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Design of Druglike Small Molecules for Possible Inhibition of Antiapoptotic BCL-2, BCL-W, and BFL-1 Proteins 可能抑制抗凋亡BCL-2、BCL-W和bcl -1蛋白的类药物小分子设计
IF 2.8
Biomedical Engineering and Computational Biology Pub Date : 2010-01-01 DOI: 10.4137/BECB.S5575
D. S. Dalafave
{"title":"Design of Druglike Small Molecules for Possible Inhibition of Antiapoptotic BCL-2, BCL-W, and BFL-1 Proteins","authors":"D. S. Dalafave","doi":"10.4137/BECB.S5575","DOIUrl":"https://doi.org/10.4137/BECB.S5575","url":null,"abstract":"New druglike small molecules with possible anticancer applications were computationally designed. The molecules formed stable complexes with antiapoptotic BCL-2, BCL-W, and BFL-1 proteins. These findings are novel because, to the best of the author's knowledge, molecules that bind all three of these proteins are not known. A drug based on them should be more economical and better tolerated by patients than a combination of drugs, each targeting a single protein. The calculated drug-related properties of the molecules were similar to those found in most commercial drugs. The molecules were designed and evaluated following a simple, yet effective procedure. The need for substantial computational resources often precludes researchers in many countries and small institutions from participating in the field. The procedure presented here offsets the problem by reducing the cost of involvement. The procedure can be used efficiently in the early phases of drug discovery to evaluate promising lead compounds in time- and cost-effective ways.","PeriodicalId":42484,"journal":{"name":"Biomedical Engineering and Computational Biology","volume":"2 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BECB.S5575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70686011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
An Event-Related Study for Dynamic Analysis of Corticomuscular Connectivity 皮质肌连通性动态分析的事件相关研究
IF 2.8
Biomedical Engineering and Computational Biology Pub Date : 2010-01-01 DOI: 10.4137/BECB.S5546
O. Bai, Dandan Huang, P. Lin, Jinglong Wu, Xuedong Chen, D. Fei
{"title":"An Event-Related Study for Dynamic Analysis of Corticomuscular Connectivity","authors":"O. Bai, Dandan Huang, P. Lin, Jinglong Wu, Xuedong Chen, D. Fei","doi":"10.4137/BECB.S5546","DOIUrl":"https://doi.org/10.4137/BECB.S5546","url":null,"abstract":"Corticomuscular coupling estimated by EEG-EMG coherence may reveal functional cortical driving of peripheral muscular activity. EEG-EMG coherence in the beta band (15–30 Hz) has been extensively studied under isometric muscle contraction tasks. We attempted to study the time-course of corticomuscular connectivity under a dynamic target tracking task. A new device was developed for the real-time measurement of dynamic force created by pinching thumb and index fingers. Four healthy subjects who participated in this study were asked to track visual targets with the feedback forces. Spectral parameters using FFT and complex wavelet were explored for reliable estimation of event-related coherence and EEG-EMG correlogram for representing corticomuscular connectivity. Clearly distinguishable FFT-based coherence and cross-correlogram during the visual target tracking were observed with appropriate hyper-parameters for spectral estimation. The system design and the exploration of signal processing methods in this study supports further exploration of corticomuscular connectivity associated with human motor control.","PeriodicalId":42484,"journal":{"name":"Biomedical Engineering and Computational Biology","volume":"2 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BECB.S5546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70685997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
On Robust State Estimation of Gene Networks 基因网络的鲁棒状态估计
IF 2.8
Biomedical Engineering and Computational Biology Pub Date : 2010-01-01 DOI: 10.1177/117959721000200001
Chia-Hua Chuang, Chun‐Liang Lin
{"title":"On Robust State Estimation of Gene Networks","authors":"Chia-Hua Chuang, Chun‐Liang Lin","doi":"10.1177/117959721000200001","DOIUrl":"https://doi.org/10.1177/117959721000200001","url":null,"abstract":"Gene networks in biological systems are not only nonlinear but also stochastic due to noise corruption. How to accurately estimate the internal states of the noisy gene networks is an attractive issue to researchers. However, the internal states of biological systems are mostly inaccessible by direct measurement. This paper intends to develop a robust extended Kalman filter for state and parameter estimation of a class of gene network systems with uncertain process noises. Quantitative analysis of the estimation performance is conducted and some representative examples are provided for demonstration.","PeriodicalId":42484,"journal":{"name":"Biomedical Engineering and Computational Biology","volume":"1 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/117959721000200001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65350394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Biomedical Engineering and Computational Biology 生物医学工程与计算生物学
IF 2.8
Biomedical Engineering and Computational Biology Pub Date : 2009-01-01 DOI: 10.1177/117959720900100001
K. Najarian
{"title":"Biomedical Engineering and Computational Biology","authors":"K. Najarian","doi":"10.1177/117959720900100001","DOIUrl":"https://doi.org/10.1177/117959720900100001","url":null,"abstract":"This is an open access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction provided the original work is properly cited. Open Access Full open access to this and thousands of other papers at http://www.la-press.com. Biomedical Engineering and Computational Biology","PeriodicalId":42484,"journal":{"name":"Biomedical Engineering and Computational Biology","volume":"1 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/117959720900100001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65350379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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