{"title":"Administration of Eucalyptus to Inhibit the Skin Aging Process of Rats (Rattus Norvegicus) Wistar Strains Exposed to Ultraviolet-B Light","authors":"Asira Mahrahmi, Tan Suyono, Ali Napiah Nasution","doi":"10.51601/ijhp.v4i2.340","DOIUrl":"https://doi.org/10.51601/ijhp.v4i2.340","url":null,"abstract":"Ageing weakens the skin's protective layer, causing pigmentation, inflammation, and cancer. Environmental hazards like pollution and UV radiation harm the skin. Antioxidants, like Eucalyptus globulus, protect against free radicals, making them valuable in medicinal use. The study aimed to investigate the efficacy of Eucalyptus administration in inhibiting skin ageing in rats exposed to ultraviolet-B light. A true experiment was conducted to examine the effectiveness of Eucalyptus in reducing skin ageing in Wistar rats exposed to ultraviolet-B radiation. The study used the \"3R Principle\" and SPSS to analyse the relationship between collagen quantity, Eucalyptus, and UVB radiation. The study found normal distribution for the control and treatment groups, with a significance of 0.200 and 0.091, respectively. The Levene test showed homogeneity and a T-test result 0.000, indicating a significant difference. The control group had a moderate collagen density, while the treatment group with Eucalyptus extract had a tighter collagen density. The study concludes that the Eucalyptus tree extracts, including tannins, saponins, and flavonoids, have been found to have anti-ageing and collagen-increasing effects in mice exposed to UVB light. The treatment group showed significantly increased collagen density, indicating potential anti-ageing properties in the treatment group.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"224 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141386875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shella Selviana Barus, Ali Napiah Nasution, Wienaldi Wienaldi
{"title":"Effect of Celery (Apium graveolens L.) Extract Administration on Kidney Function of White Rats (Rattus norvegicus) Wistar Strains Exposed to Lead","authors":"Shella Selviana Barus, Ali Napiah Nasution, Wienaldi Wienaldi","doi":"10.51601/ijhp.v4i3.339","DOIUrl":"https://doi.org/10.51601/ijhp.v4i3.339","url":null,"abstract":"Lead significantly affects health because of its sensitivity to the central nervous system and rapid absorption rate. The phytochemicals included in celery, such as flavonoids, may mitigate lead-induced kidney damage. This research aimed to determine how administering celery extract affected the expression of the Caspase-3 gene and the kidney TNF-α gene in Rattus Norvegicus Wistar white rats exposed to lead. The research method true experiment examined the effects of 80 mg/day celery extract on Caspase-3 gene expression and renal TNF-α gene expression in rats exposed to lead. Each of the three groups will include six rats; there will be eighteen male Wistar rats in the study. The study used SPSS 26.0 and the Saphiro Wills test to analyze data on TNF-α and Caspase 3 expression in rats exposed to lead acetate (Pb). The results showed a normal distribution for the negative control group (K-) and the positive control group (K+) and a normal distribution for the treatment group (P). However, the paired t-test showed significant differences in all treatment groups (p <0.05), indicating a normal distribution in the data. The study concludes the impact of celery extract on kidney function in lead-exposed Wistar rats, revealing various active compounds like flavonoids. Despite insignificant caspase 3 reduction, flavonoids showed potential in mitigating lead-induced kidney damage.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"208 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis Of Factors Related To The Cause Of Drug Withdrawal In Patients With Type Ii Diabetes Mellitus At Tk Ii Putri Hijau Kesdam 1/Bb Medan Hospital In 2020","authors":"Eva Sartika Dasopang, Salmah Handayani Lubis, Fenny Hasanah, Nadia Nuzulia, Annisa Almunadia","doi":"10.51601/ijhp.v4i3.345","DOIUrl":"https://doi.org/10.51601/ijhp.v4i3.345","url":null,"abstract":"Diabetes Mellitus is a disease that cannot be cured and can only be controlled by taking medication regularly. Diabetes must be treated quickly and appropriately to get a cure. Taking drugs continuously can cause a person to start to feel bored to take drugs, causing a person to stop taking drugs. The purpose of this study was to provide information on the causes of drug withdrawal of patients with type II diabetes mellitus in the outpatient installation of Putri Hijau Medan Hospital. This research is descriptive using qualitative methods. The research was conducted at TK II PUTRI HIJAU Hospital KESDAM 1 / BB