Serena Pacilè, Pauline Germaine, Caroline Sclafert, Thomas Bertinotti, Pierre Fillard, Svati Singla Long
{"title":"Evaluation of a Multi-Instant Multimodal Artificial Intelligence System Supporting Interpretive and Noninterpretive Functions.","authors":"Serena Pacilè, Pauline Germaine, Caroline Sclafert, Thomas Bertinotti, Pierre Fillard, Svati Singla Long","doi":"10.1093/jbi/wbae062","DOIUrl":"https://doi.org/10.1093/jbi/wbae062","url":null,"abstract":"<p><strong>Objective: </strong>Artificial intelligence (AI) has been shown to hold promise for improving breast cancer screening, offering advanced capabilities to enhance diagnostic accuracy and efficiency. This study aimed to evaluate the impact of a multimodal multi-instant AI-based system on the diagnostic performance of radiologists in interpreting mammograms.</p><p><strong>Methods: </strong>We designed a multireader multicase study taking into account the evaluation of both interpretive and noninterpretive tasks. The study was approved by an institutional review board and is compliant with HIPAA. The dataset included 90 cancer-proven and 150 negative cases. The overall diagnostic performance was compared between the unaided vs aided reading condition. Intraclass correlation coefficient (ICC), Fleiss's kappa, and accuracy were used to quantify the agreement and performance on noninterpretive tasks. Reading time and perceived fatigue were used as comprehensive metrics to assess the efficiency of readers.</p><p><strong>Results: </strong>The average area under the receiver operating characteristic curve increased by 7.4% (95% CI, 4.5%-10%) with the concurrent assistance of the AI system (P <.001). On average, readers found 8% more cancers in the assisted reading condition. The ICC went from 0.6 (95% CI, 0.55-0.65) in the unassisted condition to 0.74 (95% CI, 0.70-0.78) for readings done with AI (P <.001). An overall decrease of 24% in reading time and a reduction in perceived fatigue was also found.</p><p><strong>Conclusion: </strong>The incorporation of this AI system, capable of handling multiple image type, prior mammograms, and multiple outputs, improved the diagnostic proficiency of radiologists in identifying breast cancer while also reducing the time required for combined interpretive and noninterpretive tasks.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Randy C Miles, Antonio R Lopez, Nhat-Tuan Tran, Christopher Doyle, Charmi Vijapura, Rifat A Wahab, David M Naeger
{"title":"A How-to Guide for Community Breast Imaging Centers: Starting a Breast Imaging Fellowship.","authors":"Randy C Miles, Antonio R Lopez, Nhat-Tuan Tran, Christopher Doyle, Charmi Vijapura, Rifat A Wahab, David M Naeger","doi":"10.1093/jbi/wbae069","DOIUrl":"https://doi.org/10.1093/jbi/wbae069","url":null,"abstract":"<p><p>Opportunities exist to provide high-quality breast imaging fellowship training in the community setting. Various challenges exist, however, including obtaining funding for a fellowship position, creating an educational curriculum in a potentially nonacademic environment, and developing an overall competitive program that will attract radiology trainees. Here, we explore factors that contribute to the establishment of an academic breast imaging fellowship program in the community setting based on experience, including (1) providing guidance on how to secure funding for a breast imaging fellowship position; (2) developing a training curriculum based on established guidelines from the Accreditation Council for Graduate Medical Education, American College of Radiology, and Society of Breast Imaging; and (3) navigating the landscape of the recruitment process, from program branding to matching applicants.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason Shames, Adrien Nguyen, Maria Sciotto, Lisa Zorn, Theresa Kaufman, Annina Wilkes, Alexander Sevrukov, Chhavi Kaushik, Ripple Patel, Suzanne Pascarella, Ashlee Byrd, Lydia Liao
{"title":"Can Contrast-Enhanced Mammography Improve Positive Predictive Value for Diagnostic Workup of Suspicious Findings? A Single-Arm Prospective Study.","authors":"Jason Shames, Adrien Nguyen, Maria Sciotto, Lisa Zorn, Theresa Kaufman, Annina Wilkes, Alexander Sevrukov, Chhavi Kaushik, Ripple Patel, Suzanne Pascarella, Ashlee Byrd, Lydia Liao","doi":"10.1093/jbi/wbae081","DOIUrl":"https://doi.org/10.1093/jbi/wbae081","url":null,"abstract":"<p><strong>Objective: </strong>To assess the positive predictive value-3 (PPV3) and negative predictive value (NPV) of contrast-enhanced mammography (CEM) when added to the diagnostic workup of suspicious breast findings.</p><p><strong>Methods: </strong>This prospective study was IRB approved. We recruited 99 women with abnormal findings on digital breast tomosynthesis (DBT) and/or US to undergo CEM prior to biopsy. Based on final pathology outcomes, PPV3 and NPV were calculated and compared using N-1 chi-squared tests with P-values and 95% CIs.