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Study of XAV-939 effect on cancer stem cells of human colorectal cancer in heterotopic models in vivo XAV-939对人结直肠癌异位模型体内肿瘤干细胞作用的研究
Yakut Medical Journal Pub Date : 2023-09-30 DOI: 10.25789/ymj.2023.83.01
А. С. Гончарова, G. Yu. Egorov, Evgeniy N. Kolesnikov, A. Yu. Maksimov, M.V. Romanova, A. B. Sagakyants, E.S. Bondarenko
{"title":"Study of XAV-939 effect on cancer stem cells of human colorectal cancer in heterotopic models in vivo","authors":"А. С. Гончарова, G. Yu. Egorov, Evgeniy N. Kolesnikov, A. Yu. Maksimov, M.V. Romanova, A. B. Sagakyants, E.S. Bondarenko","doi":"10.25789/ymj.2023.83.01","DOIUrl":"https://doi.org/10.25789/ymj.2023.83.01","url":null,"abstract":"The purpose of this study was to investigate the numbers of cells with CSC markers in samples of human colorectal cancer (CRC) xenografts isolated in animals with tumors after exposure to the small molecule XAV-939, 5-fluorouracil, and to the combination of XAV-939 with 5-fluorouracil. The model was created in Balb/c Nude mice. Tumor fragments of human CRC were transplanted into adipose tissue of animals under the skin of the right thigh. The fourth xenograft generation was used for the study. Animals were divided into groups receiving XAV-939, 5-fluorouricil, their combination, and the control group. Tumor nodes were measured twice a week; at the end of the experiment, the number of cells with the CSC phenotype was determined in the tumor material of the animals. By the end of the experiment, tumor nodules in the group of animals receiving the combination of drugs were significantly smaller than in the control group. The highest levels of cells with phenotypic signs of CSCs were characteristic of samples from the control group, and for samples obtained from the group receiving 5-fluorouracil as monotherapy. Decreased numbers of these cells were observed in groups receiving XAV-939 and the combination of XAV-939 and 5-fluorouracil. Keywords: colorectal cancer, CRC, cancer stem cells, CD44, CD133.","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"83 3","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The content of the main chemical elements in the blood serum of present-day Evenks, the indigenous ethnic group of the Russian Arctic 俄罗斯北极地区的土著民族——今天的埃文克斯人的血清中主要化学元素的含量
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.23
E. N. Sivtseva, S. S. Shadrina, T. K. Davydova, S. Sivtsev, V. Melnikov, I.A. Kirensky
{"title":"The content of the main chemical elements in the blood serum of present-day Evenks, the indigenous ethnic group of the Russian Arctic","authors":"E. N. Sivtseva, S. S. Shadrina, T. K. Davydova, S. Sivtsev, V. Melnikov, I.A. Kirensky","doi":"10.25789/ymj.2023.81.23","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.23","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84251125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical and demographic situation in the Republic of Sakha (Yakutia) 萨哈共和国(雅库特)的医疗和人口状况
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.13
L. Afanasyeva, A. Alekhnovich, A. Kalininskaya, A. V. Lazarev, M. Kizeev
{"title":"Medical and demographic situation in the Republic of Sakha (Yakutia)","authors":"L. Afanasyeva, A. Alekhnovich, A. Kalininskaya, A. V. Lazarev, M. Kizeev","doi":"10.25789/ymj.2023.81.13","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.13","url":null,"abstract":"In the Republic of Sakha (Yakutia) for the period 2015-2020, an increase in mortality and a decrease in fertility were noted, higher rates of primary morbidity were noted, including in the class of respiratory diseases, 1.4 times higher than in the Russian Federation, while the incidence rate of COVID-19 was higher;higher incidence of digestive diseases was noted (1.7 three times higher than in the Russian Federation). Indicators of primary morbidity of children and adolescents are higher than the total population in almost all classes of diseases for all 6 years of analysis (2015-2020). Differences in the indicators of primary morbidity in the uluses of the Republic of Sakha (Yakutia) by 3.3 times, which are associated with different availability of medical care in different areas of residence. The information obtained is important for the development of management decisions at the regional level.","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"25 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79219866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical parameters of blood in the mass-wrestlers during the training period 大众摔跤运动员训练期间血液生化指标的研究
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.29
E. Zasimova, A. Golderova, E. D. Okhlopkova, E.P. Kudrin, A.I. Yugova, N. A. Dmitriev
