GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW最新文献

{"title":"A comparative profile of total protein and six angiogenically-active growth factors in three platelet products.","authors":"Scott Custo,&nbsp;Byron Baron,&nbsp;Alex Felice,&nbsp;Elisa Seria","doi":"10.3205/iprs000167","DOIUrl":"https://doi.org/10.3205/iprs000167","url":null,"abstract":"<p><strong>Objectives: </strong>Platelet-derived products have been shown as promising novel therapeutic agents for chronic wounds. However, their clinical use requires a greater degree of method standardisation, part of which involved more extensive cataloguing of their biochemical composition. This study aimed to quantify and compare total protein and 6 angiogenically-active growth factors in three distinct platelet products.</p><p><strong>Methods: </strong>Platelet Lysate (PL, n=5), Calcium-activated Platelet Rich Plasma (Ca-PRP, n=5) and Platelet-Rich Fibrin (PRF, n=5) were prepared from pooled platelet apheresis products (n=10). Ca-PRP and PRF were prepared from the same units (n=5) by activation with 20 mmolL^-1 calcium chloride. PL was prepared from the remaining (n=5) units using an established lysate. Total protein was quantified with the Bradford Assay. Sandwich enzyme-linked immunosorbent assay was used to quantify six growth factors: epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), stromal cell derived growth factor-1α (SDF-1α), endostatin, and transforming growth factor-β1 (TGF-β1).</p><p><strong>Results: </strong>Protein retrieval differed significantly (p<0.05) between the three products: PL (11.35±0.80 mg/mL) < Ca-PRP (20.44±8.17 mg/mL) < PRF (40.67±3.13 mg/mL). Growth factor yield was considerable in all three products and differed significantly for: VEGF (PL<PRF); EGF (Ca-PRP<PRF); HFG (PL<Ca-PRP); Endostatin (PL<Ca-PRP, PRF<Ca-PRP, PL<PRF) and TGF-β1 (Ca-PRP<PL, Ca-PRP<PRF).</p><p><strong>Conclusions: </strong>Platelet apheresis products contain a substantial quantity of the investigated pro- and anti-angiogenic growth factors. Their release varies depending on the manufacturing protocol used. Clinically, alternate products could thus be combined to provide a therapeutically optimal mix of growth factors.</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":" ","pages":"Doc06"},"PeriodicalIF":0.4,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40658109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New and innovative biomaterials, techniques and therapy concepts: Biologization in maxillofacial surgery, oral surgery and dentistry is in full swing. PRF, PRGF, PRP, blood plasma-stabilized augmentations, supplementation of micronutrients and vitamins - what opportunities do such \"biological\" approaches actually offer? We introduce them here.","authors":"Ralf Smeets,&nbsp;Anders Henningsen,&nbsp;Oliver Zernial,&nbsp;Ewa Stürmer,&nbsp;Imke Fiedler,&nbsp;Sogand Schäfer,&nbsp;Martin Gosau,&nbsp;Robert Gaudin,&nbsp;Carolin Stolzer,&nbsp;Anna Reinelt,&nbsp;Sandra Fuest","doi":"10.3205/iprs000166","DOIUrl":"https://doi.org/10.3205/iprs000166","url":null,"abstract":"<p><p>Biomaterials of natural origin have recently gained increasing attention in the field of dental implantology. The requirements for such materials, however, are very high. In addition to high clinical efficiency in tissue regeneration, wound healing should be demonstrably positively influenced. The translational division for regenerative orofacial medicine of the Clinic and Polyclinic for Oral and Maxillofacial Surgery of the University Medical Center Hamburg-Eppendorf (UKE) is examining this research topic by investigating which innovative treatment methods for the reconstruction of bone defects or for augmentative procedures can be applied in the future or are already being applied in the field of oral and maxillofacial surgery.</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":" ","pages":"Doc05"},"PeriodicalIF":0.4,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40658110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of fracture severity on postoperative outcome and quality of life after locking plate fixation of proximal humeral fractures","authors":"S. Thelen, J. Grassmann, M. Schneider, C. Jaekel, Dana M. Meier, M. Betsch, M. Hakimi, M. Wild","doi":"10.3205/iprs000164","DOIUrl":"https://doi.org/10.3205/iprs000164","url":null,"abstract":"Objective: For proximal humeral fractures open reduction und internal fixation (ORIF) with a fixed-angle plate is considered the gold standard for surgical management. However, it can lead to poor functional outcomes and is associated with postoperative complications. Therefore, the purpose of this study was to investigate the influence of fracture severity by applying a new classification (simple versus complex) on clinical outcome and quality of life after ORIF of proximal humerus fractures. Methods: We conducted a prospective clinical study with an average follow-up period of 12 (SD 1) months after ORIF of proximal humeral fractures with a fixed-angle plate. The postoperative function and quality of life was measured using the