Journal of Kidney Cancer and VHL最新文献_第5页

Von Hippel-Lindau is Associated to Pancreatic Neuroendocrine Tumors: A Comprehensive Review. Von Hippel-Lindau与胰腺神经内分泌肿瘤相关:综述

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i2.272

Danilo Coco, Silvana Leanza

{"title":"Von Hippel-Lindau is Associated to Pancreatic Neuroendocrine Tumors: A Comprehensive Review.","authors":"Danilo Coco, Silvana Leanza","doi":"10.15586/jkcvhl.v10i2.272","DOIUrl":"https://doi.org/10.15586/jkcvhl.v10i2.272","url":null,"abstract":"Multiorgan tumors are a hallmark of the autosomal dominant genetic disorder known as Von Hippel-Lindau syndrome (VHL), which is typically the result of inherited aberrations of the VHL tumor suppressor gene. The most frequent cancer is retinoblastoma, which can also occur in the brain and spinal cord, renal clear cell carcinoma (RCCC), paraganglioma, and neuroendocrine tumors. There may also be lymphangiomas, epididymal cysts, and pancreatic cysts or pancreatic neuroendocrine tumors (pNETs). The most frequent causes of death are metastasis from RCCC and neurological complications from retinoblastoma or central nervous system (CNS). Pancreatic cysts are present in 35-70% of VHL patients. Simple cysts, serous cysts, or pNETs are possible presentations, and the likelihood of malignant degeneration or metastasis is no greater than 8%. Although VHL has been associated with pNETs, their pathological characteristics are unknown. Furthermore, it is unknown whether variations in the VHL gene cause the development of pNETs. Hence, this retrospective study was undertaken with the main aim to examine whether pNETs are connected to VHL from a surgical perspective.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 2","pages":"13-20"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent Improvements in Adult Wilms Tumor Diagnosis and Management: Review of Literature. 成人肾母细胞瘤诊断和治疗的最新进展:文献综述。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i3.281

Vishnupriya Sakthivel, Ismail Z Adeeb, Devashree Vijayabalan

引用次数: 1

Leiomyoma of Kidney. 肾平滑肌瘤。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i2.264

Vishnu Karayil R, Mini Bhaskarashenoy, Geetha Sukumaran

引用次数: 0

Role of Angular Interface Sign in Characterizing Small Exophytic Renal Masses in Computed Tomography; Prospective Study. 角界面征象在计算机断层诊断肾外生性小肿块中的作用前瞻性研究。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i2.262

Mohamed Sharafeldeen, Mohamed Shaaban, Ahmed Hafez Afif, Mohamed Elsaqa, Nagy Naguib, Sara Elnaggar, Ahmad Beltagy

{"title":"Role of Angular Interface Sign in Characterizing Small Exophytic Renal Masses in Computed Tomography; Prospective Study.","authors":"Mohamed Sharafeldeen, Mohamed Shaaban, Ahmed Hafez Afif, Mohamed Elsaqa, Nagy Naguib, Sara Elnaggar, Ahmad Beltagy","doi":"10.15586/jkcvhl.v10i2.262","DOIUrl":"https://doi.org/10.15586/jkcvhl.v10i2.262","url":null,"abstract":"The widespread use of computed tomography (CT) has increased the incidence of small renal cell masses. We aimed to evaluate the usefulness of the angular interface sign (ice cream cone sign) to differentiate a broad spectrum of small renal masses using CT. The prospective study included CT images of patients with exophytic renal masses ≤ 4 cm in maximal dimension. The presence or absence of an angular interface of the renal parenchyma with the deep part of the renal mass was assessed. Correlation with the final pathological diagnosis was performed. The study included 116 patients with renal parenchymal masses of a mean (± SD) diameter of 28 (± 8.8) mm and a mean age of 47.7 (±12.8) years. The final diagnosis showed 101 neoplastic masses [66 renal cell carcinomas (RCC), 29 angiomyolipomas (AML), 3 lymphomas, and 3 oncocytomas] and 15 non-neoplastic masses [11 small abscesses, 2 complicated renal cysts, and 2 granulomas]. Angular interface sign was statistically comparable in neoplastic versus non-neoplastic lesions (37.6% versus 13.3%, respectively, P = 0.065). There was a statistically higher incidence of the sign when comparing benign versus malignant neoplastic masses (56.25 vs. 29%, respectively, P = 0.009). Also, comparing the sign in AML versus RCC was statistically significant (52% of AML versus 29% of RCC, P = 0.032). The angular interface sign seems beneficial in predicting the nature of small renal masses. The sign suggests benign rather than malignant small renal masses.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 2","pages":"33-39"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Von Hippel-Lindau Disease (VHL): Characteristic Lesions with Classic Imaging Findings. Von Hippel-Lindau病(VHL):典型影像学表现的特征性病变。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i3.293

Suryansh Bajaj, Darshan Gandhi, Divya Nayar, Ali Serhal

引用次数: 2

Renal Cell Carcinoma Arising from Isthmus of Horseshoe K. 马蹄峡肾细胞癌。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i2.267

Sanjay M Khaladkar, Sai Sabari Vinay Kumar Parripati, Deepak Koganti, Satvik Dhirawani, Urvashi Agarwal

引用次数: 0

Screening for Latent Polycythemia Vera in Renal Cell Carcinoma-Associated Erythrocytosis. 肾细胞癌相关红细胞增多症的潜伏性真性红细胞增多症筛查。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i1.276

