Biomedical Engineering and Computational Biology最新文献_第8页

Computational Identification of Putative miRNAs from Felis Catus 猫类推测mirna的计算鉴定

IF 2.8

Biomedical Engineering and Computational Biology Pub Date : 2010-01-01 DOI: 10.4137/BECB.S5233

G. Sathyamurthy, N. Swamy

{"title":"Computational Identification of Putative miRNAs from Felis Catus","authors":"G. Sathyamurthy, N. Swamy","doi":"10.4137/BECB.S5233","DOIUrl":"https://doi.org/10.4137/BECB.S5233","url":null,"abstract":"microRNAs represent a class of noncoding small RNAs of approximately 20–23 nt length, which are evolutionarily conserved and play a vital role in various biological processes by either degrading or repressing mRNA translation. The Felis catus (cat) genome sequence has been published, and just revealed the number of miRNAs in the genome–-without mention of any further details on these miRNAs. This paper discusses an in silico comparative approach using all known sequences of vertebrate pre-miRNA as query sequence, and report 405 putative miRNAs from cat genome. We determine the identity values of pre-miRNAs and mature miRNAs besides statistical sequence characteristics. Interestingly, among 405 miRNAs–-90, 53 and 50 showed 100% identity to cattle, human and dog, respectively. Further, we have validated 6 miRNAs, whose identity are <85% with the query sequence and validated them using MiPred algorithm. We also identify 25 miRNA clusters in cat based on their homologs in other vertebrates. Most importantly, based on identities among pre-miRNA, mature miRNA, miRNA families and clusters, we observe that miRNAs from cat are more identical to cattle, than humans. Our results, therefore may add a new dimension to the studies related to the evolution of cat.","PeriodicalId":42484,"journal":{"name":"Biomedical Engineering and Computational Biology","volume":"2 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BECB.S5233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70685951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Design of Druglike Small Molecules for Possible Inhibition of Antiapoptotic BCL-2, BCL-W, and BFL-1 Proteins 可能抑制抗凋亡BCL-2、BCL-W和bcl -1蛋白的类药物小分子设计

IF 2.8

Biomedical Engineering and Computational Biology Pub Date : 2010-01-01 DOI: 10.4137/BECB.S5575

D. S. Dalafave

引用次数: 7

IF 2.8

Biomedical Engineering and Computational Biology Pub Date : 2010-01-01 DOI: 10.4137/BECB.S5546

O. Bai, Dandan Huang, P. Lin, Jinglong Wu, Xuedong Chen, D. Fei

{"title":"An Event-Related Study for Dynamic Analysis of Corticomuscular Connectivity","authors":"O. Bai, Dandan Huang, P. Lin, Jinglong Wu, Xuedong Chen, D. Fei","doi":"10.4137/BECB.S5546","DOIUrl":"https://doi.org/10.4137/BECB.S5546","url":null,"abstract":"Corticomuscular coupling estimated by EEG-EMG coherence may reveal functional cortical driving of peripheral muscular activity. EEG-EMG coherence in the beta band (15–30 Hz) has been extensively studied under isometric muscle contraction tasks. We attempted to study the time-course of corticomuscular connectivity under a dynamic target tracking task. A new device was developed for the real-time measurement of dynamic force created by pinching thumb and index fingers. Four healthy subjects who participated in this study were asked to track visual targets with the feedback forces. Spectral parameters using FFT and complex wavelet were explored for reliable estimation of event-related coherence and EEG-EMG correlogram for representing corticomuscular connectivity. Clearly distinguishable FFT-based coherence and cross-correlogram during the visual target tracking were observed with appropriate hyper-parameters for spectral estimation. The system design and the exploration of signal processing methods in this study supports further exploration of corticomuscular connectivity associated with human motor control.","PeriodicalId":42484,"journal":{"name":"Biomedical Engineering and Computational Biology","volume":"2 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BECB.S5546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70685997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

On Robust State Estimation of Gene Networks 基因网络的鲁棒状态估计

IF 2.8

Biomedical Engineering and Computational Biology Pub Date : 2010-01-01 DOI: 10.1177/117959721000200001

Chia-Hua Chuang, Chun‐Liang Lin

引用次数: 6

Biomedical Engineering and Computational Biology 生物医学工程与计算生物学

IF 2.8

Biomedical Engineering and Computational Biology Pub Date : 2009-01-01 DOI: 10.1177/117959720900100001

K. Najarian

引用次数: 9