Current Microwave Chemistry最新文献

{"title":"Microwave Facilitated Discovery of Substituted 1,2,4-triazaspiro[4.5]dec-2-en-3-amines: Biological and Computational Investigations","authors":"Parth P. Patel, N. Patel, M. S. Tople, V. M. Patel, Mitesh B. Solanki","doi":"10.2174/2213335610666230818092826","DOIUrl":"https://doi.org/10.2174/2213335610666230818092826","url":null,"abstract":"\u0000\u0000Tuberculosis is an effectual infectious disease caused by the spread of tubercular bacteria within the lungs via droplets of coughs and sneezes. In 2021, 1.6 million people died due totuberculosis, which is the 13th leading killer disease and 2nd leading after COVID-19 infectious disease.\u0000\u0000\u0000\u0000Many drugs are available as antitubercular drug, but still, requires more efficacious drug molecules with lower toxicity, side effects and small-sized molecules. To fulfill said prospective, computational study such as molecular docking and ADMET studies guides towards an ideal drug molecule with small -sized, unique spiro structures.\u0000\u0000\u0000\u0000Conventional and microwave-initiated Reaction of cyclohexanone, hydrazine carbothioamide, and 2-amino-4-methoxy-6-methyl-1,3,5-triazine affords compound 1, which is subjected to the Schiff base reaction with diverse aldehydes. All structures are defined using IR, 1H NMR, 13C NMR, and mass spectroscopy. The entire series is exposed to in vitro antibacterial and antitubercular and in silico molecular docking and ADMET studies.\u0000\u0000\u0000\u0000Compounds 2c and 2b have been established to be potential antibacterial agents, whereas compounds 2d, 2e, 2j, 2k and 2l are extremely effective against tubercular strains. Furthermore, molecular docking of related molecules is performed, and compounds 2d, 2e, 2j, 2k, and 2l have higher affinities toward antitubercular proteins. ADMET parameters such as water solubility, SA score, PCaco2 value, and TPSA values are satisfactory.\u0000\u0000\u0000\u0000The microwave method has been proven to be a greener method as compared to the conventional heating method. Comparative results of in vitro analysis are obtained with referenced antibacterial drugs and antitubercular drugs. In silico observations supports their in vitro assessments. Appraisal obtained from the ADMET study leads to the formation of ideal drug molecules.\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48872822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic study of novel polymer dextran in aqueous media at 12 MHz","authors":"Subhraraj Panda","doi":"10.2174/2213335610666230810094605","DOIUrl":"https://doi.org/10.2174/2213335610666230810094605","url":null,"abstract":"\u0000\u0000The characteristics of matter and the dynamics of molecular processes are examined by acoustic approaches. The primary techniques in molecular acoustics are the measurement of sound speed and sound absorption, as well as the relationship between these quantities and different physical variables including pressure, temperature, and wave frequency. Molecular acoustics emerged as a separate field in the 1930s. When it was discovered that many substances disperse the speed of sound during the transmission of sound waves through them and that the classical law, which states that the coefficient of absorption is proportional to the square of the frequency, however, it does not adequately describe how sound is absorbed.\u0000\u0000\u0000\u0000The ultrasonic technique is employed because it is one of the most popular techniques, which is very easy to use, and provides precise velocity results. With careful analysis of the results, the correlation between solute and solvent was discovered. In the pharmaceutical, agricultural, and cosmetics industries, dextran and its derivatives from a few select strains have found a wide range of uses. This is why we have chosen it for our study. For assessing the impact of temperature and concentration on the aqueous medium containing the polymer dextran, ultrasonic properties are crucial. Pycnometer, Ostwald viscometer, and ultrasonic interferometer were used respectively to measure density (ρ), viscosity (η), and ultrasonic speed (u) at \"303 K, 308 K, 313 K, 318 K, and 323 K.\" The experimental parameters are used to determine the acoustic parameters \"adiabatic compressibility, Intermolecular free length, relaxation time, acoustic impedance, and Gibb's free energy\".\u0000\u0000\u0000\u0000To measure the density, viscosity, and ultrasonic velocity of the solution using a pycnometer, an Ostwald's viscometer, and an ultrasonic interferometer, and to calculate the thermo acoustical parameters based on the measured parameters.\u0000\u0000\u0000\u0000Applications for examining the physico-chemical behaviour of aqueous dextran using ultrasound include understanding the nature of molecular interactions.\u0000\u0000\u0000\u0000It was investigated how concentration and temperature affected the thermoacoustic characteristics of aqueous dextran. Hydrogen bonds, charge transfer complexes, and the dissolution of hydrogen bonds and complexes are only a few examples of the forces that exist between molecules and how the analysis has interpreted their nature. Weak intermolecular forces exist.