{"title":"Task-Driven CT Image Quality Optimization for Low-Contrast Lesion Detectability with Tunable Neural Networks.","authors":"Matthew Tivnan, Tzu-Cheng Lee, Ruoqiao Zhang, Kirsten Boedeker, Liang Cai, Jeremias Sulam, J Webster Stayman","doi":"10.1117/12.2653936","DOIUrl":"10.1117/12.2653936","url":null,"abstract":"<p><p>Low-contrast lesions are difficult to detect in noisy low-dose CT images. Improving CT image quality for this detection task has the potential to improve diagnostic accuracy and patient outcomes. In this work, we use tunable neural networks for CT image restoration with a hyperparameter to control the variance/bias tradeoff. We use clinical images from a super-high-resolution normal-dose CT scan to synthesize low-contrast low-dose CT images for supervised training of deep learning CT reconstruction models. Those models are trained using with multiple noise realizations so that variance and bias can be penalized separately. We use a training loss function with one hyperparameter called the denoising level, which controls the variance/bias tradeoff. Finally, we evaluate the CT image quality to find the optimal denoising level for low-contrast lesion detectability. We evaluate performance using a shallow neural network model classification model to represent a suboptimal image observer. Our results indicate that the optimal networks for low-contrast lesion detectability are those that prioritize bias reduction rather than mean-squared error, which demonstrates the potential clinical benefit of our proposed tunable neural networks.</p>","PeriodicalId":43507,"journal":{"name":"EIRE-IRELAND","volume":"54 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88396409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EIRE-IRELANDPub Date : 2022-09-01DOI: 10.1353/eir.2022.0020
Robert O'Sullivan
{"title":"Repeal, Revolution, Abolitionism: The Formation of Irish American Identity, 1840–45","authors":"Robert O'Sullivan","doi":"10.1353/eir.2022.0020","DOIUrl":"https://doi.org/10.1353/eir.2022.0020","url":null,"abstract":"","PeriodicalId":43507,"journal":{"name":"EIRE-IRELAND","volume":"57 1","pages":"141 - 170"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47560474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EIRE-IRELANDPub Date : 2022-09-01DOI: 10.1353/eir.2022.0003
T. Inglis
{"title":"John McGahern: The Sociology of Honor, Status, and Shame","authors":"T. Inglis","doi":"10.1353/eir.2022.0003","DOIUrl":"https://doi.org/10.1353/eir.2022.0003","url":null,"abstract":"","PeriodicalId":43507,"journal":{"name":"EIRE-IRELAND","volume":"57 1","pages":"32 - 6"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66305033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EIRE-IRELANDPub Date : 2022-09-01DOI: 10.1353/eir.2022.0021
Constantin Torve
{"title":"The Scab Incarnate? A Critical Reassessment of Pinkerton James McParlan","authors":"Constantin Torve","doi":"10.1353/eir.2022.0021","DOIUrl":"https://doi.org/10.1353/eir.2022.0021","url":null,"abstract":"","PeriodicalId":43507,"journal":{"name":"EIRE-IRELAND","volume":"57 1","pages":"171 - 195"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66305251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EIRE-IRELANDPub Date : 2022-09-01DOI: 10.1353/eir.2022.0024
Brian Griffin
{"title":"Jack B. Yeats's Punch Cartoons during the Great War","authors":"Brian Griffin","doi":"10.1353/eir.2022.0024","DOIUrl":"https://doi.org/10.1353/eir.2022.0024","url":null,"abstract":"","PeriodicalId":43507,"journal":{"name":"EIRE-IRELAND","volume":"57 1","pages":"254 - 282"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48125181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EIRE-IRELANDPub Date : 2022-09-01DOI: 10.1353/eir.2022.0017
Sarah L. Townsend
{"title":"Direct Provision, Immigrant Detention, and the Wonderful World of Avoca","authors":"Sarah L. Townsend","doi":"10.1353/eir.2022.0017","DOIUrl":"https://doi.org/10.1353/eir.2022.0017","url":null,"abstract":"","PeriodicalId":43507,"journal":{"name":"EIRE-IRELAND","volume":"57 1","pages":"64 - 91"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66305196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EIRE-IRELANDPub Date : 2022-09-01DOI: 10.1353/eir.2022.0025
Caoimhín de Barra
{"title":"\"This Abominable Evil Is the Source of Fetid Corruption\": The IRA's 1920 War on Poitín","authors":"Caoimhín de Barra","doi":"10.1353/eir.2022.0025","DOIUrl":"https://doi.org/10.1353/eir.2022.0025","url":null,"abstract":"","PeriodicalId":43507,"journal":{"name":"EIRE-IRELAND","volume":"57 1","pages":"283 - 310"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66305314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}