Journal of Diabetes and Endocrinology Research最新文献

{"title":"A miRNA-PEPTIDE FUSION AS A VACCINE CANDIDATEAGAINST THE NOVEL CORONAVIRUS (COVID-19)","authors":"","doi":"10.47485/2693-2458/1010","DOIUrl":"https://doi.org/10.47485/2693-2458/1010","url":null,"abstract":"A new coronavirus named COVID-19 was reported in Wuhan, China in December 2019. The COVID-19 epidemic is spreading rapidly all over the world, (Sun P. and col, 2020). Based on published data on COVID-19, we have designed a preventive vaccine in Silico aimed to protect against COVID-19 infection and transmission (Cascella M. and col, 2020). One aim of this is to better understand potential dormant repositories of outbreaks and potential spread of those repositories, together with potential geogenic terrain factors (Wang Z., 2019). Here, we present to the miRNA-peptide fusion more stable as antiviral (Waterhouse A. and col 2018). As RNA target we used primers from Kemp V. “miRNA repertoire and host immune factor regulation upon avian coronavirus infection in eggs”: primers Biolegio, Nijmegen, The Netherlands (Kemp V. and col, 2019). Our analysis identified a miRNA-peptide with theorical fusion value stability FS=64.28, to treat COVID-19, named LCR_2020_B008-1. Additionally, peptide LCR_2020_B008 can be used in solutions as disinfectant and antiviral, having a fast-hygienic utility to avoid contagion or the propagation of the Covid-19 disease. With respect to antiviral action, the candidate manifests LCR_2020_B008-1, in Silico, manifesting partial inhibiting activity on the VIH-1, and therefore readjustments on this chimera miRNA-peptide could reach a representative antiviral activity against the VIH-1.","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"345 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116532119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Predictive Geological Tool of Type 3 Diabetes (Alzheimer’s Disease): The Polygonal Vortex Mineralisation Model a Medical Geology Perspective","authors":"","doi":"10.47485/2693-2458/1011","DOIUrl":"https://doi.org/10.47485/2693-2458/1011","url":null,"abstract":"Essential selenium and zinc deficiencies biochemistry and physiology is reviewed to impact neurobiology and Alzheimer’s significantly whilst metal pollutants impact early Alzheimer’s progression. A predictive bio-geospatial tool for such impacts considers Taranjebin-Mannagum selenium, by way of the Polygonal Vortex Mineralization Model (PVM) in the central Asian Metallogene. Manna becomes Taranjebin on selenium hyper-accumulation, then highly valued ethnomedically for immune disorders, hyperbilirubinemia, also mitigating diabetes, including Alzheimer’s risk, combating low birth weight known to influence diabetes. Diabetes mitigation source regions of hyper accumulating organic selenium are described within deficient desert terrains. PVM was initially developed as a predictive mineral exploration tool. It is proposed for the first time a novel use as a geological framework of potential public health risks including diabetes. PVM is now intended to cover all forms of mineralization and anthropogenic by products. Similarly, to mineral exploration targeting, PVM can help ‘prospect’ for health risks. That’s helpful, as most communities never undergo geogenic epidemiological studies. PVM defines mineralization fluid pathways, often in polygonal fracture sets, from microscopic to macro fractal niche scaled, as previously reported, providing high fracture surface activity. Essential minerals and or pollutants are then geologically remobilization to biota, impacting health through food bowl, water and air quality. Significantly, PVM-geogenic models may provide mappable ‘Medical Geology indicators’ of essential elements or pollution when qualified biogeochemically, as “Geogenic Public Health Indices” (PVM-HI). Ideally, they and other indices help produce “The Medical Geology Map of The Globe”, supporting public health in developing countries and where epidemiological and Metallogene supervision of it is sparse. One should add warfare and industrial metalliferous debris ‘indices’. The author’s expectation is this paper will engender PVM-HI debate on such “prospecting” utilities for unrecognized Alzheimer’s, other health risks, and help unravel their core pathways through bio-geospatial analysis. Taranjebin selenium biogeochemical-ethnomedical qualified data varying with geology provide PVM-HI examples. Selenium-bio-fertility is herein linked to plate subduction beneath former Iran-Pakistan-Afghanistan micro plate collision boundaries. Interestingly, present country borders conform to former micro plate boundaries, though cultural aspects follow geological features. This has physiographic-geogenic mobility implications for selenium and community Medical Geology. Selenium, sourced primarily from evolving calc-alkaline to alkalic Cenozoic magmatism and fault fracture networks (PVM), confers Taranjebin ethnomedical quality, transitioning higher towards back arc environments respectively. The Cimmerian orogenesis responsible effected the Eurasian plate between T","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121385868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super Power of Antioxidant in Oxidative Stress and Diabetes Mellitus","authors":"S. Mariyam, J. Jose, S. Kumar, Parmar My","doi":"10.47485/2693-2458/1009","DOIUrl":"https://doi.org/10.47485/2693-2458/1009","url":null,"abstract":"Diabetes mellitus is a group of metabolic disorder characterized by peculiarly high levels of blood glucose due to complete or relative insufficiency of insulin secretion as well as disturbances in carbohydrate, fat and protein metabolism. Increasing indication revealed that oxidative stress plays a main role in the pathogenesis of diabetes mellitus. Free radicals are formed excessively in diabetes by glucose oxidation and non-enzymatic protein glycation. