Egyptian Pediatric Association Gazette最新文献

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Platelet indices as a predictive marker in neonates with respiratory distress 作为新生儿呼吸窘迫预测指标的血小板指数
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-05-01 DOI: 10.1186/s43054-024-00265-3
Sarah Abdelrashid, Manar Aref
{"title":"Platelet indices as a predictive marker in neonates with respiratory distress","authors":"Sarah Abdelrashid, Manar Aref","doi":"10.1186/s43054-024-00265-3","DOIUrl":"https://doi.org/10.1186/s43054-024-00265-3","url":null,"abstract":"The neonatal intensive care unit (NICU) frequently gets admissions due to respiratory distress (RD). Platelet indices are a beneficial biomarker in order to gauge the severity of neonatal RD. We aimed to assess platelet indices as a potential predictor in neonates with RD. This prospective research involved 120 neonates who had been admitted to the NICU with evidence of RD. On admission and after respiratory support was reduced; a complete blood count (CBC) was performed to determine platelet count (PC), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW), platelet mass index (PMI), and platelet large cell ratio (PLCR). MPV and PDW were significantly higher after respiratory support reduction. PC and PMI were significantly higher in neonates exhibiting moderate and severe distress. PC of 276.5*109/L had the highest degree of predictability of RD severity (area under curve (AUC) 0.762, sensitivity 81.5%, specificity 64.3%), 95% confidence interval (0.7–0.9), while PMI of 2473.5 fL/nL was the best cut-off point to predict severity of RD (AUC 0.663, sensitivity 63%, specificity 57.1%) 95% confidence interval (0.6–0.8). There was a significant difference in the average PC between different oxygen modes. Higher PMI and PC are associated with moderate and severe RD and can be used to predict the severity of neonatal RD.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"12 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Right iliopsoas kaposiform hemangioendothelioma: a case report 右髂腰卡波状血管内皮瘤:病例报告
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-30 DOI: 10.1186/s43054-024-00272-4
Neng Ren, Ye Gu, Na Song, Wen Qian, Wenhui Gao, Yunfeng Zhang
{"title":"Right iliopsoas kaposiform hemangioendothelioma: a case report","authors":"Neng Ren, Ye Gu, Na Song, Wen Qian, Wenhui Gao, Yunfeng Zhang","doi":"10.1186/s43054-024-00272-4","DOIUrl":"https://doi.org/10.1186/s43054-024-00272-4","url":null,"abstract":"Kaposiform hemangioendothelioma (KHE) is a rare neoplasm of vascular origin. It may involve skin, bone, connective tissue, and parenchymal organs, and it is difficult to make a definite diagnosis in the early stage because Kasabach-Merritt phenomenon may occur in some cases. On June 12, 2022, a 19-month boy was admitted to our department with the chief complaint of flexion of the right hip joint for over 1 year. An exploratory laparotomy and pelvic lesion resection were conducted and the resection of the iliopsoas muscle mass was performed. The intraoperative resection of the neoplasm confirmed the pathological diagnosis of kaposiform hemangioendothelioma. The vital signs of the child were stable and recovered well after surgery, and the platelet and coagulation indices were normal. KHE is a rare disease in clinics, the number of confirmed cases in the world is still relatively few, and the etiology and mechanism of the disease are still unknown, which could result in misdiagnose and delayed treatment in the disease early stages. It is necessary to continue to collect relevant cases, to unify the standard treatment guidelines as soon as possible, to reduce the mortality rate, and to improve the quality of life of the cases.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"89 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting VR training in developmental disorders, is it a friend or foe? A scoping systematic review of randomized controlled trials 重新审视发育障碍中的虚拟现实训练,它是敌是友?随机对照试验的范围界定系统回顾
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-29 DOI: 10.1186/s43054-024-00281-3
Antoine Fakhry AbdelMassih, Waad I. AlHammadi, Hind A. AlHosani, Sara AlHosani, Fatima AlHammadi, Shooq A. AlShehhi
