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Ketogenic diet and beta-hydroxybutyrate modulate the hepatic expression of AKT/PI3K/mTOR pathway during treatment of obesity in rats. 生酮饮食和β-羟丁酸在大鼠肥胖症治疗过程中调节肝脏AKT/PI3K/mTOR通路的表达。
Journal of the Medical Research Institute Pub Date : 2024-04-01 DOI: 10.21608/jmalexu.2024.279483.1014
Walaa Salim, Maher Kamel, Madiha Helmy, Nesma A Ghazal
{"title":"Ketogenic diet and beta-hydroxybutyrate modulate the hepatic expression of AKT/PI3K/mTOR pathway during treatment of obesity in rats.","authors":"Walaa Salim, Maher Kamel, Madiha Helmy, Nesma A Ghazal","doi":"10.21608/jmalexu.2024.279483.1014","DOIUrl":"https://doi.org/10.21608/jmalexu.2024.279483.1014","url":null,"abstract":"Ketogenic diet and beta-hydroxybutyrate modulate the hepatic expression of AKT/PI3K/mTOR pathway during treatment of obesity in rats","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"79 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PD-1/PD-L1 AXIS INHIBITORS AS PROMISING STRATEGY FOR MANAGEMENT OF HEPATOCELLULAR CARCINOMA: EXPECTATIONS, BOUNDARIES AND PITFALLS 将 PD-1/pd-l1 轴抑制剂作为治疗肝细胞癌的有效策略：期望、界限和陷阱
Journal of the Medical Research Institute Pub Date : 2023-12-01 DOI: 10.21608/jmalexu.2023.323222
Yousra El Banna, Raghda Abo Ayana, Magda Nasr, Maged Helmy
{"title":"PD-1/PD-L1 AXIS INHIBITORS AS PROMISING STRATEGY FOR MANAGEMENT OF HEPATOCELLULAR CARCINOMA: EXPECTATIONS, BOUNDARIES AND PITFALLS","authors":"Yousra El Banna, Raghda Abo Ayana, Magda Nasr, Maged Helmy","doi":"10.21608/jmalexu.2023.323222","DOIUrl":"https://doi.org/10.21608/jmalexu.2023.323222","url":null,"abstract":": Hepatocellular carcinoma (HCC), the most prevalent primary liver cancer and a leading cause of cancer-related deaths worldwide","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VALUE OF SERUM INTERLEUKIN-22 IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION TO DISEASE CHARACTERISTICS 慢性淋巴细胞白血病患者血清白细胞介素-22的价值及其与疾病特征的关系
Journal of the Medical Research Institute Pub Date : 2023-11-28 DOI: 10.21608/jmalexu.2023.327836
Rania Elmeligy, Magda Sultan, Amal Ghanem, Hala Sultan, Maha El-gammal, O. Balbaa
{"title":"VALUE OF SERUM INTERLEUKIN-22 IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION TO DISEASE CHARACTERISTICS","authors":"Rania Elmeligy, Magda Sultan, Amal Ghanem, Hala Sultan, Maha El-gammal, O. Balbaa","doi":"10.21608/jmalexu.2023.327836","DOIUrl":"https://doi.org/10.21608/jmalexu.2023.327836","url":null,"abstract":": Background : Chronic lymphocytic leukaemia (CLL) is a common type of leukaemia characterized by progressive accumulation of monoclonal B cells. The survival and proliferation of CLL cells are stimulated by T-helper cytokines and could be correlated with disease progression. The aim of this study is to assess the value of serum interleukin-22 in patients with chronic lymphocytic leukemia and its relation to disease characteristics. Methods: The study was carried out on 40 CLL patients (newly diagnosed) and 10 healthy controls. Routine hematological and laboratory investigations were performed for all subjects in addition to interleukin-22 (IL-22) level and ZAP-70 expression. Results: Mean values of IL-22 level among CLL patients were significantly higher than in the control group. IL-22 mean values were significantly higher in patients with positive ZAP-70 expression. Moreover, there was a significant positive correlation between serum IL-22 level and ZAP-70. According to the ROC curve, the area under the curve was statistically significant (AUC=0.809 p=0.001). Conclusion : IL-22 & ZAP-70 could act in alliance to maintain survival of CLL cells and its proliferation and could be used as diagnostic as well as prognostic markers. Our findings strongly recommend the incorporation of IL-22 level into routine CLL work up.","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139222694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ARGON PLASMA COAGULATION VERSUS BAND LIGATION IN GASTRIC ANTRAL VASCULAR ECTASIA IN CHRONIC HCV-RELATED LIVER CIRRHOSIS 氩等离子体凝固法与带状结扎法治疗慢性丙肝相关性肝硬化患者的胃前部血管异位症
Journal of the Medical Research Institute Pub Date : 2023-06-01 DOI: 10.21608/jmalexu.2023.330097
Mohamed El-Hasafy, Gamal Amin, Hoda Ahmed, Manal Mahmoud
