n末端激酶抑制剂对白细胞介素-17诱导mrna表达的影响

Journal of IMAB Pub Date : 2023-09-19 DOI: 10.5272/jimab.2023293.5108

Boncho Grigorov, Magdalena Platikanova, Zlatka Dobreva, Antonia Grigorova, Spaska Stanilova

{"title":"EFFECT OF SAHA AND C-JUN N-TERMINAL KINASE INHIBITOR ON THE INDUCIBLE MRNA EXPRESSION OF INTERLEUKIN-17","authors":"Boncho Grigorov, Magdalena Platikanova, Zlatka Dobreva, Antonia Grigorova, Spaska Stanilova","doi":"10.5272/jimab.2023293.5108","DOIUrl":"https://doi.org/10.5272/jimab.2023293.5108","url":null,"abstract":"Interleukin-17 (IL-17A) is a critical cytokine for immune defence against extracellular bacterial and fungal infections. Excess production during chronic inflammation has been associated with many inflammatory and autoimmune disorders. On the other hand, the inducible expression of many cytokine genes is regulated by the receptor-activated intracellular signaling pathways, including the JNK pathway, and different epigenetic mechanisms, including histone deacetylation by HDACs. We investigated the comparative effect of the HDACs inhibitor Suberoylanilide Hydroxamic Acid (SAHA) and an inhibitor of the JNK signaling pathway in the regulation of the inducible IL-17 expression at the mRNA level in PBMCs from healthy donors. For the detection of IL-17 mRNA transcripts was used qRT-PCR. We detected significantly increased levels of IL-17mRNA under the stimulation of the PBMC cultures with lipopolysaccharide (LPS) or C3 binding glycoprotein (C3bgp) in the presence of an inhibitor of the JNK transduction pathway. The inhibition of the JNK signaling pathway leads to the upregulation of the expression of IL-17mRNA. SAHA did not demonstrate a significant effect on the IL-17mRNA transcription compared to the inhibitor of the JNK pathway. In conclusion, we suppose that the synthesis of IL-17 mRNA is regulated by both the JNK transduction pathway and HDAC activity, but with different effects.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135014472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APPLICATION OF PLATELET-RICH PLASMA (PRP) FOR REGENERATION OF VERTICAL BONE DEFECTS 富血小板血浆(prp)在垂直骨缺损再生中的应用

Journal of IMAB Pub Date : 2023-09-18 DOI: 10.5272/jimab.2023293.5103

Tsvetalina Gerova-Vatsova, Stefan Peev

{"title":"APPLICATION OF PLATELET-RICH PLASMA (PRP) FOR REGENERATION OF VERTICAL BONE DEFECTS","authors":"Tsvetalina Gerova-Vatsova, Stefan Peev","doi":"10.5272/jimab.2023293.5103","DOIUrl":"https://doi.org/10.5272/jimab.2023293.5103","url":null,"abstract":"In recent years, there has been a sharp increase in the number of chronic periodontal diseases. The problem of their widespread distribution and the need for their treatment is one of the priorities of modern dentistry. Periodontal bone defects are the result of chronic periodontitis if timely measures are not taken to stop the inflammatory process. The goal of periodontal treatment is to remove all deposits of supra- and subgingival dental plaque and calculus (containing periodontopathogens) and their plaque-retentive factors and to promote complete regeneration of the tooth-supporting structures lost up to that point. Until now, autogenous, platelet-rich plasma has been widely used in various fields of medicine. Because of the equivalent results obtained and the lower cost, in dentistry, autogenous platelet-rich plasma is increasingly the preferred material over others that have proven to be reliable over time. Summarizing the results of various authors who used autogenous platelet-rich plasma alone or in combination with other materials for the purpose of regeneration of vertical bone defects, it is clear that PRP significantly accelerates the restorative and regenerative processes in the periodontium.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135153797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COMPARATIVE ANALYSIS OF PANDEMICS HIV/AIDS AND COVID-19 大流行艾滋病毒/艾滋病与COVID-19的比较分析

