Oncology in Clinical Practice最新文献

筛选
英文 中文
Management of melanoma central nervous system metastases 中枢神经系统转移黑色素瘤的治疗
Oncology in Clinical Practice Pub Date : 2023-10-17 DOI: 10.5603/ocp.2023.0042
Piotr Rutkowski, Dorota Kiprian, Tomasz Świtaj, Radosław Michalik, Mateusz Spałek, Katarzyna Kozak, Tomasz Mandat, Bożena Cybulska-Stopa, Monika Dudzisz-Śledź
{"title":"Management of melanoma central nervous system metastases","authors":"Piotr Rutkowski, Dorota Kiprian, Tomasz Świtaj, Radosław Michalik, Mateusz Spałek, Katarzyna Kozak, Tomasz Mandat, Bożena Cybulska-Stopa, Monika Dudzisz-Śledź","doi":"10.5603/ocp.2023.0042","DOIUrl":"https://doi.org/10.5603/ocp.2023.0042","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-drug related costs of treatment with pertuzumab and trastuzumab in HER2-positive breast cancer patients in Poland 波兰her2阳性乳腺癌患者使用帕妥珠单抗和曲妥珠单抗治疗的非药物相关费用
Oncology in Clinical Practice Pub Date : 2023-10-10 DOI: 10.5603/ocp.97426
Michał Seweryn, Tomasz Banaś, Joanna Augustyńska, Agnieszka Leszczyńska, Paweł M. Potocki
{"title":"Non-drug related costs of treatment with pertuzumab and trastuzumab in HER2-positive breast cancer patients in Poland","authors":"Michał Seweryn, Tomasz Banaś, Joanna Augustyńska, Agnieszka Leszczyńska, Paweł M. Potocki","doi":"10.5603/ocp.97426","DOIUrl":"https://doi.org/10.5603/ocp.97426","url":null,"abstract":"Introduction. HER2-positive breast cancer represents 10–20% of all breast tumors. This study aimed to create a model-based cost-minimization analysis that compared non-drug related costs of different therapies used in the treatment of HER2-positive breast cancer in Poland: pertuzumab SC plus trastuzumab SC (Pert/TrasSC) vs. pertuzumab IV plus trastuzumab IV (PertIV + TrasIV) vs. pertuzumab IV plus trastuzumab SC (PertIV + TrasSC). Material and methods. The cost-minimization analysis was based on the results of a questionnaire addressed to leading oncology centers in Poland. The model was broken down into three categories of cost savings: reduced labor costs of nurses, pharmacists and non-drug related consumables, and from two categories of treatment time reduction: occupation of infusion chair and duration of hospital stay. Data on resources used and costs were collected in the first half of 2022. Results. Data were obtained from four oncology centers. The savings generated per patient from healthcare personnel’s work and from non-drug consumables for the Pert/TrasSC arm were 178 PLN compared to PertIV + TrasIV and 168 PLN compared to PertIV + TrasSC. Full adaptation of Pert/TrasSC was estimated to result in average 8-fold higher savings in healthcare personnel workload per patient and in a treatment capacity increase of 241 patients. Conclusions. Our model shows that Pert/TrasSC treatment is associated with significantly lower labor costs for nurses and pharmacists and lower costs of non-drug consumables compared to the other treatment options. Moreover, it reduced patients’ chair time due to shorter administration/observation time and released capacity in chemotherapy infusion sites.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136359724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on Encorafenib plus cetuximab in patients with BRAFV600E-mutated metastatic colorectal cancer — Polish multicenter experience 恩科非尼联合西妥昔单抗治疗brafv600e突变的转移性结直肠癌——波兰多中心经验
Oncology in Clinical Practice Pub Date : 2023-10-10 DOI: 10.5603/ocp.97067
Barbara Radecka
{"title":"Commentary on Encorafenib plus cetuximab in patients with BRAFV600E-mutated metastatic colorectal cancer — Polish multicenter experience","authors":"Barbara Radecka","doi":"10.5603/ocp.97067","DOIUrl":"https://doi.org/10.5603/ocp.97067","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136359440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Encorafenib plus cetuximab in patients with BRAFV600E-mutated metastatic colorectal cancer — Polish multicenter experience 恩科非尼加西妥昔单抗治疗brafv600e突变的转移性结直肠癌-波兰多中心经验
Oncology in Clinical Practice Pub Date : 2023-10-10 DOI: 10.5603/ocp.96898
Marek Gełej, Patryk Zając, Maria Dąbrowska, Anna Dejws-Wątróbowska, Bogumiła Galińska, Łukasz Galus, Agnieszka Gwóźdź-Cieślik, Katarzyna Hetman, Maciej Kawecki, Mateusz Malik, Joanna Streb, Katarzyna Wierzbicka, Piotr Wiosek, Barbara Radecka
