Acta Oncologica Turcica最新文献

{"title":"Parosteal Osteosarcoma: Radiologic and Prognostic Features","authors":"O. Aycan, Muhammet Alptekin Kocaoğlu, M. Arslan, M. Mert, Alper Köksal","doi":"10.5505/aot.2021.73549","DOIUrl":"https://doi.org/10.5505/aot.2021.73549","url":null,"abstract":"Aim: The aim of this study is to evaluate significance of Magnetic Resonance Imaging (MRI) characteristics and their effects on surgical margins, prognosis, oncological and functional outcomes of parosteal osteosarcoma in our clinic. Patients and method: Fifteen patients (4 male/11 female) who operated with the diagnosis of parosteal osteosarcoma in our clinic were retrospectively reviewed. The epidemiological data, biopsy method and delay in diagnosis are noted. The lesions maximum circumferential extension, intramedullary involvement and neurovascular extension in MRI sections were evaluated. The resection type (segmental articular/hemicortical) and surgical margins were noted. Functional and oncological results at last follow-up were assessed. Results: The mean age was 31.7 (17-71) years; mean follow-up was 50.1 (24-176) months. The most common site was distal femur. The closed biopsies were related with increased number of re-biopsies and misdiagnosis/improper interventions. (p<0.001,p=0.023) Intramedullary involvement percentage was related with maximum circumferential extension percentage (p=0.006) The intramedullary involvement ratio of ≤25% suggested no recurrence or metastasis. The mean MSTS score was 87.8% (range, 60-100%). The neurovascular involvement was related with metastatic disease, deep infections and complication related surgeries. (p=0.017, p=0.002,p=0.005) The most common resection type was segmental articular resection (9 patients). Hemicortical resections with biological reconstructions had the best MSTS scores. (p=0.002) The maximum circumferential extension percentage, intramedullary involvement percentage and neurovascular involvement showed lower MSTS scores. The 5-year overall survival was 92.3%, local recurrence-free survival was 86.2% and metastasis-free survival was 86.2%. Conclusion: The reliability of needle biopsy sampling is controversial in parosteal osteosarcomas. The lesions extent of intramedullary involvement, neurovascular bundle proximity and maximum periosteal circumferential extension on MRI should be considered when planning the surgery. The evaluation of maximum circumferential extension on MRI is crucial for the resection margins.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115940551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison the Clinical Features of Newly Diagnosed Multiple Myeloma Patients According to CD23 Expression Status","authors":"U. Iltar, O. Salim, T. Ulaş, S. Berker Karaüzüm, C. Aydin, L. Undar","doi":"10.5505/aot.2022.13008","DOIUrl":"https://doi.org/10.5505/aot.2022.13008","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"384 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115989781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standart Prophylactic Granulocyte Colony Stimulating Factor Usage As A Part Of Autologous Stem Cell Transplantati̇on Procedure","authors":"Lale Aydın Kaynar, Z. N. Özkurt, F. Can, Z. Yeğin, Özlem Güzel Tunçcan, M. Yağcı","doi":"10.5505/aot.2022.47113","DOIUrl":"https://doi.org/10.5505/aot.2022.47113","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116669488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Optimal Treatment Approaches and Prognostic Factors In Elderly Patients with Advanced Stage Biliary Tract Tumors","authors":"Sabin Göktaş Aydın, Burçin Çakan Demirel, A. Bilici, C. Yilmaz, A. Topçu, M. Aykan, S. Kahraman, M. Atçı, I. Akbıyık, Fahri Akgül, Ö. Ölmez, A. Aydin","doi":"10.5505/aot.2023.03708","DOIUrl":"https://doi.org/10.5505/aot.2023.03708","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"1121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116072966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"False-positive MRI Findings in Breast Cancer After Neoadjuvant Chemotherapy and Correlation Between Tumor Response Patterns and HER2 Status","authors":"Aydan Avdan Aslan, Servet Erdemli, I. Erdogdu, Serap Gültekin, C. Uras, F. Tokat, A. Arıcan, Leyla Özer, Kemal Behzatoğlu, N. Meydan, F. Taşkın","doi":"10.5505/aot.2023.60973","DOIUrl":"https://doi.org/10.5505/aot.2023.60973","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126752425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are platelet and eosinophil parameters indicators of predicting the development of erectile dysfunction after radical prostatectomy?","authors":"I. Selvi, E. Öztürk","doi":"10.5505/AOT.2019.75436","DOIUrl":"https://doi.org/10.5505/AOT.2019.75436","url":null,"abstract":"INTRODUCTION: Erectile dysfunction(ED) may develop in 14-90% following radical prostatectomy(RP). Development of ED is due to neurovascular damage during surgery. In our study, we aimed to evaluate whether the platelet and eosinophil parameters are prognostic factors in predicting ED after prostatectomy. METHODS: Data of 181 patients who underwent RP between January 2010 and December 2016 were analyzed retrospectively. In the preoperative period, platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and eosinophil count were recorded. The patients were evaluated for ED according to the International Erectile Function Index in preoperatively and postoperatively. In the postoperative 12th month, ED was observed in 128 patients