Sabuncuoglu Serefeddin Health Sciences最新文献

{"title":"Trends in Vertebral Augmentation Practice for Osteoporotic Vertebral Fracture","authors":"Ahmet Gökyar","doi":"10.55895/sshs.1398464","DOIUrl":"https://doi.org/10.55895/sshs.1398464","url":null,"abstract":"Osteoporosis is characterized by low bone mass, primarily affecting older individuals and a common complication is vertebral fractures. The collapse-induced height loss in vertebrae can result in spinal instability and progressive kyphotic deformity. Surgical intervention for osteoporotic vertebrae poses challenges due to poor bone quality and frequent medical comorbidities. In recent years, it has become the predominant method for vertebral augmentation in acute fractures, aiming to relieve pain, strengthen the vertebral structure, and prevent deformities by restoring height. These procedures involve percutaneous placement of cannulas into each collapsed vertebral body through a unipedicular or bipedicular approach. Novel products are emerging to strengthen vertebrae in treating osteoporotic compression fractures. Balloon kyphoplasty and vertebroplasty are widely accepted and recognized as effective vertebral augmentation methods. Treatment guidelines are evolving with the introduction of innovative systems like Vertebral Body Stenting, Titanium Mesh, and Sky Bone Expander, claiming to achieve exceptional vertebral height restoration. Controversies persist regarding the optimal timing for vertebral augmentation post-fracture. Polymethylmethacrylate cement is extensively used to stabilize fractured vertebral bodies. Additionally, new calcium phosphate-based nanocomposite cements are gaining prominence. These advancements underscore the ongoing development in the treatment of osteoporotic vertebral compression fractures. Each innovative implant introduces unique features and indications. Precise confirmation of the source of the painful fracture is crucial for effective and safe treatment, ensuring proper timing and indication.","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"19 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139145973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL ASSESSMENT OF PEDIATRIC BURNS: A RETROSPECTIVE STUDY","authors":"Ezgi GÜN SOYTÜRK, Ümmühan Kiliç, M. Oruç","doi":"10.55895/sshs.1404349","DOIUrl":"https://doi.org/10.55895/sshs.1404349","url":null,"abstract":"Burn injuries represent a significant aspect of pediatric traumas, particularly prevalent during early childhood, involving a critical patient population characterized by elevated mortality and morbidity rates. This study explores burn incidents in children aged 0-6 years admitted to the Burn Unit of a tertiary hospital between January 1, 2016, and June 20, 2023, within the context of the existing literature. Additionally, it conducts an analysis of burn etiology, distribution, severity, and treatment interventions, categorizing a sample of 241 pediatric burn patients, predominantly within the 0-18 month age range. Children are categorized into three groups based on Sigmund Freud's \"psychosexual development stages\": 0-18 months, 18-36 months, and 36-72 months. Statistical analyses were performed using SPSS 25, with a predetermined significance level of 0.05. Burns commonly present as scalds, flames, and chemical burns, primarily falling within the 11-20% range and predominantly involving second-degree burns. Treatment approaches include a combination of dressing and medical treatment in 68% of cases, debridement under general anesthesia in 16.2%, and grafting in 15.8%. The infection rate is 10.8%, with Pseudomonas Aeruginosa emerging as the predominant pathogen, and the mortality rate reported at 0.8%. The average hospitalization duration is 9 days. Highlighting the paramount importance of meticulous planning in managing burns in children under 6 years old and emphasizing the influence of parental factors, the study advocates for educating parents on safety measures as a crucial step in mitigating burn incidence. Stressing the pivotal role of epidemiological investigations in comprehending and preventing the root causes of burns, the research suggests that more extensive age-range studies and multicenter approaches could provide more robust epidemiological insights for the effective management of burn cases.","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAN ELIMINATION DIETS BE PROMISINGFOR NEURODEGENERATIVE DISEASES?","authors":"Aybüke Afra Babacan, İlknur Gökçe Yıldırım","doi":"10.55895/sshs.1358104","DOIUrl":"https://doi.org/10.55895/sshs.1358104","url":null,"abstract":"Medical nutrition interventions are an integral part of the multidisciplinary management of different medical disorders. Food allergies are becoming increasingly common and better recognized. \"Elimination diets\" are a dietary approach based on the elimination of certain allergenic foods or, in cases where it is not known which foods are