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Real-World Experiences of CAR T-Cell Therapy for Large B-Cell Lymphoma: How Similar Are They to the Prospective Studies? CAR T 细胞疗法治疗大 B 细胞淋巴瘤的真实世界经验：与前瞻性研究有多相似？
4区 历史学
HISTORIAN Pub Date : 2021-08-05 eCollection Date: 2021-08-01 DOI: 10.36401/JIPO-21-2
Kevin Tang, Loretta J Nastoupil
{"title":"Real-World Experiences of CAR T-Cell Therapy for Large B-Cell Lymphoma: How Similar Are They to the Prospective Studies?","authors":"Kevin Tang, Loretta J Nastoupil","doi":"10.36401/JIPO-21-2","DOIUrl":"10.36401/JIPO-21-2","url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR) T cell therapy has emerged as a revolutionary treatment option for highly aggressive B cell malignancies. Clinical trials of CD19 CAR T cells for the management of relapsed and/or refractory non-Hodgkin lymphoma (NHL) have shown markedly improved survival and response rates. The goal of this review is to evaluate whether the results from these clinical trials are reflective of real-world practices through the analysis of published literature of the commercially available CAR T cell products. We have found that despite the significantly different patient characteristics, the adverse events and response rates of real-world patients were similar to those of the clinical trials. Of interest, several groups excluded from the clinical trials, such as patients with HIV infection, chronic viral hepatitis, and secondary CNS (central nervous system) lymphoma, had case reports of promising outcomes.</p>","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"71 1","pages":"150-159"},"PeriodicalIF":0.0,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85564435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
You never forget your first: a biography of George Washington 你永远不会忘记你的第一本书:乔治·华盛顿的传记
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2017609
Robert Shaffer
{"title":"You never forget your first: a biography of George Washington","authors":"Robert Shaffer","doi":"10.1080/00182370.2021.2017609","DOIUrl":"https://doi.org/10.1080/00182370.2021.2017609","url":null,"abstract":"of any kind of gender politics that may have affected his mother’s silence, nor is he alert to the possibility that her silence (more complete than his father’s) was connected to sexual trauma she may have experienced or witnessed. Harootunian’s central goals of bringing the everyday experience of genocide survivors into historical understanding and of understanding the way in which the unspoken is his heritage are both laudable ones, but they would have been better served by a more thorough exploration of extant oral and social historical literature on the subject.","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"391 - 392"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45237801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Getting right with Reagan: the struggle for true conservatism, 1980-2016 正确对待里根:为真正的保守主义而斗争，1980-2016
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2018299
A. E. Eckes
{"title":"Getting right with Reagan: the struggle for true conservatism, 1980-2016","authors":"A. E. Eckes","doi":"10.1080/00182370.2021.2018299","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018299","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"404 - 405"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45942794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giannozzo Manetti: the life of a Florentine humanist Giannozzo Manetti:佛罗伦萨人文主义者的一生
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2018389
Stefano U. Baldassarri
{"title":"Giannozzo Manetti: the life of a Florentine humanist","authors":"Stefano U. Baldassarri","doi":"10.1080/00182370.2021.2018389","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018389","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"415 - 418"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46153754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The idealist: Wendell Willkie’s wartime quest to build one world 理想主义者:温德尔·威尔基战时寻求建立一个世界
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2018284
Ralph B. Levering
{"title":"The idealist: Wendell Willkie’s wartime quest to build one world","authors":"Ralph B. Levering","doi":"10.1080/00182370.2021.2018284","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018284","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"401 - 402"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44461030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hitler’s Jewish refugees: hope and anxiety in Portugal 希特勒的犹太难民:葡萄牙的希望与焦虑
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2018388
Susanna Kokkonen
