Johana Andrea Lineros-Hurtado, Pilar Romero-Romero, Yuly Milena Salgado-Lerma, Carolina Wiesner-Ceballos
{"title":"Características operativas de técnicas moleculares empleadas para la detección del virus del papiloma humano en el proyecto ESTAMPA","authors":"Johana Andrea Lineros-Hurtado, Pilar Romero-Romero, Yuly Milena Salgado-Lerma, Carolina Wiesner-Ceballos","doi":"10.35509/01239015.106","DOIUrl":"https://doi.org/10.35509/01239015.106","url":null,"abstract":"The development and innovation of new technologies has improved the detection of high-risk human papillomavirus infection. Hybrid capture II is an assay that is based on hybridization and chemiluminescence. Cobas HPV Test is a qualitative PCR and Aptima HPV Assay allows to detect the expression of messenger RNA of the high-risk HPV E6 / E7 oncoproteins. These techniques have advantages, in comparison, with conventional cytology that is routinely used for the detection of cervical cancer. In the ESTAMPA study, 13,691 prosecutions were carried out that allowed to identify that for the planning of research projects or for the implementation of HPV screening tests, it is necessary to analyze the advantages and disadvantages of market tests.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48230984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In memoriam Jose Fernando Robledo","authors":"C. Duarte","doi":"10.35509/01239015.721","DOIUrl":"https://doi.org/10.35509/01239015.721","url":null,"abstract":"Es difícil expresar los sentimientos ante la pérdida de un colega y amigo que fue parte del Instituto Nacional de Cancerología (INC) y un gran líder clínico en el campo de la mastología a nivel nacional. El Dr. José Fernando Robledo realizó sus estudios de cirugía general, cirugía de mama y de tejidos blandos en el INC desde 1983 hasta 1989 donde entró a formar parte del Grupo de mama y tejidos blandos.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43932132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retos para el control del cáncer en Colombia: ante todo más acción.","authors":"L. Gonzalez","doi":"10.35509/01239015.712","DOIUrl":"https://doi.org/10.35509/01239015.712","url":null,"abstract":"La disminucion de la mortalidad por Cancer de Mama, demostrada en algunos paises del mundo, se ha conseguido gracias a la administracion de tratamientos oportunos e integrales y posiblemente a una estrategia de tamizacion formal que incluya a la mamografia como eje principal. La funcion principal de la mamografia de tamizacion es el diagnostico temprano de la enfermedad para lograr reducir la mortalidad por esta causa. \u0000La implementacion de estrategias de deteccion temprana en cancer de mama, en Colombia, intenta ejecutarse bajo importantes limitaciones y logisticas de nuestro sistema de salud. Estas estrategias se han venido construyendo de la mano de centros de tratamiento oncologico integral como el INC, asociaciones cientificas y la experiencia de cientos de medicos especialistas en el manejo de dicha enfermedad.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48398806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Alejandra Baquero Serrano, Luis Andrés López Martínez, Silvia Nathalia Vera Campos, Sergio Andrés Rosales Rueda, Natalia Jaramillo Botero, Miguel Ochoa Vera
{"title":"Prevalencia de tejido mamario denso en una población en la ciudad de Bucaramanga, Colombia","authors":"María Alejandra Baquero Serrano, Luis Andrés López Martínez, Silvia Nathalia Vera Campos, Sergio Andrés Rosales Rueda, Natalia Jaramillo Botero, Miguel Ochoa Vera","doi":"10.35509/01239015.94","DOIUrl":"https://doi.org/10.35509/01239015.94","url":null,"abstract":"Introduction: The presence of dense breast tissue in women is a condition that makes it difficult to assess and adequately interpret mammography, possibly masking suspicious lesions of malignancy. Recent studies suggest the performance of complementary studies for the screening and diagnostic approach of these patients. \u0000Objective: To establish the prevalence of women over 50 with dense breasts in Bucaramanga city studied by mammography and evaluate the performance of complementary studies \u0000Materials and methods: A retrospective descriptive study was conducted during the period from January 1, 2014 to August 31, 2015, 10,110 mammograms were reviewed in patients over 50 years of age. Subsequently, a review of the literature in the main databases was made. \u0000Results: 10110 mammograms were performed, 4448 were found to be positive for dense breast. 39.69% was heterogeneously dense breast tissue, and 4.29% extremely dense; The result was 43.9% patients with positive dense breasts \u0000Discussion: Breast density is an independent risk factor for breast cancer, being of medium importance compared to other factors. As the breast density increases, the overlap of the radiopaque breast tissue that can hide and delay the diagnosis of an underlying cancer is generated \u0000Conclusion: Given the high prevalence of dense breast tissue found in our population, current evidence suggests complementing screening with other imaging methods, individualizing each patient.