Turkish Journal of Endocrinology and Metabolism最新文献

{"title":"Steroid Secreting Dedifferentiated Liposarcoma: A Unique Presentation","authors":"L. R. Santos, M. Duarte, J. V. L. Júnior","doi":"10.25179/tjem.2019-71188","DOIUrl":"https://doi.org/10.25179/tjem.2019-71188","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"210 1","pages":"101-104"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77616577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of Papillary and Medullary Thyroid Carcinoma: A Rare Entity","authors":"Emel Bayrak, R. Serter","doi":"10.25179/tjem.2019-72499","DOIUrl":"https://doi.org/10.25179/tjem.2019-72499","url":null,"abstract":"Introduction Papillary thyroid carcinoma (PTC) are the most common of all thyroid cancers (>70%). It originates from follicular thyroid cells and shows multifocal growth in nearly 29% cases. Immunohistochemical results of PTC are positive for thyroglobulin and Thyroid Transcription Factor-1 (TTF-1). PTC cells are negative for calcitonin, Carcinoembryonic Antigen (CEA), and chromogranin. PTC The coexistence of different types of thyroid carcinomas is rather unusual. It has been considered coincidental and linked to the growing incidence of papillary thyroid carcinoma (PTC). This paper presents a case of multifocal PTC and coexistent medullary thyroid carcinoma (MTC) distinct from each other, along with PTC lymph node metastasis. The 44year-old female patient underwent subtotal thyroidectomy with a pre-operative diagnosis of multinodular goiter. Histological reports revealed PTC in the right lobe and PTC beside a tumoral area morphologically suspicious for MTC in the left thyroid lobe. Immunohistochemistry confirmed the diagnosis of MTC. Post-operative ultrasound and subsequent fine needle aspiration biopsy revealed lymph node metastases of PTC in the right anterior cervical area. Complementary thyroidectomy, central neck dissection, and right modified neck dissection were carried out with subsequent I-131 ablation therapy. In conclusion, the biological behaviors and prognoses of MTC and PTC are different. Therefore, the entity demands a different clinical approach in treatment and follow-up.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"149 1","pages":"168-172"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83962292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism","authors":"M. Hemmatabadi, Samaneh Azizimanesh, F. Esfahanian, M. M. Tehrani, N. Shirzad","doi":"10.25179/tjem.2019-71845","DOIUrl":"https://doi.org/10.25179/tjem.2019-71845","url":null,"abstract":"Objective: Several lines of evidence suggest that the symptoms of hypothyroidism, including psychological symptoms and metabolic effects, persist in a significant percentage of patients treated with levothyroxine (L-T4). A hypothesis to explain this phenomenon is that the triiodothyronine (L-T3) serum levels may not be completely normalized. This study aimed to compare the level of serum free T3 (FT3) in patients who are biochemically euthyroid after L-T4 monotherapy with different underlying causes of hypothyroidism. Material and Methods: This cross-sectional study was conducted on patients with hypothyroidism who received L-T4 monotherapy and were biochemically euthyroid. The serum levels of thyroid-stimulating hormone (TSH), free T4 (FT4), FT3, and FT3/FT4 ratio were measured in these patients. Patients were divided into three groups based on the cause of hypothyroidism (radioiodine therapy, thyroidectomy and Hashimoto), and the results of biochemical tests of the thyroid were compared in three groups. Results: Of the 78 patients studied, 12 (15.4%) cases were male, and 66 (84.6%) cases were female. Among the variables studied, only the mean value of FT3 was significantly different in the three groups (p=0.006), where the highest mean value was seen in the Hashimoto group, and the lowest mean value was seen in the radioiodine therapy group. Conclusion: The results of this study showed that although hypothyroidism patients can be optimally treated with L-T4 alone, in many of these patients, the level of FT3 will not be in therapeutic range, and the mean serum FT3 levels in these patients could be related to their hypothyroidism causes.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"46 1","pages":"138-143"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72999866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum 25(OH) Vitamin D Levels in Severely Obese Patients Evaluated Before Bariatric Surgery","authors":"H. G. Gunhan, M. Uygur, E. Imre, O. Elbasan, D. Yavuz","doi":"10.25179/tjem.2019-71778","DOIUrl":"https://doi.org/10.25179/tjem.2019-71778","url":null,"abstract":"Objective: Obesity is a risk factor for vitamin D deficiency, which is reported to be detected differently in each population. This study aimed to evaluate the 25(OH) vitamin D (25(OH)D) levels, intact parathormone (iPTH) levels, and their relationship with body mass index (BMI) in obese patients, screened prior to bariatric surgery. Material and Methods: This retrospective study comprised of 1.082 obese patients (41±10 years, female/male: 823/259) who were candidates for bariatric surgery. BMI, waist circumference (WC), serum 25(OH)D, iPTH, calcium, phosphorus values of these patients were recorded from patient files. Results: BMI, WC, iPTH, and 25(OH)D levels were 48±8.9 