following RP. Among them, 82 patients with postoperative ED were included in Group I, and 46 patients without postoperative ED were included in Group II. RESULTS: Age (p=0.281) and body mass index (p=0.851) had no significant difference between groups. In preoperative period, mean platelet count (292.18±51.62 vs. 240.15±46.25, p<0.001), mean MPV value (8.77±1.24 vs. 6.17±0.87, p<0.001) and mean eosinophil count (0.57±0.16 vs. 0.47±0.10, p<0.001) were higher Orijinal Çalışma 137 Adress for correspondence: İsmail Selvi, Karabük Üniversitesi Eğitim ve Araştırma Hastanesi, Üroloji Kliniği 78200 Merkez / Karabük – Türkiye e-mail: ismselvi33@hotmail.com Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi in Group I. Mean PDW value (16.21±1.84 vs.16.75±1.77, p=0.110) had no significantly difference. According to ROC analysis, the cut-off values for platelet, MPV and eosinophil were 242 (AUC: 0.783, p<0.001), 7.24 (AUC: 0.951, p<0.001) and 0.5 (AUC: 0.675, p=0.001), respectively. In multivariate analysis, MPV and eosinophil were found to be more important independent factors in predicting ED after RP. DISCUSSION and CONCLUSION: It is shown that platelet, MPV and eosinophil are independent predictive factors in predicting ED following prostatectomy.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128184949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric tonsil hypertrophy may be a sign of Burkitt’s lymphoma","authors":"S. Aydın, E. Boldaz","doi":"10.5505/AOT.2019.47550","DOIUrl":"https://doi.org/10.5505/AOT.2019.47550","url":null,"abstract":"A 4-year-old boy has had cryptic membranous tonsillitis episode 5-6 times since last year and applied to our Ear Nose and Throat (ENT) clinic for the last 3 months of onset of odynophagia. Patient showed asymmetric hypertrophy of the left tonsil (grade 4) and the appearance of ulcerated surface was observed (Figure 1). In computerized tomography; (sections crossing oropharynx levels) it was interpreted as a mass that could be malignant in the soft tissue density of the contour of the left parapharyngeal lesion of approximately 41x31 mm. Tonsillectomy was performed with general anesthesia. Histopathologic and immunohistochemical findings were compatible with Burkitt's lymphoma (BL), CD20 (+) and Ki67 proliferation index were 90% positive (Figure 2). The patient was referred to the oncology clinic for chemotherapy.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124929690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of patients diagnosed with multiple myeloma: A single center experience","authors":"M. Şimşek, P. Tarkun, A. Hacıhanefioğlu","doi":"10.5505/aot.2019.24582","DOIUrl":"https://doi.org/10.5505/aot.2019.24582","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121751245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Adjuvant Intravesical Mitomycin-C Treatment in Non-Muscle Invaziv High-Grade Bladder Cancer: Singe center experience","authors":"O. U. Cakici, N. Hamidi","doi":"10.5505/aot.2019.50479","DOIUrl":"https://doi.org/10.5505/aot.2019.50479","url":null,"abstract":"INTRODUCTION: The aim of the present study is to evaluate and report the clinical efficiacy of adjuvant intravesical mitomycin-c in the treatment of non-muscle invaziv high-grade bladder cancer patients of a tertiary single health-care center. MATERIAL and METHODS: Electronic records of the patients who had undergone endoscopic treatment of bladder tumors between Jan 2012 and Dec 2018 are retrospectively reviewed. Data of the patients who were diagnosed with non-invasive high-grade urothelial carcinoma are further evaluated if adjuvant intravesical mitomycin-c therapy had been initiated and included in the study. Patient demographics, cystoscopy findings, pathological findings, and outpatients record are included in the analysis. RESULTS: Total of 54 patients included in this study. Among them 50 patients had pT1 disease while 4 patients had pTa disease. None of the patients in this cohort had carcinoma-in-situ. Mean tumor diameter was 1.4 cm. Mean time from initial transurethral resection to the application of the adjuvant therapy was 2 weeks (1-4 weeks). Mean follow-up time was 21 months. During the follow-up, tumor progression was observed in 14 (26%) patients, high-grade tumor recurrence was observed in 22 (41%) patients, and low-grade tumor recurrence was observed in 4 (7%) patients. Among the 22 patients who had high-grade recurrence, 6 patients had also tumor progression during the follow-up Orijinal Çalışma 156 Adress for correspondence: Özer Ural Çakıcı, Yenimahalle Eğitim ve Araştırma Hastanesi, Üroloji Kliniği, Ankara Türkiye e-mail: ozerural@hotmail.com Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi DISCUSSION AND CONCLUSION: Non-invasive high-grade bladder cancer holds significant risk of stage progression and recurrence. The contemporary clinical guidelines endorse adjuvant intravesical BCG treatment in the management of non-muscle invasive bladder cancer. Due to our results, adjuvant intravesical mitomycin-c therapy can be considered as a accomplished alternative.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131283628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic impact of tumor budding in lung squamous cell carcinoma","authors":"M. Tepeoğlu","doi":"10.5505/aot.2019.76768","DOIUrl":"https://doi.org/10.5505/aot.2019.76768","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116603944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}