Biomaterials Science Series最新文献

Chapter 9. Metal-based Antimicrobials 第9章。金属抗菌素

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00252

N. K. Monych, N. Gugala, R. Turner

引用次数: 2

Chapter 8. Antimicrobial Biomaterials in Ophthalmology 第八章。抗菌生物材料在眼科中的应用

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00228

Debarun Dutta, Renxun Chen, N. Kumar, M. Willcox

引用次数: 0

Chapter 5. Synthetic Cationic Water-soluble Antimicrobial Polymers: An Alternative to Conventional Small-molecule Antibiotics 第五章。合成阳离子水溶性抗菌聚合物:传统小分子抗生素的替代品

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00137

Steven Mankoci, Chao Peng, Abraham Joy

{"title":"Chapter 5. Synthetic Cationic Water-soluble Antimicrobial Polymers: An Alternative to Conventional Small-molecule Antibiotics","authors":"Steven Mankoci, Chao Peng, Abraham Joy","doi":"10.1039/9781788012638-00137","DOIUrl":"https://doi.org/10.1039/9781788012638-00137","url":null,"abstract":"The emergence of microbial resistance to several antimicrobials of last resort is causing a global crisis and presents a scenario where hospitals will be unable to address healthcare issues that become complicated due to drug-resistant bacteria. Natural or synthetic antimicrobials are the standard of care for addressing bacterial infections. However, due to the rapid emergence of resistance to these classes of antimicrobials, alternative platforms such as antimicrobial polymers are being evaluated as viable options. In this regard, synthetic cationic water-soluble polymers are an emerging class of antimicrobials that deserve a closer look. Over the decades, several classes of antimicrobial polymers have been explored and have been demonstrated to have good antimicrobial activity, which is normally due to the cationic nature of the polymers. The challenge in such cationic polymers is to maximize their bacterial activity while minimizing the collateral damage to mammalian cells. In this chapter, various classes of synthetic cationic water-soluble antimicrobial polymers are described, spanning both older versions such as polyhexanide and newer cationic polyurethanes.","PeriodicalId":433412,"journal":{"name":"Biomaterials Science Series","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124562890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chapter 4. Biomimetic Antimicrobial Polymers 第四章。仿生抗菌聚合物

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00113

Upayan Baul, Satyavani Vemparala

{"title":"Chapter 4. Biomimetic Antimicrobial Polymers","authors":"Upayan Baul, Satyavani Vemparala","doi":"10.1039/9781788012638-00113","DOIUrl":"https://doi.org/10.1039/9781788012638-00113","url":null,"abstract":"Increased levels of antibiotic drug resistance of virulent bacteria is an urgent healthcare issue that needs to be rethought, not in terms of producing more potent antibiotics, but requiring a paradigm shift. A class of small proteins called host defense peptides are a promising area to understand the evolution of such peptides as an integral part of innate immunity system, and learn design principles which can be used to develop biomimetic synthetic polymers with antimicrobial properties. The goal of such research is to understand at a fundamental level the role of oft-repeated specific motifs present in such peptides, including presence of both charged and hydrophobic entities and facial amphiphilicity in their antimicrobial mechanism, and adopt them into the synthetic polymers. Another goal of such research is to use these peptides or biomimetic polymers as a platform to investigate a fundamental paradigm of biology: structure–function relationship. Recent studies show that many biomimetic polymers and a class of proteins called intrinsically disordered proteins are capable of acquiring functional structures under specific conditions without such a structure built into the system. Such capabilities open up the possibilities of design of smart polymers, which may be very cost-effective and functionally relevant when required. In this chapter we primarily focus on mechanistic design and computational details of biomimetic antimicrobial polymers and their interaction with model membranes, particularly highlighting the effect of such polymers on structural integrity of membranes.","PeriodicalId":433412,"journal":{"name":"Biomaterials Science Series","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127976618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Chapter 13. Recent Advances in Antimicrobial Hydrogels 第13章。抗菌水凝胶的最新进展

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00348

K. R. Kunduru, A. Domb

引用次数: 0

Chapter 2. Introduction to Microbes and Infection in the Modern World 第二章。现代世界微生物与感染导论

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00038

Joshua C. Doloff

{"title":"Chapter 2. Introduction to Microbes and Infection in the Modern World","authors":"Joshua C. Doloff","doi":"10.1039/9781788012638-00038","DOIUrl":"https://doi.org/10.1039/9781788012638-00038","url":null,"abstract":"Microbial infections single-handedly account for many diseases, acute as well as chronic, throughout the modern world, in developed as well as developing nations. In many cases, microbes are required for normal immune function, as germ-free animals have dysfunctional immunity. As a consequence, the traditional idea that all bacteria are bad, and thus the over-prescription of broad-spectrum antibiotics has led not only to multi-drug resistance, but also an imbalance of innocuous vs. harmful pathogens outside in warm bodies of water where we swim, as well as on and inside of our bodies (skin, mouth, lung, gut, urinary tract, vagina, etc.). This has created many difficulties, not only for patients, but also for healthcare providers, who not only have hospital-specific profiles for which drug-resistant bacterial strains (Gram-negative and/or positive) are prevalent in various patient-care facilities, but also worries about complicating and life-threatening incurable infections, obtained by traditional modes of transmission, or following invasive surgical procedures (e.g., implants, cancer resections, corrective surgery, etc.), and spread among patients, as well as the nurses and doctors who treat them. The Human Microbiome Project is a recent initiative to help derive essential understanding of how to discern which microbes are helpful vs. harmful, in an effort to determine improved preventative healthcare (probiotic maintenance, etc.), and in cases of diagnosed disease, the best course of treatment and how we may innovate more effective therapies.","PeriodicalId":433412,"journal":{"name":"Biomaterials Science Series","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130336910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chapter 17. Overview of Antimicrobial Resistance and Nanoparticulate Drug Delivery Approach to Combat Antimicrobial Resistance 第十七章。抗菌素耐药性概述和纳米颗粒给药方法对抗抗菌素耐药性