{"title":"Biochemical parameters of blood in the mass-wrestlers during the training period","authors":"E. Zasimova, A. Golderova, E. D. Okhlopkova, E.P. Kudrin, A.I. Yugova, N. A. Dmitriev","doi":"10.25789/ymj.2023.81.29","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.29","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87247589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein markers of negative effects in children under the influence of natural cold 自然寒对儿童蛋白质标志物的负面影响
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.21
N. V. Zaitseva, M. Zemlyanova, Yu. V. Koldibekova, E. V. Peskova, N. Bulatova
{"title":"Protein markers of negative effects in children under the influence of natural cold","authors":"N. V. Zaitseva, M. Zemlyanova, Yu. V. Koldibekova, E. V. Peskova, N. Bulatova","doi":"10.25789/ymj.2023.81.21","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.21","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"84 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84305296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of intraoperative use of beta-adrenoblockers in endoscopic rhinosinus surgery under general anesthesia 全麻下鼻内镜手术术中β -肾上腺素阻滞剂的应用效果
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.09
V. Pavlov, L. Kolotilov, S. Karpishchenko
{"title":"Effects of intraoperative use of beta-adrenoblockers in endoscopic rhinosinus surgery under general anesthesia","authors":"V. Pavlov, L. Kolotilov, S. Karpishchenko","doi":"10.25789/ymj.2023.81.09","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.09","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84397330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of vitamin D level as a factor of bronchial asthma control in children of the Amur region 评估维生素D水平对阿穆尔河地区儿童支气管哮喘控制的影响
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.03
E. Suprun, S. Suprun, N. Kuderova, G. Evseeva, O. Lebedko
{"title":"Assessment of vitamin D level as a factor of bronchial asthma control in children of the Amur region","authors":"E. Suprun, S. Suprun, N. Kuderova, G. Evseeva, O. Lebedko","doi":"10.25789/ymj.2023.81.03","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.03","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"92 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79608573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relative leukocyte telomere length in patients with chronic alcohol addiction depending on clinical and anamnestic characteristics 慢性酒精成瘾患者的相对白细胞端粒长度取决于临床和记忆特征
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.01
A. Kazantseva, Y. Davydova, G. Faskhutdinova, R. Enikeeva, Y. Fedorova, A. Gareeva, A. Asadullin, A. Mikhailova, R. Valinurov, E. Khusnutdinova
{"title":"Relative leukocyte telomere length in patients with chronic alcohol addiction depending on clinical and anamnestic characteristics","authors":"A. Kazantseva, Y. Davydova, G. Faskhutdinova, R. Enikeeva, Y. Fedorova, A. Gareeva, A. Asadullin, A. Mikhailova, R. Valinurov, E. Khusnutdinova","doi":"10.25789/ymj.2023.81.01","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.01","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"172 ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72545671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association analysis of polymorphic variants in ALDH7A1, AOC1, PSAP, ADCYAP1 genes involved in the histamine metabolism with asthma development in individuals from the republic of Bashkortostan 巴什科尔托斯坦共和国个体中参与组胺代谢的ALDH7A1、AOC1、PSAP、ADCYAP1基因多态性变异与哮喘发展的相关性分析
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.02
O. N. Savelieva, A. Karunas, Y. Fedorova, A.O. Vlasova, A. Biktasheva, R. Gatiyatullin, E. Etkina, E. Khusnutdinova
{"title":"Association analysis of polymorphic variants in ALDH7A1, AOC1, PSAP, ADCYAP1 genes involved in the histamine metabolism with asthma development in individuals from the republic of Bashkortostan","authors":"O. N. Savelieva, A. Karunas, Y. Fedorova, A.O. Vlasova, A. Biktasheva, R. Gatiyatullin, E. Etkina, E. Khusnutdinova","doi":"10.25789/ymj.2023.81.02","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.02","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77496513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of the elemental composition of the hair of children living in areas with different anthropogenic load 不同人为负荷地区儿童头发元素组成特征
IF 0.1
Yakut Medical Journal Pub Date : 2023-01-01 DOI: 10.25789/ymj.2023.81.15
G. R. Allayarova, T. K. Larionova, R. Daukaev, E. E. Zelenkovskaya, S. R. Afonkina, E. Aukhadieva, D. E. Musabirov
{"title":"Features of the elemental composition of the hair of children living in areas with different anthropogenic load","authors":"G. R. Allayarova, T. K. Larionova, R. Daukaev, E. E. Zelenkovskaya, S. R. Afonkina, E. Aukhadieva, D. E. Musabirov","doi":"10.25789/ymj.2023.81.15","DOIUrl":"https://doi.org/10.25789/ymj.2023.81.15","url":null,"abstract":"","PeriodicalId":42701,"journal":{"name":"Yakut Medical Journal","volume":"54 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81388735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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