{"title":"Mnemonics for Key Function of Prefrontal Cortex","authors":"Hanim Kwon, Hyung-Soo Lee, Moon Ho Park","doi":"10.17340/jkna.2023.0098","DOIUrl":"https://doi.org/10.17340/jkna.2023.0098","url":null,"abstract":"","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characteristics and Risk Factors of Seizure-related Injuries in Patients Presenting with Seizures to the Emergency Room","authors":"Jae Gun Park, Se-Jin Lee","doi":"10.17340/jkna.2023.0096","DOIUrl":"https://doi.org/10.17340/jkna.2023.0096","url":null,"abstract":"Background: The goal of this study was to investigate the incidence and type of seizurerelated injuries (SRIs) in patients presenting with seizures to the emergency department (ED) and to determine the risk factors of SRIs.Methods: In this retrospective cross-sectional study, we surveyed all seizure patients aged 18 years and older who visited the ED of Yeungnam University Hospital between October 2017 and September 2019. We excluded patients who developed seizures secondary to cardiac arrest or acute head trauma.Results: A total of 165 patients were enrolled and SRIs occurred in 33 patients (20.0%). The most common SRI was head injury (35.3%), followed by soft tissue injury (29.4%) and orolingual injury (17.6%). Most injuries were single, minor injury and required little or no treatment. Death occurred in one patient (3.0%) with SRIs due to intracranial hemorrhage. On univariate analysis, young age (p<0.001), history of alcohol use disorder (p=0.005), hypertension (p=0.022) and stroke (p=0.032), falling during seizure (p<0.001), seizure cluster (p=0.001), convulsive status epilepticus (p=0.034), generalized tonic-clonic seizure (p=0.010), initial blood ammonia level (p=0.007), and alcohol-related seizure (p=0.032) predicted the occurrence of SRIs. All patients with SRIs were independent in daily activities. On multiple logistic regression analysis, five variables remained significant: young age (p=0.037), history of alcohol use disorder (p=0.040), falling during seizure (p<0.001), seizure cluster (p=0.013), and convulsive status epilepticus (p=0.032).Conclusions: Young age, history of alcohol use disorder, falling during seizure, seizure cluster, and convulsive status epilepticus predicted SRIs in people presenting with seizure.","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"287 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characteristics and Risk Factors of Seizure-related Injuries in Patients Presenting with Seizures to the Emergency Room","authors":"Jae Gun Park, Se-Jin Lee","doi":"10.17340/jkna.2023.0096","DOIUrl":"https://doi.org/10.17340/jkna.2023.0096","url":null,"abstract":"Background: The goal of this study was to investigate the incidence and type of seizurerelated injuries (SRIs) in patients presenting with seizures to the emergency department (ED) and to determine the risk factors of SRIs.Methods: In this retrospective cross-sectional study, we surveyed all seizure patients aged 18 years and older who visited the ED of Yeungnam University Hospital between October 2017 and September 2019. We excluded patients who developed seizures secondary to cardiac arrest or acute head trauma.Results: A total of 165 patients were enrolled and SRIs occurred in 33 patients (20.0%). The most common SRI was head injury (35.3%), followed by soft tissue injury (29.4%) and orolingual injury (17.6%). Most injuries were single, minor injury and required little or no treatment. Death occurred in one patient (3.0%) with SRIs due to intracranial hemorrhage. On univariate analysis, young age (p<0.001), history of alcohol use disorder (p=0.005), hypertension (p=0.022) and stroke (p=0.032), falling during seizure (p<0.001), seizure cluster (p=0.001), convulsive status epilepticus (p=0.034), generalized tonic-clonic seizure (p=0.010), initial blood ammonia level (p=0.007), and alcohol-related seizure (p=0.032) predicted the occurrence of SRIs. All patients with SRIs were independent in daily activities. On multiple logistic regression analysis, five variables remained significant: young age (p=0.037), history of alcohol use disorder (p=0.040), falling during seizure (p<0.001), seizure cluster (p=0.013), and convulsive status epilepticus (p=0.032).Conclusions: Young age, history of alcohol use disorder, falling during seizure, seizure cluster, and convulsive status epilepticus predicted SRIs in people presenting with seizure.","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139890717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Giant Brainstem Arteriovenous Malformation with Spiral Venous Ectasia","authors":"Jusuck Lee, Yoonha Hwang, Sang-Mi Noh","doi":"10.17340/jkna.2023.0056","DOIUrl":"https://doi.org/10.17340/jkna.2023.0056","url":null,"abstract":"","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"6 5-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi-Seul Choo, Ga Eun Koo, Yu-Jin Kang, Dongwook Kang, Young Jun Ko, Ji Young Park, Chan-Young Park, Su-Hyun Han
