Ceska Gynekologie-Czech Gynaecology最新文献

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Differences in the provision of lactation consulting based on the type of education of lactation consultants. 基于哺乳咨询师教育类型提供哺乳咨询的差异。
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026186
Adéla Švestková, Ľudmila Matulníková, Hynek Heřman, Lenka Vrlová
{"title":"Differences in the provision of lactation consulting based on the type of education of lactation consultants.","authors":"Adéla Švestková, Ľudmila Matulníková, Hynek Heřman, Lenka Vrlová","doi":"10.48095/cccg2026186","DOIUrl":"10.48095/cccg2026186","url":null,"abstract":"<p><strong>Introduction: </strong>Lactation consulting plays a key role in supporting breastfeeding. The quality of recommendations may influence both the duration and exclusivity of breastfeeding, which is defined as the provision of breast milk only, without additional fluids or foods, except for medications, vitamins, or oral rehydration solution. In the Czech Republic, lactation consultants include those with healthcare education and those without one who have completed specialized training courses. Differences in care approaches may exist between these groups.</p><p><strong>Objective: </strong>To compare the recommendations provided by lactation consultants with and without healthcare education and determine whether they differ significantly.</p><p><strong>Methods: </strong>A quantitative survey was conducted using an online questionnaire completed by 460 breastfeeding women from the Czech Republic and Slovakia. Respondents had consulted either lactation consultants with healthcare education (N = 241, professional lactation consultants) or those without such an education who had completed a specialized course (N = 219, non-professional lactation consultants). Data were analyzed using the chi-square test (P < 0.05).</p><p><strong>Results: </strong>Significant differences were found between the groups (P < 0.001). Professional consultants more frequently recommended breastfeeding on demand, alternative supplementation methods, and were more cautious in recommending aids. Non-professional consultants more often recommended bottle feeding and fixed breastfeeding intervals.</p><p><strong>Conclusion: </strong>Results indicate a difference in the level of expertise between the groups and confirm the importance of professional education in the field of lactation consulting. The study supports the need for unified care standards and an emphasis on evidence-based recommendations.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 3","pages":"186-192"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cervical cancer screening in the European context - from cytology to primary HPV testing. 宫颈癌筛查在欧洲的背景下-从细胞学到原发性HPV检测。
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg202669
Nikola Janovská, Lukáš Rob, Tomáš Pichlík, Borek Sehnal, Karolína Robová, Michael Jiří Halaška, Helena Robová
{"title":"Cervical cancer screening in the European context - from cytology to primary HPV testing.","authors":"Nikola Janovská, Lukáš Rob, Tomáš Pichlík, Borek Sehnal, Karolína Robová, Michael Jiří Halaška, Helena Robová","doi":"10.48095/cccg202669","DOIUrl":"10.48095/cccg202669","url":null,"abstract":"<p><p>Cervical cancer remains a major global health challenge, despite the availability of effective preventive measures such as human papillomavirus (HPV) vaccination, early detection and treatment of precancerous lesions, and timely management of early-stage disease. In recent years, several European countries have introduced substantial changes to their screening strategies -shifting from conventional cytology to primary HPV testing. This shift, supported by the World Health Organization and International Agency for Research on Cancer recommendations, is underpinned by numerous clinical studies demonstrating the superior sensitivity of HPV testing for detecting high-grade cervical lesions. This article provides an up-to-date overview of cervical cancer screening across Europe, with a focus on screening methods, testing intervals, program organization, and the emerging role of self-sampling.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 1","pages":"69-76"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perinatal outcomes in severe preeclampsia with peritoneal ascites - a single tertiary center experience. 严重子痫前期伴腹膜腹水的围产期结局-单一三级中心经验。