Journal of IMAB Pub Date : 2023-09-12 DOI: 10.5272/jimab.2023293.5094

Mariyana Stoycheva, Nikolay Vatev, Milena Karcheva

{"title":"COMPARATIVE ANALYSIS OF PANDEMICS HIV/AIDS AND COVID-19","authors":"Mariyana Stoycheva, Nikolay Vatev, Milena Karcheva","doi":"10.5272/jimab.2023293.5094","DOIUrl":"https://doi.org/10.5272/jimab.2023293.5094","url":null,"abstract":"During recent four decades, the world has faced two horrific, deadly pandemics. In the background of the ongoing pandemic HIV/AIDS, the people were affected with the newly emerging Corona virus SARS-CoV-2, that rapidly turned into pandemic dimensions. There are data that, in various aspects, HIV infection was similar to SARS-CoV-2. The purpose of this review was to search for similarities and differences between both pandemics in view to use the experience of the past and knowledge we have acquired in order to better overcome current and future pandemics. Material/Methods: The iterature used is based on databases PubMed, Embase and random search on the Internet with the keywords COVID-19 and HIV, as well the Boolean operator \"AND\" to achieve a search of \"COVID-19 and HIV\". Review Results: In the present review summary, we provide data for similarities and differences regarding virological, immunologic, clinical and pharmacological aspects of HIV and SARS-CoV-2 infections and associated with them pandemics. Conclusion: SARS-CoV-2 was here and will remain here. COVID-19 is not the last pandemic, and people should be prepared for new encounters with agents of high virulence and pandemic potential.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"524 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135830268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-6, D-DIMER AND HIGH-SENSITIVITY C-REACTIVE PROTEIN IN HIV INFECTION – PRELIMINARY STUDY Il-6、d -二聚体和高敏c反应蛋白在HIV感染中的初步研究

Journal of IMAB Pub Date : 2023-09-12 DOI: 10.5272/jimab.2023293.5099

Ivaylo Pakov, Adelaida Ruseva, Irena Gencheva, Tsetsa Doichinova, Milena Karcheva, Kalina Terzieva, Lyudmila Pakova, Biserka Vasileva, Galya Gancheva

{"title":"IL-6, D-DIMER AND HIGH-SENSITIVITY C-REACTIVE PROTEIN IN HIV INFECTION – PRELIMINARY STUDY","authors":"Ivaylo Pakov, Adelaida Ruseva, Irena Gencheva, Tsetsa Doichinova, Milena Karcheva, Kalina Terzieva, Lyudmila Pakova, Biserka Vasileva, Galya Gancheva","doi":"10.5272/jimab.2023293.5099","DOIUrl":"https://doi.org/10.5272/jimab.2023293.5099","url":null,"abstract":"Combined antiretroviral therapy (cART) provides HIV-infected people life expectancy comparable with HIV-uninfected people and turns the disease into a manageable chronic condition necessitating the need for innovative inflammatory markers. Our purpose was to determine the correlation between IL-6, D-dimer and high-sensitivity C-reactive protein (hsCRP) levels among HIV-infected and the presence of chronic inflammation during general and immunological aging and drug exposure. Material and methods: Comparative prospective study was conducted at 37 HIV-positive persons from the Center for Monitoring and Treatment of HIV-positive Patients at the Clinic for Infectious Diseases, UMBAL “Dr. G. Stranski” – Pleven (target group) and 18 HIV-negative individuals from outpatient practice (control group), aged ≥18 years. Results: The median age of seropositive persons was 40 years (24÷70 years), of the control group – 51 years (29÷72 years); 78% of the target group and 61% of the controls are men. The average duration of ART is 4 years (1÷9 years). The study of specified biomarkers in the target group found increased IL-6 in 8.11% of patients (mean 3.67±1.86 pg/mL; range 1.5÷8.62; 95% CI 3.11-5.02), increased D-dimer in 8.11% (mean 0.37±0.28 µg/mL; 0.21÷1.96; 95% CI 0.3691-0.37459) and increased hsCRP in 10.81% (mean 2.10±1.99 µg/mL; 0.19÷7.0; 95% CI 1.89-2.31). In the control group IL-6 was not increased (mean 2.75±1.67 pg/mL; 1.5÷6.91), D-dimer was increased in 16.67% (mean 0.37±0.17 µg/mL; 0.09÷0.8) and increased hsCRP – in 5.56% (mean 1.76±1.75 µg/mL; 0.19÷5.66). Il-6 was significantly higher in the target group. Conclusion: The implementation of sensitive biomarkers is crucial in the general diagnostic-therapeutic approach in aging with HIV.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASSESSMENT OF THE SITUATION DURING PAIN BY PATIENTS WITH CHRONIC PAIN 慢性疼痛患者疼痛时的情况评估

