Gomal Journal of Medical Sciences最新文献_第4页

NEUROTRANSMITTERS FOR MATH BRAIN: A NEW FINDING 数学大脑的神经递质:一项新发现

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Gomal Journal of Medical Sciences Pub Date : 2022-01-18 DOI: 10.46903/gjms/19.04.954

Taimoor Hassan

引用次数: 0

SERUM LEVELS OF OXIDATIVE STRESS MARKERS IN SUBCLINICAL AND OVERT HYPOTHYROIDISM VERSUS CONTROL GROUP IN POPULATION OF KUTAHYA CITY, TURKEY 土耳其库塔希亚市亚临床和显性甲状腺功能减退患者血清氧化应激标志物水平与对照组比较

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Gomal Journal of Medical Sciences Pub Date : 2022-01-18 DOI: 10.46903/gjms/19.04.935

Mustafa Yontem, Serap Arslan, B. S. Erdogdu, F. E. Kocak

{"title":"SERUM LEVELS OF OXIDATIVE STRESS MARKERS IN SUBCLINICAL AND OVERT HYPOTHYROIDISM VERSUS CONTROL GROUP IN POPULATION OF KUTAHYA CITY, TURKEY","authors":"Mustafa Yontem, Serap Arslan, B. S. Erdogdu, F. E. Kocak","doi":"10.46903/gjms/19.04.935","DOIUrl":"https://doi.org/10.46903/gjms/19.04.935","url":null,"abstract":"Background: Overproduction of oxygen-related free radicals and inadequate antioxidant defense are critical in hypothyroidism, as they might lead to future life-threatening diseases. The objectives of this study were to compare serum levels of oxidative stress markers; total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and arylesterase (ARYL) in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) versus healthy controls in population of Kutahya city, Turkey.Materials Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey, from July to December, 2016. Three study groups of 45 each were formed as healthy controls, patients with SH and OH. Serum levels of TOS, TAS, OSI, PON-1, and ARYL were five research variables with ratio scale, but skewed, so described by median and IQR with 95% Cl. Kruskal-Wallis and multiple comparison tests were used for hypotheses testing.Results: Serum levels of TOS and OSI were higher in SH group (p-values 0.032; .0001; respectively) and OH group (p-values .0001; .0001, respectively) than healthy controls, while serum levels of TAS, PON-1 and ARYL were lower in SH group (p-values .0001; .0001; .0001, respectively) and OH group (p-values .0001; .0001; .0001, respectively) than control group.Conclusion: Our study showed that serum levels of TOS and OSI were higher in subclinical and overt hypothyroidism than in healthy controls; while serum levels of TAS, PON-1, and ARYL were lower in subclinical and overt hypothyroidism than in healthy controls.","PeriodicalId":44174,"journal":{"name":"Gomal Journal of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43379032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PREVALENCE OF ASYMPTOMATIC BACTERIURIA AND ITS DISTRIBUTION BY SEX AND AGE GROUPS IN CHILDREN COMING FOR ROUTINE IMMUNIZATION IN DISTRICT PESHAWAR, PAKISTAN 巴基斯坦白沙瓦地区接受常规免疫接种儿童中无症状细菌的患病率及其按性别和年龄组的分布

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Gomal Journal of Medical Sciences Pub Date : 2022-01-18 DOI: 10.46903/gjms/19.04.887

Jahanzeb khan Afridi, R. Karim, Hidayat Gul, Mukhtiar Ahmad Afridi, Muhammad Ibrahim

