SLAVIC AND EAST EUROPEAN JOURNAL最新文献

A looming epidemic: combating the recurrent outbreaks of diphtheria in Nigeria. 迫在眉睫的流行病:防治尼日利亚白喉的反复爆发。

IF 1.2 4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2023-08-28 eCollection Date: 2023-01-01 DOI: 10.11604/pamj.2023.45.186.41328

Olufemi Nicholas Olulaja, Emmanuel Temitope Anjorin, Olabode Ekerin, Oluwatoyosi Tolulope Afolabi, Jemimah Mayowa Inuojo

{"title":"A looming epidemic: combating the recurrent outbreaks of diphtheria in Nigeria.","authors":"Olufemi Nicholas Olulaja, Emmanuel Temitope Anjorin, Olabode Ekerin, Oluwatoyosi Tolulope Afolabi, Jemimah Mayowa Inuojo","doi":"10.11604/pamj.2023.45.186.41328","DOIUrl":"10.11604/pamj.2023.45.186.41328","url":null,"abstract":"Nigeria has endured several diphtheria outbreaks over the last few decades, mirroring a suboptimal population immunity across several demographics within the country. The country's northern region has been affected mainly by this infectious disease; it directly depicts the effect of poor DPT vaccine uptake amongst children in this region compared to other geopolitical zones in Nigeria. Whilst pharmaceutical intervention and surveillance activities have commenced as directed by the NCDC, to combat this public health menace, top leaders of the Nigerian healthcare system - public and private sectors, must understudy the predisposing factors gearing the recurrence of diphtheria in Nigeria and provide robust, research-based and scientific mechanisms to arrest the root causes of the incessant outbreaks. This article discusses the factors promoting the recurrent diphtheria outbreaks in Nigeria, the preexisting interventions with their existential deterrents, and new strategies recommended to curb the further resurgence of the disease.","PeriodicalId":44070,"journal":{"name":"SLAVIC AND EAST EUROPEAN JOURNAL","volume":"36 1","pages":"186"},"PeriodicalIF":1.2,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90701753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Structural characterization of the homotropic cooperative binding of azamulin to human cytochrome P450 3A5. 氮杂环丁烷与人类细胞色素 P450 3A5 同向协同结合的结构特征。

4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2022-05-01 Epub Date: 2022-04-06 DOI: 10.1016/j.jbc.2022.101909

Mei-Hui Hsu, Eric F Johnson

{"title":"Structural characterization of the homotropic cooperative binding of azamulin to human cytochrome P450 3A5.","authors":"Mei-Hui Hsu, Eric F Johnson","doi":"10.1016/j.jbc.2022.101909","DOIUrl":"10.1016/j.jbc.2022.101909","url":null,"abstract":"Cytochrome P450 3A4 and 3A5 catalyze the metabolic clearance of a large portion of therapeutic drugs. Azamulin is used as a selective inhibitor for 3A4 and 3A5 to define their roles in metabolism of new chemical entities during drug development. In contrast to 3A4, 3A5 exhibits homotropic cooperativity for the sequential binding of two azamulin molecules at concentrations used for inhibition. To define the underlying sites and mechanisms for cooperativity, an X-ray crystal structure of 3A5 was determined with two azamulin molecules in the active site that are stacked in an antiparallel orientation. One azamulin resides proximal to the heme in a pose similar to the 3A4-azamulin complex. Comparison to the 3A5 apo structure indicates that the distal azamulin in 3A5 ternary complex causes a significant induced fit that excludes water from the hydrophobic surfaces of binding cavity and the distal azamulin, which is augmented by the stacking interaction with the proximal azamulin. Homotropic cooperativity was not observed for the binding of related pleuromutilin antibiotics, tiamulin, retapamulin, and lefamulin, to 3A5, which are larger and unlikely to bind in the distal site in a stacked orientation. Formation of the 3A5 complex with two azamulin molecules may prevent time-dependent inhibition that is seen for 3A4 by restricting alternate product formation and/or access of reactive intermediates to vulnerable protein sites. These results also contribute to a better understanding of sites for cooperative binding and the differential structural plasticity of 3A5 and 3A4 that contribute to differential substrate and inhibitor binding.","PeriodicalId":44070,"journal":{"name":"SLAVIC AND EAST EUROPEAN JOURNAL","volume":"40 1","pages":"101909"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90749761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04). 静脉注射依托泊苷治疗癫痫瘤复发患者的 II 期研究（CNS 2001 04）。

4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2022-04-13 eCollection Date: 2022-01-01 DOI: 10.1093/noajnl/vdac053

John R Apps, Shanna Maycock, David W Ellison, Timothy Jaspan, Timothy A Ritzmann, Donald Macarthur, Conor Mallucci, Keith Wheatley, Gareth J Veal, Richard G Grundy, Susan Picton