Journal of IMAB Pub Date : 2023-09-11 DOI: 10.5272/jimab.2023293.5089

Tatyana Telbizova, Svetlin Varbanov

{"title":"ASSESSMENT OF THE SITUATION DURING PAIN BY PATIENTS WITH CHRONIC PAIN","authors":"Tatyana Telbizova, Svetlin Varbanov","doi":"10.5272/jimab.2023293.5089","DOIUrl":"https://doi.org/10.5272/jimab.2023293.5089","url":null,"abstract":"The way a person perceives and interprets the situation during pain provokes a variety of emotional and behavioral responses. Aim: The aim of the study was to analyze the assessment of the situation during pain by patients with chronic pain. Materials and methods: A sample of 120 patients with chronic pain was studied. Sixty-one of them had clinically manifested symptoms of depression, and fifty-nine had no depression. The patients were evaluated using the following scales: HAM-D-17, Spielberger questionnaire – STAI – form Y1 and form Y2 and VAS. A model of four situations was applied to assess the situation during pain: unique, risky, routine and situation of uncertainty. Results: The mean age of the sample was 51.90±11.94. Women predominate (81.7%) over men (18.3%). The group with depression had moderate severity of depression and pain intensity and high state and trait anxiety. A majority of them (48.4%) assessed the situation during pain as a risk and/or an uncertainty. The group without depression had moderate state and trait anxiety and mild pain intensity. More than half of them (62.7%) assessed the situation as routine. Conclusion: Depression and anxiety affect the perceived situation during pain. Assessing and understanding the specific links between them is essential for forming adaptive ways of coping with chronic pain.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135982424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METHOD OF DELIVERY IN MULTIPLE PREGNANCY 多胎妊娠的分娩方法

Journal of IMAB Pub Date : 2023-09-08 DOI: 10.5272/jimab.2023293.5085

Svilen Lazarov, Nikolay Lazaro

引用次数: 0

TUMEFACTIVE MULTIPLE SCLEROSIS: A DIAGNOSTIC ENIGMA. A CASE REPORT 肿瘤性多发性硬化症:一个诊断难题。病例报告

Journal of IMAB Pub Date : 2023-06-05 DOI: 10.5272/jimab.2023292.4943

Magdalina Yanakieva, Maya Danovska, Emilia Ovcharova, Diana Marinova, Nicholas Shepherd

