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Skin Penetration Ability of 12 Hyaluronic Acids with Different Molecular Weights After Topical Application 12 种不同分子量的透明质酸局部使用后的皮肤渗透能力
JOJ Dermatology & Cosmetics Pub Date : 2023-07-19 DOI: 10.19080/jojdc.2023.05.555665
Silvana Giardina
{"title":"Skin Penetration Ability of 12 Hyaluronic Acids with Different Molecular Weights After Topical Application","authors":"Silvana Giardina","doi":"10.19080/jojdc.2023.05.555665","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555665","url":null,"abstract":"Objective: Hyaluronic acid (HA) is a fundamental component of the extracellular matrix, regulating numerous biological processes. In humans, almost half of the total HA concentrates in the skin, but its availability decreases with age. Therefore, topical exogenous supplies of HA can reduce the aging process of the skin and can represent a valid alternative to the costly and invasive treatments based on injectable HA-based fillers. However, for cosmetically effective topical preparations, it is crucial to determine the properties favouring percutaneous HA penetration, such as HA molecular weight (MW). Therefore, the ability of 12 HA molecules with different MWs to penetrate the skin using an in vitro model was examined. Materials and Methods: The Franz diffusion cell experimental system was used to estimate the penetration of the HA molecules across three epidermal tissues. The relationship between MW and penetration was inspected by applying a Pearson’s correlation test.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139357826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Series of Clinical Cases of Psychocutaneous Disorders in a Dermatology Unit in Albania 阿尔巴尼亚皮肤科的一系列精神皮肤疾病的临床病例
JOJ Dermatology & Cosmetics Pub Date : 2023-04-18 DOI: 10.19080/jojdc.2023.05.555664
Sabina D
{"title":"A Series of Clinical Cases of Psychocutaneous Disorders in a Dermatology Unit in Albania","authors":"Sabina D","doi":"10.19080/jojdc.2023.05.555664","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555664","url":null,"abstract":"This study aims to represent our clinical experience with several psychocutaneous disorders, such as trichotillomania, neurotic excoriation, dermatitis artefacta, and parasitic delusion. Lightening the human mind’s way of function has always been a challenge and has attracted medical interest through the years. Psychodermatology has recently received attention because different mechanisms of psychoneuroimmunology are being explored. They can successfully explain different clinical presentations and drug therapy. Awareness, recognizing important risk factors (suicide, serious self-harm, other people harm, child abuse, and neglect), associated psychiatric diagnoses, adequate screening, seeking a specialized referral, and reasonable security measures should be on focus. The proper management needs a multidisciplinary team, including the dermatologist, the psychiatrist, the family physician, and the social support.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122484095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel PTCH1 Mutation in Patient with Gorlin-Goltz Syndrome and its Management, A Case Report Gorlin-Goltz综合征患者一种新的PTCH1突变及其治疗，1例报告
JOJ Dermatology & Cosmetics Pub Date : 2023-04-04 DOI: 10.19080/jojdc.2023.05.555663
V. Panasiti
{"title":"A Novel PTCH1 Mutation in Patient with Gorlin-Goltz Syndrome and its Management, A Case Report","authors":"V. Panasiti","doi":"10.19080/jojdc.2023.05.555663","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555663","url":null,"abstract":"Gorlin-Goltz syndrome (GS), also known as nevoid basal cell carcinoma syndrome or basal cell naevus syndrome, is a rare autosomal dominant hereditary disease characterized by systemic and diverse developmental abnormalities and neoplastic lesions [1]. Patients with Gorlin-Goltz syndrome develop commonly multiple odontogenic keratocysts around the age of 20, and basal cell carcinomas (BCCs) especially in middle-aged patients. The diagnosis of GS is based on clinical, radiological, and genetic elements. The criteria reported by Kimonis et al. [2] are the most used. This method includes six major criteria: basal cell carcinoma, palmar plantar small depression, jaw bone cyst, rib abnormalities, calcified falx cerebri, and family history of the disease within the first degree; and six minor criteria: macrocephaly, ovarian fibromas, congenital malformation, skeletal abnormalities, X-ray abnormalities, and medulloblastomas. Follow these criteria, we can make a diagnosis when the patient presents two major criteria, or one major and two minor criteria [2]. The confirm of the diagnosis is related to gene mutation analysis. So genetic counseling is mandatory after genetic diagnosis.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"187 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133162994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Presentation of Metastatic Hepatocellular Carcinoma to The Finger, Case report and Review of the literature 罕见的肝细胞癌转移至手指，病例报告及文献复习
