Cardiovascular Endocrinology & Metabolism最新文献_第7页

Type 2 diabetes prevalence in Pakistan: what is driving this? Clues from subgroup analysis of normal weight individuals in diabetes prevalence survey of Pakistan. 巴基斯坦的 2 型糖尿病患病率：是什么导致了这一现象？巴基斯坦糖尿病患病率调查中对体重正常者进行的亚组分析提供的线索。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-19 eCollection Date: 2020-12-01 DOI: 10.1097/XCE.0000000000000212

Azizul Hasan Aamir, Zia Ul-Haq, Sheraz Fazid, Basharat Hussain Shah, Abbas Raza, Ali Jawa, Saeed A Mahar, Ibrar Ahmad, Faisal Masood Qureshi, Adrian H Heald

{"title":"Type 2 diabetes prevalence in Pakistan: what is driving this? Clues from subgroup analysis of normal weight individuals in diabetes prevalence survey of Pakistan.","authors":"Azizul Hasan Aamir, Zia Ul-Haq, Sheraz Fazid, Basharat Hussain Shah, Abbas Raza, Ali Jawa, Saeed A Mahar, Ibrar Ahmad, Faisal Masood Qureshi, Adrian H Heald","doi":"10.1097/XCE.0000000000000212","DOIUrl":"10.1097/XCE.0000000000000212","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is a global health tissue. We determined factors relating to the likelihood of developing T2DM in normal BMI individuals.Methodology: This was a cross-sectional community-based representative survey, of people aged ≥20 years in Pakistan, using HBA1c as the screening tool. The prevalence of T2DM/prediabetes in people having normal BMI together with associated risk factors was estimated.Results: Of 6824 normal BMI individuals, there was still a high prevalence of T2DM 14.92% and in underweight at 10.14% (overall prevalence 16.96%). Corresponding rates for prediabetes for the normal BMI category: 9.79% and underweight 8.99%. Multivariate logistic regression modeling for normal BMI individuals, showed a significantly increased risk of T2DM with increasing age (odds ratio [OR] 2.1, 3.3, 4.5 and 4.8, P < 0.001 for 31-40, 41-50, 51-60 and 61 years and above respectively, compared to age decade 20-30 years). Similarly, there was a significantly high risk of T2DM with lower education level [OR for no vs graduate 2.4, 95% confidence interval (CI) 1.5-3.8]. There was a significantly increased risk of T2DM in individuals having a positive family history [OR 4.3 (95% CI 7.0-11.5)]. Overall the influence of overweight/obese on T2DM occurrence (20% increased risk) was much less than in other regions of the world.Conclusion: There are higher than expected rates of T2DM/prediabetes in Pakistani ethnicity normal BMI individuals. Targeted screening of older individuals with historical lack of educational opportunity, with a family history of T2DM even if of normal BMI may result in a significant benefit in the Pakistan population.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 4","pages":"159-164"},"PeriodicalIF":2.3,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673776/pdf/xce-9-159.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38641604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peroxisome proliferator-activated receptor agonists and reversal of vascular degeneration through DNA repair, a step toward drug-induced regenerative medicine. 过氧化物酶体增殖物激活受体激动剂和通过DNA修复逆转血管变性，迈向药物诱导再生医学的一步。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-16 eCollection Date: 2020-12-01 DOI: 10.1097/XCE.0000000000000217

Peter Afdal, Habiba-Allah Ismail, Mirette Ashraf, Nada Hafez, Nardine Nasry, Nouran Hafez, Nourhan Youssef, Nourhan Samy, Rana Saeed, Antoine Fakhry AbdelMassih