Oxford Shoulder Score (OSS) and the Constant Score. Data was tested for statistical significance with the Mann-Whitney test and Fisher's exact test. Based on the findings of this study a simplified fracture classification system has been developed. Results: Seventy-two patients with a mean age of 65 years (SD 12) with 69% being males were included. According to the Neer classification, 35% (n=25) non-displaced (“one-part fractures”), 19% (n=14) two-part fractures, 15% (n=11) three-part fractures and 31% (n=22) four-part fractures were detected. Regarding the AO/OTA classification, 18% (n=13) were type A fractures, 43% (n=31) type B and 39% (n=28) type C fractures. From these criteria we derived our own fracture classification, including 50% (n=36) simple and 50% (n=36) severe fractures. Patients with simple fracture types achieved significantly higher total values in the Constant Score as well as the OSS (p=0.008; p=0.013). The cumulative incidence of complications in the entire patient collective was 14% (n=10) with humeral head necrosis (n=5) occurring only in the severe fracture group. Conclusions: The postoperative clinical outcome as well as the incidence of humeral head necrosis after ORIF of proximal humeral fractures with a fixed-angle plate correlates with the fracture type and severity. The newly derived fracture classification into simple and severe fractures is suitable with regard to clinical results and complication rate. However, prospective studies comparing ORIF vs. conservative treatment of proximal humeral fractures of the same severity are required. Level of Evidence: III","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45365475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional and aesthetic outcome of different methods of reconstruction of full thickness lip defects","authors":"A. Shaikh, A. Khan, S. Tated, Naveen Khubchandani","doi":"10.3205/iprs000163","DOIUrl":"https://doi.org/10.3205/iprs000163","url":null,"abstract":"Background: The lip has functional and aesthetic importance. Lip defects occur due to the variety of etiology and the choice of their reconstruction has profound effect on functions and cosmesis. There are multiple options available for reconstruction according to defect size, but superiority of one method over another is still debated and hence the methods and their outcome were analyzed prospectively. Material and method: Twenty-one patients with all sizes and locations of defects in upper and lower lip with acquired etiology were included in the evaluation. Reconstruction was performed according to defect size, availability of local/regional and distant donor tissue, defect location, patients’ comorbid conditions and patients’ preference. Patients were assessed at 1 month and 6 months postoperatively. Observers’ and patients’ input were also taken into account for outcome. Results: Out of 21 patients, 5 free radial artery forearm flap reconstructions, 4 nasolabial flap reconstructions, 5 primary closures of defect, 4 Estlander flap reconstructions, 2 lip advancements, and one Karapandzic flap reconstruction were done. Free flap and nasolabial flap had hypoesthesia and incompetence if commissure is reconstructed and problem of bulk, restricted mobility and vermilion mismatch. Local and lip flaps were associated with decreased stoma size and some form of local scarring and asymmetry. However, all patients were satisfied with the functional and aesthetic outcome. Conclusion: Local flaps are better in terms of functional and aesthetic outcome but with some degree of microstomia which was well tolerated by most patients. Regional and distant flaps provide reconstruction where no other option is available and provide good functional support and acceptable cosmesis.","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":"11 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44793834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective evaluation of 182 free flaps in extremity reconstruction and review of the literature.","authors":"Sergey Arakelyan,&nbsp;Emrah Aydogan,&nbsp;Nick Spindler,&nbsp;Stefan Langer,&nbsp;Olimpiu Bota","doi":"10.3205/iprs000162","DOIUrl":"https://doi.org/10.3205/iprs000162","url":null,"abstract":"<p><p><b>Introduction</b>: During the past decades, free flaps have been given a central role in the reconstructive surgery. Especially in the extremities, where there is a scarcity of available tissues for local flaps, free flaps play a central part. The aim of this study was to evaluate the risk factors contributing to partial and total flap failure. <b>Patients and methods</b>: In a retrospective cohort study, all data concerning patients who underwent free flap reconstruction of the extremities during the first five years since the founding of the department of plastic surgery were gathered. Patient- and surgery-related risk factors were analyzed in correlation to the postoperative complications. <b>Results</b>: In total, 182 free flaps were included in this study. Partial and total flap failure were noted in 21.42% and 17.03%, respectively. A correlation was seen between the time lapsed from debridement until flap coverage, with flaps performed between day 4 and 14 having the least quote of flap failure (p=0.022). Gender, age, arterial hypertension, nicotine abuse, diabetes mellitus, peripheral arterial disease and the number of anastomosed veins were not significantly associated with free flap failure. <b>Conclusion</b>: Our study showed that free flaps can be safely performed in healthy patients as well as in patients with risk factors, with an acceptable flap loss rate. Randomized controlled studies are needed to clarify the exact role of each risk factor in free flap surgery.