JOJ Dermatology & Cosmetics Pub Date : 2023-03-30 DOI: 10.19080/jojdc.2023.05.555662
A. Gabra
{"title":"Rare Presentation of Metastatic Hepatocellular Carcinoma to The Finger, Case report and Review of the literature","authors":"A. Gabra","doi":"10.19080/jojdc.2023.05.555662","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555662","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a primary tumor of the liver that develops in the setting of chronic liver disease. HCC is difficult to diagnosis due to it requiring the use of multiple imaging modalities with the goal to detect tumors when they are less than or equal to 2 cm in size to allow all possible treatment options to be used. Herein, we discuss a 69-year-old male with stage IV liver cancer residing in hospice presenting with left middle finger osteomyelitis and extreme pain. Radiology revealed a destructive lesion, but pathology provided the diagnosis of metastatic hepatocellular carcinoma in his finger. Even though HCC can be diagnosed on imaging alone, this case highlights the need for biopsy to provide an accurate diagnosis","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130861076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Region Myomodulation and Skin Rejuvenation With Polydioxanone Threads and Hyaluronic Acid Filler: Cross-Filler Technique 用聚二氧环酮线和透明质酸填充剂调节口腔肌肉和皮肤年轻化:交叉填充技术
JOJ Dermatology & Cosmetics Pub Date : 2023-03-23 DOI: 10.19080/jojdc.2023.05.555661
Maria Clara Almeida Issa
{"title":"Oral Region Myomodulation and Skin Rejuvenation With Polydioxanone Threads and Hyaluronic Acid Filler: Cross-Filler Technique","authors":"Maria Clara Almeida Issa","doi":"10.19080/jojdc.2023.05.555661","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555661","url":null,"abstract":"The facial aging process is progressive, and rejuvenation of the oral region is challenging, as the skin alterations also reflect the changes in the fat, muscles, ligaments, and bone. Therefore, the procedures for improving this region must be combined to optimize the result. The use of polydioxanone (PDO) threads has been increasing in cosmetic dermatology in the last few years. Different types of threads, barbed, molded, non-barbed, straight, screwed, filler, etc., are available in the market bringing new options for treatment. Here, we want to present a new technique using a particular type of PDO thread, called solid filler thread, which was developed to fill folds in the face, replacing hyaluronic acid (HA) gel in some cases. Based on its purpose, it could also act as HA filler for myomodulation with the advantage of not promoting volume next to modiolus. In our technique, we associated HA filler gel in the areas where volume was desired, such as lips and mental area. We will report some cases to illustrate our technique and show the improvement in static and dynamic wrinkles, restructuring the oral region.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127059536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air Pollution, Cigarette Smoking, Diet, and Acne: Do Environmental and Habitual Factors Affect Acne? 空气污染、吸烟、饮食和痤疮:环境和习惯因素会影响痤疮吗?
JOJ Dermatology & Cosmetics Pub Date : 2023-02-16 DOI: 10.19080/jojdc.2023.05.555659
Serap Maden
{"title":"Air Pollution, Cigarette Smoking, Diet, and Acne: Do Environmental and Habitual Factors Affect Acne?","authors":"Serap Maden","doi":"10.19080/jojdc.2023.05.555659","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555659","url":null,"abstract":"Acne vulgaris is a common skin condition that is mostly seen in young adults. It has always been an enigma for physicians and patients if diet or environmental factors are responsible for developing acne. This article presents the relationship between air pollution, cigarette smoking, dietary factors and acne through the pathogenesis of acne.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"198 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121850550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Lupus Erythematosus: An Overview of Clinical Manifestations 皮肤红斑狼疮:临床表现综述
JOJ Dermatology & Cosmetics Pub Date : 2023-02-15 DOI: 10.19080/jojdc.2023.05.555658
Laura Sofia Trivino
{"title":"Cutaneous Lupus Erythematosus: An Overview of Clinical Manifestations","authors":"Laura Sofia Trivino","doi":"10.19080/jojdc.2023.05.555658","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555658","url":null,"abstract":"Cutaneous lupus erythematosus (CLE) is one of the four main types of lupus, a well-known chronic inflammatory autoimmune disease. Subtypes are currently grouped based on histology, duration, clinical findings, and laboratory tests. Lupus erythematosus is a connective tissue disease with a complex involvement of immunologic, genetic, and environmental factors. Although the etiology is poorly understood, insights elucidate the importance of disrupting hemostasis from the immunoregulatory disarray, immunologic tolerance, complement system, and development of autoantibodies","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125007183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Biologic Therapies in the Management of Psoriatic Arthritis: An Overview 银屑病关节炎的新生物疗法:综述