{"title":"Peroxisome proliferator-activated receptor agonists and reversal of vascular degeneration through DNA repair, a step toward drug-induced regenerative medicine.","authors":"Peter Afdal, Habiba-Allah Ismail, Mirette Ashraf, Nada Hafez, Nardine Nasry, Nouran Hafez, Nourhan Youssef, Nourhan Samy, Rana Saeed, Antoine Fakhry AbdelMassih","doi":"10.1097/XCE.0000000000000217","DOIUrl":"10.1097/XCE.0000000000000217","url":null,"abstract":"Endothelial dysfunction with subsequent degeneration and vasoocclusive remodeling is the hallmark of many cardiovascular disorders including pulmonary vascular disease (PVD). To date, the available treatments slows disease progression but does not prevent deterioration. Reversing such pathologies would spare many patients risky surgeries and long waiting lists for a possible organ donor. Peroxisome proliferator-activated receptor agonists were first introduced as sole insulin sensitizers, however, there is increasing body of evidence that they have different actions on DNA which might help reverse vascular degeneration. This effect appears to be mainly achieved through enhancement of DNA damage responses (DDR). The aforementioned effect could offer new insights about repurposing drugs for achieving organ or tissue regeneration, an understudied field named drug-induced regenerative medicine.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 4","pages":"128-131"},"PeriodicalIF":2.3,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673771/pdf/xce-9-128.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38631724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The FreeStyle Libre flash glucose monitoring system: how it has improved glycaemic control for people with type 1 diabetes in Eastern Cheshire, UK. FreeStyle Libre瞬时血糖监测系统:如何改善英国柴郡东部1型糖尿病患者的血糖控制。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-16 eCollection Date: 2020-12-01 DOI: 10.1097/XCE.0000000000000216

Ghasem Yadegarfar, Simon G Anderson, Zohaib Khawaja, Gabriela Cortes, Kathryn Leivesley, Ann Metters, Linda Horne, Tom Steele, Adrian H Heald

{"title":"The FreeStyle Libre flash glucose monitoring system: how it has improved glycaemic control for people with type 1 diabetes in Eastern Cheshire, UK.","authors":"Ghasem Yadegarfar, Simon G Anderson, Zohaib Khawaja, Gabriela Cortes, Kathryn Leivesley, Ann Metters, Linda Horne, Tom Steele, Adrian H Heald","doi":"10.1097/XCE.0000000000000216","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000216","url":null,"abstract":"Introduction: Many people with type 1 diabetes continue to run high HbA1c levels with associated elevated risk of cardiovascular events and increased mortality. We describe here how use of the FreeStyle Libre flash monitor has improved the glycaemic control of many people with type 1 diabetes where the new technology has been intensively deployed.Methods: We report the outcomes of 92 consecutive adults (18 years of age or more) with type 1 diabetes who have begun using the FreeStyle Libre flash glucose monitor in East Cheshire, UK. Initiation was with education and support from one of the diabetes specialist nurses. An HbA1c of 60 mmol/mol (7.6%) was taken as the threshold for suboptimal glycaemic control.Results: The mean cohort age was 43 years for men and 39 years for women (overall range 17-83 years). In 92 consecutive users, HbA1c decreased by an average of 10.7 mmol/mol (0.98%) after 3 months, and by 16.1 mmol/mol (1.47%) after 6 months. There was also a narrowing of the distribution of HbA1c, with many fewer people running high HbA1c ≥80 mmol/mol (9.5%). After the 6-month follow-up, two 2/92 users did not wish to continue with the monitoring.Conclusion: Flash glucose monitoring has great potential for the management of type 1 diabetes in the adult population and improving metabolic control/quality of life for people across the world. The technology provides significantly more data than the intermittent results obtained by traditional subcutaneous blood glucose monitoring, which may not capture intervals of extreme variability or nocturnal events.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 4","pages":"171-176"},"PeriodicalIF":2.3,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38641606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Is it infection or rather vascular inflammation? Game-changer insights and recommendations from patterns of multi-organ involvement and affected subgroups in COVID-19. 是感染还是血管炎症?来自COVID-19多器官受累模式和受影响亚群的改变游戏规则的见解和建议。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-11 eCollection Date: 2020-09-01 DOI: 10.1097/XCE.0000000000000211