{"title":"Encorafenib plus cetuximab in patients with BRAFV600E-mutated metastatic colorectal cancer — Polish multicenter experience","authors":"Marek Gełej, Patryk Zając, Maria Dąbrowska, Anna Dejws-Wątróbowska, Bogumiła Galińska, Łukasz Galus, Agnieszka Gwóźdź-Cieślik, Katarzyna Hetman, Maciej Kawecki, Mateusz Malik, Joanna Streb, Katarzyna Wierzbicka, Piotr Wiosek, Barbara Radecka","doi":"10.5603/ocp.96898","DOIUrl":"https://doi.org/10.5603/ocp.96898","url":null,"abstract":"Introduction. The BRAF mutation occurs in 8–12% of patients with colorectal cancer. This is associated with unfavorable prognosis — in metastatic disease, median survival does not exceed one year. Molecularly targeted treatment — encorafenib with cetuximab — is the standard of care in cases of chemotherapy failure. Material and methods. Medical data of 18 patients treated with encorafenib and cetuximab in 2021–2023 in 10 oncology centers in Poland were assessed. We analyzed clinical, pathomorphological, and molecular factors, as well as the effectiveness and safety of treatment. Results. The median age in the group was 63 years. Patients with metastases limited to one location predominated (78%). Treatment with encorafenib and cetuximab was used not only in the third (in 50% of patients) or fourth (in 28%) lines of treatment but also in the second (in 22%). The objective response rate was 29.4%, and the disease control rate was 76.4%. Due to the short follow-up period, median progression-free survival was not reached. Four patients (22%) had a response lasting over 12 months. Conclusions. This study confirmed the efficacy and safety of targeted treatment with encorafenib and cetuximab in patients with metastatic colorectal cancer with the BRAF V600E mutation.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136359439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sotorasib for non-small cell lung cancer — current options and perspectives Sotorasib治疗非小细胞肺癌-目前的选择和观点
Oncology in Clinical Practice Pub Date : 2023-10-02 DOI: 10.5603/ocp.97414
Magdalena Knetki-Wróblewska, Bartosz Wasąg
{"title":"Sotorasib for non-small cell lung cancer — current options and perspectives","authors":"Magdalena Knetki-Wróblewska, Bartosz Wasąg","doi":"10.5603/ocp.97414","DOIUrl":"https://doi.org/10.5603/ocp.97414","url":null,"abstract":"KRAS regulates several cellular processes, such as cell proliferation, cell cycle regulation, metabolic changes, cell survival, and cell differentiation. Abnormalities in the KRAS gene are found in approximately 30% of patients with non-small cell lung cancer, usually in patients diagnosed with nonsquamous cancer and more often in Caucasian patients, women, and smokers. The p.G12C variant is most frequently found in KRAS-positive patients. Sotorasib is the first drug approved for this population. The superiority of sotorasib over docetaxel after failure of immunochemotherapy was demonstrated in the CodeBreak 200 phase III study for the primary endpoint — median progression-free survival was 5.6 months [95% confidence interval (CI) 4.3–7.8] vs . 4.5 months (3.0–5.7); hazard ratio = 0.66 (95% CI 0.51–0.86; p = 0–0017), while the 12-month progression-free survival rate was 24.8% for sotorasib and 10.1% for docetaxel. Currently, sotorasib monotherapy, at an initial dose of 960 mg/day, is indicated for use in adults with advanced non-small cell lung cancer with the KRAS p.G12C mutation who have experienced disease progression after at least one previous line of systemic treatment. More randomized trials are needed to determine the optimal place of sotorasib in the systemic treatment sequence in this patient population.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135835280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Timed Up and Go test for screening vulnerability and frailty in older cancer patients 在老年癌症患者中筛查易感和虚弱的time Up and Go试验的评价
Oncology in Clinical Practice Pub Date : 2023-09-29 DOI: 10.5603/ocp.96855
Teodoro J. Oscanoa, Edwin Cieza-Macedo, Xavier Vidal, Roman Romero-Ortuno
{"title":"Evaluation of the Timed Up and Go test for screening vulnerability and frailty in older cancer patients","authors":"Teodoro J. Oscanoa, Edwin Cieza-Macedo, Xavier Vidal, Roman Romero-Ortuno","doi":"10.5603/ocp.96855","DOIUrl":"https://doi.org/10.5603/ocp.96855","url":null,"abstract":"Introduction. The need for comprehensive geriatric assessment (CGA) in older adults with cancer is increasing, which makes it necessary to have a screening instrument to identify those who would benefit from this evaluation. This study aimed to investigate diagnostic performance of the Timed Up and Go test (TUG) for identifying vulnerable or frail older adults with cancer who might benefit from CGA. Material and methods. This observational and retrospective study took place at the geriatric center of Almenara Hospital in Lima, Peru. We extracted CGA reports from electronic medical records of outpatients and inpatients aged 60 years and