Journal of Multiscale Modelling最新文献

{"title":"Mooring System Design and Verification for a Floating Vertical Axis Wind Turbine","authors":"Fausto Raschioni, R. Longo, A. Mehmanparast, C. Rizzo","doi":"10.1142/s1756973720500031","DOIUrl":"https://doi.org/10.1142/s1756973720500031","url":null,"abstract":"The aim of this study is to investigate the technical feasibility of an innovative vertical axis floating wind turbine concept with the main focus on the design and verification of the mooring system. The study is developed through iterative processes in order to identify the optimum design for the new floating wind turbine concept. The Ultimate Limit State (ULS) criteria have been considered to verify the integrity of the mooring system in the extreme environmental conditions with a 50-year return period. For this purpose, time domain dynamic analysis has been performed using the commercial software OrcaFlex [Orcina website, OrcaFlex software, https://www.orcina.com/ ]. Although the analysis is carried out for a specific site deemed suitable for the project, the results can be used as an input for any future application in other locations. The present study is intended to be a proof of concept with a proposed scientific framework for optimization of the mooring system which is considered to be a crucial part in the design of floating wind turbines due to their complex dynamic behavior.","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2020-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/s1756973720500031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49124511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study.","authors":"Emmanuel S Antonarakis, Josep M Piulats, Marine Gross-Goupil, Jeffrey Goh, Kristiina Ojamaa, Christopher J Hoimes, Ulka Vaishampayan, Ranaan Berger, Ahmet Sezer, Tuomo Alanko, Ronald de Wit, Chunde Li, Aurelius Omlin, Giuseppe Procopio, Satoshi Fukasawa, Ken-Ichi Tabata, Se Hoon Park, Susan Feyerabend, Charles G Drake, Haiyan Wu, Ping Qiu, Jeri Kim, Christian Poehlein, Johann Sebastian de Bono","doi":"10.1200/JCO.19.01638","DOIUrl":"10.1200/JCO.19.01638","url":null,"abstract":"<p><strong>Purpose: </strong>Pembrolizumab has previously shown antitumor activity against programmed death ligand 1 (PD-L1)-positive metastatic castration-resistant prostate cancer (mCRPC). Here, we assessed the antitumor activity and safety of pembrolizumab in three parallel cohorts of a larger mCRPC population.</p><p><strong>Methods: </strong>The phase II KEYNOTE-199 study included three cohorts of patients with mCRPC treated with docetaxel and one or more targeted endocrine therapies. Cohorts 1 and 2 enrolled patients with RECIST-measurable PD-L1-positive and PD-L1-negative disease, respectively. Cohort 3 enrolled patients with bone-predominant disease, regardless of PD-L1 expression. All patients received pembrolizumab 200 mg every 3 weeks for up to 35 cycles. The primary end point was objective response rate per RECIST v1.1 assessed by central review in cohorts 1 and 2. Secondary end points included disease control rate, duration of response, overall survival (OS), and safety.</p><p><strong>Results: </strong>Two hundred fifty-eight patients were enrolled: 133 in cohort 1, 66 in cohort 2, and 59 in cohort 3. Objective response rate was 5% (95% CI, 2% to 11%) in cohort 1 and 3% (95% CI, < 1% to 11%) in cohort 2. Median duration of response was not reached (range, 1.9 to ≥ 21.8 months) and 10.6 months (range, 4.4 to 16.8 months), respectively. Disease control rate was 10% in cohort 1, 9% in cohort 2, and 22% in cohort 3. Median OS was 9.5 months in cohort 1, 7.9 months in cohort 2, and 14.1 months in cohort 3. Treatment-related adverse events occurred in 60% of patients, were of grade 3 to 5 severity in 15%, and led to discontinuation of treatment in 5%.</p><p><strong>Conclusion: </strong>Pembrolizumab monotherapy shows antitumor activity with an acceptable safety profile in a subset of patients with RECIST-measurable and bone-predominant mCRPC previously treated with docetaxel and targeted endocrine therapy. Observed responses seem to be durable, and OS estimates are encouraging.