</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":" ","pages":"Doc01"},"PeriodicalIF":0.4,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39883023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of the effects of the IMAGE MD^® skin care regimen on skin surface features via modern imaging technology with the Visia^® complexion analysis camera system.","authors":"Helga Henseler","doi":"10.3205/iprs000170","DOIUrl":"https://doi.org/10.3205/iprs000170","url":null,"abstract":"<p><strong>Objective: </strong>Objective analysis of the effects of a series of skin care products by application of modern imaging technology.</p><p><strong>Method: </strong>A study was conducted in 25 volunteers who attended a plastic surgical clinic. The cosmeceuticals chosen for investigation were from the IMAGE MD^® series provided by the company IMAGE Skincare. Facial images were taken with the Visia^® camera system by the company Canfield Scientific. The volunteers stopped their own skin care regimen after the initial facial captures and applied a series of the products for three months. 19 volunteers returned and underwent again facial capture. Eight different skin aspects - spots, wrinkles, skin texture, pores, UV spots, brown spots, red marks and porphyrins - as well as the skin age were determined and analysed.</p><p><strong>Results: </strong>Overall, the volunteers turned out to appear younger by 1.4 years, however not at a significant level. There was a spread in the results and a tendency for a stronger reduction of the measured skin age in women under 55 years old by 3.2 years. Best effects of the studied product line were obtained for the skin aspects red areas and brown spots. For the criteria spots, texture, pores and UV spots at least two thirds of the comparisons between the two time points, before and after treatment, were positive. In wrinkles and porphyrins, results did not improve. Altogether the majority of the examined skin criteria improved.</p><p><strong>Conclusion: </strong>The IMAGE MD^® product series caused the volunteer testers overall to appear slightly younger. An objective measurement of skin changes over time by application of the Visia^® imaging technology was found to be possible.</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":"11 ","pages":"Doc09"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10785236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the precision of the Visia^® complexion analysis camera system in the assessment of skin surface features.","authors":"Helga Henseler","doi":"10.3205/iprs000169","DOIUrl":"https://doi.org/10.3205/iprs000169","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The aim of this study was to independently investigate the precision of the high resolution Visia&lt;sup&gt;®&lt;/sup&gt; camera, from Canfield Scientific, to capture several skin surface features.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;Facial images of eight volunteers were taken with closed eyes and a relaxed face. The capture was conducted in a resting position within a positioning rig. Frontal view images were taken. In the first capture session, the images were captured three times in a row with the head steadily resting in the capture rig. Each volunteer then left the capture rig and returned to it one week later repositioning the face, and the capture was repeated three times. On the basis of this study, it was additionally investigated which number of study participants would be required in order to make a claim as to the reproducibility of the captures. As a possible approach to making this determination, a power analysis was considered. In order to conduct this analysis, it was necessary to determine which differences between individual image captures would be clinically acceptable. To answer this question, a subjective assessment of the repeated image captures for all study participants and for all skin surface features was conducted in order to identify any differences that were visible with the human eye.