older with cancer, who were evaluated between November 2022 and July 2023. Patients were classified based on SIOG-2 (International Society of Geriatric Oncology) criteria as fit, vulnerable, or frail, based on scales including Activities of Daily Living (ADL), Instrumental ADL, Mini-Nutritional Assessment (MNA), Mini-Mental State Exam (MMSE), Geriatric Depression Scale, and Cumulative Illness Rating Scale-Geriatrics (CIRS-G). For the study, two groups were formed: fit patients and non-fit patients (vulnerable plus frail). We estimated sensitivity, specificity, and positive predictive values of the TUG test. The accuracy of the TUG test was analyzed using the area under the receiver operating characteristic curve (AUC). Results. Among the 283 included patients, 154 were men (54.4%) and 129 women (45.6%), and the mean age was 76.8 ± 15.8 years. The most common neoplasms were colorectal (19.4%), stomach (15.2%), prostate (9.9%), and bile duct cancers (8.1%). The percentage of fit and non-fit patients was 21.9% and 78.1%, respectively. When the TUG test was equal to or greater than 15.5 seconds, sensitivity, specificity, positive predictive value, and AUC were 68.5% (95% CI 61.9–74.5), 88.5% (77.8–95.3), 95.6% (91.1–98.2), and 84.8% (0.80–0.90), respectively. Conclusions. A TUG test result equal to or greater than 15.5 seconds demonstrated good screening properties for identifying older cancer patients who were vulnerable or frail and could benefit from CGA.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pembrolizumab in combination with chemotherapy in patients with advanced squamous cell lung cancer — clinical trials and real-world data Pembrolizumab联合化疗治疗晚期鳞状细胞肺癌患者-临床试验和现实世界数据
Oncology in Clinical Practice Pub Date : 2023-09-22 DOI: 10.5603/ocp.2023.0047
Magdalena Knetki-Wróblewska, Dariusz M. Kowalski
{"title":"Pembrolizumab in combination with chemotherapy in patients with advanced squamous cell lung cancer — clinical trials and real-world data","authors":"Magdalena Knetki-Wróblewska, Dariusz M. Kowalski","doi":"10.5603/ocp.2023.0047","DOIUrl":"https://doi.org/10.5603/ocp.2023.0047","url":null,"abstract":"Advanced squamous-cell lung carcinoma remains a disease with an unfavorable prognosis. Until recently, chemotherapy was used in systemic treatment, and its effectiveness was limited. Implementation of immune check-point inhibitors allowed for an improvement in treatment results. The KEYNOTE-407 study included patients with squamous-cell lung cancer who received 4 immunochemotherapy cycles followed by maintenance treatment with pembrolizumab. Median overall survival of 17.2 months versus 11.6 months for chemotherapy was obtained (risk of death reduction by 29%) while the percentage of patients remaining in follow-up was 18%. Analysis of patients with good performance status treated in clinical practice confirms the results from the registration study and emphasizes the importance of taking into consideration clinical factors while qualifying patients for treatment.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vinorelbine plus platinum compared to vinorelbine plus capecitabine in treatment of patients with metastatic triple negative breast cancer previously treated with anthracycline and taxane: a prospective randomized study 长春瑞滨加铂与长春瑞滨加卡培他滨治疗转移性三阴性乳腺癌患者的比较:一项前瞻性随机研究
Oncology in Clinical Practice Pub Date : 2023-09-18 DOI: 10.5603/ocp.96278
Heba Mohamed El-Zawahry, Ayman Abd Al-Samie Gaber, Amany Abd-Elhameed Abou-Bakr, Marwa Nabil Abd-Elhafez, Ahmed Mohamed El-Debawy
{"title":"Vinorelbine plus platinum compared to vinorelbine plus capecitabine in treatment of patients with metastatic triple negative breast cancer previously treated with anthracycline and taxane: a prospective randomized study","authors":"Heba Mohamed El-Zawahry, Ayman Abd Al-Samie Gaber, Amany Abd-Elhameed Abou-Bakr, Marwa Nabil Abd-Elhafez, Ahmed Mohamed El-Debawy","doi":"10.5603/ocp.96278","DOIUrl":"https://doi.org/10.5603/ocp.96278","url":null,"abstract":"Introduction. This study aims to investigate the efficacy and tolerability of the vinorelbine-based combination chemotherapy with either cisplatin or capecitabine in metastatic triple-negative breast cancer (mTNBC) pretreated with anthracycline and taxane. Material and methods. This is an open-labeled randomized prospective single-institute study, that included all patients who received chemotherapy for mTNBC in the period between 1st of July 2016 and 30th of June 2017 and were pretreated with anthracycline and taxane. Patients were randomized to either vinorelbine 25 mg/m2 I.V on days 1 and 8 plus oral capecitabine 1000 mg/m2 twice daily, on days 1–14 (NX); or vinorelbine 25 mg/m2 I.V on days 1 and 8 plus cisplatin 75 mg/m2 (NP), every 21 days. The primary endpoint was time to progression (TTP), whereas the secondary endpoints were objective response rate (ORR), safety, and overall survival (OS). Results. Median TTP was 9.9 months with NP vs. 8 months with NX, (p = 0.22). ORR was 40% with NP vs . 