Antoine Fakhry AbdelMassih, Aya Kamel, Fady Mishriky, Habiba-Allah Ismail, Layla El Qadi, Lauris Malak, Miral El-Husseiny, Mirette Ashraf, Nada Hafez, Nada AlShehry, Nadine El-Husseiny, Nora AbdelRaouf, Noura Shebl, Nouran Hafez, Nourhan Youssef, Peter Afdal, Rafeef Hozaien, Rahma Menshawey, Rana Saeed, Raghda Fouda

{"title":"Is it infection or rather vascular inflammation? Game-changer insights and recommendations from patterns of multi-organ involvement and affected subgroups in COVID-19.","authors":"Antoine Fakhry AbdelMassih, Aya Kamel, Fady Mishriky, Habiba-Allah Ismail, Layla El Qadi, Lauris Malak, Miral El-Husseiny, Mirette Ashraf, Nada Hafez, Nada AlShehry, Nadine El-Husseiny, Nora AbdelRaouf, Noura Shebl, Nouran Hafez, Nourhan Youssef, Peter Afdal, Rafeef Hozaien, Rahma Menshawey, Rana Saeed, Raghda Fouda","doi":"10.1097/XCE.0000000000000211","DOIUrl":"10.1097/XCE.0000000000000211","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a serious illness that has rapidly spread throughout the globe. The seriousness of complications puts significant pressures on hospital resources, especially the availability of ICU and ventilators. Current evidence suggests that COVID-19 pathogenesis majorly involves microvascular injury induced by hypercytokinemia, namely interleukin 6 (IL-6). We recount the suggested inflammatory pathway for COVID-19 and its effects on various organ systems, including respiratory, cardiac, hematologic, reproductive, and nervous organ systems, as well examine the role of hypercytokinemia in the at-risk geriatric and obesity subgroups with upregulated cytokines' profile. In view of these findings, we strongly encourage the conduction of prospective studies to determine the baseline levels of IL-6 in infected patients, which can predict a negative outcome in COVID-19 cases, with subsequent early administration of IL-6 inhibitors, to decrease the need for ICU admission and the pressure on healthcare systems. Video abstract: http://links.lww.com/CAEN/A24.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 3","pages":"110-120"},"PeriodicalIF":2.3,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38271997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Cardiovascular and cardiometabolic prevention: high-level priority in the era of COVID-19. 心血管和心脏代谢预防：COVID-19 时代的高度优先事项。

IF 1.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-11 eCollection Date: 2020-09-01 DOI: 10.1097/XCE.0000000000000215

Devinder Dhindsa, Nathan D Wong, Laurence Sperling

引用次数: 0

Obese communities among the best predictors of COVID-19-related deaths. 肥胖社区是covid -19相关死亡的最佳预测指标之一。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-11 eCollection Date: 2020-09-01 DOI: 10.1097/XCE.0000000000000218

Antoine Fakhry AbdelMassih, Ramy Ghaly, Abeer Amin, Amr Gaballah, Aya Kamel, Bassant Heikal, Esraa Menshawey, Habiba-Allah Ismail, Hend Hesham, Josephine Attallah, Kirollos Eshak, Mai Moursi, Mariam Khaled-Ibn-ElWalid, Marwa Tawfik, Mario Tarek, Mayan Mohy-El-Din, Menna Habib, Nada Hafez, Odette Bahnan, Passant Ismail, Sara Senoussy, Sherry Ghaly, Sousanna Farah, Rafeef Hozaien, Veronia Adel, Mariam Khaled