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43108434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vacunas basadas en neoantígenos y control del cáncer: perspectivas","authors":"Raúl Hernando Murillo Moreno","doi":"10.35509/01239015.195","DOIUrl":"https://doi.org/10.35509/01239015.195","url":null,"abstract":"La supervivencia global y la calidad de vida son objetivos primarios del tratamiento del cáncer. El desarrollo de terapias blanco promovió el concepto de tratamientos personalizados, los que se han evaluado principalmente mediante desenlaces centrados en el tumor y han tenido foco en tumores de baja frecuencia y estados avanzados. La inmunoterapia rompe esta tendencia y genera expectativa por su efecto en la supervivencia global y su potencial uso en una gama amplia de tumores. Dentro de esta, las vacunas basadas en neoantígenos han mostrado alta eficacia y seguridad debido a su afinidad con células T y su elevada especificidad. Basado en sus principios biológicos se revisa su posible impacto en la carga de enfermedad según la relación entre potencial inmunogénico y prevalencia por tipo de tumor, el posible efecto en la práctica clínica por su combinación con otras modalidades de tratamiento, y el efecto en el acceso al tratamiento dado su proceso de desarrollo y producción y la disponibilidad de información propia.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45087089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carolina Wiesner-Ceballos, D. Puerto, Sandra Diaz-Casas, O. Sánchez, Raul Hernando-Murillo, L. Bravo
{"title":"Políticas basadas en la evidencia científica: el caso del control del cáncer de mama en Colombia","authors":"Carolina Wiesner-Ceballos, D. Puerto, Sandra Diaz-Casas, O. Sánchez, Raul Hernando-Murillo, L. Bravo","doi":"10.35509/01239015.261","DOIUrl":"https://doi.org/10.35509/01239015.261","url":null,"abstract":"Colombia ranks at an intermediate risk leve/ regarding the development of breast cancer, with an age-standardized incidence rate of 44.1 per 100,000 women. Although mammography screening and annual Clinical Breast Examination for women aged 50 to 69 are recommended in Colombia, as well as early detection for symptomatic women regardless of age, mortality from this cause has not been reduced in Colombia. Multiple causes seem to explain this problem: low participation of the target population in mammography screening activities, poor quality of mammography, and access barriers for timely diagnosis and comprehensive treatment. In view of this problem, the House of Representatives approved in first debate last October 3 Bill no. 259 of 2019 \"by means of which measures and other provisions for prevention, diagnosis, timely treatment, rehabilitation, and palliative care of breast cancer are set up\". The Colombian Ilational Cancer Institute IIIC, held a forum on December 9, 2019, aimed at reviewing the scientific support of the content of the bill and contribute to its proper discussion. The purpose of this paper is to present the analysis of the most controversial points from a scientific perspective, as a basis for appropriate decision-making in public health policy.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43753518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patricia Cruz-Castellanos, L. Gutiérrez, D. Sánchez-Cabrero, F. Castro
{"title":"Pancreatitis aguda en carcinoma de célula pequeña de pulmón (CPCP) resulta con quimioterapia","authors":"Patricia Cruz-Castellanos, L. Gutiérrez, D. Sánchez-Cabrero, F. Castro","doi":"10.35509/01239015.15","DOIUrl":"https://doi.org/10.35509/01239015.15","url":null,"abstract":"Small cell lung cancer is a subtype of neoplasm that has typically been associated with smoking and is characterized by its aggressiveness and poor prognosis in the short term. As an entity it can metastasize in any organ, but pancreatic metastases are rare and most of the time asymptomatic. Therefore, the presence of neoplastic pancreatitis as in our case is exceptional and even more so when it presents refractoriness to conventional medical treatment, responding instead to systemic cytotoxic treatment. Therefore, we expose our clinical experience and discuss the presence of this rare entity and its management.