allergenic, the elimination of potentially allergenic foods from the diet. Maintaining elimination diets can be highly effective in reducing the symptoms of food allergies. The gut microbiota has important effects on the structure and function of the enteric and central nervous system, including human behavior and brain regulation. The gut-microbiome-brain axis is now recognized as an important part in the regulation of systemic metabolism and homeostasis. Nutrients can cause inflammation by affecting the neural pathways through the vasoconstrictor or vasodilator effects of some of the substances they contain. Therefore, maintaining the gut microbiota and prioritizing anti-inflammatory nutrients and eliminating certain nutrients that are predicted to cause damage to the body are important in the nutritional treatment of neurodegenerative diseases. Elimination diets, which are mainly used for food allergies, have been suggested to be effective in the treatment of neurodegenerative diseases. For this reason, it has become the focus of more intensive research in neurological and psychiatric pathologies, especially as it may alleviate emotional eating disorders such as anxiety and depression. The evidence in this review summarizes balanced and high-quality elimination diets as a promising medical nutrition therapy to support immune and neuronal homeostasis.","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"70 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139172303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Brucellosis Seroprevalence and Associated Risk Factors in Amasya Province","authors":"Berkhan Topaktas, Aslı Memis, Zeliha Karapeli̇t, Elif Menekşe, Fikriye MİLLETLİ SEZGİN, Meryem Çeti̇n","doi":"10.55895/sshs.1371133","DOIUrl":"https://doi.org/10.55895/sshs.1371133","url":null,"abstract":"Objective: It is important to determine the current seroprevalence by investigating Brucellosis disease, which is an important cause of morbidity, in the general population. In this study, it was aimed to determine brucellosis seroprevalence and associated risk factors in the population residing in the city center of Amasya. Materiels and Methods: The population of this study consisted of the population aged fifteen and over living in the city center of Amasya. For the cross-sectional study, it was aimed to reach 464 people with the multi-stage sampling method. As a cluster unit, villages representing rural areas and family health centers representing neighborhoods in urban areas were taken. The data of the study were collected between 16/05/2022-22/02/2023. After the individuals included in the sample were informed about the purpose of the study and the procedures to be applied, a questionnaire form prepared by the researchers was applied to those who agreed to participate. Following the application of the questionnaire, venous blood sample was taken and specific immunoglobulins were investigated by Brucellacapt test in serum sample. Statistical significance level was accepted as p","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139213842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF CTLA 4 GENE +49A/G AND CT60 A/G POLYMORPHISMS IN ALOPECIA AREATA PATIENTS","authors":"N. Bozkurt, Kübra Şahi̇n, Saime SEZER SONDAŞ, Ö. Ateş, G. Kalkan","doi":"10.55895/sshs.1335300","DOIUrl":"https://doi.org/10.55895/sshs.1335300","url":null,"abstract":"Abstract \u0000Alopecia areata (AA) is a common, has organ-specific semptoms and an autoimmune disease that targets hair follicles and causes scarring, hair or hair loss. Although the etiopathogenesis of AA has not been clarified yet; In addition to attitude, psychological factors and persistence factors, autoimmune and inflammatory cells have a polygenic character in which genes are effective. Immunological hair follicle dysfunction process in AA are controlled by activated T cells. It is thought that cytokines released in T cells may cause hair loss in AA. Studies have reported that various genes of the immune system, such as interleukin and cytotoxic T lymphocyte-associated antigen 4 (CTLA4), are effective in the development of the cell membrane, and dysfunction of the CTLA-4 antigen may be associated with various diseases. The CTLA-4 gene polymorphism is thought to be associated with impaired control of T cell proliferation, and this gene is thought to be a candidate gene for susceptibility to autoimmunity. This study was conducted to investigate whether CTLA4 CT60 A/G and +49AG polymorphisms have a role in susceptibility to Alopecia Areata. 