Klimik Journal最新文献

{"title":"Evaluation of the Correlation Between Serum Tumor Necrosis Factor Alpha, Transforming Growth Factor-Beta, Interleukin-10 and Alanine Aminotransferase Levels and Liver Histological Activity in Naive Chronic Hepatitis C Patients","authors":"Barış Balasar, I. Erayman, E. Turk-Aribas","doi":"10.36519/kd.2023.3588","DOIUrl":"https://doi.org/10.36519/kd.2023.3588","url":null,"abstract":"Objective: In this study serum tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF- beta), interleukin-10 (IL–10) and alanine transferase (ALT) levels were measured in naive chronic hepatitis C patients and healthy control group. The relationship between the values and the histological activity of the liver was evaluated to make predictions about liver histology without the need for biopsy.\u0000\u0000Methods: A total of 86 individuals including 43 patients and 43 controls participated in the study. Serum AST, ALT, TNF-alpha, TGF- beta and IL–10 values were analyzed in patient and control groups. The correlation between liver fibrosis degree (stage) and histological activity index (HAI) scores and the IL–10, TNF-alpha, IL-10, TGF-BETA values of the case and control group was evaluated.\u0000\u0000Results: A very strong correlation was found between HAI and TNF-alpha (rho=0965). A significant relation was found between HAI and TGF-beta (rho=0.446) and statistical correlation was not found between HAI and IL-10. A significant relation was found between HAI and serum ALT values in the patient group.\u0000\u0000Conclusion: Liver biopsy is an invasive procedure with complications which may have severe results. There is a need for biochemical or radiological markers which extrapolate to liver biopsy. In our study, measurement of serum cytokine and ALT values was observed as a noninvasive method which can help to meet this need.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45543312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crimean-Congo Hemorrhagic Fever (CCHF) and Brucellosis Coinfection in Alanya: A Case Report","authors":"A. Erdogan, H. Erdoğan","doi":"10.36519/kd.2023.4063","DOIUrl":"https://doi.org/10.36519/kd.2023.4063","url":null,"abstract":"The combination of Crimean-Congo hemorrhagic fever (CCHF) and brucellosis is unusual and can easily go unnoticed. Herein we report a case of CCHF and brucellosis coinfection and review the pertinent literature. The presented case occurred in Alanya, where the non-endemic region of CCHF and critical bradycardia was present during the course. As Alanya is a tourism center and tours are given in the rural areas surrounding the city, it is essential to watch for possible signs of CCHF in patients.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47088135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HBV and HCV Coinfection in Patients Living with HIV","authors":"S. Tekin, G. Cınar, Orçun Barkay, I. Çelik","doi":"10.36519/kd.2023.4473","DOIUrl":"https://doi.org/10.36519/kd.2023.4473","url":null,"abstract":"Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected individuals results in increased hepatic complications. HBV and HIV viruses are transmitted by blood and unprotected sexual intercourse. People with HIV and HBV coinfection are at increased risk for liver-related morbidity and mortality. HCV-related liver injury progresses more rapidly among people coinfected with HIV. HCV coinfection may also affect the management of HIV infection. This review aims to go over the management of HIV-HCV and HIV-HBV coinfections.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49224915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination Findings of Type 2 Diabetes Patients’ Feet with and without Ulcers","authors":"Sahizer Eraydin","doi":"10.36519/kd.2023.4166","DOIUrl":"https://doi.org/10.36519/kd.2023.4166","url":null,"abstract":"Objective: We conducted this study to determine the factors that cause foot ulcers in patients with type 2 diabetes mellitus (DM) with or without diabetic foot ulcer (DFU).\u0000\u0000Methods: This cross-sectional, descriptive study compared the feet examination results of 43 Type 2 DM patients with or without DFU. The study data were collected using a patient identification form and a diabetic foot examination form. Data are presented as percent, mean, and standard deviation. Chi-square and Fisher’s exact tests were used for statistical analysis. The statistical significance level was taken as p<0.05.