{"title":"Evaluation of the relationship between serum levels of 25-hydroxyvitamin D and prognostic factors in breast cancer.","authors":"Naeimeh Heiranizadeh, Fatemeh Sadat Alavizadeh, Jamal Jafari Nodooshan, Mahdi Neshan","doi":"10.5604/01.3001.0015.9281","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9281","url":null,"abstract":"<p><p><b> Introduction:</b> Breast cancer is the most frequent invasive malignancy in women worldwide. There is a modifiable risk factor (such as serum vitamin D level) for this cancer. We decided to conduct this study since the influence of serum vitamin D levels on breast cancer is still controversial. </br></br> <b> Methods and materials:</b> In this analytical cross-sectional study, 103 patients who were diagnosed with breast cancer were included. Patients' demographic, clinical and pathological features were all recorded. After the laboratory provided the serum vitamin D level, it was included in the checklist. Serum vitamin D level was categorized into 3 groups: <10 ng/ml, 1030 ng/ml and >30 ng/ml. The chi-square test was used to assess the relationship between vitamin D levels and clinicopathological features of the patients in SPSS software. The results were considered statistically significant at P-value < 0.05. </br></br> <b> Results:</b> The mean age of the patients was 47.97 8.8 years. The mean serum vitamin D level was 28.72 19.9 ng and it was divided into three groups: 1) deficient (10 ng), which included 20 (19.4%) patients, 2) insufficient (10-30 ng), which included 48 (46.6%) patients, and 3) normal (>30 ng), which included 35 (34%) patients. Low vitamin D level (<320 ng/ml) was mainly detected in premenopausal cases (P-value = 0.001) with poor prognosis high grade of the disease (P-value = 0.001), positive nodal involvement (P-value = 0.025) and positive Ki-67 (P = 0.021). Furthermore, patients with lower serum vitamin D levels interact in fewer outdoor activities (P-value = 0.007), sleep less during the day (P-value = 0.001) and sleep later at night (P-value = 0.009). </br></br> <b>Conclusion:</b> Decreased serum 25(OH) D levels were linked with a higher histological grade of the tumor and lymph node involvement. Low serum 25(OH) D levels were also related to prognostic factors such as high Ki67 expression and the presence of negative hormone receptors (ER and PR). Our data support negative correlations between vitamin D levels and the risk of breast cancer with poor prognostic characteristics, based on observational research.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 2","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9306814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Legal nature of guidelines of scientific societies in the light of the Polish legal system.","authors":"Maciej Śmietański, Piotr Rączka","doi":"10.5604/01.3001.0015.9579","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9579","url":null,"abstract":"<p><strong>Introduction: </strong>The paper aims to establish the legal nature of the guidelines in the Polish legal system and the possible formal consequences of introducing such guidelines (litigation, professional responsibility) as well as practical implications concerning the method of treating patients.</p><p><strong>Methods: </strong>Analysis is clarifying fundamental issues that largely determine the content of the study. The basic assumption is to analyze the legal nature of the prepared guidelines from the point of view of public law, i.e. from the point of view of the relations occurring between the state, as the primary public law entity, and individual, private entities, such as natural persons, legal persons, or organizational units without legal personality, i.e., to be more precise, e.g., the relations between state authorities and persons practicing the medical professionConclusions:Treatment guidelines fall outside the scope of the universally applicable law subsystem. Therefore, they do not constitute sources of universally binding law. 2. Furthermore, the guidelines do not constitute sources of domestic law, as the issuing bodies have no legal authority to issue them and to mould the legal situation of their addressees. 3. In the regulations shaping the rules of practicing the medical profession, both statutory and corporate (the Medical Ethics Code), the guidelines may constitute the basis for adjudicating on the professional (disciplinary) liability of a physician. 4. The guidelines may pose a barrier to the development of medicine, especially in cases where their issuance by ad hoc groups and the lack of updates lead to the consolidation of outdated clinical practice and inhibit the research potential generated from the bottom up.