A. Parshina, E. Moskaleva, A. Petrova, L. V. Rychkova, O. Ogarkov, E. Orlova, A. Vanyarkina, E. Novikova, E. D. Kazantseva
{"title":"SARS-CoV-2 VIRAL LOAD IN NEWBORNS WITH COVID-19","authors":"A. Parshina, E. Moskaleva, A. Petrova, L. V. Rychkova, O. Ogarkov, E. Orlova, A. Vanyarkina, E. Novikova, E. D. Kazantseva","doi":"10.25789/ymj.2023.81.16","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.16","url":null,"abstract":"The article presents the results of investigation of SARS-CoV-2 viral load in newborns with RT-PCR confirmed COVID-19 of different severity. It has been revealed that total amount of SARS-CoV-2 RNA on nasopharyngeal mucosa of newborns is significantly higher as compared to elder children and is not associated with disease severity and lung injury.","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"14 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84963572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transanal endoscopic resection of rectal neoplasms","authors":"A. Ilkanich, Y. Voronin, F. Aliev","doi":"10.25789/ymj.2023.81.11","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.11","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84223607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of COVID-19 on Gognitive change","authors":"R. Mustafin, A. Kazantseva, E. Khusnutdinova","doi":"10.25789/ymj.2023.81.25","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.25","url":null,"abstract":"We hypothesize that cognitive impairment in humans after COVID-19 is due to a change in the epigenetic regulation of brain neurons due to the activation of retroelements under the influence of SARS-CoV-2 virus. In order to confirm the role of transposons in changing the functioning of the brain in patients with COVID-19, the scientific literature and the results of meta-analyses over the past 3 years were studied. As a result, we found that SARS-CoV-2 affects the brain not only through its direct effect, induction of inflammation and coagulopathy, but also through the activation of retroelements, the transcripts of which are processed into microRNAs. This is reflected in changes in the epigenetic regulation of genes in brain neurons, which is reflected in cognitive functions. The mechanisms of integration of the cDNA of SARS-CoV-2 virus into the human genome with the help of retroelement enzymes are described, which is reflected in the development of long-term changes in cognitive functions after COVID-19.","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"41 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85439301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. M. Sivtseva, T. M. Klimova, R. Zakharova, E. Ammosova, V. Osakovsky
{"title":"The role of FADS gene polymorphic variants in adaptation to the Northern climatic conditions and metabolic disorders","authors":"T. M. Sivtseva, T. M. Klimova, R. Zakharova, E. Ammosova, V. Osakovsky","doi":"10.25789/ymj.2023.81.26","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.26","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"98 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79834657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intercellular interactions and the level of aggregation of blood cells in the area of inflammation in people living in the European North of Russia","authors":"L. Dobrodeeva, S. N. Balashova, A. Samodova","doi":"10.25789/ymj.2023.81.22","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.22","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89324042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Savvina, T. Nelunova, T. Burtseva, T. M. Klimova, V. Egorova, V. Chasnyk
{"title":"The role of social factors in the formation of congenital heart disease in the Republic of Sakha (Yakutia)","authors":"M. Savvina, T. Nelunova, T. Burtseva, T. M. Klimova, V. Egorova, V. Chasnyk","doi":"10.25789/ymj.2023.81.27","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.27","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"32 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87946450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Sofronova, A. Romanova, V. Nikolaev, M. P. Kirillina
{"title":"The frequency of metabolic syndrome and its components in the non-indigenous population of South Yakutia","authors":"S. Sofronova, A. Romanova, V. Nikolaev, M. P. Kirillina","doi":"10.25789/ymj.2023.81.08","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.08","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83467329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship of lipid profile and blood pressure in men in the European North of Russia","authors":"L. B. Kim, A. Putyatina","doi":"10.25789/ymj.2023.81.24","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.24","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"2 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75309381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Ushnitsky, T. V. Alekseeva, E. Nikiforova, M. Solovyova, I. Savvina
{"title":"Structural characteristics of dental anomalies in schoolchildren due to the vault height of the hard palate with different degrees of severity of connective tissue dysplasia","authors":"I. Ushnitsky, T. V. Alekseeva, E. Nikiforova, M. Solovyova, I. Savvina","doi":"10.25789/ymj.2023.81.05","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.05","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76009926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Ishchenko, E. Voropaeva, E. Kazachkova, Yu.V. Khaydukova, E. Kazachkov, T. Shamaeva, D. D. Voropaev, A. Voropaeva, Y. Ishchenko
{"title":"Frequency and outcomes of extremely early preterm birth in pregnant women with new coronavirus infection COVID-19","authors":"L. Ishchenko, E. Voropaeva, E. Kazachkova, Yu.V. Khaydukova, E. Kazachkov, T. Shamaeva, D. D. Voropaev, A. Voropaeva, Y. Ishchenko","doi":"10.25789/ymj.2023.81.20","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.20","url":null,"abstract":"The frequency of extremely early preterm birth (ERPR), their obstetric and perinatal outcomes, morphological features of the placenta in pregnant women in the city of Chelyabinsk and the Chelyabinsk region (CO) with a new coronavirus infection (NCI) in periods 1-2 and 3-4 waves of the COVID pandemic were studied. -19. The results obtained indicate that there is no increase in the frequency of ERPR in pregnant women with NCI. Delivery by caesarean section is associated mainly with the increase in acute respiratory distress syndrome (ARDS) of the mother. In the period of waves 3-4 of the COVID-19 pandemic, an increase in the perinatal mortality rate was noted compared to the period of waves 1-2 without statistical significance of these indicators. At the same time, antenatal fetal death during the 3rd-4th wave of the NCI pandemic was observed statistically significantly more often (p=0.033). The features of placental damage to the placentas in patients with NCI with ERPR and antenatal fetal death during the 3rd-4th wave of the pandemic are severe maternal and fetal vascular malperfusion and severe acute inflammatory lesions of the placenta (2,3 stages and 2,3 degrees).","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"36 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81137149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}