{"title":"PREVALENCE OF ASYMPTOMATIC BACTERIURIA AND ITS DISTRIBUTION BY SEX AND AGE GROUPS IN CHILDREN COMING FOR ROUTINE IMMUNIZATION IN DISTRICT PESHAWAR, PAKISTAN","authors":"Jahanzeb khan Afridi, R. Karim, Hidayat Gul, Mukhtiar Ahmad Afridi, Muhammad Ibrahim","doi":"10.46903/gjms/19.04.887","DOIUrl":"https://doi.org/10.46903/gjms/19.04.887","url":null,"abstract":"Background: Asymptomatic bacteriuria (ASB) in not an uncommon disease in children. It may lead to symptomatic infection and later on renal damage. The objectives of this study were to determine the prevalence of ASB and its distribution by sex and age groups in children coming for routine immunization in District Peshawar, Pakistan.Material and methods: This cross-sectional study was conducted in Department of Pediatrics, Khyber Girls Medical College, Peshawar, Pakistan form March 2017 to August 2017. 146 children presenting for routine immunization were selected. Sex, age groups, age in years and presence of ASB were variables. Sex, age groups and presence of ASB were analyzed by count and percentage with 80%CL. Age in years was analyzed by mean, SD and range with 95%CI.Results: Out of 146 children, 65 (44.52%) were males and 81 (55.48%) females, and 51 (34.93%) in age group ≤3 years, 52 (35.62%) in 3.0-6.50 years and 43 (29.45%) in 6.51-10 years. Mean age of sample was 4.82±2.81 (09-9.50, range 8.60) (95%CI 4.36-5.28) years. ASB was found in 16 (10.96%) cases. Prevalence of ASB was higher 4.11% in boys than 6.856% girls. It was highest 6.85% in age group 3.0-6.50 years, followed by 2.74% in 6.51-10 years and 1.37% in age group ≤3.0 years.Conclusion: Asymptomatic Bacteriuria is quite common in our children. It is a significant health risk especially among females, and we suggest more studies to find out the underlying factors and follow up studies on its complications.","PeriodicalId":44174,"journal":{"name":"Gomal Journal of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43715864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DISTRIBUTION OF ACTIVE HEPATITIS C INFECTED POPULATION BY SEX AND AGE GROUPS IN DISTRICT D.I.KHAN, PAKISTAN 巴基斯坦迪伊汗地区活动性丙型肝炎感染人群的性别和年龄分布

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Gomal Journal of Medical Sciences Pub Date : 2021-12-24 DOI: 10.46903/gjms/19.03.1018

Imran Ullah, Nisar Khan, Z. Khan, Fahimullah Khan, A. Khan, Shafaat Ur Rehman

{"title":"DISTRIBUTION OF ACTIVE HEPATITIS C INFECTED POPULATION BY SEX AND AGE GROUPS IN DISTRICT D.I.KHAN, PAKISTAN","authors":"Imran Ullah, Nisar Khan, Z. Khan, Fahimullah Khan, A. Khan, Shafaat Ur Rehman","doi":"10.46903/gjms/19.03.1018","DOIUrl":"https://doi.org/10.46903/gjms/19.03.1018","url":null,"abstract":"Background: Untreated hepatitis C virus infection is major cause of cirrhosis and hepatocellular carcinoma causing significant morbidity and mortality. Our objectives were to determine distribution of active hepatitis C infected population by sex and age groups in District D.I.Khan, Pakistan.Materials Methods: This cross-sectional study was conducted at District Health Office, D.I.Khan, Pakistan from 25 April 2021 to 12 May 2021. Data was collected for period from 11 February 2017 to 22 April 2021. 1062 active hepatitis C infected cases were selected from population at risk consecutively. Sex (nominal) and age groups (ordinal) were variables. Distribution was analyzed by count, percentage and confidence intervals for proportion for population. Hypotheses for distribution were substantiated by chi-square goodness-of-fit test.Results: Out of 1062 active hepatitis C infected population, 569 (53.58%) were men 493 (46.42%) women, and 51 (4.80%) in age group 0-20 years, 433 (40.77%) in 21-40, 476 (44.82%) in 41-60 102 (9.61%) in 60 years. Our distribution by sex (p.00001) and age groups (p.00001) was different than expected.Conclusion: In our study, active hepatitis C infection was more common in men than women and most common in age group 41-60 years, followed by 21-40, 60 0-20 years. Our observed prevalence of active hepatitis C infection in men was lower than expected in women it was higher than expected. Our observed prevalence of active hepatitis C infection in the four age groups was not similar to expected.","PeriodicalId":44174,"journal":{"name":"Gomal Journal of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42286766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

POST-OPERATIVE ORAL ANTIBIOTICS IN REDUCING FREQUENCY OF SURGICAL SITE INFECTION FOLLOWING NON-PERFORATED APPENDECTOMY IN POPULATION OF SOUTH WAZIRISTAN AGENCY, PAKISTAN 巴基斯坦南瓦济里斯坦机构人群术后口服抗生素减少无穿孔阑尾切除术后手术部位感染的频率