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026109
Huriye Ezveci, Sukran Doğru, Fatih Akkuş, Fikriye Karanfil Yaman, Melike Sena Harmancı, Ülfet Sena Metin, Ali Acar
{"title":"Perinatal outcomes in severe preeclampsia with peritoneal ascites - a single tertiary center experience.","authors":"Huriye Ezveci, Sukran Doğru, Fatih Akkuş, Fikriye Karanfil Yaman, Melike Sena Harmancı, Ülfet Sena Metin, Ali Acar","doi":"10.48095/cccg2026109","DOIUrl":"10.48095/cccg2026109","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate maternal and neonatal outcomes of women with severe preeclampsia (PE) with and without peritoneal ascites.</p><p><strong>Methods: </strong>In this retrospective cohort study, 76 pregnant women diagnosed with severe PE between January 2019 and January 2024 were evaluated, including 23 with peritoneal ascites and 53 without. Maternal demographic, clinical, and laboratory parameters including neonatal outcomes were compared between the two groups.</p><p><strong>Results: </strong>Women with severe PE and peritoneal ascites had higher rates of previous preeclampsia (30.4 vs. 7.5%; P = 0.009), visual symptoms (52.2 vs. 22.6%; P = 0.011), and maternal blood transfusion (47.8 vs. 13.2%; P = 0.001). They also exhibited significantly higher urea levels and proteinuria (P < 0.05). In terms of neonatal outcomes, the ascites group delivered earlier (31.5 ± 3.9 vs. 33.8 ± 3.1 weeks; P = 0.008), had lower birth weights (median 1,400 g vs. 1,990 g; P = 0.015), and higher NICU admission (60.9 vs. 34.0%; P = 0.029) with longer NICU stays (P = 0.003). One case of HELLP syndrome was observed in the ascites group.</p><p><strong>Conclusion: </strong>Presence of peritoneal ascites in severe PE is associated with worse maternal and neonatal outcomes, including increased transfusion requirement and adverse perinatal indicators. Detection of ascites may serve as an important clinical marker of disease severity, highlighting the need for closer surveillance and timely intervention.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 2","pages":"109-115"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological data of pregnant women with fetuses or newborns diagnosed with amniotic band syndrome in Brazil. 巴西诊断为羊膜带综合征的孕妇或新生儿的流行病学资料
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026193
Ynnaê Côrtes Da Silva Neri, Edward Araujo Júnior, Raquel Mendes Moreira, Lorenza Machado Teixeira, Luísa Moreira de Ávila
{"title":"Epidemiological data of pregnant women with fetuses or newborns diagnosed with amniotic band syndrome in Brazil.","authors":"Ynnaê Côrtes Da Silva Neri, Edward Araujo Júnior, Raquel Mendes Moreira, Lorenza Machado Teixeira, Luísa Moreira de Ávila","doi":"10.48095/cccg2026193","DOIUrl":"10.48095/cccg2026193","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze epidemiological aspects in Brazil related to women who had fetuses or newborns diagnosed with amniotic band syndrome (ABS), to assess perinatal outcomes of the newborns who received this diagnosis, and to examine the patients' perception regarding the knowledge and support provided by healthcare professionals involved at the time of diagnosis.</p><p><strong>Methods: </strong>This was a quantitative, descriptive, analytical, retrospective, and cross-sectional study based on an online questionnaire administered at a single time point. The sample was randomly defined and included voluntary participation of female patients with a history of pregnancy affected by ABS.</p><p><strong>Results: </strong>Twenty-two questionnaires were analyzed. There was a predominance of cesarean deliveries and miscarriages among women with a history of ABS. ABS most frequently affected the upper limbs, particularly the hands and arms. A healthcare professional made the diagnosis during prenatal care via ultrasonography in 54.5% of the cases; however, only 40.9% of professionals were reported to be well-informed and to have provided full support. Fetal surgery was performed in only one case diagnosed during prenatal care. Cesarean delivery was predominant, as reported by 17 participants. Out of the 21 children who survived, 54.5% weighed > 2,500 g.</p><p><strong>Conclusion: </strong>ABS should receive greater emphasis during medical education and professional training updates to enable early diagnosis, intrauterine surgical treatment when indicated, and - most importantly - to ensure adequate guidance and support to the families.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 3","pages":"193-197"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometrioma of Bartholin's gland. 巴氏腺子宫内膜异位瘤。