{"title":"Hitler’s Jewish refugees: hope and anxiety in Portugal","authors":"Susanna Kokkonen","doi":"10.1080/00182370.2021.2018388","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018388","url":null,"abstract":"behavior, and political organization have persisted beyond the dictator’s death and the democratic transition. If “the uncertainty about the dictatorship’s ending was a feature of the Francoist era,” she writes, uncertainty “persists today, albeit in an inverted form: . . . as a critique of the regime’s continued presence within Spanish democracy”: “While the regime was haunted by the prospect of its ending, the postFranco era is haunted by the dictatorship’s non-ending” (5, 7). It is best to read this book less as a standard scholarly monograph – for which the bibliography is too eclectic and the dialogue with existing specialized scholarship too spotty – than as an essayistic, nuanced, theoretically informed reflection that, in turn, invites its readers to question their assumptions about the last 90 years of Spanish history.","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"414 - 415"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47345782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
How the few became the proud: crafting the Marine Corps mystique, 1874-1918 少数人是如何成为骄傲的：打造海军陆战队的神秘感，1874-1918
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2018283
Ross Phillips
{"title":"How the few became the proud: crafting the Marine Corps mystique, 1874-1918","authors":"Ross Phillips","doi":"10.1080/00182370.2021.2018283","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018283","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"399 - 401"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47899967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isaak Levitan’s enduring appeal and Russian national identity, 1891-present 艾萨克·列维坦的持久魅力与俄国的民族认同，1891年至今
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.1999049
C. McDaniel
{"title":"Isaak Levitan’s enduring appeal and Russian national identity, 1891-present","authors":"C. McDaniel","doi":"10.1080/00182370.2021.1999049","DOIUrl":"https://doi.org/10.1080/00182370.2021.1999049","url":null,"abstract":"ABSTRACT Since the late nineteenth century, the landscapist Isaak Levitan (1860–1900) has been praised for his ability to convey the Russian countryside’s beauty and mood. Throughout the czarist and Soviet eras, Levitan remained respected and often admired, and in post-Soviet Russia, Levitan is considered one of Russia’s foremost landscapists. Although Levitan has remained an important figure in Russian cultural history, he is somewhat understudied in the English-speaking world. Moreover, scholars who have discussed Levitan in English- and Russian-language publications have situated him within the context of a specific timeframe, such as late-Imperial Russia or the Soviet era. In order to gain insight into the reasons for the continuous respect and appreciation for Levitan amid Russia’s changing political dynamics, my examination focuses upon the writings of art critics and historians in late-czarist/imperial Russia (1890–1917), communist Russia/Soviet Union (1917–1991), and post-Soviet Russia (1991-Present). Specifically, my inquiry expands upon existing research 1) through an analysis of scholars’ perceptions of the Russian Realists’ (the Itinerants) and Western European artists’ influence upon Levitan, and 2) through an exploration of the varying interpretations of two of his most famous paintings, Tikhaia obitel (Quiet Monastery) (1890) and Nad vechnym pokoem (Above Eternal Peace) (1894). Through a study of these two topics, my article demonstrates that writings from scholars in the late-czarist, Soviet and post-Soviet eras reflect prominent political ideas and ideological beliefs within these three eras, and that these scholars’ interpretations emphasize aspects that have defined and that currently accent Russia’s distinct character.","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"323 - 355"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45962158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Native hoops: the rise of American Indian basketball, 1895-1970 本土篮球：1895-1970年美国印第安人篮球的兴起
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2018282
Jeffrey P. Beck
{"title":"Native hoops: the rise of American Indian basketball, 1895-1970","authors":"Jeffrey P. Beck","doi":"10.1080/00182370.2021.2018282","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018282","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"398 - 399"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45174983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paradoxes of stasis: literature, politics, and thought in Francoist Spain 停滞的悖论：法语国家西班牙的文学、政治和思想
IF 0.2 4区 历史学
HISTORIAN Pub Date : 2021-07-03 DOI: 10.1080/00182370.2021.2018371
S. Faber
{"title":"Paradoxes of stasis: literature, politics, and thought in Francoist Spain","authors":"S. Faber","doi":"10.1080/00182370.2021.2018371","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018371","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"413 - 414"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49447527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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