\u0000\u0000\u0000\u0000Recent developments in ultrasonic techniques have made them an effective tool for evaluating information regarding the physical and chemical behaviour of liquid molecules.\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48466963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our Contribution to Microwave-Assisted Conversions of Bioactive Compounds","authors":"B. Das, Nayaki Salva Reddy, A. Rathod, S. Avula, R. Das","doi":"10.2174/2213335610666230609121927","DOIUrl":"https://doi.org/10.2174/2213335610666230609121927","url":null,"abstract":"\u0000\u0000The microwave chemistry of several bioactive natural products and synthetic compounds was studied by us. The compounds of different types, such as alkaloid, terpenoid, lignan, etc. were considered for our investigation. Some indole compounds, as well as organosulfur and miscellaneous carbonyl compounds, were also included. The substrates were irradiated under microwave irradiation for a short time and the resulting products were characterized. The conversion was conducted without using any solvent. The catalysts were not required in many transformations, but in some cases, catalysts, mainly heterogeneous catalysts were needed. The experimental procedures were convenient, less expensive, and generally eco-friendly. The interesting results of our efforts are briefly discussed in the present article.\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45971759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of microwave radiation on the solvent-free synthesis of phthaloylamino acids","authors":"N. Pankrushina, M. O. Korotkikh, A. N. Mikheev","doi":"10.2174/2213335610666230523114340","DOIUrl":"https://doi.org/10.2174/2213335610666230523114340","url":null,"abstract":"\u0000\u0000In recent years, microwave radiation has been widely used in organic synthesis, including solvent-free mode. However, the reaction conditions of phthalic anhydride with amino acids under solvent-free microwave activation have not been studied so far.\u0000\u0000\u0000\u0000In the present work, the effect of microwave activation on the interaction of phthalic anhydride with amino acids in solvent-free conditions has been studied in detail.\u0000\u0000\u0000\u0000The microwave heating dynamics of phthalic anhydride, glycine and their equimolar mixture under microwave conditions have been investigated, and the dependence of the heating rate on the microwave power is defined.\u0000\u0000\u0000\u0000The common conditions for the synthesis of phthaloylamino acids have been determined as continuous heating at a power of 200 W at 130 °C for 5-6 min and additional heating for 5-10 min at a temperature close to the melting point of the corresponding amino acid. We apply the developed two-step solvent-free microwave reaction protocol successfully for the synthesis of phthaloyl derivatives of glycine, alanine, β-alanine, 4-aminobenzoic acid, γ-aminobutyric acid, isoleucine, leucine, phenylalanine.\u0000\u0000\u0000\u0000Reaction conditions for synthesizing phthaloylamino acids by microwave activation without solvent have been established. The solvent-free microwave reaction between phthalic anhydride and amino acid has been found to proceed in the melted phthalic anhydride.\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44091129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-assisted Synthesis of 3-amino-2-phenylquinazolin-4(3H)-one (QH) and 4-oxo-2-phenylquinazoline-3(4H)-carbothioamide (QTh)","authors":"D. Sengupta, Ranjan Kumar Das, Debdulal Sharma, S. Paul","doi":"10.2174/2213335610666230516165046","DOIUrl":"https://doi.org/10.2174/2213335610666230516165046","url":null,"abstract":"\u0000\u0000Microwave synthesis has developed as a powerful tool for the cost-effective and greener synthesis of organic molecules, including quinazolines. Irradiation with microwave leads to the excitation of molecules and equitable distribution of thermal energy in a much shorter time than conventional synthesis. This results in shorter reaction time and, more often than not, higher efficiency.\u0000\u0000\u0000\u0000The primary objective of the work presented in this article was to prepare hydrazine hydrate or thiourea derivative of quinazolines through microwave synthesis as small-molecule scaffolds for further need-based functionalisation, isolation, and characterisation. We, herein, report the synthesis of two quinazolinone derivatives of thiourea and hydrazine, 3-amino-2-phenylquinazolin-4(3H)-one (QH) and 4-oxo-2-phenylquinazoline-3(4H)-carbothioamide (QTh), respectively.\u0000\u0000\u0000\u0000A multi-step synthetic strategy starting from anthranilic acid was employed to synthesise the small molecule quinazolinones 3-amino-2-phenylquinazolin-4(3H)-one (QH) and 4-oxo-2-phenylquinazoline-3(4H)-carbothioamide (QTh). The compounds were synthesised by reacting hydrazine and thiourea with 2-benzamidobenzoyl chloride in DMF under microwave irradiation (800 W at 135 °C for 4 min) in the presence of potassium carbonate. The acid chloride was prepared by chlorination of 2-benzamidobenzoic acid, which in turn was synthesised from anthranilic acid by benzoylation. This method is an efficient alternative approach to synthesising quinazolinones from benzoxazin-4-ones.