{"title":"Obese communities among the best predictors of COVID-19-related deaths.","authors":"Antoine Fakhry AbdelMassih, Ramy Ghaly, Abeer Amin, Amr Gaballah, Aya Kamel, Bassant Heikal, Esraa Menshawey, Habiba-Allah Ismail, Hend Hesham, Josephine Attallah, Kirollos Eshak, Mai Moursi, Mariam Khaled-Ibn-ElWalid, Marwa Tawfik, Mario Tarek, Mayan Mohy-El-Din, Menna Habib, Nada Hafez, Odette Bahnan, Passant Ismail, Sara Senoussy, Sherry Ghaly, Sousanna Farah, Rafeef Hozaien, Veronia Adel, Mariam Khaled","doi":"10.1097/XCE.0000000000000218","DOIUrl":"10.1097/XCE.0000000000000218","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is the largest outbreak to strike the world since the Spanish flu in 1918. Visual examination of the world map shows a wide variation of death tolls between countries. The main goal of our series is to determine the best predictors of such discrepancy.Methods: This is a retrospective study in which the rate of COVID-19 deaths was correlated with each of the following independent variables: total tests per 1 million population, gross domestic product (GDP), average temperatures per country, ultraviolet index, median age, average BMI per country, food supply, Bacille Calmette-Guerin compulsory status, and passenger traffic.Results: BMI per country proved to be the second best predictor of death rate with an R value of 0.43, and GDP being the best predictor with R = 0.65.Conclusion: This article shows a tight correlation between average BMI, food supply per country, and COVID-19-related deaths. Such predisposing factors might operate by upregulating the inflammation pathway in heavily struck countries, leading to easier triggering of the infamous cytokine storm syndrome. Obesity also increases cardiovascular and respiratory morbidities, which are coupled to increased ICU demand and deaths among infected cases.Video abstract: http://links.lww.com/CAEN/A25.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 3","pages":"102-107"},"PeriodicalIF":2.3,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38271995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data. 估计糖尿病损失的寿命年:来自国家糖尿病审计和国家统计局数据分析的结果。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-02 eCollection Date: 2020-12-01 DOI: 10.1097/XCE.0000000000000210

Adrian H Heald, Mike Stedman, Mark Davies, Mark Livingston, Ramadan Alshames, Mark Lunt, Gerry Rayman, Roger Gadsby

{"title":"Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data.","authors":"Adrian H Heald, Mike Stedman, Mark Davies, Mark Livingston, Ramadan Alshames, Mark Lunt, Gerry Rayman, Roger Gadsby","doi":"10.1097/XCE.0000000000000210","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000210","url":null,"abstract":"With sustained growth of diabetes numbers, sustained patient engagement is essential. Using nationally available data, we have shown that the higher mortality associated with a diagnosis of T1DM/T2DM could produces loss of 6.4 million future life years in the current UK population. In the model, the 'average' person with T1DM (age 42.8 years) has a life expectancy from now of 32.6 years, compared to 40.2 years in the equivalent age non diabetes mellitus population, corresponding to lost life years (LLYs) of 7.6 years/average person. The 'average' person with T2DM (age 65.4 years) has a life expectancy from now of 18.6 years compared to the 20.3 years for the equivalent non diabetes mellitus population, corresponding to LLY of 1.7 years/average person. We estimate that for both T1DM and T2DM, one year with HbA1c >58 mmol/mol loses around 100 life days. Linking glycaemic control to mortality has the potential to focus minds on effective engagement with therapy and lifestyle recommendation adherence.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 4","pages":"183-185"},"PeriodicalIF":2.3,"publicationDate":"2020-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673790/pdf/xce-9-183.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38641608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66

Hypertension and diabetes mellitus in patients with COVID 19: a viewpoint on mortality. 新冠肺炎合并高血压和糖尿病患者的死亡率观点。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-06-02 eCollection Date: 2020-09-01 DOI: 10.1097/XCE.0000000000000213