kg/m2, 128±11.9 cm, 64±36 pg/mL, and 15±18 ng/mL, respectively. Mean 25(OH)D level of 79.1% of the patients belonged to the deficiency range. Very low 25(OH) vitamin D levels (<10 ng/mL) were witnessed among 40.9% (443/1.082) of the study group. Female obese subjects possessed significantly lower serum 25(OH)D levels as compared to male obese patients. Significant negative correlations were perceived between 25(OH)D levels and iPTH (r=-0.34, p<0.0001), BMI (r=-0.20, p<0.0001), and waist circumferences (r=-0.14, p=0.002) in the whole group. Multivariate analysis indicated that BMI to be an independent risk factor for vitamin D deficiency. Conclusion: A high rate of vitamin D deficiency was documented in our morbidly obese patients who were candidates for bariatric surgery. BMI is a determinant of 25(OH)D levels. It is essential to screen for vitamin D deficiency and possible osteomalacia among the candidates for bariatric surgery of obese patients and should be treated appropriately before bariatric surgery.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"106 1","pages":"115-121"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79257684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between C-Peptide Index and Proteinuria in Patients with Type 2 Diabetes Mellitus","authors":"B. Katipoglu, M. Comoglu, I. Ateş, N. Yılmaz, D. Berker","doi":"10.25179/tjem.2019-71377","DOIUrl":"https://doi.org/10.25179/tjem.2019-71377","url":null,"abstract":"Objective: Though the C-peptide index (CPI) has been a reliable marker for estimation of the beta-cell reserve, its association with microvascular complications in Type 2 diabetes mellitus (DM) patients has not been elucidated as yet. This study, therefore, aimed to investigate the relationship between C-peptide levels and CPI with microvascular complications in Type 2 DM patients. Material and Methods: Type 2 DM patients, over 18 years of age, whose C-peptide levels were analyzed in the endocrinology and internal medicine clinics between 2014 and 2018, having normal kidney functions (glomerular filtration rate >60 mL/min) and who are not dependent on any insulin secretagogue oral antidiabetic agent (i.e., sulfonylurea) were enrolled the study. Blood samples were collected after at least 12 h of fasting, without any drug or insulin administration. Hemogram, hemoglobin A1c (HbA1c), lipid, glucose, C-peptide parameters were analyzed from the same serum sample. The patients were classified into three groups according to the spot urine albumin/creatinine ratio. Patients with no proteinuria, patients with microalbuminuria, and patients with macroalbuminuria were defined as group 1, group 2, and group 3, respectively. Results: A statistically significant difference between CPI levels in the groups was observed (p<0.001). CPI levels of Groups 2 and 3 were lower than that of group 1 (p=0.007 and p<0.001). In addition, the CPI level of group 3 was significantly lower than that of group 2 (p=0.015). An inverse association between CPI level and proteinuria was thus recognized. HbA1c and proteinuria were found to be positively correlated (p<0.001). Conclusion: This study highlights the association between C-peptide, CPI, and diabetic nephropathy in Type 2 DM patients.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"15 1","pages":"23-28"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80134523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Hyperandrogenemia in Women with Prolactinoma","authors":"M. Ünal, Z. Karaca, K. Ünlühızarcı, F. Keleştemur","doi":"10.25179/tjem.2019-72018","DOIUrl":"https://doi.org/10.25179/tjem.2019-72018","url":null,"abstract":"Objective: Differential diagnosis of androgen excess disorders revealed the occurrence of hyperprolactinemia. However, an elevated level of prolactin (hyperprolactinemia) is a very infrequent cause of hyperandrogenemia in clinical practice. This study aimed to investigate the presence of hyperandrogenism/hyperandrogenemia in women with prolactinoma before and after treatment with cabergoline. Material and Methods: Twenty women diagnosed with prolactinoma in the recent past and 15 healthy women between the ages of 18 to 50 were enrolled in the study. Patients were evaluated at the baseline and after six months of cabergoline treatment. Patients were carefully noted for any signs and symptoms of hyperandrogenemia and concentration of androgen in blood. Further, adrenocorticotropin stimulation test was performed to analyze cortisol, dehydroepiandrosterone sulfate (DHEAS), androstenedione, 11-deoxycortisol (11-S), and 17-hydroxyprogesterone (17-OHP) responses. Results: A significantly higher level of prolactin compared to the control group was seen in prolactinoma patients, which reverted to normal levels after cabergoline treatment. Estradiol (E2) concentration was lower in patients with prolactinoma than control group and it did not show a significant increase after being treated with cabergoline. Patients with prolactinoma exhibited decreased sex hormone-binding globulin (SHBG) concentration in blood, which also increased significantly after the treatment. The levels of basal androstenedione, DHEAS, 17-OH progesterone, 11-S, and cortisol were found to be similar between the two groups. Basal and stimulated DHEAS and androstenedione levels decreased significantly after cabergoline treatment in prolactinoma patients. The presence of acne, hirsutism, and androgenic alopecia were similar in both groups. Pelvic ultrasonography revealed polycystic ovary (PCO) in nine patients with prolactinoma, which was significantly more frequent than in the control group. Among the 9 PCO patients, normal ovarian morphology was restored in three patients after the treatment. Conclusion: From the data, it may be suggested that hyperprolactinemia may not lead to clinically significant hyperandrogenemia and hirsutism. Moreover, the treatment of hyperprolactinemia does not lead to significant improvement in hirsutism score of the patients, if exists.