Major Histocompatibility Complex最新文献

筛选

英文中文

Immune profiling and immune monitoring for organ transplantation 器官移植的免疫分析和免疫监测

Major Histocompatibility Complex Pub Date : 1900-01-01 DOI: 10.12667/mhc.28.94

H. Ohdan

{"title":"Immune profiling and immune monitoring for organ transplantation","authors":"H. Ohdan","doi":"10.12667/mhc.28.94","DOIUrl":"https://doi.org/10.12667/mhc.28.94","url":null,"abstract":"It is practicable to extract immunologically high-risk cases, which may be at risk of rejection or infection with uniform immunosuppressive therapy, on the basis of genomic information of immune function molecules, and to apply focused personalized immunosuppressive therapy by immune-monitoring. Therefore, we comprehensively analyzed the candidate gene polymorphisms of immune-related molecules associated with organ transplantation outcomes. Among them, we found that single nucleotide polymorphisms (SNPs) of FcγR genes FCGR2A (rs 1801274) [131 H/R] and FCGR3A (rs396991) [158 F/V] were significantly associated with the onset and causative organisms of sepsis in liver transplant recipients and urinary tract infection in kidney transplant recipients, and that SNP of FOXP 3 promoter region (rs3761547) [33499 A/G] was associated with sensitivity of liver transplant recipients to pulsed steroid therapy, which is used to treat acute rejection. We performed a mixed lymphocyte reaction assay using carboxyfluorescein diacetate succinimidyl ester (CFSE) cytoplasmic staining and multiparameter flow cytometry to minimize immunosuppressive therapy in the recipients with risk factors to optimize the dosage of immunosuppressive drugs by fine tuning based on immune-monitoring.","PeriodicalId":426753,"journal":{"name":"Major Histocompatibility Complex","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121294457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HLA antibody testing criteria and interpretation of the results HLA抗体检测标准及结果解释

Major Histocompatibility Complex Pub Date : 1900-01-01 DOI: 10.12667/mhc.26.95

F. Nakajima

引用次数: 0

首页上一页