Medan for three months from March to May 2021. This study took samples in a presumptive way, namely by using the Non Random Sampling Technique with the accidental sampling technique method by collecting data through observation and interviews then the data was processed in thematic form. The results of the interview research obtained were 3 out of 5 respondents experienced drug withdrawal which was predominantly male (40%). the age of the late elderly (56-65 years) as much as (40%). The majority of occupations are self-employed (60%). And have suffered from diabetes from 6-10 years (60%). The fact of drug discontinuation is due to advanced age, occupation, and compliance with taking medication. The gender factor is very influential in the occurrence of diseases, especially DM, the female sex is more susceptible to Diabetes Mellitus because women have premenstrual syndrome after menapouse, but the results of the research obtained are predominantly male. Meanwhile, 2 female-dominant respondents did not drop out of medication but were less compliant in taking medication.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"33 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Sartika Dasopang, Desy Natalia Siahaan, Fenny Hasanah, Salmah Handayani Lubis, Yohana Yuni M, Ramona Pane
{"title":"The Relationship Between Covid-19 Vaccination And The Incidence Of Covid-19 At The Hospital Putri Hijau Hospital, Medan","authors":"Eva Sartika Dasopang, Desy Natalia Siahaan, Fenny Hasanah, Salmah Handayani Lubis, Yohana Yuni M, Ramona Pane","doi":"10.51601/ijhp.v4i2.338","DOIUrl":"https://doi.org/10.51601/ijhp.v4i2.338","url":null,"abstract":"Vaccination is the process of entering vaccines to stimulate the body's immune system, as a preventive effort in reducing morbidity and mortality caused by the coronavirus. Putri Hijau Hospital in Medan City, which participated in the second dose of Covid-19 vaccination, confirmed that the respondents who were still affected by Covid-19 needed to be developed, so in particular knowing the number of cases of Covid-19 that appeared in respondents who had been infected. received a second dose of vaccination. The purpose of this study was to see whether there was a relationship between vaccination and the incidence of Covid-19 at Putri Hijau Hospital in Medan.This type of research uses a quantitative approach method by using a questionnaire distributed through the Google Form platform on a smartphone to store all the answers that have been filled in by the respondent based on the questionnaire guidelines that have been made previously with the target of respondents who have vaccinated the second dose of Covid-19.The results showed that from 100 respondents there were 28 male patients (28%) and 72 female patients (72%). Judging from the age of most patients at the age of 15 to 25 years. There were 8 people and 92 people who were not exposed. With the symptoms of Covid-19, such as fever, cough, sore throat, and loss of sense of smell. This is because the respondents had antibodies that were formed slightly after vaccination, were active outside the home, did not apply health protocols and maintained their immune system so that they were exposed to Covid-19.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"78 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukman Prayitno, Novita Novita, Sonya Esther, Erlina Puspitaloka Mahadewi
{"title":"The Usage Of Government Formulary For BPJS Inpatients With Ischemic Stroke In Indonesia","authors":"Lukman Prayitno, Novita Novita, Sonya Esther, Erlina Puspitaloka Mahadewi","doi":"10.51601/ijhp.v4i3.347","DOIUrl":"https://doi.org/10.51601/ijhp.v4i3.347","url":null,"abstract":"Introduction: Ischemic stroke patients tend to use some medicine. In National Health Security (JKN), the government has created a government formulary as quality control and cost control. The study aims to determine the percentage of government formulary in Hospitals and the affected factors. Method: It was cross sectional quantitative research. It used retrospective data from medical record and prescription of ischemic stroke inpatients from January to June 2019. The data collected include hospital characteristics, patient characteristics, supporting characteristics and treatment costs. Result: The data cames from 17 hospitals. Based on the inclusion and exclusion criteria, 257 medical records were analyzed. The average percentage of drug use was 73.22%. Its was influenced by the hospital class, the number of supporting examinations, the number of drug items. Type B and C hospitals used non government formulary. There were citicolin, mecobalamin, piracetam, neurotropic multivitamin, flunarizine. Conclusion: The average percentage of drug use was still less than 100%. There were still non government formulary drugs used for the therapy of inpatient ischemic stroke. The use of non government formulary drugs was influenced by the hospital class, the number of supporting examinations, the number of drug items.