Conventional vs. microwave-assisted synthesis: A comparative study on the synthesis of tri-substituted imidazoles

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY
Deepali Bansode, Tanvi Goel, Naman Jain
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引用次数: 0

Abstract

The organic and peptide synthesis, various nanotechnology, and biochemistry processes are being carried out using microwave irradiation. The use of microwaves for synthesis has increased in the past two decades. The microwave offers several advantages such as ease of handling, lesser reaction times, quality of the product, and eco-friendly, which is green. The conventional method of synthesis, on the other hand, requires a longer time, is difficult to handle and maintenance of temperature is also difficult. The use of microwave-assisted reactions over conventional methods is advantageous in medicinal chemistry research as they will be less time-consuming and crucial in drug discovery and development. On the other side, they might not work in bulk synthesis due to their limited capacity for loading the reaction mixture. The present work aims to compare reaction time, temperature and percentage of yield of the microwave-assisted synthesis method against the conventional method. A novel, simple, and green method was developed for the synthesis of tri-substituted imidazoles by microwave irradiation. Both derivatives from conventional and microwave-assisted synthesis were characterized by IR spectroscopy, Mass spectrometry, and 1H-NMR spectroscopy. The same derivatives were also synthesized by the conventional method for comparison. A comparison of both methods was made by comparing the reaction time and the percentage yield. It was found that microwave-assisted reactions produced greater yield in the minimal time, though at different reaction temperatures. It can be concluded from the present comparison study that the use of the microwave for synthesis provides numerous advantages; thus, newer molecules are developed quickly anthat are developed quickly. To further proceed in this direction and to produce evidences, synthesis of more derivatives may be required. The only disadvantage is that it cannot be used for bulk synthesis of the compounds.
常规与微波辅助合成:三取代咪唑合成的比较研究
有机和多肽合成、各种纳米技术和生物化学过程正在利用微波辐射进行。在过去的二十年里,微波合成的使用有所增加。微波炉有很多优点,比如操作方便、反应时间短、产品质量好、环保(绿色)。另一方面,传统的合成方法需要较长的时间,难以处理和维持温度也困难。微波辅助反应在药物化学研究中比传统方法更有优势,因为微波辅助反应在药物发现和开发中更节省时间和至关重要。另一方面,由于它们装载反应混合物的能力有限,它们可能无法在散装合成中工作。本工作旨在比较微波辅助合成方法与常规方法的反应时间、温度和产率。提出了一种新的、简单的、绿色的微波辐射合成三取代咪唑的方法。通过红外光谱、质谱和核磁共振光谱对常规合成和微波辅助合成的衍生物进行了表征。用常规方法合成了相同的衍生物进行比较。通过反应时间和产率的比较,对两种方法进行了比较。结果表明,在不同的反应温度下,微波辅助反应能在最短的时间内获得较高的产率。从目前的比较研究中可以得出结论,使用微波进行合成具有许多优点;因此,新分子和旧分子迅速发展。为了进一步在这个方向上进行并提供证据,可能需要合成更多的衍生物。唯一的缺点是它不能用于化合物的批量合成。
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来源期刊
Current Microwave Chemistry
Current Microwave Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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