\u0000\u0000\u0000\u0000We have successfully synthesised, isolated, and characterised the quinazolinone derivative QH (yield: 81%) and QTh (yield: 85%). The structures of the compounds were established through spectroscopic techniques. Theoretical optimisation of the structures was also achieved using DFT. The HOMO-LUMO difference for QH and QTh was calculated to be 4.60 and 4.47 eV, respectively.\u0000\u0000\u0000\u0000The reported protocol is advantageous over conventional methods of quinazoline synthesis from benzoxazin-4-ones. The time required for the reaction is much less (4 min) as compared to the usual requirements of reflux (> 4 h); the higher energy gap of QTh indicates greater stability than that of QH.\u0000Keywords: 3-amino-2-phenylquinazolin-4(3H)-one (QH), 4-oxo-2-phenylquinazoline-3(4H)-carbothioamide (QTh), HOMO-LUMO, DMF, microwave irradiation.\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47817560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking, Microwave-Assisted Synthesis, Characterization and Pharmacological Evaluation of 2,4,5-trisubstituted Imidazole’s","authors":"Deepali Amol Bansode, Tanvi Goel, Raihan Arikkattel Abdu, S. Dev","doi":"10.2174/2213335610666230420085314","DOIUrl":"https://doi.org/10.2174/2213335610666230420085314","url":null,"abstract":"\u0000\u0000Nitrogen containing heterocycles such as azoles have gained popularity in medicinal chemistry research due to their versatile pharmacological activities. Imidazole’s are one such class of adaptable compounds. The aim of the study was to explore pharmacological activities of 2,4,5-trisubstituted imidazole’s and also to develop a novel method of synthesis using microwave chemistry.\u0000\u0000\u0000\u0000In the present study, the in-silico studies of 2,4,5-trisubstituted imidazole’s was carried out to predict their anti-leishmanial as well as COX-2 inhibitory activity. Although, the results are not satisfactory for the anti-leishmanial activity, the molecules showed comparable docking scores with standard celecoxib for the COX-2 inhibitory activity. Later, the microwave-assisted green synthesis of tri-substituted imidazole’s was attempted using green catalyst and solvent, molecular iodine and ethanol respectively. The synthesised derivatives (TG-1-4) were purified and characterised.\u0000\u0000\u0000\u0000The derivatives were subjected to in-vitro COX-2 inhibitory assay, which showed good results. The molecules under study showed exemplary results against COX-2 PDB in molecular docking studies. A novel microwave-irradiation method was developed for the synthesis and also the in-vivo studies carried out for testing COX-2 inhibition was fruitful.\u0000\u0000\u0000\u0000the microwave-assisted green synthesis of tri-substituted imidazole’s was attempted using green catalyst and solvent, molecular iodine and ethanol respectively. The synthesised derivatives were purified and characterised.\u0000\u0000\u0000\u0000In conclusion, the selected derivatives can be further studied in-vivo to develop new COX-2 inhibitors.\u0000\u0000\u0000\u0000-\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41796507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Editorial Board Member","authors":"Béla Török","doi":"10.2174/221333561001230717153237","DOIUrl":"https://doi.org/10.2174/221333561001230717153237","url":null,"abstract":"","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135722644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-Proline Catalyzed Organic Reactions via Microwave-Activation","authors":"","doi":"10.2174/2213335610666230330164520","DOIUrl":"https://doi.org/10.2174/2213335610666230330164520","url":null,"abstract":"\u0000\u0000In the past few years, using microwave power to heat and wield chemical reactions has become a gradually more popular subject in the scientific community. Microwave-supported organic synthesis is confirmed to be involved in the rapid synthesis of novel compounds with selectivity and enhanced biological activities. Microwave flash heating for chemical synthesis is a spectacular reduction in reaction times, high yield and purity of the products, etc. A catalysis field wherein small organic molecules like L-Proline is an efficiently and selectively catalyze organic transformations. Microwave-assisted L-Proline catalyzed reactions are valuable tools for the making of different acyclic, heterocycles, and carbocyclic scaffolds that signify the main framework of most of the bio-active compounds. The areas of synthetic organic chemistry, microwave irradiation is speedily discarded the conventional heating methods in the world of multicomponent as well as step-wise synthetic chemistry. In this review, we discuss only L-Proline Catalyzed Organic Reactions under microwave activation using modern organic transformations including condensation, addition, asymmetric, multi-components, and other modular reactions.