{"title":"TUMEFACTIVE MULTIPLE SCLEROSIS: A DIAGNOSTIC ENIGMA. A CASE REPORT","authors":"Magdalina Yanakieva, Maya Danovska, Emilia Ovcharova, Diana Marinova, Nicholas Shepherd","doi":"10.5272/jimab.2023292.4943","DOIUrl":"https://doi.org/10.5272/jimab.2023292.4943","url":null,"abstract":"Purpose: To present a clinical case of tumefactive multiple sclerosis (TMS), which is an inflammatory demyelinating disease of the central nervous system considered to be a rare form of multiple sclerosis (MS). It belongs to the group of borderline forms of MS – a collective term used to define a spectrum of demyelination-associated neurological conditions that share similar clinical, neuroimaging and histopathological features but vary widely in severity, clinical course and outcome. Materials/Methods: We describe the case of a 31-year-old female who was admitted to the Neurology clinic of UMHAT “Dr Georgi Stranski” in Pleven, Bulgaria, with a rapid onset of neurological deficit including right-sided hemiparesis, dysarthria, imbalance, cognitive impairment and urinary incontinence. MRI of the brain showed several tumor-like concentric lesions of demyelination surrounded by moderate brain edema, consistent with the radiological criteria for the demyelinating disease. Results: High-dosage corticosteroids were applied intravenously for this patient as acute therapy. A progressive improvement in the patient was achieved after the extended pulse corticosteroid therapy in combination with physiotherapy. Glatiramer acetate as a disease-modifying treatment was initiated within three months and had substantial efficacy. Conclusions: The diagnosis of TMS is always difficult and requires not only complex clinical and neuroimaging investigations but also an extensive follow-up of the patient. It is believed that TMS usually has a progressive course and an unfavorable outcome, but a relapsing-remitting course of TMS, albeit rare, is also possible. Our case report confirms that such benign variants of TMS exist. We believe that highlighting such complex clinical cases will contribute to a better understanding of the mystery of MS.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135658755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WATER SORPTION AND WATER SOLUBILITY OF 3D PRINTED AND CONVENTIONAL PMMA DENTURE BASE POLYMERS 3d打印和传统pmma义齿基托聚合物的吸水性和水溶性

Journal of IMAB Pub Date : 2023-05-30 DOI: 10.5272/jimab.2023292.4939

Mariya Dimitrova, Angelina Vlahova, Rada Kazakova, Bozhana Chuchulska, Magdalina Urumova

{"title":"WATER SORPTION AND WATER SOLUBILITY OF 3D PRINTED AND CONVENTIONAL PMMA DENTURE BASE POLYMERS","authors":"Mariya Dimitrova, Angelina Vlahova, Rada Kazakova, Bozhana Chuchulska, Magdalina Urumova","doi":"10.5272/jimab.2023292.4939","DOIUrl":"https://doi.org/10.5272/jimab.2023292.4939","url":null,"abstract":"Background: Patients who cannot afford more expensive prosthetic restorations, such as implant-supported fixed prostheses, prefer removable dentures. Removable dentures have been manufactured with different types of acrylics, including conventional polymer polymethyl methacrylate (PMMA) and the popular nowadays three–dimensional(3D) printed resins. Water sorption and water solubility often occur because these prosthetic restorations are constantly immersed in saliva and always have interactions with oral fluids. Review results: Alternating processes of imbibition and drying of acrylics lead to internal stresses and fatigue. As a result, dental resins undergo significant dimensional changes. The water diffuses into the dental resin and inflicts a gradual expansion and volume increase, which may cause aging of the material and discomfort during masticatory function. Denture base resins have low water solubility, which results from the leaching out of unreacted monomer and soluble additives into the oral cavity. This is an undesired property and may cause soft tissue reactions. Conclusion: The affinity of dental resins for water degrades their mechanical and physical properties and causes dimensional changes in the denture base, which results in internal stresses that have a negative impact on the denture's long-term success.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135643360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SUPPLEMENT 12 SEEC & 32 IMAB, Section Dental Medicine 附录12 SEEC &32 IMAB，口腔医学科

Journal of IMAB Pub Date : 2023-03-20 DOI: 10.5272/jimab.2022supplement2

引用次数: 0

SUPPLEMENT 12 SEEC & 32 IMAB, Section Varia 附录12 SEEC &32 IMAB, Varia分部

Journal of IMAB Pub Date : 2023-03-20 DOI: 10.5272/jimab.2022supplement3

引用次数: 0