The Turkish Journal of Endocrinology and Metabolism最新文献

{"title":"Comparison of Mental Health and Quality of Life in Euthyroid Patients Under Levothyroxine Mono-therapy Based on the Causes of Hypothyroidism","authors":"M. Hemmatabadi, Nasrin Asgari- -SORAN, F. Esfahanian, Elham Sharafi, M. Qorbani, Nooshin Shirza","doi":"10.25179/tjem.2021-83124","DOIUrl":"https://doi.org/10.25179/tjem.2021-83124","url":null,"abstract":"*Department of Endocrinology, Vali-Asr Hospital, Endocrinology and Metabolism Research Center, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, IRAN **Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IRAN ***Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, IRAN ****Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, IRAN Original Article Turk J Endocrinol Metab. 2021;25:288-294","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133764548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study of the Prevalence of Cardiovascular Disease in Adults with Type 2 Diabetes in Türkiye: The CAPTURE Study","authors":"F. Bayram, T. Bayraktaroğlu, M. Sargin, I. Sahin, Sibel Güldiken, Ayşegül Dalbeler, A. Sönmez","doi":"10.25179/tjem.2021-86803","DOIUrl":"https://doi.org/10.25179/tjem.2021-86803","url":null,"abstract":"Division of Endocrinology and Metabolism, Erciyes University Faculty of Medicine, Kayseri, TURKIYE *Division of Endocrinology and Metabolism, Zonguldak Bülent Ecevit University Obesity and Diabetes Application and Research Center, Zonguldak, TURKIYE **Department of Family Medicine, İstanbul Medeniyet University Faculty of Medicine, İstanbul, TURKIYE ***Division of Endocrinology and Metabolism, İnönü University Faculty of Medicine, Malatya, TURKIYE ****Division of Endocrinology and Metabolism, Trakya University Faculty of Medicine, Edirne, TURKIYE *****Medical and Scientific Affairs Department/CMRQ, Novo Nordisk Health Products Tic. Ltd. Şti., İstanbul, TURKIYE ******Division of Endocrinology and Metabolism, University of Health Sciences Gülhane Faculty of Medicine, Ankara, TURKIYE Original Research","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133906862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and Clinical Features of Medullary Thyroid Carcinoma","authors":"P. Şişman, B. Bicer, H. Oztop, S. Cander, O. O. Gul, G. Ocakoglu, C. Ersoy, E. Ertürk","doi":"10.25179/tjem.2019-66818","DOIUrl":"https://doi.org/10.25179/tjem.2019-66818","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133012826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Spectrum and Outcome of Patients with Graves’ Disease: A Single-Center Experience from a Tertiary Care Institution in the Kashmir Valley, India","authors":"Mohammad Hayat Bhat, J. Bhat, S. Masoodi, W. Qureshi, Junaid Rashid Dar, M. Bhat","doi":"10.25179/TJEM.2020-77446","DOIUrl":"https://doi.org/10.25179/TJEM.2020-77446","url":null,"abstract":"Objective: Graves’ disease (GD) is a common autoimmune disorder with variable outcomes. We aim to study the clinical manifestations and treatment outcome of GD in the post-iodization scenario. Material and Methods: The present study was designed as a cross-sectional study, in which a total of 180 patients with GD (127 males and 53 females) attending our center were reviewed retrospectively. The demographic data, modes of treatment, comorbidities, remission, and recurrence rates were determined for the patients. All patients were initially treated with anti-thyroid drugs (ATDs), with the subsequent management depending on the course of the disease. Results: The mean (±SD) age at diagnosis was 38.30 (10.73) years and the lag period between the onset of symptoms and the diagnosis was 5.12 (2.69) months, with the male patients having a significantly shorter duration of illness compared to females (4.36 vs. 5.44 months; P=0.015). Majority of the patients presented with the typical symptoms and signs associated with hyperthyroidism and/or goiter, although the atypical presentations were not uncommon. ATDs were the most preferred treatment modality employed to achieve clinical and biochemical remission. The mean duration of achieving euthyroidism and the normalization of TSH levels were 3.31±1.51 and 7.45±3.35 months, respectively. On follow-up at three months, 46.1% of the patients were euthyroid, with normalization of the TSH levels in 15.6% of them. Failure to achieve early remission/disease control was significantly higher in males (p=0.003) and smokers (p=0.036). Among the 72 patients who completed medical therapy, 49 patients achieved remission, of whom 20 patients relapsed with a first-year relapse rate of 20.4%. Disease relapse was