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 3","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced Recovery After Surgery (ERAS) protocol in minimally invasive gynecological surgery: a review of the literature.","authors":"Stanislav Slavchev, Angel Yordanov","doi":"10.5604/01.3001.0015.8687","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8687","url":null,"abstract":"<p><p>Enhanced Recovery After Surgery (ERAS) is a complex system of procedures that necessitates multidisciplinary patient care during the preoperative, intraoperative, and postoperative phases. Over the last two decades, the ERAS protocol, which was initially described in colorectal surgery, has gradually expanded to other surgical specialties. Gynecological surgery is no exception, whether for benign or malignant conditions. The ERAS program's primary objective is to overcome the pathophysiological processes associated with surgical stress and to facilitate the patient's rapid recovery, while minimizing complications, hospital stays, and costs. The objectives of minimally invasive surgical procedures largely overlap with the objectives of the ERAS program. We analyzed scientific data from studies examining the ERAS system's application in minimally invasive gynecological surgery (MIGS) and present them in this review. The central question is whether the ERAS protocol can provide additional benefits beyond those inherent in minimally invasive surgical procedures.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 3","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10822931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Szymon Salamaga, Hubert Stępak, Zbigniew Krasiński
{"title":"Supera stent implantation for the treatment of isolated popliteal artery disease systematic review and evaluation of current endovascular strategies.","authors":"Szymon Salamaga, Hubert Stępak, Zbigniew Krasiński","doi":"10.5604/01.3001.0015.9578","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9578","url":null,"abstract":"<p><p><b>Introduction:</b> The anatomical location of the popliteal artery is one of the greatest challenges for percutaneous interventions. The biomechanical attributes of the vessel lead to higher rates of restenosis, stent fracture, and occlusion. Some surgeons consider the popliteal artery as a no stenting zone. Many specialists favor percutaneous transluminal angioplasty to be the first line of endovascular treatment in the popliteal artery with bail-out stent implantation if the results are suboptimal. The Supera peripheral stent system is a novel stent that has been manufactured with a high degree of flexibility and supposedly might be appropriate for implantation in the popliteal artery. </br></br> <b>Aim:</b> Evaluation of the performance of Supera stent in isolated popliteal artery disease in comparison to other methods of treatment. </br></br> <b>Methods:</b> As many as 92 articles were found in the databases and after full-text review, 4 studies matched the inclusion criteria and were evaluated. </br></br> <b>Results:</b> Primary patency rates of Supera implantation in an isolated popliteal artery at 12 months ranged from 68% to 90%. In all four studies, no stent fractures were observed. Only one study provided longer follow-up than 12 months and evaluated the performance of the Supera stent 36 months after implantation. </br></br> <b>Conclusion:</b> In conclusion, mentioned studies show promising and superior to other stent patency rates of the Supera stent regarding popliteal artery lesions. What is more, no stent fracture is promising regarding longer follow-up. However, more studies with longer follow-ups and direct comparison to other methods are required to fully evaluate Supera's performance in the popliteal artery.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 4","pages":"1-7"},"PeriodicalIF":0.6,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10767224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical and pharmaceutical treatment of superficial vein thrombosis of the lower limbs: what has changed over the last 5 years?","authors":"Chrysanthi Papageorgopoulou, Konstantinos Nikolakopoulos, Aspasia Papageorgopoulou, Charalampos Seretis","doi":"10.5604/01.3001.0015.9280","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9280","url":null,"abstract":"<p><strong>Introduction: </strong>Superficial vein thrombosis of the lower limbs is a common condition encountered by a wide spectrum of clinical specialties. In contrast to deep vein thrombosis of the lower limbs though, there is significant variability in terms of its treatment with respect to the type and duration of pharmacotherapy, as well as regarding the potential role of operative management.</p><p><strong>Methods: </strong>Systematic review of the literature in a best evidence topic manner, including only prospective and randomized controlled studies on the treatment of lower limb SVT, focusing on the emerged data over the last 5 years.</p><p><strong>Results: </strong>A total of 17 prospective observational and randomized clinical studies met our set criteria. Despite the major differences in study designs, outcomes and intervention types, upfront pharmaceutical treatment with fondaparinux or intermediate dose of low molecular weight heparins, combined with regular clinical and radiological follow-up, seem to be effective and safe as first-line approaches. Upfront surgical treatment of lower limb SVT can also be safely performed in selected cases in the presence of clinical expertise.</p><p><strong>Conclusions: </strong>Our review revealed the presence of considerable variability in the therapeutic options of the lower limb superficial venous thrombosis, highlighting the need for further randomized controlled trials in the field in order to establish and standardize its optimal treatment.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 4","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sajad Ahmad Salati, Mohammed Alfehaid, Saleh Alsuwaydani, Lamees AlSulaim
