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International Journal of Cancer and Biomedical Research最新文献

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Toxicological and pathophysiological alterations accompanied treating cancer with the Egyptian cobra (Naja haje) crude venom on mice 用埃及眼镜蛇(Naja haje)粗毒液治疗小鼠癌症的毒理学和病理生理变化
International Journal of Cancer and Biomedical Research Pub Date : 2022-03-01 DOI: 10.21608/jcbr.2022.77445.1215
Hosni Neweigy, M. Gouida, M. Salem, M. el Naggar
{"title":"Toxicological and pathophysiological alterations accompanied treating cancer with the Egyptian cobra (Naja haje) crude venom on mice","authors":"Hosni Neweigy, M. Gouida, M. Salem, M. el Naggar","doi":"10.21608/jcbr.2022.77445.1215","DOIUrl":"https://doi.org/10.21608/jcbr.2022.77445.1215","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129385587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metformin treatment improves the hepato-renal dysfunctions induced in Type-II diabetes in male rats 二甲双胍治疗可改善2型糖尿病雄性大鼠肝肾功能障碍
International Journal of Cancer and Biomedical Research Pub Date : 2022-03-01 DOI: 10.21608/jcbr.2021.95272.1231
M. Elwan, E. El-Nahass, M. Basyony, E. Elshennawy, S. El-Naggar
{"title":"Metformin treatment improves the hepato-renal dysfunctions induced in Type-II diabetes in male rats","authors":"M. Elwan, E. El-Nahass, M. Basyony, E. Elshennawy, S. El-Naggar","doi":"10.21608/jcbr.2021.95272.1231","DOIUrl":"https://doi.org/10.21608/jcbr.2021.95272.1231","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134103756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T1107 polymer expressed potential anti-tumor effects against HepG2 cell line T1107聚合物对HepG2细胞株表达了潜在的抗肿瘤作用
International Journal of Cancer and Biomedical Research Pub Date : 2022-03-01 DOI: 10.21608/jcbr.2021.92796.1227
E. Kenawy, M. Salem, Noura Sanoh, Mohamed M. Azaam
{"title":"T1107 polymer expressed potential anti-tumor effects against HepG2 cell line","authors":"E. Kenawy, M. Salem, Noura Sanoh, Mohamed M. Azaam","doi":"10.21608/jcbr.2021.92796.1227","DOIUrl":"https://doi.org/10.21608/jcbr.2021.92796.1227","url":null,"abstract":"Background : Polymeric nanoparticles (NPs) are obtained naturally, semi-synthetically or synthetically by a polymerization reaction. Tetronics based ethylene oxide-propylene oxide copolymers have gained a great of interest. It demonstrated interactions with cell membranes with potential for developing new biomaterials for application in nanomedicine . Aim: The primary aim of the current study is to test the direct anticancer activity of unmodified tetronic (T1107), P-HB+aminated tetronic and N, N DMAB+aminated tetronic polymersand the associated by apoptosis and cell cycle. Materials and Methods : Synthetic polymers were prepared and characterized to confirm the modification. Antitumor activity was examined in vitro using human hepatocellular carcinoma (HepG2) cell line. Cell viability (MTT), cell cycle and apoptosis were evaluated by flow cytometry. Results : Unmodified tetronic (T1107) decreased HepG2 viability (by 30%) than untreated HepG2 cells. Treatment with P-HB+aminated tetronic and N,N DMAB+aminated did not give a significant effect on Hepg-2 cells. Treatment of HepG2 with unmodified tetronic (T1107) induced cell cycle arrest at G0 phase (39.4%), while P-HB+aminated tetronic and N,N DMAB+aminated tetronic induced cell cycle arrest at G1 phase (by 54.8% and 48.2%, respectively as compared to treatment with the doxorubicin (DOX) as a reference drug, which induced Hepg-2 cell cycle arrest at GO phase (by 39.1%). The unmodified tetronic (T1107) increased the numbers of late apoptotic cells (by 49.4%), while P-HB+aminated tetronic and N,N DMAB+aminated tetronic did not induced significant apoptosis. Conclusion :.Unmodified Tetronic T1107 induces an anticancer effect more than modified Tetronic polymers.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123050364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of neoadjuvant chemotherapy on circulating immune cells in breast cancer patients: A pilot study 新辅助化疗对乳腺癌患者循环免疫细胞的影响:一项初步研究
International Journal of Cancer and Biomedical Research Pub Date : 2022-03-01 DOI: 10.21608/jcbr.2022.110181.1239
Nahla El Wakkad
{"title":"Effect of neoadjuvant chemotherapy on circulating immune cells in breast cancer patients: A pilot study","authors":"Nahla El Wakkad","doi":"10.21608/jcbr.2022.110181.1239","DOIUrl":"https://doi.org/10.21608/jcbr.2022.110181.1239","url":null,"abstract":"Likewise, immune cell subsets may have a promising approach in prognosis and treatment strategies. Aim: The aim of this pilot study was to investigate the neoadjuvant paclitaxel’s effect on the relative and absolute numbers of lymphocytes, monocytes, granulocytes and CD11b and its maturation markers and their role in breast cancer patients’ clinical response . Patients and Methods: Breast cancer patients (n=10) and healthy donors (n=4) were recruited from Tanta Cancer Center, Egypt. Peripheral blood samples (2ml) were collected in EDTA tubes from breast cancer patients during neoadjuvant chemotherapy (prior to each cycle of paclitaxel) as well as healthy volunteers. The relative and absolute numbers of lymphocytes, monocytes and granulocytes were obtained using gating strategy after