significantly associated with higher initial 99 mTechnetium (99mTc) uptake (p=0.022) and higher grade of goiter (p=0.026) at presentation. The logistic regression analysis revealed male gender (p=0.048) and orbitopathy (p=0.036) as the independent risk factors predicting relapse of the GD. Conclusion: Graves’ disease manifests with varied clinical manifestations, including the atypical ones, warranting careful clinical assessment to ensure an accurate diagnosis. Gender and orbitopathy are the independent risk factors predicting the relapse of the disease.","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115874586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Role of Ga–68 DOTATATE PET-CT in a Patient with Neuroendocrine Tumor and Second Primary Cancer","authors":"T. Telli, M. Tuncel, S. Kılıçkap","doi":"10.25179/tjem.2018-62733","DOIUrl":"https://doi.org/10.25179/tjem.2018-62733","url":null,"abstract":"D O I: 10 .2 51 79 /t je m .2 01 862 73 3 A 70-year-old female with the diagnosis of the metastatic neuroendocrine tumor was referred to our clinic with new abdominal lymph nodes in computed tomography (CT). This finding was considered as the disease progression, and Capecitabine along with Temozolomide was added to her current Lanreotide therapy. The origin of the new lymph nodes was uncertain due to no response to chemotherapy and the stability of the lymph nodes. 68Ga-DOTATATE PET-CT was performed to resolve the inconsistency in clinical and imaging findings. PET-CT images showed high 68GaDOTATATE uptake in abdominal, cervical, left supraclavicular lymph nodes, and few metastatic foci in the liver, which were compatible with a neuroendocrine tumor. Additionally, there were bilaterally enlarged lymph nodes in the neck, axillary, intra-abdominal and inguinal area with no tracer uptake. The incongruent findings of PET-CT suggested a biopsy of non-radio-avid lymph nodes for the possible exclusion of other etiologies. Biopsy revealed that the enlargement of the lymph nodes was caused by small lymphocytic lymphoma (SLL) rather than neuroendocrine metastases. 68GaDOTATATE PET-CT led to a critical change in the disease management and confirmed the diagnosis of the secondary tumor with the aid of biopsy. A high radiotracer uptake of neuroendocrine metastases on Ga-68 DOTATATE PET-CT suggested to change the chemotherapy (Capecitabine + Temozolomide) to Y-90/Lu-177 DOTATATE therapy, which led to disease stabilization and minor regression. Her newly diagnosed stable SLL was followed accordingly. It can be concluded that 68Ga-DOTATATE PET-CT plays a critical role in the management of patients with neuroendocrine tumors and should be used as a problem solving tool in patients with the discrepancy between clinical and imaging findings.","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131019267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine is Strongly Associated with Central Obesity Than with General Obesity: A Case-Control Study","authors":"Bilal Natiq Nuaman, Asaad M M Sadik","doi":"10.25179/TJEM.2018-63282","DOIUrl":"https://doi.org/10.25179/TJEM.2018-63282","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126676295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Atypical Femur Fracture in a Patient Under Bisphosphonate Treatment","authors":"D. Karamanlioğlu, M. Kaysin, Naciye Bilgin Badur, F. Ozkan, I. Aktas","doi":"10.25179/tjem.2018-64415","DOIUrl":"https://doi.org/10.25179/tjem.2018-64415","url":null,"abstract":"Introduction Typical characteristics of osteoporosis include low bone mass with microarchitectural disruption and skeletal fragility, with increased risk of vertebral and nonvertebral fracture (1). Bisphosphonates suppress osteoclast activity, resulting in the inhibition of bone resorption. The beneficial effects of bisphosphonates on prevention of vertebral and nonvertebral osteoporotic fractures and increase in bone mineral density have been substantiated by several clinical trial data (2-4). Despite the beneficial effects of bisphosphonates, a meta-analysis of six cohorts and five case-control studies reported an increased risk of atypical fracture in bisphosphonate users (5). Vitamin D deficiency is a co-determinant causing fractures, which is a common issue, especially in the elderly population. Clinical studies indicate an association between vitamin D deficiency, osteoporosis, and increased risk of fractures due to falls (6-9). We present here the case of a 79-year-old woman who has been on bisphosphonate treatment for eight years (alendronate for five years, ibandronate for three years). She had bilateral femur diaphyseal