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"11 2 1","pages":"55-62"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81248828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet Activation is a Risk Factor for Obesity","authors":"S. Çeçen","doi":"10.25179/tjem.2019-72995","DOIUrl":"https://doi.org/10.25179/tjem.2019-72995","url":null,"abstract":"Objective: Obesity is known to be a triggering factor for many chronic diseases. Blood parameters, especially platelet (PLT)-related factors, have gained importance for a better understanding of obesity. In this study, we investigated the correlation between PLT-related parameters and bodily factors to enhance our knowledge of this important area of research. Material and Methods: Consenting volunteers between 18 and 65 years were included in the study. Their heights, weights, body mass indices (BMI), fat percentages, fat masses (FM), and fat-free masses (FFM) were determined. Fat mass index (FMI=fat mass/height m2) and fat-free mass index (FFMI=fat free mass/height m2) were calculated. Blood samples were taken to determine the parameters such as PLT, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). Results: In males, PLT increased with weight, fat percentage, FM, and FMI. However, there was no change in PCT values with these parameters. In females, PLT decreased with age, increased with weight, BMI, fat percentage, FM, FFM, and FMI. PCT increased with weight, BMI, fat percentage, FM, FFM, and FMI. Conclusion: A significant relationship between PLT activation and body fat content was observed in both genders in the present study. Thus, these blood parameters can be a useful tool for investigating inflammation-related complications in obese individuals. It is speculated that obese individuals may be encouraged toward becoming thrombocyte apheresis donors to reduce their PLT counts, which may lead to a decrease in the risk of obesity-related inflammation in such individuals.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"40 1","pages":"132-137"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87831478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of New and Old Body Shape Indices to Estimate Body Fat in Obese and Morbid Obese Turkish Females","authors":"Merve Melikoğlu, Can Öner, S. Tüzün, Ş. Temizkan, Ekrem Orbay","doi":"10.25179/tjem.2019-66730","DOIUrl":"https://doi.org/10.25179/tjem.2019-66730","url":null,"abstract":"Objective: The estimation of fat mass with indirect techniques is beneficial in daily clinical practice. This study aimed to compare new and old body shape indices using bioimpedance analysis for the assessment of body fat mass in obese and morbid obese Turkish females. Material and Methods: Four hundred thirty-eight obese and morbid obese females were enrolled in the study. Anthropometric measurements of the study participants were completed using standard techniques. Body mass index (BMI), body adiposity index (BAI), a body shape index, waist to hip ratio and body roundness index (BRI) were calculated. The body fat ratio was evaluated using TANITA-48M. Results: All the anthropometric indices except waist circumference, waist-to-hip ratio, and ABSI correlated with body fat (%). BMI and BAI were the best predictors of body fat ratio derived from bioimpedance analysis for all participants. Only for obese females, BAI alone as well as BAI and BMI together were the best predictive methods of body fat (%). In the morbid obese group, BAI alone proved to be the best predictive method for body fat (%) estimation. Conclusion: In clinical practice, the determination of body fat ratio with indirect techniques may help physicians estimate the risk of diseases in obese and morbid obese patients. BAI can help estimate body fat ratio easily.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"43 1","pages":"1-8"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81550627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of Stump Healing Among Diabetic Population","authors":"S. Ashraff, Muhammad A. Siddiqui, D. Santos, T. Carline","doi":"10.25179/TJEM.2018-59880","DOIUrl":"https://doi.org/10.25179/TJEM.2018-59880","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"174 1","pages":"91-97"},"PeriodicalIF":0.2,"publicationDate":"2018-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73076421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of causes of high parathyroid hormone levels in elderly","authors":"P. Tutuncuoğlu, F. Saraç","doi":"10.1530/ENDOABS.56.EP30","DOIUrl":"https://doi.org/10.1530/ENDOABS.56.EP30","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"29 1","pages":"46-46"},"PeriodicalIF":0.2,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}