{"title":"Revisiting VR training in developmental disorders, is it a friend or foe? A scoping systematic review of randomized controlled trials","authors":"Antoine Fakhry AbdelMassih, Waad I. AlHammadi, Hind A. AlHosani, Sara AlHosani, Fatima AlHammadi, Shooq A. AlShehhi","doi":"10.1186/s43054-024-00281-3","DOIUrl":"https://doi.org/10.1186/s43054-024-00281-3","url":null,"abstract":"Immersive and non-immersive VR technology has been increasingly employed in training. This has encouraged physicians working in skill development to try using it to improve the learning, emotional recognition, and social skills of various disorders. This study aimed to explore the controlled trials employing VR in autism, ADHD, and dyslexia. A literature review has been conducted, on PubMed, Scopus, and Web of Science. Any controlled trial in the pediatric age group, involving the comparison of VR training with other types of therapies in autism, ADHD, and dyslexia was included. Only 4 controlled trials were identified, comprising a total of 208 patients, with ages ranging from 6 to 16 years. Out of these studies, two involved patients with autism, one with ADHD, and one with dyslexia. VR was successful in improving emotional recognition but not social interaction in autism. All trials did not mention thoroughly possible complications of prolonged use of VR. Despite being a promising technology, there is still a long road to prove the validity of using VR in skills development. Few controlled trials have been tailored to explore VR advantages over conventional training and therapies, most of them have a limited sample size, a short training course, and no mention of possible setbacks, such as ocular effects and social isolation.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"107 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140811370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of thymic area with clinical-epidemiological variables and values of T-lymphocyte subpopulations in peripheral blood of children with recurrent infections 胸腺面积与反复感染儿童外周血中 T 淋巴细胞亚群的临床流行病学变量和数值的关系
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-22 DOI: 10.1186/s43054-024-00263-5
Francisco Sotomayor Lugo, Yaíma Zúñiga Rosales, Oliver Pérez Martín, Evelyn Hernández Reyes, Evelyn M. Antiguas Valdés, Hermes Fundora Hernández, Katia Rodríguez Guitiérrez, Yaima Matas González, Imilla Casado Hernández, Carlos Agustín Villegas Valverde, Bárbara Torres Rives, Lázara Minerva Tam Rey, Ihosvany González Díaz, Yaquima Hernández Rego, Ana María Simón Pita, Consuelo Macías Abraham, Beatriz Marcheco Teruel
{"title":"Relationship of thymic area with clinical-epidemiological variables and values of T-lymphocyte subpopulations in peripheral blood of children with recurrent infections","authors":"Francisco Sotomayor Lugo, Yaíma Zúñiga Rosales, Oliver Pérez Martín, Evelyn Hernández Reyes, Evelyn M. Antiguas Valdés, Hermes Fundora Hernández, Katia Rodríguez Guitiérrez, Yaima Matas González, Imilla Casado Hernández, Carlos Agustín Villegas Valverde, Bárbara Torres Rives, Lázara Minerva Tam Rey, Ihosvany González Díaz, Yaquima Hernández Rego, Ana María Simón Pita, Consuelo Macías Abraham, Beatriz Marcheco Teruel","doi":"10.1186/s43054-024-00263-5","DOIUrl":"https://doi.org/10.1186/s43054-024-00263-5","url":null,"abstract":"Recurrent infections in childhood are the main cause of remission to the immunology service. T lymphocytes generated in the thymus are essential for fighting infection, making the thymus area an important predictor of the immune system’s competence. This study aimed to identify the possible relationship of the thymic area with clinical-epidemiological variables and values of subpopulations of T lymphocytes in the peripheral blood of children with recurrent infections. We conducted applied research using a transversal analytical design at the National Medical Genetics Center (Havana, Cuba), from January to August 2022. The study covered 73 children of which we analyzed clinical-epidemiological variables and the size of the thymus through ultrasound. Furthermore, we determined the relative and absolute values of the subpopulations of T cells using flow cytometry. Of the children studied, 