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00481

M. Saravanan, Melaku Ashagrie, Omar Ali, Balajee Ramachandran

{"title":"Chapter 17. Overview of Antimicrobial Resistance and Nanoparticulate Drug Delivery Approach to Combat Antimicrobial Resistance","authors":"M. Saravanan, Melaku Ashagrie, Omar Ali, Balajee Ramachandran","doi":"10.1039/9781788012638-00481","DOIUrl":"https://doi.org/10.1039/9781788012638-00481","url":null,"abstract":"Although high numbers of novel antibiotics are available in the market currently, it is still a challenge to treat intracellular pathogens. These therapeutic agents always need to be used in high doses, as their antibiotic concentrations are often sub-therapeutic. This is expensive and results in adverse systemic and localized side effects. The current rising threat of antibiotic resistance further complicates the treatment of intracellular pathogenic diseases. As a result, there is a crucial need for methods and systems that enable physicians to attain therapeutically effective intracellular concentrations of those antibiotics. In this scenario, the use of drug delivery systems carrying antibiotics showing targeted and effective antibacterial activity in vitro need to be considered and given due attention. Incorporating or encapsulating antibacterial drugs within these unique drug delivery systems offers better control of pharmacokinetic behavior of the active bactericidal molecule. Such new and advanced methods will replace old conventional antibiotics, which are becoming unusable due to resistance or toxicity. They are vital in rescuing the last-line therapeutic antibiotics through advancing the therapeutic index, broadening the antibiotic antimicrobial spectrum and avoiding failure due to membrane permeability problems, and thus shortening the current time required by classical treatments and reducing the extent of drug resistance. Hence, new and improved drug carriers have been established for treating intracellular pathogens, including antibiotics loaded into hydrogels, liposomes, micelles, polymeric carriers, and metal nanoparticles. This chapter focuses on the role of a drug delivery system as a potential tool against intracellular bacterial pathogens.","PeriodicalId":433412,"journal":{"name":"Biomaterials Science Series","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122248913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Chapter 15. Dendrimers and Hyperbranched Polymers as Antimicrobial Agents 第15章。树状大分子和超支化聚合物作为抗菌剂

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00421

Chandrakala Ummadisetti, K. R. Kunduru, A. Domb

引用次数: 0

Chapter 3. Controlled Release of Antimicrobial Small Molecules 第三章。抗菌小分子控制释放

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00068

M. Zilberman, E. Koren, H. Guez, Lior Matsliah

{"title":"Chapter 3. Controlled Release of Antimicrobial Small Molecules","authors":"M. Zilberman, E. Koren, H. Guez, Lior Matsliah","doi":"10.1039/9781788012638-00068","DOIUrl":"https://doi.org/10.1039/9781788012638-00068","url":null,"abstract":"Controlled release of antimicrobial small molecules is designed to be used for prevention and/or treatment infections associated with a large variety of wound occurrences, ranging from traumatic skin tears and burns to chronic ulcers and complications following surgery and device implantations. The main goal in treating infections is to decrease the bacterial load in the wound site to a level that enables wound healing processes to take place. Local delivery of antibiotics by either topical administration or a delivery device should enable the maintenance of a high local antibiotic concentration for an extended duration of release without exceeding systemic toxicity. The antimicrobial delivery system should be made of biocompatible and biodegradable materials, able to carry a sufficient drug concentration, and release the drug at the appropriate rate for an optimal treatment of the infected tissue. In recent years, various platforms have been developed in order to carry different types of antimicrobial small molecules and treat numerous organs and infections. This chapter describes the main types of these systems. These are based on nanoparticles, fibers, dendrimers, liposomes, nanotubes, and films. Emphasis is placed on processing techniques, nanostructure/microstructure, drug release profiles, biocompatibility and other relevant aspects necessary for advancing the therapeutic field of antimicrobial delivery devices. The final part of this chapter is dedicated to novel concepts in antibiotic-loaded bioresorbable films that we have developed. It focuses on structuring effects of dense and porous films, as well as novel soy protein based systems.","PeriodicalId":433412,"journal":{"name":"Biomaterials Science Series","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121851049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chapter 1. Antimicrobial Materials—An Overview 第1章。抗菌材料综述

Biomaterials Science Series Pub Date : 2019-07-31 DOI: 10.1039/9781788012638-00001

Shaheen Mahira, Anjali Jain, Wahid Khan, A. Domb

引用次数: 19