Clinical Medicine Insights- Pathology最新文献_第4页

Cytomorphological Aspects of Hashimoto's Thyroiditis: Our Experience at a Tertiary Center. 桥本甲状腺炎的细胞形态学方面:我们在三级中心的经验。

Clinical Medicine Insights- Pathology Pub Date : 2014-01-16 eCollection Date: 2014-01-01 DOI: 10.4137/CPath.S13580

Monika Rathi, Faiyaz Ahmad, Satish Kumar Budania, Seema Awasthi, Ashutosh Kumar, Shyamoli Dutta

{"title":"Cytomorphological Aspects of Hashimoto's Thyroiditis: Our Experience at a Tertiary Center.","authors":"Monika Rathi, Faiyaz Ahmad, Satish Kumar Budania, Seema Awasthi, Ashutosh Kumar, Shyamoli Dutta","doi":"10.4137/CPath.S13580","DOIUrl":"https://doi.org/10.4137/CPath.S13580","url":null,"abstract":"Introduction: Hashimoto's thyroiditis is the most common form of acquired hypothyroidism. Fine needle aspiration cytology is one important tool in diagnosing Hashimoto's thyroditis, along with clinical, biochemical, immunological and ultrasonographical modalities. The present study examines cytological aspects of Hashimoto's thyroiditis along with their correlation with clinical, biochemical and immunological findings, whenever available.Materials and methods: This is a retrospective study of 50 cases of Hashimoto's thyroiditis. Cytological findings were reviewed and correlated with clinical, biochemical and immunological findings whenever available.Results: The majority of the patients were middle-aged females, with a female to male ratio of 6.14:1. Most patients presented with diffuse thyromegaly (68%) and/or hypothyroidism (56.09%). The antibody profile was available in 22% of patients. Of these, anti-thyroid peroxidase antibodies were raised in 81.81% of patients and anti-thyroglobulin antibodies were raised in 63.63% of patients. In the present study, high lymphoid to epithelial cell ratio was seen in 78% of cases, and 74% of cases showed Hurthle cell change. Follicular atypia was seen in 36% of cases. Lymphoid follicle formation was seen in seen in 54% of cases. Follicular cell infiltration by lymphocytes, eosinophils and neutrophils was seen in 72%, 48% and 26% of cases, respectively. Plasma cells were seen in 18% of cases.Conclusion: Thyroid function tests and immunological tests cannot diagnose all cases of Hashimoto's thyroiditis. Fine needle aspiration cytology continues to be a diagnostic tool of significance in diagnosing Hashimoto's thyroiditis. The presence of inflammatory cells, particularly lymphocytes and eosinophils, was detected in a significant proportion of cases.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CPath.S13580","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32117572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Benign pairs: a significant entity in aspiration cytology smears from breast lesions. 良性对:乳腺病变吸吸细胞学涂片的重要组成部分。

Clinical Medicine Insights- Pathology Pub Date : 2013-11-28 eCollection Date: 2013-01-01 DOI: 10.4137/CPath.S13273

Monika Rathi, Pooja Kala, Atul Gupta, Satish Kumar Budania, Harshkiran Ahuja

{"title":"Benign pairs: a significant entity in aspiration cytology smears from breast lesions.","authors":"Monika Rathi, Pooja Kala, Atul Gupta, Satish Kumar Budania, Harshkiran Ahuja","doi":"10.4137/CPath.S13273","DOIUrl":"https://doi.org/10.4137/CPath.S13273","url":null,"abstract":"Introduction: Fine needle aspiration cytology (FNAC) is a reliable diagnostic tool used to diagnose breast lesions preoperatively. However, FNAC is also associated with diagnostic pitfalls. Further studies are needed to improve its diagnostic efficacy. We noticed ovoid, bare nuclei arranged in closely touching diads (benign pairs) in a significant number of cytology smears. This prompted us to assess their diagnostic utility.Materials and methods: This was a prospective study conducted in Sarojini NaiduMedical College, Agra, India. Quantitative estimation of benign pairs per 1000 ductal cells in at least 20 high power field was attempted in cytology smears of 128 cases.Results: The average number of pairs in benign and malignant lesions was calculated as 7.07 + 5.96 and 0.28 + 0.78, respectively. Statistical analysis showed a significant difference between the number of pairs in benign and malignant cases (P < 0.0005).Conclusions: Quantitative estimation of benign pairs is helpful in distinguishing benign from malignant cases.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CPath.S13273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31944154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain 自杀后海马中BDNF、NGF及其受体mRNA和蛋白表达的减少:对人类死后大脑的分析