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026121
Dubravko Habek, Vedran Kardum, Josipa Vlahović
{"title":"Endometrioma of Bartholin's gland.","authors":"Dubravko Habek, Vedran Kardum, Josipa Vlahović","doi":"10.48095/cccg2026121","DOIUrl":"10.48095/cccg2026121","url":null,"abstract":"<p><p>We present a case of extrapelvic endometriosis of Bartholin's gland in a healthy 40-year-old woman with two deliveries. After the last delivery 10 years ago, she had cyclical pain with swelling in the Bartholin's gland area and dyspareunia with vulvodynia. Primary excision was performed, and Bartholin's gland endometriosis was pathohistologically proven as an extremely rare gynaecological entity. A follow-up examination 2 months after surgery proved complete recovery without vulvodynia and dyspareunia.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 2","pages":"121-123"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic interposition of the mesorectum during low anterior resection of the rectum for endometriosis using tissue perfusion assessment with indocyanine green. 应用吲哚菁绿组织灌注评估子宫内膜异位症直肠低位前切术中直肠系膜的机器人介入。
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg202646
Vladimír Baláž, Vladimír Teplan, Kamila Benková, Jiří Presl
{"title":"Robotic interposition of the mesorectum during low anterior resection of the rectum for endometriosis using tissue perfusion assessment with indocyanine green.","authors":"Vladimír Baláž, Vladimír Teplan, Kamila Benková, Jiří Presl","doi":"10.48095/cccg202646","DOIUrl":"10.48095/cccg202646","url":null,"abstract":"<p><strong>Introduction: </strong>Rectal endometriosis is a serious disease, and its surgical treatment belongs among demanding procedures, often requiring a multidisciplinary approach. It is associated with a significant risk of peri- and postoperative complications, the most serious being the development of rectovaginal fistula, which may occur in up to 10% of resections for rectal endometriosis. Preventive measures include the choice of surgical technique, such as a two-stage procedure (resection with terminal stoma followed by stoma closure and bowel anastomosis), which is not optimal for the patient due to the necessity of having two surgeries. Another option is the interposition of the patient's vital tissues into the site of anastomosis or intestinal wall suture. For this purpose, an omental flap is often used, or part of the mesorectum may be utilized. The ability to verify the vitality of such a flap should be considered crucial in preventing anastomotic leakage.</p><p><strong>Methods: </strong>A patient underwent robotic-assisted laparoscopic segmental resection of severe rectal endometriosis involving the rectovaginal septum and vagina, classified as #ENZIAN A3 and C3, with interposition of the mesorectum and intraoperative tissue perfusion assessment using indocyanine green.</p><p><strong>Conclusion: </strong>The use of tissue perfusion assessment when performing interposition of patient-derived flaps may, in the future, improve surgical precision, enhance success rates, and contribute to the prevention of rectovaginal fistula formation.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 1","pages":"46-51"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis on the association of the COMT Val158Met variant with preeclampsia risk. COMT Val158Met变异与子痫前期风险相关性的meta分析
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026314
Sagar Jangde, Babul Meher, Nisha Sahu, Henu Kumar Verma, L V K S Bhaskar
