Middle East Research Journal of Pharmaceutical Sciences最新文献_第2页

A Medicinal Potential worth of Caesalpinia bonducella 山葵的药用价值

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2023-01-20 DOI: 10.36348/merjps.2023.v03i01.001

G. Singh, Sunil Kumar, J. Malik

引用次数: 0

Hepatoprotective Potential of Caesalpinia bonducella: Molecular Insight bonducella Caesalpinia的保肝潜能:分子观察

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2022-06-01 DOI: 10.36348/merjps.2022.v02i01.004

M. Bhatt, J. Malik

{"title":"Hepatoprotective Potential of Caesalpinia bonducella: Molecular Insight","authors":"M. Bhatt, J. Malik","doi":"10.36348/merjps.2022.v02i01.004","DOIUrl":"https://doi.org/10.36348/merjps.2022.v02i01.004","url":null,"abstract":"Abstract: Liver fibrosis is a wound healing process initiated in response to chronic liver damage caused by viruses, toxins, and hepatotoxic drugs. The disease is characterized by inflammation followed by deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) has been identified as a host cofactor for hepatitis C virus (HCV) entry. The plant Caesalpinia bonducella is used in a variety of systems a traditional medicine used to treat human ailments and affiliation prickly shrub belonging to the Caesalpiniaceae family found throughout the world, especially tropical region. It is a very valuable medicinal plant because all parts of the plant have medicinal properties. It was like traditional Indian herbal medicine considered an important therapeutic modality for the treatment of various diseases. As per literature survey the plants containing kaempferol and quercetin-3-methylether are traditionally utilized for the cure of cancer and liver related disorders from the immortal time. The exact mechanism of action for the hepatoprotective action of kaempferol and quercetin-3-methylether was still not revealed. With intent to propose the most probable mechanism of action of kaempferol and quercetin-3-methylether the docking based computational analysis has been performed against the hepatoprotective drug targets like PPARα enzyme.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"2675 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124154784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linezolid as Potent Inhibitor of SARS-CoV-2 Nsp13 Helicase: Grid Based Docking Approach 利奈唑胺作为SARS-CoV-2 Nsp13解旋酶的有效抑制剂:基于网格的对接方法

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2022-05-27 DOI: 10.36348/merjps.2022.v02i01.003

N. Singh, J. Malik

{"title":"Linezolid as Potent Inhibitor of SARS-CoV-2 Nsp13 Helicase: Grid Based Docking Approach","authors":"N. Singh, J. Malik","doi":"10.36348/merjps.2022.v02i01.003","DOIUrl":"https://doi.org/10.36348/merjps.2022.v02i01.003","url":null,"abstract":"Abstract: A diversified originator in humans and wildlife, the corona virus (COVID-19) is an enveloped RNA virus. Six different species have been shown to be the root of human sickness. Human diseases are greatly influenced by viral infections, and one of the most recent global epidemics is the appearance of the new corona. The SARS (Severe Acute Respiratory Syndrome) virus, a potentially fatal viral infection, was caused by the SS-RNA virus from the enveloped corona virus family. In many nations around the world, disease is rapidly expanding. 462,684 confirmed cases and 20,834 fatalities had been reported as of March 26, 2020, internationally. On March 11, 2020, COVID-19 was declared a pandemic by the World Health Organization (WHO). There are numerous medication trials ongoing, and some of the outcomes are encouraging. However, since there is no vaccine, the only approach to fight the virus is through preventative measures. Patients with bacterial nosocomial pneumonia were successfully treated with the antibiotic \"Linezolid\" by receiving an intravenous dose of 600 mg of linezolid every 12 hours for 7 to 10 days. All of the patients made a full recovery and were allowed to leave the hospital. Additionally, previous studies have shown that linezolid is more clinically and microbiologically effective than other antibiotics (vancomycin). The goal of the current study was to use a molecular docking approach to evaluate linezolid's potential against SAR-CoV-2 infection.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122896536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-Silico Consideration of Anti-Microbial Prospective of Plant Phenolic and Flavonoids 植物酚类和黄酮类化合物抑菌前景的计算机模拟研究

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2022-02-28 DOI: 10.36348/merjps.2022.v02i01.001

Amit Kumar, J. Malik

引用次数: 0

Formulation and Evaluation of Controlled Release Matrix Tablets of Cefixime Trihydrate 三水合头孢克肟控释基质片的研制与评价

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2021-12-30 DOI: 10.36348/merjps.2021.v01i01.005