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"88-91"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42329993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validación para utilización en Colombia de la escala EORTC QLQ C-30 para evaluación de la calidad de vida de los pacientes con cáncer","authors":"Ricardo Sánchez Pedraza, Adriana Valderamar","doi":"10.35509/01239015.128","DOIUrl":"https://doi.org/10.35509/01239015.128","url":null,"abstract":"Objective: To validate the Colombian version of the EORTC QLQ-C30 questionnaire for measuring the quality of life in patients with cancer in Colombia. \u0000Methods: The validity of the questionnaire was evaluated using exploratory and confirmatory analyses. In addition, correlation between domains of EORTC QLQ-C30 and FACT-G was used to measure concurrent validity. For measuring reliability, internal consistency analyses (Cronbach Alpha, McDonald’s Omega and GLB coefficients) and repeated measures analyses were performed. \u0000Results: A total of 486 patients recruited at the National Cancer Institute (Instituto Nacional de Cancerologia), in Colombia, were included in the study. Both, the standard model (14 domains) and an empirical solution having 5 domains (Physical, Psychological, Weakness, Socioeconomic and Global Score) showed to be adequate for representing the construct. The correlation between domains of FACT-G and EORTC QLQ-C30 showed low values in the domains related with social functioning. The correlation between repeated measures had values of correlation-concordance between 0.51 and 0.8; the limits of agreement of Bland and Altman scored between -38 and 43 around an expected value of 0. The values of Cronbach’s Alpha, GLB and McDonald’s Omega had values of 0.94 – 0.96 and 0.93, respectively. \u0000Conclusion: The EORTC QLQ-C30 questionnaire is a valid and reliable tool for measuring the quality of life of patients with cancer in Colombia.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"61-71"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47575803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaranto Suarez Matos, Ingrid Aristizábal, Ana María Infante, C. Narváez, L. Barajas, M. Piña, G. Rincón, A. Calderón
{"title":"Mejoría en la supervivencia de los niños con leucemia mieloide aguda en el Instituto Nacional de Cancerología de Colombia","authors":"Amaranto Suarez Matos, Ingrid Aristizábal, Ana María Infante, C. Narváez, L. Barajas, M. Piña, G. Rincón, A. Calderón","doi":"10.35509/01239015.16","DOIUrl":"https://doi.org/10.35509/01239015.16","url":null,"abstract":"Objective: Describe the demographic and clinical characteristics of patients with acute myeloid leukemia, and evaluate the mortality and survival of children treated with the LMA-INC 2004 protocol (modified from BFM 93) in our pediatric oncology clinic of the National Cancer Institute of Colombia between May 2002 and December 2014. \u0000Patients and methods: Retrospective descriptive observational study of a cohort with survival analysis of patients under 18 years of age with a diagnosis of acute myeloid leukemia treated with intensive chemotherapy without maintenance or transplantation. \u0000Results: We analyzed 41 patients diagnosed with myeloid leukemia except acute myeloid leukemia type M3, who were, treated with LMA-INC 2004 protocol. Complete remission was achieved in 75.6% of patients. The annual relapse rate was 27.4% and the death rate 20.3%. Cumulative overall survival at 2 and 5 years was 60% and 53.5%, respectively, with an average follow-up of 4.3 years (3.2 - 5.2 years); and the 5-year relapse-free survival was 42% with an average follow-up time of 3.5 years (3.3 - 4.6 years). \u0000Conclusion: The results showed a 30% improvement in the survival of patients with acute myeloid leukemia attributed to a more intense treatment that included the administration of high doses of cytarabine and mitoxantrone in consolidation and intensification; which implies improvement in supportive care.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"72-79"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44372730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Necesitamos menos investigación!","authors":"Jairo Echeverry","doi":"10.35509/01239015.700","DOIUrl":"https://doi.org/10.35509/01239015.700","url":null,"abstract":"Con casi medio millón de citaciones encontradas en Google Académico como coautor de investigaciones en el campo y en estándares de estadística y ublicación biomédica, desde su posición como profesor de la Universidad de Oxford, director del Centro de Estadística en Medicina y de la investigación en Cáncer del Reino Unido, de la Colaboración Cochrane y de la red EQUATOR2 , Altman transformó la manera tradicional en que se presentaban los resultados de las investigaciones, promocionando y divulgando los staments para el sometimiento de manuscritos ante las revistas. Esto significa, se 2 infiere, que debe existir una especie de método de publicación para cada tipo de investigación que tiene que ver con la pregunta y los métodos empleados.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"57-60"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42131712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}