</p><p><strong>Results: </strong>Final pathologic outcome yielded 56.6% (56/99) benign, 5.1% (5/99) benign with upgrade potential (BWUP), and 38.4% (38/99) malignant lesions. Final pathologic outcomes for the 63 positive CEMs yielded 33.3% (21/63) benign, 6.3% (4/63) BWUP, and 60.3% (38/63) malignant lesions. Adding CEM to the diagnostic workup significantly increased PPV3 from 38.4% (38/99) to 60.3% (38/63) (P <.01; 95% CI, 6.1-36.2). Negative predictive value was 100% (36/36) for CEM, 92.9% (13/14; P = .1; 95% CI, -4.2 to 31.4) for DBT, and 75.9% (22/29; P <.05; 95% CI, 8.8-42.1) for US. The number of unnecessary biopsies could be reduced by 36.4% (from 100% [99/99] to 63.6% [63/99]).</p><p><strong>Conclusion: </strong>Adding CEM to the diagnostic workup of suspicious breast findings could improve PPV3 to prevent unnecessary biopsies.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subcutaneous Staining of the Breast from Superparamagnetic Iron Oxide Nanoparticle Tracer Injection.","authors":"Victoria A Wells, Eun L Langman","doi":"10.1093/jbi/wbae070","DOIUrl":"https://doi.org/10.1093/jbi/wbae070","url":null,"abstract":"","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unknown Case: Asymmetric Breast Uptake on Sestamibi Scan.","authors":"Jolie Jean, Janine T Katzen","doi":"10.1093/jbi/wbae072","DOIUrl":"https://doi.org/10.1093/jbi/wbae072","url":null,"abstract":"","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Performance of Abbreviated Breast MRI in High-Risk Patients in a Tertiary Care Academic Medical Center.","authors":"Tamara Zaza, Kapil Chandora, Ceren Yalniz, Kathryn Watts Zamora, Stefanie Zalasin, Yufeng Li, Stefanie Woodard","doi":"10.1093/jbi/wbae071","DOIUrl":"https://doi.org/10.1093/jbi/wbae071","url":null,"abstract":"<p><strong>Introduction: </strong>The development of abbreviated breast MRI (AB-MRI) protocols reduce scan times. This paper reports the performance of AB-MRI at a tertiary care public academic medical center in comparison with established literature.</p><p><strong>Methods: </strong>This HIPAA-compliant IRB-approved retrospective study reviewed 413 AB-MRI screenings in high-risk patients from June 2020 to March 2023. Data were collected from 3 databases (MagView, Cerner PowerChart, and Prism Primordial). Demographics and overall BI-RADS assessment were recorded. For all positive (BI-RADS 0, 3, 4, 5) examinations, manual review of each case was performed. Performance metrics (sensitivity, specificity, cancer detection rate [CDR], recall rate, positive predictive value [PPV] 3 and negative predictive value [NPV]) were calculated. PubMed and Google Scholar were used to review similar AB-MRI studies to compare performance metrics.</p><p><strong>Results: </strong>There were 413 AB-MRI examinations from 413 unique patients. The majority of cases were audit-negative BI-RADS 1 or 2 (83.8%, 346/413). There were 67 (16.2%, 67/413) audit-positive cases with 3.6% (15/413) BI-RADS 3, 10.9% (45/413) BI-RADS 4, 0.7% (3/413) BI-RADS 5, and 1.0% (4/413) BI-RADS 0. Performance metrics showed a sensitivity of 100.0% (95% CI, 63.1%-100.0%) and a specificity of 85.7% (95% CI, 81.9%-88.9%). The PPV3 was 14.3% (95% CI, 5.1%-23.5%), and the NPV was 100.0% (95% CI, 99.0%-100.0%). The CDR was 19.4 per 1000 screenings. The results are comparable to prior literature and benchmark data.</p><p><strong>Conclusion: </strong>This study demonstrates high sensitivity (100.0%) and NPV (100.0%) of AB-MRI with comparable specificity (85.7%) and CDR (19.4/1000) to the literature, adding support to the use of AB-MRI. Further research is needed to optimize AB-MRI protocols.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alison Lynn Chetlen, Jeanine Beatty-Chadha, Angela I Choe
{"title":"Developing a Career as a Clinician-Educator in Breast Imaging.","authors":"Alison Lynn Chetlen, Jeanine Beatty-Chadha, Angela I Choe","doi":"10.1093/jbi/wbae075","DOIUrl":"https://doi.org/10.1093/jbi/wbae075","url":null,"abstract":"<p><p>For the breast imaging radiologist, developing a career as a clinician-educator can be accomplished in a number of ways. Whether it be a new graduate or perhaps a radiologist making a midcareer or late-career pivot to the academic world, there are several opportunities and resources that can support a faculty member at any stage in this journey. In this article, the breast imaging radiologist will learn a variety of methods to strengthen their professional identity and career path as a clinician-educator through the early-, mid-, and late-career professional journey.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Digital Breast Tomosynthesis Screening Improves Early Breast Cancer Detection and Survival in Taiwan.","authors":"Pei-Shan Wu, Yu-Ting Hong, Chiao-Hsuan Shen, Chao-Hsien Lee, Chen-Pin Chou","doi":"10.1093/jbi/wbae044","DOIUrl":"10.1093/jbi/wbae044","url":null,"abstract":"<p><strong>Objective: </strong>Our objective was to compare the efficacy of digital breast tomosynthesis (DBT) and digital mammography (DM) in breast cancer screening and their impact on long-term overall survival (OS).