{"title":"ARGON PLASMA COAGULATION VERSUS BAND LIGATION IN GASTRIC ANTRAL VASCULAR ECTASIA IN CHRONIC HCV-RELATED LIVER CIRRHOSIS","authors":"Mohamed El-Hasafy, Gamal Amin, Hoda Ahmed, Manal Mahmoud","doi":"10.21608/jmalexu.2023.330097","DOIUrl":"https://doi.org/10.21608/jmalexu.2023.330097","url":null,"abstract":": Background and aim: Gastric antral vascular ectasia (GAVE) is a rare but serious cause of upper gastrointestinal bleeding. Argon plasma coagulation (APC) is used to treat GAVE, with considerable failure rate. The present study aimed to compare between APC and endoscopic band ligation (EBL) for GAVE treatment in HCV-related liver cirrhosis patients regarding efficacy and safety. Patients","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139371844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECTIVE TREATMENT OF MENINGITIS CAUSED BY MULTIPLE ORGANISMS INCLUDING MDR E. COLI, MDR KLEBSIELLA PNEUMONIAE AND MRSA: A CASE REPORT 有效治疗由耐多药大肠杆菌、耐多药肺炎克雷伯菌和耐甲氧西林金黄色葡萄球菌等多种生物引起的脑膜炎:1例报告
Journal of the Medical Research Institute Pub Date : 2022-12-01 DOI: 10.21608/jmalexu.2022.307268
E. Hamza, Shahinda Rezk
{"title":"EFFECTIVE TREATMENT OF MENINGITIS CAUSED BY MULTIPLE ORGANISMS INCLUDING MDR E. COLI, MDR KLEBSIELLA PNEUMONIAE AND MRSA: A CASE REPORT","authors":"E. Hamza, Shahinda Rezk","doi":"10.21608/jmalexu.2022.307268","DOIUrl":"https://doi.org/10.21608/jmalexu.2022.307268","url":null,"abstract":": Following neurosurgical intervention, meningitis caused by resistant microorganisms progresses with substantial morbidity and mortality. Treatment is challenging because there are few antibiotics that can cross into the cerebrospinal fluid and act on these organisms. It is advised to administer intraventricular antibiotics in the treatment of meningitis. Hereby, we are presenting a 2-month-old infant presented to the hospital with fever, hypoactivity and decrease in oral intake. This infant had inserted a shunt a month before this presentation. Upon full examination, the infant was diagnosed to suffer from a meningitis caused by multiple organisms including MRSA, MDR E. coli and MDR Klebsiella pneumoniae. The infection was successfully managed with a combination therapy which included, vancomycin, meropenem, amikacin and later on colistin through different routes of administration.","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"185 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114213747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATION OF APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN (ASC) AND B-CELL LYMPHOMA PROTEIN (BCL-6) IN RELATION TO PERIPHERAL BLOOD BIOMARKERS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS 评估细胞凋亡相关斑点样蛋白(asc)和b细胞淋巴瘤蛋白(bcl-6)与复发缓解型多发性硬化症外周血生物标志物的关系
Journal of the Medical Research Institute Pub Date : 2022-12-01 DOI: 10.21608/jmalexu.2022.295162
S. Youssry, Karim Kotkata, A. Abdelhamid, A. Hussein
{"title":"EVALUATION OF APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN (ASC) AND B-CELL LYMPHOMA PROTEIN (BCL-6) IN RELATION TO PERIPHERAL BLOOD BIOMARKERS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS","authors":"S. Youssry, Karim Kotkata, A. Abdelhamid, A. Hussein","doi":"10.21608/jmalexu.2022.295162","DOIUrl":"https://doi.org/10.21608/jmalexu.2022.295162","url":null,"abstract":".","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"44 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120816111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Soluble CD163 and Monocyte Surface Markers in Hepatitis C Virus Infected Patients 可溶性CD163和单核细胞表面标志物在丙型肝炎病毒感染患者中的作用
Journal of the Medical Research Institute Pub Date : 2022-06-01 DOI: 10.21608/jmalexu.2022.281702
L. El Sayed, H. Ghoniem, Said Awda, Salwa Nayer, Reham El Tayeb, E. Osman
{"title":"Role of Soluble CD163 and Monocyte Surface Markers in Hepatitis C Virus Infected Patients","authors":"L. El Sayed, H. Ghoniem, Said Awda, Salwa Nayer, Reham El Tayeb, E. Osman","doi":"10.21608/jmalexu.2022.281702","DOIUrl":"https://doi.org/10.21608/jmalexu.2022.281702","url":null,"abstract":"","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"68 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124102609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STUDY OF THE EFFECT OF SOFOSBUVIR BASED THERAPY ON ESTIMATED GLOMERULAR FILTRATION RATE IN EGYPTIAN CHRONIC HEPATITIS C PATIENTS 索非布韦为基础的治疗对埃及慢性丙型肝炎患者肾小球滤过率的影响研究
Journal of the Medical Research Institute Pub Date : 2021-12-01 DOI: 10.21608/jmalexu.2021.244166
Elsaied Ibrahim, Mohamed A. Elbealy, A. Nassar, H. Mostafa