\u0000\u0000Results: Of the patients, 63% were male, 79% were married, their mean age was 63.16±9.43, and the mean diabetes year was 18.44±7.77. 74% of the patients had a previous DFU. Of the existing DFU, 58% were on the right foot, 49% were on the toes, 49% were Wagner grade 2, and 37% were infected. There was edema and warmth in the DFU foot (p<0.05). DFU foot had a weaker sense of touch and vibration than the other. Ankle-Brakial Index was below 0.9. Foot pulses were weak, and there were deformities.\u0000\u0000Conclusion: Patients with DFU feet have an increased risk of recurrent ulcer formation. These patients should be followed periodically and educated about ulcer formation and signs and symptoms of infection.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47576980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6th February Earthquakes and Infectious Diseases: What are the Turkish Society of Clinical Microbiology and Infectious Diseases and Klimik Journal Doing?","authors":"A. Azap","doi":"10.36519/kd.2022.4597","DOIUrl":"https://doi.org/10.36519/kd.2022.4597","url":null,"abstract":"","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41615991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of Literature on HIV/AIDS-Associated HHV-8/KSHV in Turkey: 2001-2020","authors":"Yagmur Ekenoglu-Merdan, A. Ozel, Pınar Etiz","doi":"10.36519/kd.2023.4291","DOIUrl":"https://doi.org/10.36519/kd.2023.4291","url":null,"abstract":"Objective: Human herpesvirus-8 (HHV-8) infection—also known as Kaposi sarcoma-associated herpesvirus (KSHV)—is the causative agent of Kaposi’s sarcoma, especially in human immunodeficiency virus (HIV) / acquired immune deficiency syndrome (AIDS) patients. The prevalence of HHV-8/KSHV varies according to country and geographical region. However, despite the increasing amount of research on HHV-8/KSHV after identifying the virus, few studies have systematically collected data on the scientific production process. Therefore, this study aimed to make a bibliometric evaluation of the literature on HIV/AIDS-associated HHV-8/KSHV. \u0000\u0000Methods: Scientific publications produced in Turkey were analyzed using specific keywords of AIDS-related HHV-8/KSHV in the Scopus database between 2001 and 2020. Quantitative and qualitative analysis of the collected data was reviewed using appropriate bibliometric indicators regarding the number of publications, publication language, most influential institutions, most cited publications, active authors, and active journals. In addition, the VOSviewer v.1.6.16 program (Leiden University’s Centre for Science and Technology Studies, Leiden, Holland) was used to create a keyword network map and determine research interest areas and relationships. \u0000\u0000Results: There were 40 scientific publications produced in Turkey. The first publication of AIDS-related HHV-8/KSHV in Turkey was in 2001 (n=5, 5%). Most studies were conducted in 2013 and 2020 (n=5, 12.5%). The highest number of publications were in English (82.5%), and 7.5% were published in the Journal of Microbiology Bulletin. Generally, the publications were in article form (82.5%) and in the area of medical sciences (95%). Kaposi’s sarcoma was the most frequently used word in the map created with the network analysis of the keywords.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47943848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Turkish Parental Perception on Antibiotics Scale","authors":"Caner Ozdemir, A. Ergin","doi":"10.36519/kd.2023.3996","DOIUrl":"https://doi.org/10.36519/kd.2023.3996","url":null,"abstract":"Objective: Antibiotic misuse is a significant public health problem worldwide. Parents’ perceptions of antibiotics are critical for the antibiotic intake of children. The study’s aim was to validate the Turkish Parental Perception on Antibiotics Scale.\u0000\u0000Methods: This is a scale validation study. The data were collected through a questionnaire that consisted of 15 questions about the demographic and socioeconomic characteristics of the family and the Turkish Parental Perception on Antibiotics Scale. The scale, developed by Alumran et al., is a 5-point Likert type and consists of 31 items. The high scores obtained from the non-cut-off scale indicate better antibiotics perception. Experts completed the language adaption and content validity of the scale. Confirmatory factor analysis was used for construct validity. Reliability was tested by internal consistency coefficients.