{"title":"Spilled gallstones after laparoscopic cholecystectomy: a systematic review.","authors":"Sajad Ahmad Salati, Mohammed Alfehaid, Saleh Alsuwaydani, Lamees AlSulaim","doi":"10.5604/01.3001.0015.8571","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8571","url":null,"abstract":"<p><p><b> Aim: </b> The study was conducted to analyse the recent peer-reviewed literature related to symptomatic spilled gallstones after Laparoscopic Cholecystectomy (LC). </br></br> <b>Materials and methods:</b> Articles published in the peer-reviewed journals of repute from 20122022 were evaluated for nine variables including: [I] age of the patient, [II] gender, [III] interval since index LC, [IV] index LC if emergent/difficult or elective/straightforward, [V] clinical presentation, [VI] spilled gallstones if detected by imaging, [VII] management, [VIII] approach to management, [IX] number of spilled gallstones. </br></br> <b>Results:</b> There were a total of 71 cases (37 males and 34 females) with a mean age of 63.7 years. The time of onset of symptoms from spilled gallstones, after index LC, ranged from 2 days to 15 years and 57 patients (80.3%) presented within 6 years. Forty (56.3%) patients were unaware of the fact that gallstone spillage had occurred during index LC. The retained gallstones were detected by imaging in 47 (66.1%) cases and they were multiple in 51 (71.8%). In 52 patients (73.2%), the stones manifested as abdominal abscess/foreign body granuloma; the other presentations being pelvic pain/fistula, intestinal obstruction, abdominal lump simulating malignancy, incidental finding of metastatic lesions and generalized peritonitis. The major approaches adopted to retrieve the retained stones included open surgery, laparoscopy and percutaneous drainage. There were two deaths (2.9%) due to spilled gallstones. </br></br> <b>Conclusion:</b> Retained gallstones represent a complication of laparoscopic cholecystectomy (LC) that has a potential to create morbidity and diagnostic difficulties, even after a substantial delay. There is a need to spread awareness about the adverse effects of spilled stones so that they are actively looked for and retrieved if gallbladder perforates during cholecystectomy. Whenever such a complication occurs, the patient should be properly informed and the details should be very clearly mentioned in the operation notes.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 2","pages":"1-20"},"PeriodicalIF":0.6,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9306817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Mastectomy Flap Fixation on Post-operative Fluid Drainage and Seroma Formation in Breast Cancer Patients A Double-blinded Randomised Control Trial.","authors":"Parikshith Parikshith Manjunath, Raghav Yelamanchi, Himanshu Agrawal, Ekta Ekta Yadav, Nikhil Gupta, Arun Kumar Gupta, C Durga","doi":"10.5604/01.3001.0015.8569","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8569","url":null,"abstract":"<p><p><b> Introduction:</b> Post-operative seroma formation is one of the most common complications following modified radical mastectomy (MRM). Quilting is a technique where the mastectomy flaps are sutured to the underlying chest wall muscles with sutures, obliterating the dead space. The authors hypothesised that post-mastectomy dead space obliteration by intermittent mastectomy flap fixation leads to decreased drain output and seroma formation. </br></br> <b> Material and methods: </b> A double-blinded randomised control trial with two arms was conducted from November 2019 to March 2021 in our institute located in India. Patients with non metastatic breast carcinoma planned for MRM were randomly categorised into two groups of 35 patients each. In the test group, each flap was fixed to the underlying muscle using four intermittent 3-0 polyglactin sutures, which was followed by skin closure, and only skin closure was done in the control group. </br></br> <b>Results:</b> The test and control groups did not differ significantly with respect to demographic and tumour characteristics. The average drain output of the test group (155.43 ml) was significantly less than of the control group (206.29 ml). The overall incidence of seroma formation is lower in the test group (5.7%) when compared to the control group (28.6%). The duration of hospital stay in the test group (4.63 days) was significantly shorter when compared to the control group (6.66 days). There was no significant increase in the overall operating time or complications like surgical site infection or skin dimpling due to flap fixation. </br></br> <b>Conclusions:</b> Fixation of MRM flaps is associated with better post-operative outcomes related to drain output and seroma formation without a significant increase in other morbidities or usage of resources.