{"title":"STUDY OF THE EFFECT OF SOFOSBUVIR BASED THERAPY ON ESTIMATED GLOMERULAR FILTRATION RATE IN EGYPTIAN CHRONIC HEPATITIS C PATIENTS","authors":"Elsaied Ibrahim, Mohamed A. Elbealy, A. Nassar, H. Mostafa","doi":"10.21608/jmalexu.2021.244166","DOIUrl":"https://doi.org/10.21608/jmalexu.2021.244166","url":null,"abstract":"Hepatitis C viral infection is endemic in Egypt with the highest prevalence rate of HCV Ab in the world (14.7%). [1] Direct-acting antiviral agents (DAAs) are molecules that target specific nonstructural proteins of virus C and result in disruption of viral replication and infection. [2] There are four classes of DAAs, which are defined by their mechanism of action and therapeutic target. They are; non-structural proteins NS 3/4A protease inhibitors (Simiprevir, paritaprevir), NS5B nucleoside polymerase inhibitors (Sofosbuvir), NS5B non-nucleoside polymerase inhibitors (Dasabuvir), and NS5A inhibitors (Daclatasvir). [3] National protocol of HCV treatment used in Egyptian patients infected with HCV (genotype 4) is a combination of daily sofosbuvir and any other DAAs. Compared to previously used treatments, sofosbuvir-based regimens provide a higher cure rate (>90%), fewer side effects, and a twoto fourfold reduction in duration of therapy.[4, 5]It allows most people to be treated successfully without the use of peglated interferon.[6,7]. Sofosbuvir is only administered orally. The peak concentration after oral administration is 0.5–2 hours post-dose, regardless of initial dose.[8&9] It is a prodrug. It is metabolized to the active metabolite antiviral agent GS-461203 (2'-deoxy-2'α-fluoro-β-C-methyluridine-5'triphosphate) in the liver. GS-461203 serves as a defective substrate for the NS5B protein, which is the viral RNA polymerase, thus acts as an inhibitor of viral RNA synthesis.[10] It appears to have a high barrier to develop resistance .Following a single 400mg oral dose of sofosbuvir 80٪ is excreted in urine; 14٪ is excreted in faeces, and 2.5٪ in expired air.[11] Sofosbuvir in patients with HCV infection and mild to moderate renal impairment (eGFR ≥30 ml/ min/1.73 m2) should be given according to the general recommendations. No dose Journal of the Medical Research Institute","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123699336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
URINARY NEUOTROPHIL GELATINASE ASSOCIATED LIPOCALIN AS A DIAGNOSTIC AND A PROGNOSTIC MARKER FOR RENAL INSULT IN CIRRHOTIC PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS 尿中性粒细胞明胶酶相关脂钙蛋白作为肝硬化合并自发性细菌性腹膜炎患者肾损伤的诊断和预后标志物
Journal of the Medical Research Institute Pub Date : 2021-12-01 DOI: 10.21608/jmalexu.2021.215311
M. Shater, Amr Abdel Moety, D. Hashad, Heba El-Shair, Azza Ahmed
{"title":"URINARY NEUOTROPHIL GELATINASE ASSOCIATED LIPOCALIN AS A DIAGNOSTIC AND A PROGNOSTIC MARKER FOR RENAL INSULT IN CIRRHOTIC PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS","authors":"M. Shater, Amr Abdel Moety, D. Hashad, Heba El-Shair, Azza Ahmed","doi":"10.21608/jmalexu.2021.215311","DOIUrl":"https://doi.org/10.21608/jmalexu.2021.215311","url":null,"abstract":"","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115401584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECT OF HOSPITAL BOARD GOVERNANCE PRACTICES ON PATIENT SAFETY OUTCOME 医院董事会治理实践对患者安全结果的影响
Journal of the Medical Research Institute Pub Date : 2021-06-01 DOI: 10.21608/jmalexu.2021.191790
Wael Ahmed, M. Bekheit, T. Eldomiaty, Hanaa Nagdy
{"title":"EFFECT OF HOSPITAL BOARD GOVERNANCE PRACTICES ON PATIENT SAFETY OUTCOME","authors":"Wael Ahmed, M. Bekheit, T. Eldomiaty, Hanaa Nagdy","doi":"10.21608/jmalexu.2021.191790","DOIUrl":"https://doi.org/10.21608/jmalexu.2021.191790","url":null,"abstract":"Patient safety is a healthcare discipline that can be defined as the prevention of harm caused by healthcare services with special attention to the reporting, analysis, and prevention of medical errors that may lead to an adverse health care event (IOM, 2004). Hospital board is accountable for the safety of the care its hospital provides (Feesko & Rubenstein, 2013). It therefore has a fundamental governance role in the oversight of patient safety by setting objectives, formulating strategy and designing systems of hospital control (Millar et al., 2013).","PeriodicalId":440681,"journal":{"name":"Journal of the Medical Research Institute","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127195008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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