65.8% had thymic hypoplasia. The children who breastfed for less than 6 months showed four times the risk of developing moderate-severe thymus hypoplasia (OR = 3.90, 95% CI: 1.21–12.61). A direct relationship was found between the area of the thymus and the child’s size (r = 0.238, p = 0.043) and weight (r = 0.233, p = 0.047). The relative values of CD3+ T lymphocytes decreased in the cases of mild hypoplasia (p = 0.018) and moderate-severe hypoplasia (p = 0.049). The thymus area was associated with the absolute cell count of CD8+ effector memory T cells (rs = −0.263, p = 0.024) and of the central memory T cells (r = −0.283, p = 0.015). Breastfeeding for less than 6 months, as well as the weight and size of the child, are related to their thymus area. The subpopulation values of T lymphocytes detected suggest that patients with thymic hypoplasia develop a contraction of CD3+ T cells, which can make them more vulnerable to infectious processes. This finding was combined with an expansion of the memory compartments of the subpopulations of CD8+ T cells, suggesting a greater susceptibility to intracellular viral and bacterial infections in these cases.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"5 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and laboratory spectrum of hereditary angioedema in a group of Egyptian children: a cross sectional study 一组埃及儿童遗传性血管性水肿的临床和实验室谱系:一项横断面研究
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-17 DOI: 10.1186/s43054-024-00264-4
Mohamed Almalky, Reham M. El Shabrawy, Najeeb Ali Mohammed Gheetah, Hossam Moustafa Elkady, Naglaa S. Osman, Walaa Shoman, Eman Gamal Baz
{"title":"Clinical and laboratory spectrum of hereditary angioedema in a group of Egyptian children: a cross sectional study","authors":"Mohamed Almalky, Reham M. El Shabrawy, Najeeb Ali Mohammed Gheetah, Hossam Moustafa Elkady, Naglaa S. Osman, Walaa Shoman, Eman Gamal Baz","doi":"10.1186/s43054-024-00264-4","DOIUrl":"https://doi.org/10.1186/s43054-024-00264-4","url":null,"abstract":"Hereditary angioedema (HAE) is a hereditary illness represented by repeated bouts of submucosal or subcutaneous edema. Types of HAE includes; HAE with deficient C1-inhibitor (type 1), HAE with dysfunctional C1-inhibitor (type 2), and HAE with normal C1-inhibitor. Data on the epidemiology of HAE in Egypt are limited. Therefore, we aimed to characterize HAE in Egyptian children, identify the morbidity, and clarify HAE's different clinical and laboratory presentations. In this cross-sectional study, we enrolled pediatric patients diagnosed with HAE according to the international hereditary angioedema WAO/EAACI guidelines. We gathered laboratory data on patients' mean serum C1 esterase inhibitor (C1-INH) level and activity, C4, and IgE levels. We included 18 HAE patients (14 females and 4 males). They were between the ages of 6 and 18 years. The mean age upon confirmation of diagnosis was 8.4 ± 2.4 years. The mean time required to correctly diagnose HAE was 3.2 ± 1.8 years. We detected type I in 15 cases and type II in three cases. Eleven patients had a family member with HAE. In terms of previous misdiagnoses, 50% of patients were diagnosed with allergic angioedema. The median annual frequency of episodes was 17. The mean HAE attack time was 2.9 ± 1.5 days. Edema was most typically found in the face and abdomen. Trauma was the main triggering factor. We detected a significant direct relationship between severity of attack and C1-INH activity level. This research adds a considerable clinical information about children with HAE. According to current results, there is a considerable underdiagnosis of HAE in Egypt. The detection and management of HAE can be improved by screening the relatives of HAE patients.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"18 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic cough in children: an evidence-based clinical practice guideline adapted for the use in Egypt using ‘Adapted ADAPTE’ 儿童慢性咳嗽:使用 "Adapted ADAPTE "改编的埃及循证临床实践指南
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-12 DOI: 10.1186/s43054-023-00244-0