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Differences in skin criteria of the eight volunteers in terms of means and standard deviations were collected for weeks one and two. For the criteria skin texture, UV spots, brown spots and porphyrins, these differences were less than 2% and for pores and red areas they were between 2% and 4%. The results for spots and wrinkles were around 6%. Looking at the differences between the data from week one and two as well as the standard deviations, these differences turned out to be relatively small. This finding also pointed to a quite good precision of the measurement technique. The subjective assessment of the images of the eight participants on each of the eight skin criteria revealed that no differences were detectable in the recaptured versions of the images of the participants' faces in their native digital forms solely with the human eye. There was an exception for only one participant, in whom a distinction between two image captures appeared to be subjectively visible with the human eye, but only for the criterion of red areas. As the subjective assessment revealed that no clinically relevant differences could be identified, a power analysis involving a test for significant differences between the recaptured images was discarded. As a consequence, the number of participants recruited for the study on the reproducibility of the system presented herein was deemed to be sufficient.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The precision of the Visia&lt;sup&gt;®&lt;/sup&gt; camera system was found to be satisfactory in this study. The Visia&lt;sup&gt;®&lt;/sup&gt; camera helped to visualise skin features beyond what is","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":"11 ","pages":"Doc08"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10802838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipedema in a male patient: report of a rare case - management and review of the literature.","authors":"Mattis Bertlich,&nbsp;Mark Jakob,&nbsp;Ines Bertlich,&nbsp;Reggy Schift,&nbsp;Randolf Bertlich","doi":"10.3205/iprs000161","DOIUrl":"https://doi.org/10.3205/iprs000161","url":null,"abstract":"<p><p><b>Objective:</b> Lipedema is a relatively common yet debilitating and often misdiagnosed lipodystrophy that mainly affects females. Very little is known about the etiology and pathophysiology of the disease. However, due to its high preference for female patients, hormonal factors may contribute to the pathogenesis. <b>Case:</b> A 62-year-old male patient presented to the authors with painful swelling of the thighs. The patient had been treated elsewhere for lymphedema with subsequent disease progression. Lipedema stage IV was confirmed by clinical examination and ultrasound. The patient underwent three sessions of tumescence liposuction which was well tolerated. Later on, the patient reported great improvement in terms of complaints as well as disfigurement. <b>Conclusion:</b> The etiology and pathophysiology of lipedema remain unclear. However, the case at hand shows that lipedema may, albeit rare, also present in male patients. Moreover, we show that liposuction is efficient and safe in treating lipedema even in atypical cases.</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":"10 ","pages":"Doc11"},"PeriodicalIF":0.4,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39526366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast reconstruction during the COVID-19 pandemic in resource-limited settings.","authors":"Sammy Al-Benna,&nbsp;Andreas Gohritz","doi":"10.3205/iprs000160","DOIUrl":"10.3205/iprs000160","url":null,"abstract":"<p><p>The coronavirus disease 2019 (COVID-19) is a novel, rapidly changing pandemic. It has affected specialized medical services in unprecedented ways. Surgical decision making, always the most important aspect of care has taken on an added layer of complexity in the face of the COVID-19 pandemic. Therefore, recommendations for breast reconstruction during COVID-19 remain challenging and unclear. This article reviews the impact of the COVID-19 pandemic and suggests potential approaches that could be considered in the absence of validated strategies in breast reconstruction.</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":"10 ","pages":"Doc10"},"PeriodicalIF":0.4,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39478062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of Miescher's cheilitis: a case report.","authors":"Juan Cámara-Pérez,&nbsp;José Carlo Zapata-Negreiros,&nbsp;Pedro Enrique Alonso,&nbsp;Fernando Leiva-Cepas","doi":"10.3205/iprs000159","DOIUrl":"https://doi.org/10.3205/iprs000159","url":null,"abstract":"<p><p>Miescher's cheilitis, also known as cheilitis granulomatosa, is an infrequent disease characterized by chronic recurrent swelling of one lip or both lips. It is considered as one of the three main symptoms of the triad of the Melkersson-Rosenthal syndrome, although in many cases it may develop monosymptomatically. The initial management is based on the administration of corticoids, followed in many cases by the use of other systemic treatments. Nevertheless, because recurrence is quite frequent, surgery remains in many cases as the only definitive treatment. In this report we present the case of a Caucasian woman with Miescher's cheilitis who was successfully surgically managed.</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":"10 ","pages":"Doc09"},"PeriodicalIF":0.4,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}