Clinical Medicine Insights- Pathology Pub Date : 2013-01-01 DOI: 10.4137/CPath.S12530

R. Banerjee, A. Ghosh, B. Ghosh, S. Bhattacharyya, A. Mondal

{"title":"Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain","authors":"R. Banerjee, A. Ghosh, B. Ghosh, S. Bhattacharyya, A. Mondal","doi":"10.4137/CPath.S12530","DOIUrl":"https://doi.org/10.4137/CPath.S12530","url":null,"abstract":"Despite the devastating effect of suicide on numerous lives, there is still a lack of knowledge concerning its neurochemical aspects. There is increasing evidence that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in the pathophysiology and treatment of depression through binding and activating their cognate receptors TrkB and TrkA respectively. The present study was performed to examine whether the expression profiles of BDNF and/or TrkB as well as NGF and/or TrkA were altered in the hippocampus of postmortem brain of the participants, who had committed suicide and whether these alterations were associated with specific psychopathologic conditions. These studies were performed on the hippocampus of 21 suicide victims and 19 non-psychiatric control individuals. The protein and mRNA levels of BDNF, TrkB, NGF, and TrkA were determined by sandwich enzyme-linked immunosorbent assay, Western blot and reverse transcription-PCR. Given the importance of BDNF and NGF and their cognate receptors in mediating physiological functions, including cell survival and synaptic plasticity, our findings of reduced expression of BDNF, TrkB, NGF, and TrkA on both the protein and mRNA levels of postmortem brains of suicide victims suggest that these molecules may play an important role in the pathophysiological aspects of suicidal behavior.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87355403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 119

Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain. 自杀后海马中BDNF、NGF及其受体mRNA和蛋白表达的减少:对人类死后大脑的分析。

Clinical Medicine Insights- Pathology Pub Date : 2013-01-01 DOI: 10.4137/CMPath.S12530

Ritabrata Banerjee, Anup K Ghosh, Balaram Ghosh, Somnath Bhattacharyya, Amal C Mondal

{"title":"Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain.","authors":"Ritabrata Banerjee, Anup K Ghosh, Balaram Ghosh, Somnath Bhattacharyya, Amal C Mondal","doi":"10.4137/CMPath.S12530","DOIUrl":"https://doi.org/10.4137/CMPath.S12530","url":null,"abstract":"Despite the devastating effect of suicide on numerous lives, there is still a lack of knowledge concerning its neurochemical aspects. There is increasing evidence that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in the pathophysiology and treatment of depression through binding and activating their cognate receptors TrkB and TrkA respectively. The present study was performed to examine whether the expression profiles of BDNF and/or TrkB as well as NGF and/or TrkA were altered in the hippocampus of postmortem brain of the participants, who had committed suicide and whether these alterations were associated with specific psychopathologic conditions. These studies were performed on the hippocampus of 21 suicide victims and 19 non-psychiatric control individuals. The protein and mRNA levels of BDNF, TrkB, NGF, and TrkA were determined by sandwich enzyme-linked immunosorbent assay, Western blot and reverse transcription-PCR. Given the importance of BDNF and NGF and their cognate receptors in mediating physiological functions, including cell survival and synaptic plasticity, our findings of reduced expression of BDNF, TrkB, NGF, and TrkA on both the protein and mRNA levels of postmortem brains of suicide victims suggest that these molecules may play an important role in the pathophysiological aspects of suicidal behavior.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMPath.S12530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10014852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features and differential diagnoses in laryngeal mucoepidermoid carcinoma. 喉黏液表皮样癌的临床特点及鉴别诊断。