\u0000\u0000Results: One thousand eight people participated in the study. 68.8% of the participants were mothers. The mean age of the mothers was 35.7±5.0, and the mean age of the fathers was 39.4±5.2 years. The percent of high school and above graduates was 51.2% among mothers and 56.0% among fathers. According to the confirmatory factor analysis, the fit index values were standardized root mean square residual (SRMR)=0.06, goodness-of-fit index (GFI)=0.90, root mean square error of approximation (RMSEA)=0.06, comparative fit index (CFI)=0.95, non-normed fit index (NNFI)=0.93. The fit index values were good or excellent and confirmed the 5-factor structure. It was found that the internal consistency coefficients calculated for reliability were 0.79 for the whole scale and ranged between 0.63 and 0.86 for the subscales.\u0000\u0000Conclusion: The Turkish Parental Perception on Antibiotics Scale is a valid and reliable measurement tool. Further research is needed to determine the current situation regarding antibiotic perception.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45067753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Sharps Injuries of Health Professionals Working in a Tertiary Care Hospital During Five Years","authors":"Rezan Harman-Gunerken","doi":"10.36519/kd.2023.3865","DOIUrl":"https://doi.org/10.36519/kd.2023.3865","url":null,"abstract":"Objective: This study aims to evaluate occupational injuries in healthcare professionals exposed to the blood and body fluids of patients in our hospital for five years.\u0000\u0000Methods: A retrospective analysis of applications of healthcare professionals to the Infection Control Committee (ICC) between 2013-2017 was conducted based on the “registry and follow-up form for exposure to body fluids.”\u0000\u0000Results:175 personnel applied to the ICC, and the average age of applicants was 31.5±8. 58.5% of the cases were male, and 41.5% were female. Nurses constituted the majority of applicants at 37.7%, followed by caregivers at 21.7% and interns at 17.1%. Most injuries were inflicted in operating rooms 22.3%, emergency services 18.8%, intensive care units 18.3% and surgical clinics 12.6%. 62.5% of the cases were needlestick injuries, 24.0% were due to sharps, and 13.5% were due to mucosal exposure. The source patient was identified in 144 cases (82%), whereas in 31 cases (%18), the source patient could not be identified. Sixteen of the source patients were HBsAg positive, five were anti-HCV positive, and one was anti-HIV positive. None of the personnel was infected due to the injuries.\u0000\u0000Conclusion: The number of sharp injuries can be reduced by employing more personnel, reducing work hours, and encouraging the use of personal protective equipment. In addition to providing fundamental medical knowledge, training programs should also encourage a positive attitude toward HIV / AIDS.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44659487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Adverse Effects due to Inactive COVID-19 Vaccination in Healthcare Workers with or without a History of COVID-19","authors":"Gamze Kalin-Unuvar, Zeynep Ture-Yuce, Nadir Kahveci, Orhan Yıldız, B. Aygen","doi":"10.36519/kd.2023.3829","DOIUrl":"https://doi.org/10.36519/kd.2023.3829","url":null,"abstract":"Objective: Vaccines are one of the promising approaches to control the pandemic. The aim of this study, which was conducted on healthcare workers who previously were or were not infected with COVID-19, was to evaluate the undesirable effects that developed after the CoronaVac (Sinovac Life Sciences, Beijing, China).\u0000\u0000Methods: Volunteers who were administered the first dose of inactivated CoronaVac vaccine between January 14-24, 2021, were included in this retrospective study. Demographic information was obtained from the questionnaire results and from the data of the applications made due to side effects.