acquisition with Flow-cytometer. The absolute numbers of CD11b + and its maturation markers (HLADR + and CD83 + ) were also evaluated by flowcytometry after staining with specific antibodies. The absolute number was calculated using total peripheral blood leucocytes of each subject. Results: Comparing between the absolute number of monocytes prior to each cycle, significant difference was found between the 1 st cycle vs the 3 rd cycle and the 4 th cycle. Significant difference was also found in CD11b expressing cells and its maturation markers (HLADR) between responder and non-responder patients. Conclusion: Our study concluded the importance of CD11b and its maturation marker in clinical response in neoadjuvant BC patients as a prognostic tool. Immunological parameters should be considered during application of treatment strategies as a prognostic tool and promising approach in immunotherapy.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132899763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognition of Ultrasound Images of Breast Cancer Based on Discrete Sinc Transform and Deep Learning 基于离散Sinc变换和深度学习的乳腺癌超声图像识别
International Journal of Cancer and Biomedical Research Pub Date : 2021-10-14 DOI: 10.21608/jcbr.2021.65002.1185
M. Azmy
{"title":"Recognition of Ultrasound Images of Breast Cancer Based on Discrete Sinc Transform and Deep Learning","authors":"M. Azmy","doi":"10.21608/jcbr.2021.65002.1185","DOIUrl":"https://doi.org/10.21608/jcbr.2021.65002.1185","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129385226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caspase-3 activities and androgen receptor expression in rats’ testis during the early biochemical and histopathological changes induced by a carcinogen, Diethylnitrosamine: role of probiotics and pyridazine derivatives 致癌物二乙基亚硝胺诱导大鼠睾丸早期生化和病理改变过程中Caspase-3活性和雄激素受体表达:益生菌和吡啶衍生物的作用
International Journal of Cancer and Biomedical Research Pub Date : 2021-10-14 DOI: 10.21608/jcbr.2021.74096.1207
A. Morsi, S. Ahmed, N. Saleh, R. A. Abd El-Aal, Tamer El Malah, A. Elsayed
{"title":"Caspase-3 activities and androgen receptor expression in rats’ testis during the early biochemical and histopathological changes induced by a carcinogen, Diethylnitrosamine: role of probiotics and pyridazine derivatives","authors":"A. Morsi, S. Ahmed, N. Saleh, R. A. Abd El-Aal, Tamer El Malah, A. Elsayed","doi":"10.21608/jcbr.2021.74096.1207","DOIUrl":"https://doi.org/10.21608/jcbr.2021.74096.1207","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124621710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Accuracy of Bethesda system in the diagnosis of thyroid nodules: Utility of combined histopathological and radiological reporting systems Bethesda系统诊断甲状腺结节的准确性:组织病理学和放射学联合报告系统的应用
International Journal of Cancer and Biomedical Research Pub Date : 2021-10-14 DOI: 10.21608/jcbr.2021.71741.1199
M. Fawzy, Dina Harb, Heba Sheta
{"title":"Accuracy of Bethesda system in the diagnosis of thyroid nodules: Utility of combined histopathological and radiological reporting systems","authors":"M. Fawzy, Dina Harb, Heba Sheta","doi":"10.21608/jcbr.2021.71741.1199","DOIUrl":"https://doi.org/10.21608/jcbr.2021.71741.1199","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"176 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129899550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PERI-OPERATIVE SURGICAL OUTCOME OF BREAST CANCER IN GERIATRIC AGE FEMALES IN EGYPT 埃及老年女性乳腺癌围手术期手术结果分析
International Journal of Cancer and Biomedical Research Pub Date : 2021-10-12 DOI: 10.21608/jcbr.2021.73244.1205
E. Elshikh, A. El-Gammal
{"title":"PERI-OPERATIVE SURGICAL OUTCOME OF BREAST CANCER IN GERIATRIC AGE FEMALES IN EGYPT","authors":"E. Elshikh, A. El-Gammal","doi":"10.21608/jcbr.2021.73244.1205","DOIUrl":"https://doi.org/10.21608/jcbr.2021.73244.1205","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130810244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ameliorative effect of certain plant extracts from the Egyptian flora on type II diabetes using Drosophila melanogaster as a model 以黑腹果蝇为模型研究某些埃及植物提取物对II型糖尿病的改善作用
International Journal of Cancer and Biomedical Research Pub Date : 2021-10-10 DOI: 10.21608/jcbr.2021.90207.1225
H. Elbrense, Omnia Montaser, Mona El-Aasr, W.S. Meshrif
{"title":"The ameliorative effect of certain plant extracts from the Egyptian flora on type II diabetes using Drosophila melanogaster as a model","authors":"H. Elbrense, Omnia Montaser, Mona El-Aasr, W.S. Meshrif","doi":"10.21608/jcbr.2021.90207.1225","DOIUrl":"https://doi.org/10.21608/jcbr.2021.90207.1225","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125048206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus 血清脂联素水平在肥胖患者Barrett食管评估中的作用
International Journal of Cancer and Biomedical Research Pub Date : 2021-10-09 DOI: 10.21608/jcbr.2021.80400.1214
Ayman El Lehleh, M. Ellaithy, A. Zahran, N. Elabd
{"title":"Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus","authors":"Ayman El Lehleh, M. Ellaithy, A. Zahran, N. Elabd","doi":"10.21608/jcbr.2021.80400.1214","DOIUrl":"https://doi.org/10.21608/jcbr.2021.80400.1214","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116641418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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