195 patients and 173 healthy volunteer controls were included in the study, and genotype and allele frequencies were determined by PCR-RFLP method. The obtained data were analyzed with OpenEpi. Our results showed that the +49AG polymorphism was not associated with AA susceptibility in the Turkish population, but the CT60 polymorphism might be associated with AA susceptibility. However, more studies are needed to confirm our results. \u0000 \u0000Key Words: Alopecia areata, CTLA4, Immunity, PCR-RFLP \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Özet \u0000Alopesi areata (AA), saç foliküllerini hedef alan ve yara izi, saç veya saç dökülmesine neden olan yaygın, otoimmün bir hastalıktır. AA'nın etyopatogenezi henüz netlik kazanmamış olmakla birlikte; Tutum, psikolojik faktörler ve kalıcılık faktörlerine ek olarak, otoimmün ve enflamatuar hücreler, genlerin etkili olduğu poligenik bir karaktere sahiptir. AA'daki kıl folikülü disfonksiyon mekanizmaları immünolojiktir ve aktifleştirilmiş T hücreleri tarafından kontrol edilir. T hücrelerinde salınan sitokinlerin AA'da saç dökülmesine neden olabileceği düşünülmektedir. Çalışmalar, interlökin ve sitotoksik T lenfosit ilişkili antijen 4 (CTLA4) gibi bağışıklık sisteminin çeşitli genlerinin hücre zarının gelişiminde etkili olduğunu ve CTLA-4 antijeninin işlev bozukluğunun çeşitli hastalıklarla ilişkili olabileceğini bildirmiştir. . CTLA-4 gen polimorfizminin, T hücre proliferasyonunun bozulmuş kontrolü ile ilişkili olduğu ve bu genin otoimmüniteye yatkınlık için aday bir gen olduğu düşünülmektedir. Bu çalışma, CTLA4 +49AG ve CT60 polimorfizmlerinin Alopesi Areata'ya duyarlılıkta rolü olup olmadığını araştırmak amacıyla yapılmıştır. 195 hasta ve 173 sağlıklı kontrol çalışmaya dahil edildi ve genotip ve alel frekansları PCR-RFLP yöntemi ile belirlendi. Elde edilen veriler OpenEpi ile analiz edilmiştir. Sonuçla","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128485499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF MICROBIOLOGICAL PROPERTIES OF TURKISH TRADITIONAL RAW MEATBALLS IN WINTER AND SUMMER","authors":"M. Yurttaş","doi":"10.55895/sshs.1279454","DOIUrl":"https://doi.org/10.55895/sshs.1279454","url":null,"abstract":"Raw meatball (çiğ köfte) is a popular food consumed fondly in Türkiye. The lack of being cooked and the constant hand contact during production and sale increase the risk of product contamination. This can cause food poisoning and pose a danger to public health. This study aims to determine the microbiological quality of raw meatballs sold in Çorum, Turkey. For this purpose, a total of 40 samples were studied in winter (n = 20) and summer (n = 20) months. Samples were analyzed for pH, total aerobic mesophilic bacteria, yeast-mold, E. coli, coliform, Enterobacteriaceae, Enterococcus, and Staphylococcus/Micrococcus. The pH value of raw meatball samples was 4.64-5.35 in the winter, and in summer, it was determined as 4.65–5.09. The total aerobic mesophilic bacteria, yeast-mold, coliform, Enterobacteriaceae, Enterococcus, Staphylococcus/Micrococcus count results of samples in summer and winter periods were determined respectively as","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"170 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115145484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIFFERENT ASPECTS OF VITAMIN D","authors":"Sümeyye Evsi̇le","doi":"10.55895/sshs.1231700","DOIUrl":"https://doi.org/10.55895/sshs.1231700","url":null,"abstract":"Summary \u0000Vitamin D is a steroid hormone synthesized by sunlight and this happens in the skin. It undergoes various metabolic changes in different tissues in the body and turns into its active form. Although it shows its main effect on bone tissue due to calcium phosphorus metabolism, it has also been proven to have extra-bone effects. Starting from intrauterine life until the end of life; It is effective on growth-development, immune system, neuronal development. In this review prepared in the light of up-to-date information; It is aimed to underline the importance of using vitamin D especially from childhood by reviewing the positive and negative reactions of vitamin D with different systems. \u0000Özet \u0000D vitamini güneş ışığı ile sentezlenen steroid yapıda bir hormondur. Vücutta farklı dokularda çeşitli metabolik değişikliklere uğrayarak aktif formuna dönüşür. Temel etkisini kalsiyum fosfor metabolizması dolayısı ile kemik doku üzerinde göstermekle beraber kemik dışı etkileri olduğu da kanıtlanmıştır. İntrauterin yaşamdan başlayarak hayatın sonuna kadar; büyüme gelişme, immün sistem, nöronal gelişim üzerine etkilidir. Güncel bilgiler ışığında hazırlanan bu derlemede; D vitamininin farklı sistemler üzerindeki etkilerinin gözden geçirilerek özellikle çocukluk çağından itibaren D vitamin kullanımının önemini vurgulamak amaçlanmıştır.","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131931802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IN VITRO STUDY ON ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF METHANOL EXTRACT of Helichrysum plicatum subsp. polyphyllum (Asteraceae)","authors":"","doi":"10.55895/sshs.1220434","DOIUrl":"https://doi.org/10.55895/sshs.1220434","url":null,"abstract":"Helichrysum plicatum subsp. polyphyllum (H. plicatum), is an important species belonging to the family Acteraceae, which is