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Gomal Journal of Medical Sciences Pub Date : 2021-12-24 DOI: 10.46903/gjms/19.02.936

Aftab Alam, A. Rehman, Dastageer Waheed, Muhammad Hamayun Khan, Waseem Ahmad, Irum Bashir

{"title":"POST-OPERATIVE ORAL ANTIBIOTICS IN REDUCING FREQUENCY OF SURGICAL SITE INFECTION FOLLOWING NON-PERFORATED APPENDECTOMY IN POPULATION OF SOUTH WAZIRISTAN AGENCY, PAKISTAN","authors":"Aftab Alam, A. Rehman, Dastageer Waheed, Muhammad Hamayun Khan, Waseem Ahmad, Irum Bashir","doi":"10.46903/gjms/19.02.936","DOIUrl":"https://doi.org/10.46903/gjms/19.02.936","url":null,"abstract":"Background: Acute appendicitis is most frequent cause of acute abdomen in younger population, and surgical site infection (SSI) is commonest complication of appendectomy. The objective of this trial was to compare the efficacy of post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.Materials Methods: The randomized placebo trial was conducted at Agency Headquarter Hospital, Wana, South Waziristan, Pakistan from October 1, 2016 to November 18, 2018. One hundred fifty (150) patients were randomly allocated into two groups, 75 in experimental group, to whom antibiotics were given and 75 in placebo group, to whom antibiotics were not given. Age groups and presence of SSI were two variables, being on nominal scale, were described by count and percentage with CI at 80%CL. McNemar chi-square test was applied to test the hypothesis to see the significance of difference between the experimental and placebo groups in terms of frequency of SSI at alpha .05.Results: SSI was present in nine (12%, 80%CI 7.19-16.80%) out of 75 cases in experimental group and in 12 (16%, 80%CI 10.57-21.42%) out of 75 cases in placebo group. McNemar chi-square test showed no significant difference between the experimental and placebo groups in terms of frequency of SSI (p=.2482).Conclusion: The results are comparable for post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.","PeriodicalId":44174,"journal":{"name":"Gomal Journal of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42308819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

HOW STEM CELLS ARE SHAPING OUR DRUG DISCOVERY TECHNIQUES? 干细胞是如何塑造我们的药物发现技术的?

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Gomal Journal of Medical Sciences Pub Date : 2021-12-24 DOI: 10.46903/gjms/19.03.1010

Taimoor Hassan

引用次数: 0

PREVALENCE OF MORTALITY AND ITS DISTRIBUTION BY SEX AND AGE GROUPS IN INDOOR COVID-19 PATIENTS IN D.I.KHAN DIVISION, PAKISTAN 巴基斯坦D.I.KHAN地区室内新冠肺炎患者的死亡率及其性别和年龄分布

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Gomal Journal of Medical Sciences Pub Date : 2021-12-24 DOI: 10.46903/gjms/19.03.1029