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 2","pages":"1-8"},"PeriodicalIF":0.6,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9306818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Body composition of patients suffering from pancreatic cancer.","authors":"Magdalena Kowalska, Zbigniew Kamocki","doi":"10.5604/01.3001.0015.8570","DOIUrl":"10.5604/01.3001.0015.8570","url":null,"abstract":"<p><p>Pancreatic cancer, despite significant progress in diagnosis and treatment still has poor prognosis. Surgical treatment remains the only cure option. Unfortunately, the percentage of patients in whom radical tumor removal is possible is less than 20%. Resection procedures are burdened with a high degree of difficulty, as well as a high complication rate. One of the important factors contributing to the high morbidity of the perioperative period is malnutrition, and rapidly progressing malnutrition which occurs in about 85% of pancreatic cancer patients. Abnormal nutritional status is closely related to a change in the composition in the body.The aim of the study was to determine the changes in the body composition of patients with pancreatic cancer and their consequences based on the results of the current research.The available reports have shown that the body composition of a patient with pancreatic cancer undoubtedly changes and is dependent on the stage, location and type of cancer. Furthermore, the fact if antitumor treatment is applied or not, also plays a significant role.It appears that in patients with pancreatic cancer, weight loss with a decline in parameters such as body fat and skeletal muscle mass appears early and worsens as the tumor grows and the disease progresses. The above data suggest that knowing the patient's body composition and observing its changes may be a prognostic factor for survival and the occurrence of complications. Additionally, there are reports that dosing chemotherapy based on body composition rather than conventional measures can help reduce the toxicity of the treatment. Therefore, knowing the patient's body composition seems to be an important aspect.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10747781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic value of increased postoperative carcinoembryonic antigen in patients with early intestinal anastomosis leakage who underwent right hemicolectomy surgery.","authors":"Seifollah Rezaei, Naser Masoudi, Mohammad Yasin Karami, Ehsan Sobhanian, Morteza Amestejani","doi":"10.5604/01.3001.0015.8481","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8481","url":null,"abstract":"<p><p><b> Introduction:</b> Anastomotic leak after colorectal surgery is a serious complication that causes significant postoperative morbidity and mortality. </br></br> <b>Aim:</b> This study aimed to investigate the predictive value of increased postoperative carcinoembryonic antigen (CEA) in early intestinal anastomosis leakage in patients who underwent right hemicolectomy surgery.</br></br> <b>Material and methods:</b> In this prospective study, 535 patients who underwent right colon cancer surgery with stapled anastomosis were enrolled. A subset of 315 patients was included in the study after meeting the inclusion criteria. Preoperatively, their serum CEA levels were measured, and on postoperative days 3 and 6, the levels were measured again.</br></br> <b>Results:</b> Early AL occurred in 18 patients (5.71%). The mean SD age of patients was 65.06 11.69 years. Increased CEA level was associated with increased odds of intestinal AL among the patients after three and six days of surgery (OR after three days = 1.3; 95%CI = 1.11.5, OR after six days = 1.7 95%CI = 1.142.5). The mean CEA level significantly increased among patients with anastomose leakage (P-value < 0.001). </br></br> <b>Conclusion:</b> The results showed that increasing CEA levels can be used as one of the non-invasive markers in detecting early AL in patients with right colon cancer surgery.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 1","pages":"20-24"},"PeriodicalIF":0.6,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10747778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sławomir Cieśla, Katarzyna Donabidowicz, Dawid Murawa
{"title":"Breast Cancer Conserving Treatment with Simultaneous Reconstruction of the Defect with Pedicled Adipocutaneous Flaps Early Observations.","authors":"Sławomir Cieśla, Katarzyna Donabidowicz, Dawid Murawa","doi":"10.5604/01.3001.0015.8479","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8479","url":null,"abstract":"<p><p>Breast-conserving surgery (BCS) is the gold standard for cancer treatment. The major goal isto achieve tumor-free margins while maintaining a satisfactory aesthetic result. This task canbe accomplished with the use of modern oncoplastic methods.The goal of this study is to provide the preliminary results of surgical treatment for 20 patientswith breast cancer who had their resection defect repaired with pedicled dermal-subcutaneousflaps from nearby breast areas.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":"95 2","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10816185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}