VALUE OF SERUM INTERLEUKIN-22 IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION TO DISEASE CHARACTERISTICS

Journal of the Medical Research Institute Pub Date : 2023-11-28 DOI:10.21608/jmalexu.2023.327836

Rania Elmeligy, Magda Sultan, Amal Ghanem, Hala Sultan, Maha El-gammal, O. Balbaa

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Abstract

: Background : Chronic lymphocytic leukaemia (CLL) is a common type of leukaemia characterized by progressive accumulation of monoclonal B cells. The survival and proliferation of CLL cells are stimulated by T-helper cytokines and could be correlated with disease progression. The aim of this study is to assess the value of serum interleukin-22 in patients with chronic lymphocytic leukemia and its relation to disease characteristics. Methods: The study was carried out on 40 CLL patients (newly diagnosed) and 10 healthy controls. Routine hematological and laboratory investigations were performed for all subjects in addition to interleukin-22 (IL-22) level and ZAP-70 expression. Results: Mean values of IL-22 level among CLL patients were significantly higher than in the control group. IL-22 mean values were significantly higher in patients with positive ZAP-70 expression. Moreover, there was a significant positive correlation between serum IL-22 level and ZAP-70. According to the ROC curve, the area under the curve was statistically significant (AUC=0.809 p=0.001). Conclusion : IL-22 & ZAP-70 could act in alliance to maintain survival of CLL cells and its proliferation and could be used as diagnostic as well as prognostic markers. Our findings strongly recommend the incorporation of IL-22 level into routine CLL work up.

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慢性淋巴细胞白血病患者血清白细胞介素-22的价值及其与疾病特征的关系

:背景：慢性淋巴细胞白血病（CLL）是一种常见的白血病，其特征是单克隆 B 细胞的进行性积累。CLL 细胞的存活和增殖受到 T 辅助细胞因子的刺激，可能与疾病的进展有关。本研究旨在评估慢性淋巴细胞白血病患者血清白细胞介素-22的价值及其与疾病特征的关系。研究方法研究对象为 40 名新确诊的慢性淋巴细胞白血病患者和 10 名健康对照者。除白细胞介素-22（IL-22）水平和 ZAP-70 表达外，还对所有受试者进行了常规血液学和实验室检查。结果显示CLL患者的IL-22平均值明显高于对照组。ZAP-70阳性表达的患者的IL-22平均值明显更高。此外，血清 IL-22 水平与 ZAP-70 呈显著正相关。根据 ROC 曲线，曲线下面积具有统计学意义（AUC=0.809 p=0.001）。结论：IL-22 和 ZAP-70 可共同维持 CLL 细胞的存活和增殖，可用作诊断和预后标志物。我们的研究结果强烈建议将 IL-22 水平纳入常规 CLL 检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of the Medical Research Institute

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