M. Aamir, Waleed Ahmad, B. Ahmad, A. R. Khan, Muhammad Fawad, Muhammad Abdullah

{"title":"PREVALENCE OF MORTALITY AND ITS DISTRIBUTION BY SEX AND AGE GROUPS IN INDOOR COVID-19 PATIENTS IN D.I.KHAN DIVISION, PAKISTAN","authors":"M. Aamir, Waleed Ahmad, B. Ahmad, A. R. Khan, Muhammad Fawad, Muhammad Abdullah","doi":"10.46903/gjms/19.03.1029","DOIUrl":"https://doi.org/10.46903/gjms/19.03.1029","url":null,"abstract":"Background: COVID-19 has become one of the leading causes of morbidity and mortality. The objectives of this study were to determine the prevalence of mortality and its distribution by sex and age groups in indoor COVID-19 patients in D.I.Khan Division, Pakistan.Materials Methods: This cross-sectional study was conducted in the Department of Medicine, Gomal Medical College, D.I.Khan, Pakistan. A sample of 438 patients with positive SARS-CoV-2 RT-PCR was selected. Sex age-groups were two demographic and presence of mortality was a research variable. The data type for all variables was nominal, except ordinal age groups. Prevalence distribution were described by count and percentage with 95%CI. The hypotheses were tested by chi-square goodness of fit test.Results: Out of 438 COVID-19 patients, mortality was 43 (9.82%), including 34 (7.76%) men and nine (2.06%) women. The mortality was 0% for 0-19 years, four (0.92%) for 20-39 years, 12 (2.74%) for 40-59 years and 27 (6.16%) ≥60 years. Our mortality 9.82% was lower than expected 20.95% (p=.001). It was higher in men than women (p=.001). It was highest in age group ≥60 years, while 0% in 0-19 years. It was similar to expected by sex (p=.070) and age group (p=.207).Conclusion: Our study showed 9.82% mortality in indoor COVID-19 patients. The mortality was lower than expected. The mortality was higher in men than women. It was highest in elderly, while zero in children and adolescents. It was similar to expected by sex and age group.","PeriodicalId":44174,"journal":{"name":"Gomal Journal of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44968487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADDRESSING MYTHS OF OUR MEDICAL COMMUNITY REGARDING RESEARCH 解决我们医学界对研究的误解

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Gomal Journal of Medical Sciences Pub Date : 2021-12-24 DOI: 10.46903/gjms/19.02.955

I. Ahmad

引用次数: 0

COMPLICATIONS IN ABO-INCOMPATIBLE HEMATOPOIETIC STEM CELL TRANSPLANT IN PAKISTAN 巴基斯坦ABO相容性造血干细胞移植的并发症

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Gomal Journal of Medical Sciences Pub Date : 2021-12-24 DOI: 10.46903/gjms/19.03.974

Mussawair Hussain, Imran Ullah, Nighat Shahbaz, Q. Chaudhry, M. Khan, T. Khattak

{"title":"COMPLICATIONS IN ABO-INCOMPATIBLE HEMATOPOIETIC STEM CELL TRANSPLANT IN PAKISTAN","authors":"Mussawair Hussain, Imran Ullah, Nighat Shahbaz, Q. Chaudhry, M. Khan, T. Khattak","doi":"10.46903/gjms/19.03.974","DOIUrl":"https://doi.org/10.46903/gjms/19.03.974","url":null,"abstract":"Background: Hematopoietic stem cell transplantation (HSCT) is therapeutic option for many blood diseases. It has increased risk of complications with incompatible pair. The objective of this study was to determine the frequency of complications in ABO-incompatible HSCT in Pakistan.Materials Methods: This cross-sectional study was conducted at Armed Forces Bone Marrow Transplant Centre , Rawalpindi, Pakistan from 11th August 2018 till 15th March 2021. A sample of 73 ABO-incompatible HSCT patients was selected. Variables were sex, age groups, acute delayed hemolysis, pure red cell aplasia and acute GvHD. All variables being categorical were described by count and percentage with 80%CI. Complications in sample vs. population were compared through chi-square goodness of fit test.RESULTS: Seventy three patients with ABO-incompatible HSCT included 52 (71.23%) men 21 (28.77%) women, and 49 (67.12%) in age group ≤14 years 24 (32.88%) in ≥15 years. Out of 73 patients, eight (10.96%) had acute hemolysis, 26 (35.62%) had delayed hemolysis, four (5.84%) had pure red cell aplasia and 34 (46.58%) had acute GvHD. The observed prevalence in sample was similar to population for acute (p=.46893) and delayed hemolysis (p=.30759) and acute GvHD (p=.55841), while it was different for pure red cell aplasia (p=.00006).CONCLUSION: Most common complication in our study was acute GvHD, followed by delayed hemolysis, acute hemolysis pure red cell aplasia. The observed prevalence in sample was similar to population for acute delayed hemolysis and acute GvHD, while it was different for pure red cell aplasia.","PeriodicalId":44174,"journal":{"name":"Gomal Journal of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42922809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ARE ENZYME REPLACEMENT THERAPIES EFFECTIVE AGAINST LYSOSOMAL STORAGE DISORDERS? 酶替代疗法对溶酶体储存障碍有效吗？

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Gomal Journal of Medical Sciences Pub Date : 2021-12-24 DOI: 10.46903/gjms/19.02.999

Taimoor Hassan, Xu Huadong

引用次数: 1