\u0000\u0000Results: 911 healthcare workers, 232 of whom had a history of COVID-19 were included in the study. The mean age of those with a history of COVID-19, was 36 (20-66), and 33.6% were men. 26.7% were doctors, 34.9% were nurses, 155 (66.8%) worked in internal and 62 (26.7%) in surgical units. There was no significant difference between the two groups regarding age, gender, task, and the departments they worked in. Comorbidities were present in 25.9% of the group with a history of COVID-19; the most common disease was asthma (5.6%). Allergy history was 4.3% in the group with COVID-19 and 7.8% in the other group (p=0.070). The incidence of post-vaccine adverse events (62.9%) was higher in those with a history of COVID-19 than in those without (57.1%). The most common adverse event was a headache, and it was significantly higher in the group who had COVID-19 compared to those who had not (36.6% vs. 27.7%; p=0.01).\u0000\u0000Conclusion: In our study, we observed that the rates of undesirable effects after vaccination were high in individuals with a history of COVID-19. Although it is thought that this situation may be related to the developing antibody response rates, the insufficient number of cases and the lack of determination of the antibody response after infection and vaccination are a disadvantage of the study.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49270854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hacettepe Health Cohort (HU-CoVaCS): Study Design, Baseline Characteristics and the First 3-Month-Follow Up of COVID-19 Vaccinated Students","authors":"Eda Karadogan, H. Uzar, A. Sertçelik, Mithat Temizer, S. A. Kara, Damla Ozyurek, Fahriye Has-Akdag, Mustafa Enes Ozden, A. Alp, A. Pınar, Bahar Guciz-Dogan, B. Şener, Ceyda Şahan, D. Yuce, Duygu Ayhan-Baser, Hilal Aksoy, I. Fidancı, Lütfiye Hilal Ozcebe, M. Akova, O. Portakal, Sehnaz Ozyavuz-Alp, V. Arslan, Z. Dikmen, B. Çakır","doi":"10.36519/kd.2023.4423","DOIUrl":"https://doi.org/10.36519/kd.2023.4423","url":null,"abstract":"Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade students of Medical School and 4th and 5th-grade students of Dental School; and aimed to evaluate the general health status, COVID-19 history, vaccination status, and SARS-CoV-2 antibody levels of the participants to support their physical and social health, during the pandemic period.\u0000\u0000Methods: A prospective cohort study was conducted with an integrated, matched, nested case-control study. Sociodemographic characteristics, life habits, COVID-19 history, vaccination status, compliance with mask-distance-hygiene rules, and risks (if any) for COVID-19 were inquired via online questionnaires. Physical examinations, complete blood count, biochemistry tests, and anti-SARS-CoV-2 anti-spike antibody tests were conducted for all consenting participants. All analyses were established using depersonalized data.\u0000\u0000Results: Of the 778 participants completing the baseline visit in June-July 2021, the percentages of those vaccinated with at least one, two, and three/more doses of COVID-19 vaccine were 99.1%, 98.0%, and 11.7%, respectively; one had four doses. The median (minimum-maximum) time since the last vaccination was 134 (34-166) days for those vaccinated with two doses [CoronaVac (Sinovac Life Sciences, Beijing, China)] and 25 (14-56) days for those vaccinated with three doses [two doses of CoronaVac and a last dose of Pfizer-BioNTech mRNA vaccine (Comirnaty®). The third dose was applied at a median of 164 (151-202) days after the second dose, and all were heterologous in type. The median (minimum-maximum) antibody level for the overall group was 53.55(0-5680) BAU/mL: 47.19 BAU/mL in those who received two doses, with a more than 100 times increase after a third dose (4943.64 BAU/mL). Of the 522 participants followed up to October 1, 2021, 6 PCR-positive symptomatic participants were diagnosed with COVID-19: the incidence rate was 4/1000 person-months. \u0000\u0000Conclusion: A 100-fold neutralizing antibody level following the third dose demonstrated the importance of a booster dose. Given the time lag between doses, antibody measurements of BioNTech recipients should be repeated in the upcoming months. Booster selection should involve antibody level, variant sensitivity of the vaccine, and individual characteristics of the recipient.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42754807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}