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"40 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Results from an Obesity Model in White Male Wistar Rats After Administration of Telang Flower (Clitoria Ternatea) Extract on Pancreatic Function and Histopathological Characteristics","authors":"Weni Yulisandra Rini, Fahrul Azmi Tanjung, Wilvia Wilvia","doi":"10.51601/ijhp.v4i2.323","DOIUrl":"https://doi.org/10.51601/ijhp.v4i2.323","url":null,"abstract":"Diabetes mellitus (DM) is a chronic disease affecting 95% of diabetics, characterized by high blood glucose levels due to decreased insulin production. Bioactive chemicals from plants like butterfly pea flower and Clitoria Ternatea can potentially treat DM, inhibit carbohydrate-digesting enzymes, and potentially regenerate pancreatic beta cells. This study tests butterfly pea flower extract on obesity-related pancreatic function in white rats. In obese rats given varied dosages of butterfly pea flower extract, the study evaluates pancreatic tissue histopathology and ethanol extract properties. The study examines male Wistar rats' acclimatization before treatment with butterfly pea flower extract, a high-fat diet, and butterfly pea flower extract, comparing the effects of the extract on rats. Pancreatic function is examined using enzymes amylase and lipase. Histopathological observation of pancreatic organs involves several steps, including fixation, washing, infiltration, embedding, cutting, attaching, deparaffinization, dealcoholization, staining, mounting, and scoring. A post-test-only control group design compared butterfly pea flower extract and pancreatic function in male white rats. Butterfly pea flower extract improved pancreatic histology in obese white rats at 600mg/KgWB, closer to the normal group. The extract contains secondary metabolites that repair cell tissue damaged by the rats' high-fat diet and obesity.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"1027 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140445755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison Of Buerger Allen Exercise With 3 Physical Therapy Modalities On The Value Of Ankle Brachial Index In Patients With Type Ii Diabetes Mellitus","authors":"Ikhsan Ibrahim, Nur Aisyah, Suaib Suaib","doi":"10.51601/ijhp.v4i2.329","DOIUrl":"https://doi.org/10.51601/ijhp.v4i2.329","url":null,"abstract":"Hyperglycemia is one of the problems of people with Diabetes Mellitus, poorly controlled hyperglycemia conditions can cause complications, one of which is impaired peripheral vascular flow which can cause diabetic wounds. Vascularization disorders can be prevented by Buerger Allen Exercise therapy and 3 Physical Therapy Modalities to increase Ankle Brachial Index (ABI) values. The purpose of this study was to compare the effect of Buerger Allen Exercise and 3 Physical Therapy Modalities on ABI values in people with type II Diabetes Mellitus. The design of this study was Quasi Experiment Pre and post test two groups with 15 respondents of group A given Buerger Allen Exercise intervention and 15 respondents of group B given 3 Physical Therapy Modalities intervention. The results showed that there was an increase in ABI values after intervention in both groups with the difference in the Buerger Allen Exercise group increase of 0.050 while the Modaliatas Physical Therapy group amounted to 0.113. In conclusion, there was an increase in ABI values in both groups after the intervention but group 3 Modaliatas Physical Therapy had a higher increase. Intervention 3 Modaliatas Physical Therapy can be recommended as one of the alternative therapies as a prevention of complications of peripheral arterial disease.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"37 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness Of Warm Ginger Milk Consumption In Reduce Emesis Gravidarum In 1st Trimester Pregnant Women In Pmb Karawang City Year 2023","authors":"Tetin Rismayanti, Romih Ratnaningsih","doi":"10.51601/ijhp.v4i2.278","DOIUrl":"https://doi.org/10.51601/ijhp.v4i2.278","url":null,"abstract":"Background: In early pregnancy, many mothers experience complaints of nausea, vomiting, especially in the morning, which is known as morning sickness or in medical language known as emesis gravidarum. Symptoms of emesis gravidarum in pregnant women can be treated both with conventional and non-conventional treatments or often referred to as complementary therapy, namely