Eman Mahmoud Fouda, Hala Hamdi Shaaban, Mona Mohsen Elattar, Abla Saleh Mostafa, Dina H. Hamed, Aya Samir Mohamed Saleh, Sally Raafat Ishak, Tarek Hamed, Magda Hassab Allah Mohamed, Shahenaz Mohamoud Hussien, Mohamed Mahmoud Rashad, Hala Gouda Elnady, Hoda M. Salah El Din Metwally, Laila Abd Elghaffar, Sherif Reda, Ashraf Abdel Baky, Tarek Omar, Yasser Amer, Dina Tawfeek Sarhan, Amira S. El Refay
{"title":"Chronic cough in children: an evidence-based clinical practice guideline adapted for the use in Egypt using ‘Adapted ADAPTE’","authors":"Eman Mahmoud Fouda, Hala Hamdi Shaaban, Mona Mohsen Elattar, Abla Saleh Mostafa, Dina H. Hamed, Aya Samir Mohamed Saleh, Sally Raafat Ishak, Tarek Hamed, Magda Hassab Allah Mohamed, Shahenaz Mohamoud Hussien, Mohamed Mahmoud Rashad, Hala Gouda Elnady, Hoda M. Salah El Din Metwally, Laila Abd Elghaffar, Sherif Reda, Ashraf Abdel Baky, Tarek Omar, Yasser Amer, Dina Tawfeek Sarhan, Amira S. El Refay","doi":"10.1186/s43054-023-00244-0","DOIUrl":"https://doi.org/10.1186/s43054-023-00244-0","url":null,"abstract":"We recently adopted a guideline for chronic cough in children in the Egyptian health system. Adapting clinical practice guidelines (CPGs) to the local healthcare setting is a valid alternative to de-novo development that can improve their uptake and implementation without demanding a substantial drain on resources. The objective of this study was to adapt evidence-based recommendations from global high-quality CPGs for children with a chronic cough to suit the Egyptian healthcare context. We followed the Adapted ADAPTE methodological framework for guideline adaptation. This process includes three phases: set-up, adaptation, and finalization. A guideline adaptation group (GAG) and an external review group including clinical content experts and methodologists conducted the process. The GAG adapted 10 sections of recommendations from three original CPG(s) including (i) the American College of Chest Physicians (ACCP) 2006–2020, (ii) the European Respiratory Society (ERS) 2019, (iii) the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI) 2018. A set of CPG implementation tools was added to enhance implementability including an algorithm, a slide presentation for clinical diagnosis, investigations and treatment of chronic cough, patient education, and online resources. The adapted CPG provides pediatricians and related healthcare workers with applicable evidence-based recommendations for chronic cough in children in Egypt. The project also highlighted the utility of Adapted ADAPTE and the invaluable collaboration between the clinical and methodological experts for the adaptation of pediatric national guidelines.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"36 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140594135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of serum microRNAs, mir-182-5p, and miR-590-3p and its clinical significance in neonatal sepsis 新生儿败血症中血清微小RNA、mir-182-5p和miR-590-3p的表达及其临床意义
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-08 DOI: 10.1186/s43054-024-00260-8
Soha M. Hamdy, Yomna A. Othman, Omayma O. Abdelaleem, Rehab G. Abd El-Hamid, Doaa Y. Ali
{"title":"Expression of serum microRNAs, mir-182-5p, and miR-590-3p and its clinical significance in neonatal sepsis","authors":"Soha M. Hamdy, Yomna A. Othman, Omayma O. Abdelaleem, Rehab G. Abd El-Hamid, Doaa Y. Ali","doi":"10.1186/s43054-024-00260-8","DOIUrl":"https://doi.org/10.1186/s43054-024-00260-8","url":null,"abstract":"Neonatal sepsis is one of the life-threatening diseases. MicroRNAs are non-coding RNAs that play vital roles in various diseases. This study included 50 neonates with sepsis and 60 healthy controls. RNA extraction and assessment of mir-182-5p and miR-590-3p using real-time PCR were done. Significant downregulation of mir-182-5p and miR-590-3p in neonates with sepsis compared with healthy neonates was observed. Positive correlations were confirmed between the expression levels of miR-182-5p and birth weight (R = 0.355, P = 0.012), RDW (R = 0.476, p = < 0.0001), I/T Neutrophil (R = 0.362, P = 0.012), and a negative correlations were demonstrated between miR-182-5p and each of lyomphocyte count (R = − 0.399, P = 0.004), HCO3 (R = − 0.396, P = 0.004), as well as snap score (R = − 0.321, P = 0.023). Moreover, positive