\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46509965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-assisted sustainable production of biodiesel: A comprehensive review","authors":"Samuel Lalthazuala Rokhum, Supongsenla Ao, Michael VL Chhandama, Hu Li","doi":"10.2174/2213335610666230223100707","DOIUrl":"https://doi.org/10.2174/2213335610666230223100707","url":null,"abstract":"\u0000\u0000Limited crude petroleum and growing awareness of fossil fuel depletion have enabled the development of alternative fuels and new energy sources. Biodiesel, also known as fatty acid methyl esters (FAME), has received a lot of attention due to its biodegradability, renewability, cost effective and nontoxicity. The purity of biodiesel production and uniform heating are the major hurdles for large scale biodiesel production. Recent microwave energy-based heating method has proved the potential for cleaner chemical production, short time duration, uniform heating, and purity over conventional heating method. The goal of this review is to discuss the biodiesel production using microwave-assisted heating. The different feedstocks used for biodiesel production, effects of microwave irradiation, factors affecting the rate of microwave-assisted transesterification to produce biodiesel were comprehensively discussed. Microwave irradiation has been compared to other technologies aiming to enhance the efficiency of overall process. The primary knowledge gaps in biodiesel production can be identified based on this research, ensuring the biodiesel industry's long-term sustainability.\u0000","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45827116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Synthesis Conditions on the Catalytic Performances of CuO/Al2O3 in Microwave-enhanced Fenton-like System","authors":"Guangshan Zhang, Menghan Cao, Ke Tian, F. Shi","doi":"10.2174/2213335610666230213113809","DOIUrl":"https://doi.org/10.2174/2213335610666230213113809","url":null,"abstract":"\u0000\u0000In previous work, we successfully prepared CuO/Al2O3 catalysts and evaluated their catalytic activity, kinetics and degradation mechanism for Fenton-like oxidation of p-nitrophenol (PNP) under microwave irradiation. However, we did not study the effect of important preparation parameters on the activities of catalysts.\u0000\u0000\u0000\u0000(1) The effect of preparation conditions: CuSO4 concentration of the impregnating solution, Al2O3 to CuSO4 solution ratio, type and concentration of precipitant and calcination temperature on the physico-chemical properties and catalytic activity were studied. (2) The catalytic performance of the Fenton-like oxidation reaction of PNP under microwave irradiation was evaluated and correlated with the characterization results. (3) The stability and catalytic mechanism of the catalysts were investigated.\u0000\u0000\u0000\u0000(1) The effect of preparation conditions: CuSO4 concentration of impregnating solution, Al2O3 to CuSO4 solution ratio, type and concentration of precipitant and calcination temperature on the physico-chemical properties and catalytic activity were studied. (2) The catalytic performance of the Fenton-like oxidation reaction of PNP under microwave irradiation was evaluated and correlated with the characterization results.(3) The stability and catalytic mechanism of the catalysts were investigated.\u0000\u0000\u0000\u0000The CuO/Al2O3 catalyst was prepared by the impregnation deposition method. The 20 g pretreated Al2O3 particles were immersed in 0.6 mol/L Cu (NO3)2 solution and 0.4 mol/L NaOH solution for 24 h before and after. After cleaning and drying, the samples were calcined in an air muffle furnace for 4 h at a certain temperature to obtain CuO/Al2O3 catalyst. Then the catalyst was characterized and catalyzed.\u0000\u0000\u0000\u0000The CuO/Al2O3 catalyst was prepared by impregnation deposition method. The 20 g pretreated Al2O3 particles were immersed in 0.6 mol/L Cu (NO3)2 solution and 0.4 mol/L NaOH solution for 24 hours before and after. After cleaning and drying, the samples were calcined in an air muffle furnace for 4 hours at a certain temperature to obtain CuO/Al2O3 catalyst. Then the catalyst was characterized and catalyzed.\u0000\u0000\u0000\u0000XRD, BET and FESEM results have demonstrated that the catalyst claimed at 300 and 350 ℃ showed a smaller size, a higher specific surface area and a better distribution of the CuO species than their counterparts prepared at higher calcination temperatures. The CuO/Al2O3 catalyst claimed at 300 and 350 ℃ also showed higher removal efficiencies for PNP than other catalysts prepared at higher calcination temperatures.\u0000\u0000\u0000\u0000XRD, BET and FESEM results have demonstrated that the catalyst claimed at 300 and 350 ℃ showed a smaller size, a higher specific surface area and a better distribution of the CuO species than their counterparts prepared at higher calcination temperatures. the CuO/Al2O3 catalyst claimed at 300 and 350 ℃ also showed higher removal efficiencies for PNP than other catalysts prepared at higher calcination temperatures.\u0000\u0000\u0000\u0000I","PeriodicalId":43539,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48681301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}