{"title":"Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04).","authors":"John R Apps, Shanna Maycock, David W Ellison, Timothy Jaspan, Timothy A Ritzmann, Donald Macarthur, Conor Mallucci, Keith Wheatley, Gareth J Veal, Richard G Grundy, Susan Picton","doi":"10.1093/noajnl/vdac053","DOIUrl":"10.1093/noajnl/vdac053","url":null,"abstract":"Background: Relapsed ependymoma has a dismal prognosis, and the role of chemotherapy at relapse remains unclear. This study prospectively evaluated the efficacy of intensive intravenous (IV) etoposide in patients less than 21 years of age with relapsed intracranial ependymoma (NCT00278252).Methods: This was a single-arm, open-label, phase II trial using Gehan's two-stage design. Patients received IV etoposide 100 mg/m2 on days 1-3, 8-10, and 15-17 of each 28-day cycle, up to maximum of 6 cycles. Primary outcome was radiological response after 3 cycles. Pharmacokinetic analysis was performed in 10 patients.Results: Twenty-five patients were enrolled and included in the intention-to-treat (ITT) analysis. Three patients were excluded in per-protocol (PP) analysis. After 3 cycles of etoposide, 5 patients (ITT 20%/PP 23%) had a complete response (CR), partial response (PR), or objective response (OR). Nine patients (ITT 36%/PP 41%,) had a best overall response of CR, PR, or OR. 1-year PFS was 24% in ITT and 23% in PP populations. 1-year OS was 56% and 59%, 5-year OS was 20% and 18%, respectively, in ITT and PP populations. Toxicity was predominantly hematological, with 20/25 patients experiencing a grade 3 or higher hematological adverse event.Conclusions: This study confirms the activity of IV etoposide against relapsed ependymoma, however, this is modest, not sustained, and similar to that with oral etoposide, albeit with increased toxicity. These results confirm the dismal prognosis of this disease, provide a rationale to include etoposide within drug combinations, and highlight the need to develop novel treatments for recurrent ependymoma.","PeriodicalId":44070,"journal":{"name":"SLAVIC AND EAST EUROPEAN JOURNAL","volume":"11 1","pages":"vdac053"},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90642433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Russian Views of Pushkin's Eugene Onegin 普希金尤金·奥涅金的俄罗斯观

IF 0.1 4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2021-02-15 DOI: 10.2307/309224

B. Cooke, S. Hoisington, W. Arndt

引用次数: 10

Stanislavsky in Focus 斯坦尼斯拉夫斯基的焦点

IF 0.1 4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2020-12-14 DOI: 10.2307/3086304

Nicholas Rzhevsky, S. Carnicke, A. Smeliansky, P. Miles

引用次数: 92

Socialist Realism without Shores 没有海岸的社会主义现实主义

IF 0.1 4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2020-11-25 DOI: 10.1215/9780822398097

T. Lahusen, E. Dobrenko

{"title":"Socialist Realism without Shores","authors":"T. Lahusen, E. Dobrenko","doi":"10.1215/9780822398097","DOIUrl":"https://doi.org/10.1215/9780822398097","url":null,"abstract":"\"Socialist Realism without Shores\" offers an international perspective on the aesthetics of socialist realism - an aesthetic that, contrary to expectations, survived the death of its originators and the demise of its original domain. This expanded edition of a special issue of the \"South Atlantic Quarterly\" brings together scholars from various parts of the globe to discuss socialist realism as it appears across genres in art, architecture, film, and literature and across geographic divides - from the 'centre,' Russia, to various points at the 'periphery' - China, Germany, France, Poland, remote republics of the former USSR, and the United States.The contributors argue that socialist realism has never been a monolithic art form and demonstrate, among other things, that its literature could accommodate psychoanalytic criticism; that its art and architecture could affect the aesthetic dictates of Moscow that made 'Soviet' art paradoxically heterogeneous; and that its aesthetics could accommodate both high art and crafted kitsch. \"Socialist Realism without Shores\" also addresses the critical discourse provoked by socialist realism - Stalinist aesthetics, 'anthropological' readings; ideology critique and censorship; and the sublimely ironic approaches adapted from sots art, the Soviet version of postmodernism. The contributors include: Antoine Baudin, Svetlana Boym, Greg Castillo, Katerina Clark, Evgeny Dobrenko, Boris Groys, Hans Gunther, Julia Hell, Leonid Heller, Mikhail Iampolski, Thomas Lahusen, Regine Robin, Yuri Slezkine, Lily Wiatrowski Phillips, Xudong Zhang, and Sergei Zimovets.","PeriodicalId":44070,"journal":{"name":"SLAVIC AND EAST EUROPEAN JOURNAL","volume":"43 1","pages":"224"},"PeriodicalIF":0.1,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66039695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Excerpts from “A Country Resembling Russia”: The Use of History in Boris Akunin’s Detective Novels 《一个像俄罗斯的国家》节选：历史在鲍里斯·阿库宁侦探小说中的运用

IF 0.1 4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2019-12-31 DOI: 10.1515/9781618112231-040

Elena V. Baraban

引用次数: 7

Chekhov and his Russia 契诃夫和他的俄罗斯

IF 0.1 4区文学

SLAVIC AND EAST EUROPEAN JOURNAL Pub Date : 2018-10-24 DOI: 10.2307/306481

Karl D. Kramer, W. Bruford

引用次数: 4

YOU CAN BUY THE WHOLE WORLD : THE PROBLEM OF REDEMPTION IN THE BROTHERS KARAMAZOV 你可以买下整个世界：卡拉马佐夫兄弟的救赎问题