correlations were verified between the expression level of miR-590-3p and I/T Neutrophil (R = 0.420, P = 0.003), RDW (R = 0.359, p = 0.010), CRP (R = 0.285, P = 0.45), and negative correlations were established between the expression level of miR-590-3p and platelets (R = − 0.495, P = < 0.0001), lymphocyte count (R = − 0.365, P = 0.009), and snap score (R = − 0.568, P = < 0.0001). mir-182-5p and miR-590-3p may be used as new biomarkers for neonatal sepsis suggesting that they could be used in the treatment of neonatal sepsis. Also, a significant negative correlation was noted between expression levels of mir-182-5p and miR-590-3p and snap score.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"121 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140594094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The awareness of treatment plans of craniosynostosis: guideline for patient and family version 了解颅骨发育不良的治疗方案:患者和家属指南
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-05 DOI: 10.1186/s43054-024-00273-3
Bahram Aminmansour, Samaneh Fatehi, Ali Mokhtari, Ali Riazi, Donya Sheibani Tehrani
{"title":"The awareness of treatment plans of craniosynostosis: guideline for patient and family version","authors":"Bahram Aminmansour, Samaneh Fatehi, Ali Mokhtari, Ali Riazi, Donya Sheibani Tehrani","doi":"10.1186/s43054-024-00273-3","DOIUrl":"https://doi.org/10.1186/s43054-024-00273-3","url":null,"abstract":"Functional and structural complexities associated with craniosynostosis present challenges for families of affected individuals. Additionally, these patients undergo childhood surgeries that significantly impact the role of the family/caregiver. Consequently, multiple therapeutic teams have provided various guidelines, with the most recent version in 2023 introducing the patient/family guide. The objective of this study was to evaluate the level of awareness among the patient’s family/caregiver regarding the treatment plan. The descriptive-analytical study sample consisted of 117 caregivers (parents) of children diagnosed with craniosynostosis between 2013 and 2023, who were conveniently selected for participation. The self-designed questionnaire was based on the 2023 guidelines and underwent reliability and validity testing. It comprised 14 chapters derived from the literature, with a total of 55 yes/no questions. Based on the results obtained from this study, the total correct response rate is 62.3%. The highest level of respondent awareness was associated with Chapter 12, with a correct response rate of 69%. The lowest level of awareness, at 41.8%, was related to Chapter 10. It is better to use appropriate educational aids such as educational podcasts based on the latest guidelines for craniosynostosis to educate parents.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"22 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140594098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive factors for failure of nonsurgical management of intussusception and its in-hospital recurrence in pediatric patients: a large retrospective single-center study 儿科肠套叠非手术治疗失败及其院内复发的预测因素:一项大型单中心回顾性研究
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-05 DOI: 10.1186/s43054-024-00279-x
Maria Klimeczek Chrapusta, Maciej Preinl, Zofia Łubniewska, Filip Procháska, Maria Gruba, Wojciech Górecki
{"title":"Predictive factors for failure of nonsurgical management of intussusception and its in-hospital recurrence in pediatric patients: a large retrospective single-center study","authors":"Maria Klimeczek Chrapusta, Maciej Preinl, Zofia Łubniewska, Filip Procháska, Maria Gruba, Wojciech Górecki","doi":"10.1186/s43054-024-00279-x","DOIUrl":"https://doi.org/10.1186/s43054-024-00279-x","url":null,"abstract":"This study explores the effectiveness of ultrasonography (USG)-guided saline enema reduction for ileocecal intussusception. It investigates factors, ascertainable through physical examination, ultrasound, and medical history, that impact the success of the procedure and the likelihood of recurrence. Conducted at a tertiary referral center, the study included 323 pediatric cases diagnosed with intussusception between 2017 and 2023. Patient