fractures occurring within an interval of few months. Laboratory results indicated vitamin D deficiency. We also attempted to investigate the association of atypical femur fractures with the long-term use of bisphosphonate and with vitamin D deficiency.","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117321847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Washout in Fine-Needle Aspiration Fluid for Preoperative Diagnosis of Suspicious Lesion in Patients with Insulinoma: A Case Report","authors":"M. Kocabaş, M. Karakose, M. Can, H. Ataseven, İ. Çordan, M. Kulaksızoğlu, F. Karakurt","doi":"10.25179/TJEM.2019-65964","DOIUrl":"https://doi.org/10.25179/TJEM.2019-65964","url":null,"abstract":"®Copyright 2019 by Turkish Journal of Endocrinology and Metabolism Association Turkish Journal of Endocrinology and Metabolism published by Türkiye Klinikleri Insulin Washout in Fine-Needle Aspiration Fluid for Preoperative Diagnosis of Suspicious Lesion in Patients with Insulinoma: A Case Report İnsülinoma Hastalarında Şüpheli Lezyonun Preoperatif Tanısı İçin İnce İğne Aspirasyon Sıvısında İnsülin Yıkama: Bir Olgu Sunumu","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123631492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Diseases, Metformin and the AMP Kinase Pathway","authors":"U. Soyaltin, G. Özgen, T. Kabalak","doi":"10.25179/tjem.2021-85359","DOIUrl":"https://doi.org/10.25179/tjem.2021-85359","url":null,"abstract":"Introduction Thyroid hormone and adenosine monophosphate-activated protein kinase (AMPK) are 2 major determinants of energy balance. Thyroid hormone is known to be a key factor that stimulates energy use in energy balance. It is involved in almost every stage of energy use. The uptake of energy substances into the cell, their conversion to adenosine triphosphate (ATP) in the mitochondria, and the use of ATP in all cellular processes where energy is required are under the stimulating control of tri-iodothyronine and partially 3,5-diiodo-L-thyronine. A deficiency in thyroid hormone production results in ineffective utilization of energy substrates in the cell, despite their sufficient level. A well-known example of this condiAn increase in the adenosine monophosphate (AMP)/adenosine triphosphate ratio activates AMP-activated protein kinase (AMPK), leading to inhibition of the mammalian target of rapamycin signaling pathway that is associated with autophagy, mitochondriogenesis, glucose uptake, mRNA stabilization, and cell cycle regulation. Metformin activates AMPK and inhibits mitochondrial oxidative phosphorylation. Currently, there is an increasing interest in investigating the effects of metformin on thyroid diseases. Recent data show an association between metformin treatment and lower incidence of thyroid cancer, better survival of patients with thyroid cancer, and lower thyroid volume and nodule size. Insulin-like growth factor receptor and AKT pathways are the AMPK-independent mechanisms through which metformin acts on thyroid diseases. Although metformin has a promising role in adjuvant therapy for thyroid cancers, welldesigned prospective trials are required before reaching a final decision.","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134115081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-free DNA as a Clinical Indicator in Maternal Blood","authors":"Hanan L. Al-Omary, Zainab M. Alawad, B. Husseini","doi":"10.25179/tjem.2019-65572","DOIUrl":"https://doi.org/10.25179/tjem.2019-65572","url":null,"abstract":"I. Thehistoryof cell-freeDNA(cfDNA)discovery Cell-free DNA (cfDNA) was discovered in 1948 by Mandel and Mëtais, who observed the existence of free nucleic acids in plasma (1). They found free DNA and RNA in the plasma of healthy as well as unhealthy people. In 1965, Bendich et al. suggested that cfDNA from cancer tissue could be involved in cancer metastasis. In 1966, Tan et al. found an enormous amount of cfDNA in the blood of patients with systemic lupus erythematosus (2). Technological limitations delayed the confirmation of use of cfDNA as an indicator of diseases. Figure 1 shows the presence of cfDNA in blood (3). II. Definition of cfDNA cfDNA means DNA fragments present outside the nucleus of a cell. cfDNA is mainly produced by an apoptotic or necrotic process. The fragments are also present in body fluids, so they can be considered as biological markers of pathological states (4). cfDNA has also been discovered in human seminal fluid (5).","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"57 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132360584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}