JOJ Dermatology & Cosmetics Pub Date : 2023-01-27 DOI: 10.19080/jojdc.2023.05.555657
Maria Isabel Gomez Coral
{"title":"New Biologic Therapies in the Management of Psoriatic Arthritis: An Overview","authors":"Maria Isabel Gomez Coral","doi":"10.19080/jojdc.2023.05.555657","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555657","url":null,"abstract":"Psoriatic arthritis is an inflammatory musculoskeletal condition that represents a major cause of physical and psychological disability. This disorder represents a significant diagnostic and management challenge, given that it has different forms of clinical presentation, associated comorbidities, and high rates of therapeutic resistance. Early diagnosis is of crucial importance in impacting the prognosis of the disease. Typical treatment includes the administration of non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and the use of biological medicines. Currently, multiple biological therapies have proven to be advantageous in managing psoriatic arthritis, but they have not been fully approved for use in routine clinical practice. Therefore, in this article, we aim to provide an overview of the role of new biological therapies for the management of psoriatic arthritis.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126645043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequential Therapy of Common and Plantar Warts with Salicylic Acid after Cryotherapy Versus Cryotherapy Alone: A CaseControl Study in 42 Subjects 冷冻治疗后水杨酸序贯治疗普通疣和足底疣与单独冷冻治疗:42名受试者的病例对照研究
JOJ Dermatology & Cosmetics Pub Date : 2022-09-14 DOI: 10.19080/jojdc.2022.04.555646
M. M
{"title":"Sequential Therapy of Common and Plantar Warts with Salicylic Acid after Cryotherapy Versus Cryotherapy Alone: A CaseControl Study in 42 Subjects","authors":"M. M","doi":"10.19080/jojdc.2022.04.555646","DOIUrl":"https://doi.org/10.19080/jojdc.2022.04.555646","url":null,"abstract":"Background: Common wart (CW; Verruca vulgaris) is a benign cutaneous virus infection caused by human papilloma virus commonly located in the palmar and plantar regions. Warts, especially located at pressure points, could be painful, but in general they are asymptomatic. Treatment is not always necessary but when multiple lesions, pain, immunosuppression and discomfort are present therapeutic intervention could be mandatory. Chemical or physical destructions are commonly used for the treatment of CW. Cryotherapy with liquid nitrogen is a common clinician-administered treatment. The most relevant drawbacks of this procedure are the pain associated with treatment, the need of several sessions and the recurrence of new lesion. Salicylic acid (SA) applied under tape occlusion is a convenient, effective, and safe therapy of CW, even if no effective as cryotherapy. So far, there are few data regarding the efficacy and safety of the sequential treatment of CW with cryotherapy followed by a 10-day treatment course with SA. Study Design: We evaluated in a case-control study the clinical efficacy of cryotherapy alone and cryotherapy with SA in adult immunocompetent subjects with common or plantar warts.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127838146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review on Leishmaniasis: A Neglected Global Disease 利什曼病:一种被忽视的全球性疾病
JOJ Dermatology & Cosmetics Pub Date : 2022-08-12 DOI: 10.19080/jojdc.2022.04.555644
Razi S
{"title":"Review on Leishmaniasis: A Neglected Global Disease","authors":"Razi S","doi":"10.19080/jojdc.2022.04.555644","DOIUrl":"https://doi.org/10.19080/jojdc.2022.04.555644","url":null,"abstract":"As per World Health Organization, Leishmaniasis is a neglected, tropical disease. It is initiated by intracellular transmission of a parasite to humans, by sand fly bite. Factors like population variability, climate change etc. lead to the expansion of this disease. This article provides review of epidemiology and management of leishmaniasis i.e., cutaneous, mucosal, and visceral. Literature was studied by systematic exploration in PubMed including various articles from 2012-2022 without setting any exclusion criteria. There have been reports of development of strains, resistant to traditional therapy of leishmaniasi, along with simultaneous infections like HIV/Leishmania spp., and other targeted pharmaceutical resources i.e., amphotericin B and formulations, miltefosine, pentavalent antimonials. Since long, only few drugs are available for the management of the disease, having adverse effects and toxicity due to which the treatment control program is put in check globally. New strategies are required to manage this neglected disease adequately.","PeriodicalId":443925,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133256432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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