Didem Tascioglu, Kenan Yalta, Ertan Yetkin

{"title":"Hypertension and diabetes mellitus in patients with COVID 19: a viewpoint on mortality.","authors":"Didem Tascioglu, Kenan Yalta, Ertan Yetkin","doi":"10.1097/XCE.0000000000000213","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000213","url":null,"abstract":"The outbreak of coronavirus disease 2019 (COVID 19) by the novel corona virus SARS-CoV2 is the leading worldwide healthcare problem due to its contagious nature, high morbidity and mortality rates. The present pandemic has also brought an emerging situation regarding the cardiovascular complications and comorbid disease mainly pointing out hypertension (HT) and diabetes mellitus (DM). Early clinical observations have shown that HT and DM are the main comorbid disease along with cardiovascular disease, chronic obstructive lung disease and malignancies [1]. The incidences of hypertension, cardiacerebrovascular diseases and diabetes have been found to be about twofold, three and twofold, respectively, higher in ICU/severe cases than in their non-ICU/ severe counterparts by the meta-analysis of Li et al. [2]. Similarly the age and certain co-morbidities (hypertension, diabetes, etc.) have been reported to be important risk factors for mortality among the 25 death cases of with COVID-19 [1]. This worrisome situation has been further aggravated by the potential upregulation of angiotensin converting enzyme 2 in hypertensive and diabetic patients and, more interestingly, in those receiving angiotensin converting enzyme inhibitors and angiotensin receptor antagonists, thereby facilitating the inoculation of lung tissue by COVID 19 [3]. Within this context, these findings might be regarded as an alerting scenario with gloomy consequences for those with HT and DM. This concern has been surpassed by the recommendation of cardiovascular societies against to the discontinuation of angiotensin converting enzyme inhibitors and rennin–angiotensin aldosteron antagonist due to the outbreak of COVID 19 [4].","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 3","pages":"108-109"},"PeriodicalIF":2.3,"publicationDate":"2020-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38271996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Relationship between a single measurement at baseline of body mass index, glycated hemoglobin, and the risk of mortality and cardiovascular morbidity in type 2 diabetes mellitus. 2型糖尿病患者体重指数、糖化血红蛋白基线单次测量与死亡率和心血管发病率之间的关系

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-05-25 eCollection Date: 2020-12-01 DOI: 10.1097/XCE.0000000000000202

Oliver Brown, Pierluigi Costanzo, Andrew L Clark, Gianluigi Condorelli, John G F Cleland, Thozhukat Sathyapalan, David Hepburn, Eric S Kilpatrick, Stephen L Atkin

{"title":"Relationship between a single measurement at baseline of body mass index, glycated hemoglobin, and the risk of mortality and cardiovascular morbidity in type 2 diabetes mellitus.","authors":"Oliver Brown, Pierluigi Costanzo, Andrew L Clark, Gianluigi Condorelli, John G F Cleland, Thozhukat Sathyapalan, David Hepburn, Eric S Kilpatrick, Stephen L Atkin","doi":"10.1097/XCE.0000000000000202","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000202","url":null,"abstract":"Objective: This study aims to evaluate the relationship between a single measurement at baseline of body mass index (BMI), glycated hemoglobin (HbA1c) and subsequent clinical outcomes in patients with type 2 diabetes mellitus (T2DM).Method: Patients with T2DM were recruited from an outpatient diabetes clinic in a single large teaching hospital in Kingston upon Hull, UK. At baseline, demographics and HbA1c were recorded. Patients were categorized by BMI: normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), and obese (>30 kg/m2). Multivariable Cox regression models that included demographic, risk factors, and comorbidities were separately constructed for all-cause, cardiovascular, cancer and sepsis-related mortality, using four groups of HbA1c (<6%, 6.0-6.9%, 7.0-7.9%, and >8%).Results: In total, 6220 patients with T2DM (median age 62 years, 54% male) were followed for a median of 10.6 years. HbA1c levels >8.0% were associated with increased risk of all-cause mortality and cardiovascular death. However, this increased risk was not consistent across the weight categories and reached statistical significance only in overweight patients (BMI 25-29.9 kg/m2).Conclusions: In a large cohort of patients with T2DM elevated HbA1c levels at baseline did not consistently predict increased risk of all-cause and cardiovascular mortality across the different BMI categories.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"9 4","pages":"177-182"},"PeriodicalIF":2.3,"publicationDate":"2020-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673766/pdf/xce-9-177.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38641607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Pathogenesis and remission of type 2 diabetes: what has the twin cycle hypothesis taught us? 2 型糖尿病的发病机制和缓解：双循环假说给了我们什么启示？

IF 1.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2020-05-25 eCollection Date: 2020-12-01 DOI: 10.1097/XCE.0000000000000201

Ahmad Al-Mrabeh

引用次数: 0