Stephen E Langabeer

引用次数: 0

Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation. 伴肉瘤样分化的嫌色肾细胞癌。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i3.254

Benjamin J Lichtbroun, Brian Shinder, Tina Gowda Sara, Arnav Srivastava, Biren Saraiya, Tina M Mayer, Ryan Cristelli, Evita Sadimin, Robert E Weiss, Eric A Singer

引用次数: 1

Comparison of Posterior and Antero-Lateral Renal Tumors in Retroperitoneal Laparoscopic Partial Nephrectomy: A Propensity Score Matching Analysis. 后腹腔镜肾部分切除术后肾肿瘤与前外侧肾肿瘤的比较:倾向评分匹配分析。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i3.273

Hakan Anıl, Ali Yıldız, Ahmet Güzel, Serkan Akdemir, Kaan Karamık, Murat Arslan

{"title":"Comparison of Posterior and Antero-Lateral Renal Tumors in Retroperitoneal Laparoscopic Partial Nephrectomy: A Propensity Score Matching Analysis.","authors":"Hakan Anıl, Ali Yıldız, Ahmet Güzel, Serkan Akdemir, Kaan Karamık, Murat Arslan","doi":"10.15586/jkcvhl.v10i3.273","DOIUrl":"https://doi.org/10.15586/jkcvhl.v10i3.273","url":null,"abstract":"This study aimed to compare the antero-lateral and posterior localized renal masses in laparoscopic partial nephrectomy with the retroperitoneal approach in terms of operative, functional, and oncological outcomes. Patients who underwent retroperitoneal laparoscopic partial nephrectomy by a single surgeon between January 2013 and January 2021 were included in the study. A one-to-one propensity score matching (PSM) analysis was conducted to obtain two balanced groups. The patients were divided into two groups as posterior and antero-lateral according to the localization of the mass. A total of 239 patients were included in the PSM analysis, with 65 patients allocated to each group. The mean operative time was 79.2 ± 11.2 min in the posterior group, while it was 90.0 ± 11.6 min in the antero-lateral group (P < 0.001). Warm ischemia time was 15.9 ± 2.4 min in the posterior group and 18.6 ± 2.7 min in the antero-lateral group (P < 0.001). The median decrease in eGFR at 1 year was 4.8 (IQR, 2.9-6.9) mL/min in the posterior group and 5.0 (IQR, 2.8-11) mL/min in the antero-lateral group (P = 0.219). The warm ischemia time and clamping technique were found to be significant factors for predicting eGFR change after surgery (β:0.693, 95% CI: 0.39-0.99, P < 0.001; β:6.43, 95% CI: 1.1-11.7, P = 0.017, respectively). We report that retroperitoneal laparoscopic partial nephrectomy provided longer warm -ischemia and operative time for antero-lateral renal masses than posterior masses. However, long-term oncological and functional results were similar for both localizations.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 3","pages":"9-16"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9881491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma. 梅奥黏附概率评分对局部晚期肾细胞癌没有预后价值。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-01-01 DOI: 10.15586/jkcvhl.v10i1.269

Benjamin N Schmeusser, Tad A Manalo, Yuan Liu, Yash B Shah, Adil Ali, Manuel Armas-Phan, Dattatraya H Patil, Reza Nabavizadeh, Kenneth Ogan, Viraj A Master

{"title":"Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma.","authors":"Benjamin N Schmeusser, Tad A Manalo, Yuan Liu, Yash B Shah, Adil Ali, Manuel Armas-Phan, Dattatraya H Patil, Reza Nabavizadeh, Kenneth Ogan, Viraj A Master","doi":"10.15586/jkcvhl.v10i1.269","DOIUrl":"https://doi.org/10.15586/jkcvhl.v10i1.269","url":null,"abstract":"Nephrectomy remains standard treatment for renal cell carcinoma (RCC). The Mayo Adhesive Probability (MAP) score is predictive of adherent perinephric fat and associated surgical complexity, and is determined by assessing perinephric fat and stranding. MAP has additionally predicted progression-free survival (PFS), though primarily reported in stage T1-T2 RCC. Here, we examine MAP's ability to predict overall survival (OS) and PFS in T3-T4 RCC. From our prospectively maintained RCC database, patients that underwent radical nephrectomy (2009-2016) with available abdominal imaging (<90 days preop) and T3/T4 RCC underwent MAP scoring. Survival analyses were conducted with MAP scores as individual (0-5) and dichotomized (0-3 vs 4-5) using Kaplan-Meier method. Multivariable Cox proportional hazard regression models for PFS and OS were built with backward elimination. 141 patients were included. 134 (95%) and 7 (5%) had pT3 and pT4 disease, respectively. 46.1% of patients had an inferior vena cava thrombus. Mean MAP score was 3.22±1.52, with 75 (53%) patients having a score between 0-3 and 66 (47%) having a score of 4-5. Both male gender (p=0.006) and clear cell histology (p=0.012) were associated with increased MAP scores. On Kaplan-Meier and multivariable analysis, no significant associations were identified between MAP and PFS (HR=1.01, 95% CI 0.85-1.20, p=0.93) or OS (HR=1.01, 95% CI 0.84-1.21, p=0.917). In this cohort of patients with locally advanced RCC, high MAP scores were not predictive of worse PFS or OS.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 1","pages":"19-25"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1