</p>","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":"06 1","pages":"395-405"},"PeriodicalIF":42.1,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86076021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture Mechanics Assessment of Large Diameter Wind Turbine Bearings","authors":"François Dagry, A. Mehmanparast, Patrick Müller, Klaus Pantke","doi":"10.1142/S1756973718500105","DOIUrl":"https://doi.org/10.1142/S1756973718500105","url":null,"abstract":"The structural integrity of large diameter wind turbine bearings have been investigated using the built-in “contour integral” tool in ABAQUS finite element software package by modeling three-dimens...","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":"10 1","pages":"1850010"},"PeriodicalIF":1.5,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1756973718500105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47188658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Secondary Dendrite Arm Spacing for In-738LC Gas-Tungsten-Arc-Welds","authors":"E. Bonifaz, J. M. Conde, A. Czekanski","doi":"10.1142/S1756973718500129","DOIUrl":"https://doi.org/10.1142/S1756973718500129","url":null,"abstract":"Microstructure and defect development in the gas tungsten arc weld process is influenced by the solidification and melt-pool dynamics. Melt-pool geometrical parameters which depend mainly on heat i...","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":"10 1","pages":"1850012"},"PeriodicalIF":1.5,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1756973718500129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42033485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Numerical Study on the Seismic Site Response of Rocky Valleys with Irregular Topographic Conditions","authors":"Mohammad Katebi, B. Gatmiri, P. Maghoul","doi":"10.1142/S1756973718500117","DOIUrl":"https://doi.org/10.1142/S1756973718500117","url":null,"abstract":"This paper investigates topographic effects of rocky valleys with irregular topographic conditions subjected to vertically propagating SV waves of Ricker type using a boundary element code. Valleys...","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":"10 1","pages":"1850011"},"PeriodicalIF":1.5,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1756973718500117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44572332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential Linear Analysis for the Prediction of the Symmetrical or Non-Symmetrical Character of the Debond Onset and Propagation Along a Fiber-Matrix Interface","authors":"L. Moreno, L. Távara, E. Correa, F. París","doi":"10.1142/S1756973718420040","DOIUrl":"https://doi.org/10.1142/S1756973718420040","url":null,"abstract":"In this work, a recently proposed numerical tool is used to predict the onset and growth of debonds appearing along a single glass/carbon fiber embedded in an epoxy matrix subjected to transverse loads. The fiber-matrix system is modelled using the FEA commercial code ABAQUS, together with a solving algorithm programmed in Python and named Sequential Linear Analysis (SLA). Besides, the interface behavior is modeled using the Linear Elastic Brittle Interface Model (LEBIM) included in ABAQUS by means of a UMAT subroutine. The developed models are able to reproduce the non-symmetrical (one-side) debond at the fiber-matrix interface. Moreover, the results obtained show that the appearance of a unilateral debond may be affected both by the material employed and the size of the matrix cell where the fiber is embedded.","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2019-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1756973718420040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45921857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of Gc Tests Used to Evaluate Composite–Composite Adhesive Joints","authors":"J. Cañas, L. Távara, A. Blázquez, A. Estefani","doi":"10.1142/S1756973718420027","DOIUrl":"https://doi.org/10.1142/S1756973718420027","url":null,"abstract":"The quality of composite–composite bonded joints is a very important issue for industries, especially for the aerospace sector. A deficient joint may stop the manufacturing process and its repairing may include very high costs. Nowadays, the quality of the joint is obtained by means of interlaminar fracture toughness tests, estimating the [Formula: see text] value (Energy Release Rate used to produce crack propagation) over coupons with (theoretically) the same conditions as those included in an actual part. Usually, [Formula: see text] is obtained by means of a Double Cantilever Beam (DCB) test. Although DCB is the reference test, it may present some drawbacks when a non-symmetrical coupon is used and when the adherents stiffness is low. An alternative to DCB is the Climbing Drum Peel (CDP) test which is able to address some of the DCB drawbacks. Nevertheless, both tests need the use of a universal testing machine, then they cannot be done in situ. In the present investigation, DCB and CDP main characteristics are analyzed and a new device, called Horizontal Drum Peel (HDP), which includes the advantages of previous tests and the possibility to perform the