{"title":"Hyperammonemic Encephalopathy Caused by the c.386+5G>A Mutation in OTC Gene in a Young Adult Woman","authors":"Yi-Seul Choo, Ga Eun Koo, Yu-Jin Kang, Dongwook Kang, Young Jun Ko, Ji Young Park, Chan-Young Park, Su-Hyun Han","doi":"10.17340/jkna.2023.0075","DOIUrl":"https://doi.org/10.17340/jkna.2023.0075","url":null,"abstract":"Noncirrhotic hyperammonemia as a cause of acute confusion remains diagnostic challenge. Deficiency of ornithine transcarbamylase (OTC) is the urea cycle disorder, inborn errors caused by a defect of the enzymes in the urea cycle, leading to an accumulation of ammonia mainly in newborn. There were very few cases, in which OTC deficiency result in hyperammonemia in adulthood. Herein, we report a young adult woman of hyperammonemic encephalopathy with OTC deficiency, diagnosed by high blood ammonia, glutamine and low plasma levels of citrulline. Next generation sequencing showed the c.386+5G>A mutation of the OTC gene.","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"170 S366","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139812859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Byung Kook Jeong, Joo Yeon Lee, Woo-Hyun Son, Sang-Jun Na
{"title":"Reversible Homonymous Hemianopia Associated with Focal Hyperperfusion in Hyperglycemic State","authors":"Byung Kook Jeong, Joo Yeon Lee, Woo-Hyun Son, Sang-Jun Na","doi":"10.17340/jkna.2023.0079","DOIUrl":"https://doi.org/10.17340/jkna.2023.0079","url":null,"abstract":"Hyperglycemic state frequently presents with neurologic manifestations including choreoathetosis, ballismus, dysphagia, seizures, and coma. Also, hyperglycemic hemianopia has been rarely reported to cause temporary damage to the visual cortex, resulting in homonymous hemianopia. A 65-year-old man was admitted because of right homonymous hemianopia accompanied by hyperglycemia. Brain single-photon emission computed tomography showed focal hyperperfusion in the left occipital lobe. Herein we report a case of reversible homonymous hemianopia with cerebral hyperperfusion associated hyperglycemia without seizure.","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"64 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139823864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two Patients Presenting with Resting Tremor in Upper Limbs","authors":"Su Jin Chung","doi":"10.17340/jkna.2023.0082","DOIUrl":"https://doi.org/10.17340/jkna.2023.0082","url":null,"abstract":"","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"324 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Byung Kook Jeong, Joo Yeon Lee, Woo-Hyun Son, Sang-Jun Na
{"title":"Reversible Homonymous Hemianopia Associated with Focal Hyperperfusion in Hyperglycemic State","authors":"Byung Kook Jeong, Joo Yeon Lee, Woo-Hyun Son, Sang-Jun Na","doi":"10.17340/jkna.2023.0079","DOIUrl":"https://doi.org/10.17340/jkna.2023.0079","url":null,"abstract":"Hyperglycemic state frequently presents with neurologic manifestations including choreoathetosis, ballismus, dysphagia, seizures, and coma. Also, hyperglycemic hemianopia has been rarely reported to cause temporary damage to the visual cortex, resulting in homonymous hemianopia. A 65-year-old man was admitted because of right homonymous hemianopia accompanied by hyperglycemia. Brain single-photon emission computed tomography showed focal hyperperfusion in the left occipital lobe. Herein we report a case of reversible homonymous hemianopia with cerebral hyperperfusion associated hyperglycemia without seizure.","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"28 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Spinal Muscular Atrophy Type 3a Showing Improvement in Neurofilament Light Chain of Cerebrospinal Fluid: Real-world Evidence","authors":"Pan-Woo Ko, Jong-Mok Lee","doi":"10.17340/jkna.2023.0049","DOIUrl":"https://doi.org/10.17340/jkna.2023.0049","url":null,"abstract":"A 38-year-old male was diagnosed with spinal muscular atrophy (SMA) type 3a, previously misdiagnosed as muscular dystrophy. He began treatment with nusinersen after getting approval from health insurance service. Cerebrospinal fluid (CSF) was collected when nusinersen was intrathecally injected. We measured the neurofilament light chain (NfL) level using a single molecular array as an efficacy biomarker. The CSF NfL level was markedly decreased after finishing the loading dosage. Our case implies that nusinersen is also effective in adults with SMA as a biomarker from real-world evidence.","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"17 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139890041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Namyoung Kim, Jeungwan Han, Sang Jin Park, Yoon Shik Chun, Yohan Ju, Hyun-Jae Kim
{"title":"Optic Neuritis after Infliximab Treatment in a Patient with Ulcerative Colitis","authors":"Namyoung Kim, Jeungwan Han, Sang Jin Park, Yoon Shik Chun, Yohan Ju, Hyun-Jae Kim","doi":"10.17340/jkna.2023.0087","DOIUrl":"https://doi.org/10.17340/jkna.2023.0087","url":null,"abstract":"Optic neuritis is a rare extraintestinal manifestation of inflammatory bowel disease. Antitumor necrosis factor alpha (anti-TNF-α) agents are essential treatment options in inflammatory bowel diseases. However, anti-TNF-α agents can implicate optic neuritis and other demyelinating diseases as complications of these agents. We report a patient of infliximab-induced optic neuritis in a patient with ulcerative colitis who was treated with high-dose steroids after discontinuation of infliximab.","PeriodicalId":437080,"journal":{"name":"Journal of the Korean Neurological Association","volume":"57 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139823843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}