36% with NX, (p = 0.77). Median OS was 13 months with NP vs . 13.2 months with NX (p = 0.599). Both regimens demonstrated similar rates of grade ≥ 3 vomiting and neutropenia. A higher incidence of thrombocytopenia, tinnitus, and kidney function alteration were reported with NP. A higher incidence of anorexia, diarrhea, mucositis, and hand-foot syndrome were reported with NX. Conclusions. Vinorelbine-based combination chemotherapy regimens with either cisplatin or capecitabine are active in the treatment of mTNBC pretreated with anthracycline and taxane with manageable toxicity profiles. Both regimens have comparable TTP, ORR, OS, and safety profiles.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135256800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potassium imbalances induced by systemic cancer therapy: pathophysiology and potential therapeutic strategies 全身癌症治疗引起的钾失衡:病理生理学和潜在的治疗策略
Oncology in Clinical Practice Pub Date : 2023-09-18 DOI: 10.5603/ocp.96314
Datis Kalali
{"title":"Potassium imbalances induced by systemic cancer therapy: pathophysiology and potential therapeutic strategies","authors":"Datis Kalali","doi":"10.5603/ocp.96314","DOIUrl":"https://doi.org/10.5603/ocp.96314","url":null,"abstract":"Imbalances of serum potassium levels are common complications in patients receiving systemic antineoplastic therapy. These conditions can provoke further complications such as cardiac arrhythmia and paralysis due to the significant role of potassium in muscle physiology. Many cytotoxic drugs and novel targeted therapy agents have been found to induce hypokalemia and occasionally hyperkalemia. Therefore, they should be administered carefully and a broad understanding of the topic is necessary for medical oncologists. To this end, the present narrative review explores the pathophysiology of potassium disorders induced by systemic therapy and points out some therapeutic strategies for reversing them.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135256799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-grade serous ovarian cancer with BRAFV600E mutation treated with metronomic chemotherapy — a case report and literature review 节拍化疗治疗BRAFV600E突变的低级别浆液性卵巢癌1例报告及文献复习
Oncology in Clinical Practice Pub Date : 2023-09-08 DOI: 10.5603/ocp.96964
Maria Rozpłoch-Sapa, Patrycja Mrowczyk, Łukasz Kwinta, Mateusz Łobacz, Paweł M. Potocki
{"title":"Low-grade serous ovarian cancer with BRAFV600E mutation treated with metronomic chemotherapy — a case report and literature review","authors":"Maria Rozpłoch-Sapa, Patrycja Mrowczyk, Łukasz Kwinta, Mateusz Łobacz, Paweł M. Potocki","doi":"10.5603/ocp.96964","DOIUrl":"https://doi.org/10.5603/ocp.96964","url":null,"abstract":"Introduction. Ovarian cancer (OC) is the leading cause of cancer death worldwide. In Poland, it is the fourth leading cause of death from neoplasms in women. OC is a heterogeneous disease with low-grade cases characterized by a better prognosis, but poor chemosensitivity. Metronomic chemotherapy (MC) may be a beneficial approach. Case presentation. We present a patient with low-grade serous ovarian cancer (LGSOC) with long-term disease control achieved with MC despite being resistant to standard-dose chemotherapy with paclitaxel and carboplatin. Overall survival (OS) of the patient was 65 months. MC was administered most of the time. The patient was treated with two metronomic regimens: topotecan plus cyclophosphamide and vinorelbine plus methotrexate, both in combination with hormone therapy. The cancer was found to harbor the BRAF V600E mutation (v-raf murine sarcoma viral oncogene homolog B1, a valine-to-glutamic acid substitution at position 600), but that did not impact the treatment. Conclusions. LGSOC has distinct features from high-grade serous ovarian cancer (HGSOC). MC may be a valuable option in LGSOC despite being understudied. The BRAF V600E mutation occurs in 2–33% of low-grade serous ovarian tumors. It is a more common finding in LGSOC than in HGSOC. BRAF inhibition in OC may be a new therapeutic option. Some BRAF inhibitors have already been registered for solid tumors with this mutation.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136363712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信