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and enzymes increased lipid peroxidation, and development of insulin resistance. This penalty of oxidative stress can promote the development of complications of diabetes mellitus. Antioxidants obtained from nature helps in neutralization of reactive oxygen species and significantly reduce the probability of progression of diabetic complications. A variety of nutritionally important vitamins, supplements and some constituents of natural food sources, including cappers, broccoli, tomatoes, berries, grapes, spinach, carrots, nuts, etc. naturally trim down the injury caused by oxidative stress in diabetes mellitus. The review describes the oxidative stress and super power role of antioxidants role in diabetes mellitus.","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130691637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Of Various Types of Consumer Containers in Technologies of Food Production","authors":"","doi":"10.47485/2693-2458/1007","DOIUrl":"https://doi.org/10.47485/2693-2458/1007","url":null,"abstract":"Successful sales of food products include reliable, safe and aes-thetically pleasing packaging. The buyer prefers plastic containers. When food products packed in various types of polymer containers, there are problems such as vacuum deformation of the packaging, industrial sterility of canned food, which can be solved using various technological methods and parameters.","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"88 43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130436565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Type1 Diabetes among School Children andAdolescents in Sana’a City, Yemen","authors":"","doi":"10.47485/2693-2458/1006","DOIUrl":"https://doi.org/10.47485/2693-2458/1006","url":null,"abstract":"Background: Childhood diabetes was rare and rapidly fatal at the start of the 20th century but the incidence began to increase steadily by the end of the century. This study aimed at screening for diabetes among school children and adolescents in Sana’a city, Yemen. Methods: Of a total student population of 26410 from four educational district registers in Sana’a city, 2870 students were screened for diabetes by urine glucose testing. Diagnosis of diabetes was first suspected from urine testing, then confirmed by blood glucose testing.Results: Glucosuria was detected in the urine samples of 10 out of 2870 students, giving an overall crude prevalence of 0.35% among school children and adolescents investigated. Diagnosis of type 1 diabetes was confirmed for all students with glucosuria by testing plasma glucose and Cpeptide levels of the index patients and a control group. As compared to control group, students with diabetes had significantly higher mean fasting and 2hpostprandial plasma glucose levels (P< 0.0001) but significantly lower mean fasting serum Cpeptide value (P< 0.0001). The agestandardized prevalence rate for age range 519 years (Census 1994 populationadjusted rate) is 0.36% (95% CI: 0.20.5%).Conclusion: : Pediatric-onset Type 1 diabetes is relatively prevalent among school children and adolescents in Yemen, with a slightly higher frequency in those aged ≥ 15 years, but no significant sexdifference.","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"192 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114224887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity, Diabetes mellitus and Methylenetetrahydrofolate reductase mutations: Deadly combinations? How to approach them?","authors":"","doi":"10.47485/2693-2458/1002","DOIUrl":"https://doi.org/10.47485/2693-2458/1002","url":null,"abstract":"","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"15 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114123097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smarter treatment options to tackle the silent menace of Obesity and Obstructive Sleep Apnoea (OSA)","authors":"","doi":"10.47485/2693-2458/1003","DOIUrl":"https://doi.org/10.47485/2693-2458/1003","url":null,"abstract":"Obesity is a rapidly growing global public health issue in view of its prevalence, costs, and complications. As per WHO in 2016, the worldwide prevalence of obesity (BMI>30Kg/m2) is about 13% of the world’s adult population (11% of men and 15% of women). The worldwide prevalence of obesity nearly tripled between 1975 and 2016. 29% of adults were classified as obese in England 2019, an increase from 26% in 2016 [1].","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125551219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best Approach to Prevent Diabetic Nephropathy","authors":"U. Din, M. Salem, D. Abdulazim","doi":"10.47485/2693-2458/1001","DOIUrl":"https://doi.org/10.47485/2693-2458/1001","url":null,"abstract":"The last two decades have witnessed a storm in our understanding of the pathogenesis of diabetic nephropathy. In parallel, the newly evolved hypoglycemic agents have shown different mechanisms of action that would effectively tackle the different pathogenic mechanisms involved in the development and progression of diabetic nephropathy. Several large prospective placebo controlled clinical trials have supported the significant impact of these different agents to withhold the progression of diabetic nephropathy. Almost all these trials involved type 2 diabetes mellitus (T2DM). However, most of these agents can additionally be used in type1 diabetes mellitus (T1DM) patients aiming at avoidance of long-term complications of this disease. The most recent of these trial, the DECLARE - TIMI 58 renal outcome trial, have additionally declared the preventive value of dapagliflozin in T2DM. In this review, we are going to discuss the most recent and relevant pathogenic mechanisms highlight the therapeutic and value of the early use of the different agents to prevent the development of diabetic nephropathy.","PeriodicalId":424815,"journal":{"name":"Journal of Diabetes and Endocrinology Research","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116794317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}