{"title":"Meta-analysis on the association of the COMT Val158Met variant with preeclampsia risk.","authors":"Sagar Jangde, Babul Meher, Nisha Sahu, Henu Kumar Verma, L V K S Bhaskar","doi":"10.48095/cccg2026314","DOIUrl":"10.48095/cccg2026314","url":null,"abstract":"<p><p>Catecholamine-O-methyl transferase (COMT) catalyzes the O-methylation of catechol-structured compounds such as catecholamines and catecholestrogens. A genetic variation in the human COMT gene (rs4680 or Val158Met) significantly reduces three-to-four-fold catecholamine metabolism and influences neurotransmitter levels, thereby modulating preeclampsia (PE) susceptibility. The present meta-analysis was conducted to evaluate the link between the COMT Val158Met variant and PE risk. Case-control studies published until November 20, 2025 were systematically searched from PubMed, Google Scholar, and Web of Science databases. To assess the association between the COMT Val158Met variant and PE, Odds ratios and 95% confidence intervals were calculated under three genetic models. The results indicated no significant association between the COMT Val158Met variant and PE risk across three genetic models, including the allele (Met vs. Val: Overall OR 1.19, 95% CI 1.00-1.43, P = 0.052), recessive (Met/Met + Met/Val vs. Val/Val: Overall OR 1.16, 95% CI 0.95-1.40, P = 0.137), and dominant (Met/Met vs. Met/Val + Val/Val OR 1.39, 95% CI 0.97-2.00, P = 0.075) models. Furthermore, subgroup analyses based on ethnicity also indicated no association between the Val158Met variant and PE risk in Caucasian and Asian populations. Sensitivity analyses conducted using the leave-one-out method revealed that the results are robust. Asymmetry observed in Begg's funnel plot indicated a significant publication bias in the dominant model (P = 0.012). In summary, results showed that the COMT Val158Met variant is not associated with PE risk. As this meta-analysis contradicts the biological plausibility that COMT alleles influence catecholamine neurotransmitters and PE, the results warrant careful interpretation and further investigation.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 4","pages":"314-321"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perinatal palliative care in a patient with antenatal fetal death due to severe preeclampsia with placental abruption. 严重子痫前期合并胎盘早剥致胎儿死亡患者的围产期姑息治疗
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026198
Kateřina Cardová, Andriy Suran, Helena Herainová, Miroslava Solničková, Martin Pán
{"title":"Perinatal palliative care in a patient with antenatal fetal death due to severe preeclampsia with placental abruption.","authors":"Kateřina Cardová, Andriy Suran, Helena Herainová, Miroslava Solničková, Martin Pán","doi":"10.48095/cccg2026198","DOIUrl":"10.48095/cccg2026198","url":null,"abstract":"<p><p>A 37-year-old nulliparous woman was admitted to the hospital for mild bleeding. Intrauterine fetal death and placental abruption were diagnosed. The patient had a severe form of preeclampsia associated with fetal growth restriction and anuric renal failure. The delivery was associated with significant blood loss. Immediately after the termination of pregnancy by emergency caesarean section, the patient's condition required hospitalization in the intensive care unit and temporary dialysis. In parallel with the demanding care of the patient's physical health, early perinatal palliative intervention was initiated, i.e. accompanying the family after the death of the child. SPIKES communication protocol makes it easier to navigate a difficult conversation in limited time. Commonly established hospital processes may not be prepared for such a complex and demanding situation and require exceptional involvement of the staff from all departments. Sharing our communication skills improves the cooperation with an aggressive patient. Presence of her family is beneficial for communication during difficult times.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 3","pages":"198-201"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of obesity in pregnancy in the Czech Republic - demographic context and clinical implications. 捷克共和国妊娠期肥胖的流行病学——人口背景和临床意义。
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026116
Jitka Jírová, Lenka Szczuková, Jiří Jarkovský, Antonín Pařízek