used in alternative medicine. For this reason, it was aimed to determine the antimicrobial and cytotoxic activity of H. plicatum extract in this study. Firstly, H. plicatum was extracted with methanol for 6 hours using a Soxhlet. Secondly, the antimicrobial activity of the extract was tested against Gram-positive (Staphylococcus aureus ATCC®25923, Bacillus cereus ATCC®7064, Bacillus subtilis ATCC®6633) and Gram-negative (Escherichia coli ATCC®25922, Klebsiella pneumoniae ATCC®706003, Salmonella Enteritidis ATCC®13076) bacteria and a yeast (Candida albicans ATCC®10231) using well diffusion and microdilution methods. Finally, the cytotoxic activity of H. plicatum extract on DLD-1 (human colon adenocarcinoma) and CCD-18Co (normal colon) cell lines was determined by MTT method. According to the results of the antimicrobial effect, H. plicatum extract was found to have a stronger antibacterial activity against Salmonella Enteritidis (24.13±1.15 and 156µg/mL) among Gram-negative bacteria. It was determined to have inhibitory activity against also Bacillus cereus (16.66±1.52 and 312µg/mL) among Gram-positive bacteria. In addition, the extract showed a strong antifungal effect on Candida albicans (22.66±0.57 and 312µg/mL). In addition, the H. plicatum extract did not show any cytotoxic effect on CCD-18Co cells, while the IC50 value on the DLD-1 cell line was determined as 8.17mg/mL. This indicates that the plant extract has a selective toxic effect on cancer cells. These results reveal that H. plicatum has the potential to be used for therapeutic purposes after being supported by further studies.","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133834779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VITAMIN B12 DEFICIENCY IN CHILDOOD: A SINGLE CENTRE EXPERIENCE","authors":"Gökçe Celep, Sümeyye Evsi̇le","doi":"10.55895/sshs.1228459","DOIUrl":"https://doi.org/10.55895/sshs.1228459","url":null,"abstract":"Purpose: Vitamin B12 is an essential micronutrient for neurodevelopment, growth and erythropoiesis of the human body. Deficiency is a common public health problem affecting young children; leading to neuropsychiatric and hematologic disorders. The aim of this study was to determine the rate and clinical findings of B12 deficiency among a sample of well children in a city located of middle northern Turkey. \u0000Methods: The study was carried out in the pediatric outpatient clinics of a tertiary health-care center in middle-northern Turkey between November 1, 2019 and May 31, 2022. The medical records about age, gender, clinical history and laboratory data were retrieved from the hospital information system, retrospectively. Results were presented as percentages and fractional data after the analyses based on software. \u0000Results: The study group consisted of 240 participants aged between 1-6 years old, 42.9% (n=103) of them were boys. The rate of vitamin B12 deficiency (","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"419 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115774475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF THE RATE OF HEPATITIS A IMMUNITY IN A SMALL CITY AFTER THE VACCINATION PROGRAM: ONE CENTER EXPERIENCE","authors":"Gökçe Celep, H. Özçelik, Sümeyye Evsi̇le","doi":"10.55895/sshs.1230912","DOIUrl":"https://doi.org/10.55895/sshs.1230912","url":null,"abstract":"Purpose: Hepatitis A is an infectious disease caused by hepatitis A virus (HAV). Symptomatic infection causes health care costs with loss of labor and school time. HAV outbreaks may cause economic problems by disrupting trade and tourism. The aim of this study is to determine the rate of immunity against HAV infection in a sample of pediatric population. \u0000Methods: The study group consisted of all children who underwent anti-HAV IgG evaluation for any reason between January 1, 2012 and December 31, 2020. The data about age, date of birth, sex, residence, vaccination status were retrospectively collected from the hospital record system. Anti-HAV IgG status was determined by chemiluminescent microparticle immunassay kits. The statistical analyses were presented with descriptive methods. \u0000Results: Overall 1189 children aged 1-17 years old enrolled to the study. The rate of anti HAV IgG seropositivity was 41.2% in the whole study group. The rates of completed vaccination scheme and seropositivity were 10.7% and 92.2%. Natural immunity rate was 32.6%. \u0000Conclusion: The 7-17 age group was found to be susceptible to the acute infection, they were considered as the new target population of vaccination. Vaccination seemed to be the most effective way of providing seropositivity to get rid of acute infection risk and eliminating geographic and socioeconomic differences.","PeriodicalId":443822,"journal":{"name":"Sabuncuoglu Serefeddin Health Sciences","volume":"462 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123052013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}