Clinical Medicine Insights- Pathology Pub Date : 2012-01-01 Epub Date: 2011-12-06 DOI: 10.4137/CPath.S8435

Sepideh Mokhtari, Saeedeh Mokhtari

引用次数: 14

Comparison of KRAS Mutation Assessment in Tumor DNA and Circulating Free DNA in Plasma and Serum Samples. 肿瘤DNA与血浆和血清循环游离DNA KRAS突变评估的比较。

Clinical Medicine Insights- Pathology Pub Date : 2012-01-01 Epub Date: 2012-05-15 DOI: 10.4137/CPath.S8798

Shethah R Morgan, Jessica Whiteley, Emma Donald, John Smith, Marcia T Eisenberg, Eddie Kallam, Lauren Kam-Morgan

{"title":"Comparison of KRAS Mutation Assessment in Tumor DNA and Circulating Free DNA in Plasma and Serum Samples.","authors":"Shethah R Morgan, Jessica Whiteley, Emma Donald, John Smith, Marcia T Eisenberg, Eddie Kallam, Lauren Kam-Morgan","doi":"10.4137/CPath.S8798","DOIUrl":"https://doi.org/10.4137/CPath.S8798","url":null,"abstract":"Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging. This study assessed the identification of KRAS mutations in circulating free DNA (cfDNA) using a commercially available KRAS polymerase chain reaction (PCR) kit. Matched plasma, serum and tumor samples were available from 71 patients with mCRC who had received prior therapy but whose disease progressed following therapy. Yields of cfDNA from plasma and serum samples were comparable. Analyses were successful in 70/71 plasma-extracted samples (specificity: 97%, sensitivity: 31%) and 67/71 serum- extracted samples (specificity: 100%, sensitivity: 25%). This study demonstrates that KRAS mutations can be detected in cfDNA using a commercially available KRAS PCR kit, confirming cfDNA as a potential alternative source of tumor DNA in a diagnostic setting if access to archival tumor specimens is limited.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CPath.S8798","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30663741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

Pathology of gastrointestinal stromal tumors. 胃肠道间质瘤的病理。

Clinical Medicine Insights- Pathology Pub Date : 2012-01-01 Epub Date: 2012-07-17 DOI: 10.4137/CPath.S9689

Wai Chin Foo, Bernadette Liegl-Atzwanger, Alexander J Lazar

引用次数: 78

Steroid-induced sigmoid diverticular perforation in a patient with temporal arteritis: a rare clinical pathology. 类固醇致乙状结肠憩室穿孔1例颞动脉炎:罕见的临床病理。

Clinical Medicine Insights- Pathology Pub Date : 2012-01-01 Epub Date: 2012-03-29 DOI: 10.4137/CPath.S7924

Bulent Kaya, Orhan Aras, Orhan Bat, Nuriye Esen Bulut, Kemal Memisoglu

引用次数: 7

Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy. 菊池病:发烧和淋巴结病的罕见病因。

Clinical Medicine Insights- Pathology Pub Date : 2012-01-01 Epub Date: 2012-02-26 DOI: 10.4137/CPath.S8685

A Vivekanandarajah, B Krishnarasa, M Hurford, S Gupta

引用次数: 13

Different clinical presentation of appendicolithiasis. The report of three cases and review of the literature. 阑尾结石的不同临床表现。报告三个病例并复习相关文献。

Clinical Medicine Insights- Pathology Pub Date : 2011-03-30 DOI: 10.4137/CPath.S6757

Bulent Kaya, Cengiz Eris

引用次数: 22