</p><p><strong>Methods: </strong>The study involved 48 549 consecutive mammography examinations between 2011 and 2015 at a medical center in Taiwan, identifying 545 women who were screened and diagnosed with breast cancer. Digital mammography and DBT examinations were alternated on different days. Patients were categorized based on mammographic modality, breast density, and American Joint Committee on Cancer (AJCC) stage. To determine the long-term outcome until August 2021, survival rates were analyzed using the Kaplan-Meier (K-M) survival analysis.</p><p><strong>Results: </strong>The mean age at breast cancer diagnosis was 53.2 years. Digital breast tomosynthesis examinations were significantly associated with early breast cancer (AJCC stage 0 to 2) (P = .022). The 5- and 9-year OS rates for all patients were 96.8% and 93.0%, respectively. The 5- and 9-year OS was significantly greater in the DBT group (98.4% and 96.8%) compared with the DM group (95.0% and 90.4%) (P = .030 for all). The K-M survival analysis demonstrated a significantly higher OS in the DBT group than the DM group (P = .037). Furthermore, DBT significantly improved OS in a cohort of women with stage II and III cancer (P = .032) and heterogeneously dense breasts (P = .045).</p><p><strong>Conclusion: </strong>Screening with DBT is associated with early breast cancer diagnosis and higher survival rates compared with DM.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":"601-609"},"PeriodicalIF":2.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anand K Narayan, Randy C Miles, Ryan W Woods, Lucy B Spalluto, Elizabeth S Burnside
{"title":"Methodological Considerations in Evaluating Breast Cancer Screening Studies.","authors":"Anand K Narayan, Randy C Miles, Ryan W Woods, Lucy B Spalluto, Elizabeth S Burnside","doi":"10.1093/jbi/wbae038","DOIUrl":"10.1093/jbi/wbae038","url":null,"abstract":"<p><p>In evidence-based medicine frameworks, the highest level of evidence is derived from quantitative synthesis of double-masked, high-quality, randomly assigned controlled trials. Meta-analyses of randomly assigned controlled trials have demonstrated that screening mammography reduces breast cancer deaths. In the United States, every major guideline-producing organization has recommended screening mammography in average-risk women; however, there are controversies about age and frequency. Carefully controlled observational research studies and statistical modeling studies can address evidence gaps and inform evidence-based, contemporary screening practices. As breast imaging radiologists develop and evaluate existing and new screening tests and technologies, they will need to understand the key methodological considerations and scientific criteria used by policy makers and health service researchers to support dissemination and implementation of evidence-based screening tests. The Wilson and Jungner principles and the U.S. Preventive Services Task Force general analytic framework provide structured evaluations of the effectiveness of screening tests. Key considerations in both frameworks include public health significance, natural history of disease, cost-effectiveness, and characteristics of screening tests and treatments. Rigorous evaluation of screening tests using analytic frameworks can maximize the benefits of screening tests while reducing potential harms. The purpose of this article is to review key methodological considerations and analytic frameworks used to evaluate screening studies and develop evidence-based recommendations.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":" ","pages":"577-585"},"PeriodicalIF":2.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anatomical Approach for the Evaluation of the Nipple-Areolar Complex.","authors":"Abeer Abdelhafez, Claudia Cotes","doi":"10.1093/jbi/wbae065","DOIUrl":"10.1093/jbi/wbae065","url":null,"abstract":"<p><p>The nipple-areolar complex (NAC) is an anatomically unique region from which several normal variants and pathologies arise. Understanding its anatomy is crucial for accurate clinical and imaging assessments, aiding with differential diagnosis, and ensuring radiologic-pathologic concordance. Mammography and US are commonly used for NAC evaluation; however, these are susceptible to technical limitations such as tissue superimposition and artifacts, compromising visualization of abnormalities in this area. Although MRI offers higher sensitivity, it is not the initial evaluation modality. A comprehensive clinical inspection is necessary because it may reveal abnormalities not apparent on imaging. This article offers an anatomical approach to the NAC evaluation, simplifying differential diagnoses by reviewing imaging techniques and clinical features of common NAC abnormalities.</p>","PeriodicalId":43134,"journal":{"name":"Journal of Breast Imaging","volume":"6 6","pages":"673-685"},"PeriodicalIF":2.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}