data, symptoms, signs, and outcomes were collected. Hydrostatic saline enema, performed under USG guidance, served as the primary non-operative treatment. Logistic regression models assessed the impact of clinical factors on success and recurrence rates. Out of 323 patients examined for eligibility, 184 met inclusion criteria and were analyzed. Successful reduction with saline enema was achieved in 86.7%. In-hospital recurrence occurred in 17.1%, notably higher for intussusceptions extending into the rectum (p < 0.03). Pathologic lead point was identified in 33.3% of operated cases. The study revealed a correlation between the increasing number of symptoms (p < 0.001) and reduced success rates in enema reduction, with vomiting (p < 0.02), diarrhea (p < 0.05), and peritoneal fluid (p < 0.008) negatively affecting outcomes. Symptom duration of 1–9 h (p < 0.001) and 10–24 (p < 0.01) correlated with higher success rates, but prolonged symptom duration of > 24 (p = 0.4) and 48–72 (p = 0.2) hours did not decrease chances for successful reduction. Prolonged symptom duration of over 24 and 48–72 h should not be a definitive contraindication for non-operative treatment. Cumulation of symptoms typical for intussusception might reduce the chances of success. These findings contribute valuable insights into optimizing non-operative strategies for managing pediatric intussusception.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"95 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140594106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapunzel syndrome’s silent cry: addressing neglect and psychiatric factors in pediatric cases 长发公主综合征的无声呐喊:解决儿科病例中的忽视和精神因素问题
IF 0.8
Egyptian Pediatric Association Gazette Pub Date : 2024-04-01 DOI: 10.1186/s43054-024-00259-1
Arshia Warsi, Rabeea Mushtaq, Syed Waqas Ali, Farah Anwer
{"title":"Rapunzel syndrome’s silent cry: addressing neglect and psychiatric factors in pediatric cases","authors":"Arshia Warsi, Rabeea Mushtaq, Syed Waqas Ali, Farah Anwer","doi":"10.1186/s43054-024-00259-1","DOIUrl":"https://doi.org/10.1186/s43054-024-00259-1","url":null,"abstract":"Rapunzel syndrome is a very rare form of trichobezoar. It is strongly linked to psychiatric conditions; trichotillomania and trichophagia. These conditions in the pediatric population point to the presence of childhood stressors like child neglect, abuse, etc. This case report highlights that child neglect may be an underlying contributing factor in selected cases of Rapunzel syndrome. Hence, a multidisciplinary approach should be sought in all cases of Rapunzel syndrome, catering to the emotional and psychological needs of the pediatric population. A 7-year-old girl from a low socioeconomic background presented with periorbital and facial swelling, abdominal distension, and pallor. On physical examination, she showed bilateral pitting edema and a distended abdomen with poor overall hygienic condition. Her family history was positive for Wilson’s disease. Lab investigations highlighted iron deficiency anemia (Hb 8.2 g/dL), with normal liver function. Ultrasound demonstrated ascites, liver changes, and pleural effusion. The work-up for Wilson’s disease was unremarkable. During the hospital course, her abdominal distention lessened; a non-tender epigastric mass (4 × 5 cm) was thus discovered. An abdominal X-ray revealed an entangled mass outlining the gastric shadow. Her parents also revealed a history of trichophagia. Suspecting a large trichobezoar, a laparotomy was performed. After the midline incision, the stomach was opened anteriorly between stay sutures along the curvature. It delivered a large trichobezoar, 65 cm in length extending up to the proximal jejunum. Rapunzel syndrome diagnosis was finally established. This unique presentation emphasizes the need to consider this rare etiology, even with unusual clinical histories especially with a history of child neglect, while collaborative surgical interventions facilitate successful outcomes.","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":"54 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140594007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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