with herbal plants that are easily available such as lemongrass, lemon, peppermint leaves and the most popular is ginger. Research Objectives: To determine the effectiveness of consuming warm ginger milk juice in reducing emesis gravidarum in first trimester pregnant women at PMB Karawang City in 2023 Research Methods: The type of research used in this study is quasi-experimental and post test only design one group. The population in this study were 54 mothers. The sample in this study were 35 mothers who were in PMB Karawang City. Bivariate analysis using the Wilcoxon test. Results: The average frequency of emesis gravidarum in 1st trimester pregnant women before being given warm ginger juice was 9.97, a standard deviation of 1.636, a minimum of 7 and a maximum of 13. The average frequency of emesis gravidarum in 1st trimester pregnant women after being given consumption warm ginger milk juice is 5.54, a standard deviation of 1.039, a minimum of 4 and a maximum of 7. Conclusion: It can be concluded that consumption of warm ginger milk juice is effective in reducing emesis gravidarum in first trimester pregnant women at PMB Karawang City in 2023.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"187 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Giving Black Rice Extract Ointment (Oryza Sativa L. Indica) on the Growth of Wistar Rat (Rattus Novergicus) Hair Follicles","authors":"Nancy Kartini, Cindy Denhara Wijaya, Andri Hidayat","doi":"10.51601/ijhp.v4i2.320","DOIUrl":"https://doi.org/10.51601/ijhp.v4i2.320","url":null,"abstract":"Hair loss affects many people worldwide. Hair loss is common and can be treated with vitamins and minerals. Black rice (Oryza sativa l. indica) contains phenolic and anthocyanin-rich flavonoids. The study examined whether black rice extract ointment accelerated Wistar rat (Rattus norvegicus) hair follicle growth. This was an actual experiment with 30 mice. The research involved acclimating test animals in the lab, manufacturing black rice extract, and making ointment. After an Ointment Evaluation Test, Phytochemical Screening was performed. Test the FT-IR Functional Group. DPPH testing will determine antioxidant activity. Finally, four groups (control group, treatment groups 1, 2, and 3 with 10%, 20%, and 30% ointments) received treatment for 21 days. Study results were handled using SPSS. The normality test showed 0.652 > 0.05 significance, while the Independent Samples T-Test showed 0.00 < 0.05 significance. Alkaloids, flavonoids, tannins, and steroids/triterpenoids make black rice an antioxidant, according to the active compound test. For average hair growth, 10% black rice ointment dose therapy yielded 0.681 cm, 20% 0.769 cm, and 30% 0.851 cm. The study found that black rice extract contains high antioxidants (ppm concentration value <50) that can prevent premature skin aging and promote hair and skin health.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Difference Between The Use Of Combination Injection Contraception And Medroxyprogesterone Acetate (Dmpa) Contraception With Changes In Body Weight At Tpmb Sri Haryati","authors":"Sri Haryati, Rahmadiyanti Rahmadiyanti","doi":"10.51601/ijhp.v4i2.295","DOIUrl":"https://doi.org/10.51601/ijhp.v4i2.295","url":null,"abstract":"Background: Combined injectable contraceptives contain the hormones estrogen and progestin, while DMPA contraceptives only contain progestin. This difference can affect the response of the tube to the contraception. Purpose of Writing: to determine the difference between the use of combined injection contraception and medroxyprogesterone acetate (DMPA) contraception with changes in body weight in TPMB Sri Haryati. Research Methods: The method in this study was an experimental design (quasi experiment) with a two group pretest posttest design. In this study, there were divided into two groups, namely the group using combined injection contraception and the group using the medroxyprogesterone acetate contraception (DMPA). Research Results The results of the independent test sample test obtained Asymp. Sig (2 – Sided) has a value of 0.946, because 0.946 > 0.05, the hypothesis is rejected. This means that there is no difference between combination injections and DPMA injections on weight changes before and after the use of combination injections and DPMA injections. Conclusions and Suggestions: The results of this study are expected that midwives can provide health education about family planning using injections in providing counseling both combination and DPMA have a risk of weight gain.","PeriodicalId":432290,"journal":{"name":"International Journal of Health and Pharmaceutical (IJHP)","volume":"45 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}