Rashmi Shivaji Tambare, G. Tapadiya, S. Shahi

{"title":"Formulation and Evaluation of Controlled Release Matrix Tablets of Cefixime Trihydrate","authors":"Rashmi Shivaji Tambare, G. Tapadiya, S. Shahi","doi":"10.36348/merjps.2021.v01i01.005","DOIUrl":"https://doi.org/10.36348/merjps.2021.v01i01.005","url":null,"abstract":"Abstract: The main objective of the present work was to develop sustained release matrix tablets of Cefixime Trihydrate were prepared by direct compression techniques and evaluates the effect of formulation variables such as lubricant, binder, polymer content and viscosity grades of HPMC on the behavior of Cefixime Trihydrate release. The prepared tablets were evaluated for various physico-chemical parameters. In vitro release profile was check to evaluate the sustained release matrix tablet of Cefixime Trihydrate. The drug release from the optimized formulation was found to follow zero order kinetics. Thus the phenomenon of drug release showed that the release of optimized formulation is controlled by diffusion. Administration of Cefixime Trihydrate in a sustained release dosage would be more desirable for bacterial infections effects by maintaining the plasma concentrations of the drug well above the therapeutic concentration. From In vitro dissolution profile, Formulation S3 was prepared with Hydroxypropyl methylcellulose (K15M) combination where drug release was about 99.14% at the end of 24 hrs and followed zero order with non-Fickian diffusion method. It is selected as the best formulation.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121074417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Insight Hypolipidemic Potential of Ascorbic Acid: In-Silico Molecular Docking 抗坏血酸降血脂的机制:硅分子对接

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2021-12-28 DOI: 10.36348/merjps.2021.v01i01.001

M. Yadav, J. Malik

引用次数: 0

Chlorogenic Acid a Potent Anti-inflammatory Agent: In-Silico Molecular Docking approach 绿原酸是一种有效的抗炎剂:硅分子对接方法

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2021-12-27 DOI: 10.36348/merjps.2022.v02i01.002

Shayara Bano, J. Malik

{"title":"Chlorogenic Acid a Potent Anti-inflammatory Agent: In-Silico Molecular Docking approach","authors":"Shayara Bano, J. Malik","doi":"10.36348/merjps.2022.v02i01.002","DOIUrl":"https://doi.org/10.36348/merjps.2022.v02i01.002","url":null,"abstract":"Abstract: Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation of other bioactive compounds present in food and prebiotic activity. Methods: Molecular docking of COX2, NF-κB inducing kinase (NIK) & PhospholipaseA2 (PLA2) with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -6.71, -6.31 & -4.43 kcal mol–1 respectively.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125956023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Antibacterial and Antifungal Activities of Schiff Base Complexes of Co (II) and Cu (II) Derived from Salicyldehyde and Diphenylamine 水杨醛和二苯胺合成的Co (II)和Cu (II)席夫碱配合物的抑菌和抑菌活性研究

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2021-12-27 DOI: 10.36348/merjps.2021.v01i01.003

U. B., M. C., Uba A, Muhammad A. A

{"title":"Study of Antibacterial and Antifungal Activities of Schiff Base Complexes of Co (II) and Cu (II) Derived from Salicyldehyde and Diphenylamine","authors":"U. B., M. C., Uba A, Muhammad A. A","doi":"10.36348/merjps.2021.v01i01.003","DOIUrl":"https://doi.org/10.36348/merjps.2021.v01i01.003","url":null,"abstract":"Abstract: This paper reports antibacterial and antifungal activities of Schiff base and that’s of its metal (II) complexes (Co, Cu) derived from salicyldehyde and diphenylamine. The Schiff base and its metal (II) complexes were characterized using different analytical techniques like FTIR, melting point, solubility, and molar conductance, The Schiff base and its respective metals complexes were colored. The result from IR analysis revealed bands at 1614cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. The band at 664cm-1 indicate the formation of complex which is assign to V(M-N) supporting coordination of Schiff base to respective metals. The solubility test result showed that both the Schiff base and complexes are soluble in most organic solvent and insoluble in water. Both the schiff base and complexes revealed sharp melting point and decomposition temperature. The molar conductance data of the complexes in Dimethylsulphoxide (DMSO) show low value of 9 and 10 Ohm-1cm2 mol-1) indicating the complexes are non-electrolytes. The entire compounds were tested for their antibacterial and antifungal activities. The results indicated that the growth of the tested organism was inhibited by the compounds.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124343605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Insight Antidiabetic Potential of Ursolic Acid: In-Silico Molecular Docking 熊果酸抗糖尿病潜能的机理:硅基分子对接

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2021-12-27 DOI: 10.36348/merjps.2021.v01i01.002

Priyanka Ahirwar, J. Malik

引用次数: 0