{"title":"Epidemiology of obesity in pregnancy in the Czech Republic - demographic context and clinical implications.","authors":"Jitka Jírová, Lenka Szczuková, Jiří Jarkovský, Antonín Pařízek","doi":"10.48095/cccg2026116","DOIUrl":"10.48095/cccg2026116","url":null,"abstract":"<p><strong>Objective: </strong>To describe the current epidemiology of overweight and obesity among pregnant women in Czechia in the context of demographic trends and basic perinatal outcomes.</p><p><strong>Materials and methodology: </strong>The analysis was based on data from the National Reproductive Health Registry (NRRZ) from April 1 to September 30, 2025, focusing on 1st trimester BMI. Since April 1, 2025, the new Registry Report systematically records women's height and weight at the beginning and the end of pregnancy. First-trimester BMI and its associations with selected demographic characteristics (particularly age, education, and parity) and selected clinical indicators of pregnancy and delivery outcomes were evaluated. For comparison, data from the European Union Statistics on Income and Living Conditions (EU-SILC) and European Health Interview Survey (EHIS) were also used. A total of 23,573 women with complete 1st trimester BMI data were included in the analysis.</p><p><strong>Results and conclusion: </strong>Among the 23,573 pregnant women with available BMI data, 53.4% were normal weight, 24.3% were overweight, and 17.7% were obese. Overweight and obesity were more frequent among older women, had lower educational attainment, and higher parity. Higher BMI was associated with an increased risk of preterm birth, foetal macrosomia, caesarean section, gestational hypertension, preeclampsia, and gestational diabetes. Overweight and obesity affect more than 40% of pregnant women in Czechia representing a significant risk factor for adverse perinatal outcomes. Systematic data collection allows, for the first time, a detailed national analysis and provides a basis for preventive interventions.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 2","pages":"116-120"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do adipose-derived mesenchymal stem cells improve reproductive potential in patientswith inadequate ovarian response? 脂肪源性间充质干细胞能改善卵巢反应不足患者的生殖潜能吗?
IF 0.7
Ceska Gynekologie-Czech Gynaecology Pub Date : 2026-01-01 DOI: 10.48095/cccg2026290
Mehmet Cengiz Çolakoğlu, Jule Eriç Horasanlı, Fatih Akkuş
{"title":"Do adipose-derived mesenchymal stem cells improve reproductive potential in patientswith inadequate ovarian response?","authors":"Mehmet Cengiz Çolakoğlu, Jule Eriç Horasanlı, Fatih Akkuş","doi":"10.48095/cccg2026290","DOIUrl":"https://doi.org/10.48095/cccg2026290","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether intraovarian infusion of autologous adipose-derived mesenchymal stem cells (MSCs) improves ovarian reserve parameters and oocyte retrieval outcomes in women with poor ovarian response.</p><p><strong>Materials and methods: </strong>This retrospective pre-post cohort study included 29 women aged 25-40 years who met the European Society of Human Reproduction and Embryology (ESHRE) criteria for poor ovarian response and had experienced at least one previous Assisted Reproductive Technology (ART) cycle without oocyte retrieval. A total of 1 × 10⁶ autologous adipose-derived MSCs were laparoscopically infused into four cortical quadrants of each ovary. Serum anti-Müllerian hormone (AMH) levels were measured at baseline and 2 months after treatment. Controlled ovarian stimulation using a gonadotropin-releasing hormone (GnRH) antagonist protocol was initiated two months post-infusion, followed by oocyte retrieval. Paired comparisons were performed using the Wilcoxon signed-rank test. Multivariable linear regression evaluated factors associated with change in AMH (DAMH), and binomial logistic regression assessed predictors of successful oocyte retrieval.</p><p><strong>Results: </strong>Serum AMH levels increased significantly following MSC therapy. Median AMH rose from 0.01 ng/mL (0.01-0.02) to 0.02 ng/mL (0.01-0.04) (P = 0.001). No baseline demographic or clinical variables were independently associated with DAMH (all P > 0.05). DAMH was the only variable significantly associated with successful oocyte retrieval (likelihood ratio c² = 6.54, P = 0.011). Higher DAMH values corresponded to progressively increased predicted probabilities of oocyte retrieval.</p><p><strong>Conclusion: </strong>Intraovarian administration of autologous adipose-derived MSCs was associated with modest but significant improvements in AMH levels and oocyte retrieval probability. These exploratory findings warrant confirmation in larger prospective controlled studies with definitive reproductive endpoints.</p>","PeriodicalId":43333,"journal":{"name":"Ceska Gynekologie-Czech Gynaecology","volume":"91 4","pages":"290-298"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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