test over an actual part is presented.","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2019-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1756973718420027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44490726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Temperature Combined Fatigue Tests on Full-Scale Turbine Blades","authors":"Xiaojun Yan, Xiaoyu Qin, Dawei Huang","doi":"10.1142/S1756973718420039","DOIUrl":"https://doi.org/10.1142/S1756973718420039","url":null,"abstract":"Compared with standard specimens, fatigue tests on full-scale turbine blades can take factors such as geometry and manufacturing process into consideration of life assessment. However, for combined fatigue tests of full-scale turbine blades, there exist two challenges. The first one is that it is difficult to apply combined loads of centrifugal force (low cycle fatigue, LCF) and vibration force (high cycle fatigue, HCF) properly because of the interaction between these loads. The second one is that it is hard to determine the range of HCF load/stress which the blade experiences at service conditions. To address these two challenges, firstly, a set of two-path fixture is designed to apply combined loads on the test blade, which can transfer LCF and HCF load separately by different paths. And secondly, two methods, i.e. the inverse method and the contrast method are proposed to estimate the HCF stress level for turbine blades at service conditions. The inverse method infers the HCF stress level by comparing blade failure data between field (in service) and bench tests conditions, while the contrast method obtains HCF stress level by comparing blade failure data between new and used blades under bench tests conditions. Detailed procedures of high temperature combined fatigue tests on full-scale blade are presented, and experimental life data is also included and analyzed.","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2019-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1756973718420039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47206105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of 3D Printed Trapezoidal Interfaces by Means of a Novel Cohesive-Based Analytical Approach","authors":"L. García-Guzmán, L. Távara, J. Reinoso, J. Justo, F. París","doi":"10.1142/S1756973718420015","DOIUrl":"https://doi.org/10.1142/S1756973718420015","url":null,"abstract":"The advances in manufacturing techniques allow the generation of new geometric conceptions and open a new paradigm in adhesive joints design. Structured interfaces constitute an excellent method to improve the resistance properties of these kinds of joining systems, Additive Layer Manufacturing (ALM or 3D printing) being an appropriate procedure to perform these designs. In this study, double-cantilever beam (DCB) tests with different trapezoidal patterns are investigated in terms of fracture resistance from experimental and analytical points of view in order to analyze the influence of the geometry in the energy release rate of the structure. The main goal of the current investigation is to examine the system response under the variation of the analytical approach parameters (based on a cohesive-zone model (CZM) technique). Particularly, a wider range of mixed-mode fracture conditions can be integrated by means of establishing different penalty stiffnesses in normal and shear directions, [Formula: see text] and [Formula: see text], respectively. Finally, a correlation between the experimental and analytical results for the proposed trapezoidal interfaces with different aspect ratios [Formula: see text] (where [Formula: see text] and [Formula: see text] identify the amplitude and wavelength of the interface profile, respectively) is shown. A satisfactory agreement between the predicted and the experimental data is achieved, emphasizing that the relation [Formula: see text] has a significant influence on the results obtained and, therefore, a correct characterization of the joint is needed.","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":"13 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2019-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1756973718420015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41247019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface","authors":"Elena Correa Montoto, L. Rodríguez-Tembleque","doi":"10.1142/s1756973718020031","DOIUrl":"https://doi.org/10.1142/s1756973718020031","url":null,"abstract":"","PeriodicalId":43242,"journal":{"name":"Journal of Multiscale Modelling","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45674117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}