水杨醛和二苯胺合成的Co (II)和Cu (II)席夫碱配合物的抑菌和抑菌活性研究

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2021-12-27 DOI:10.36348/merjps.2021.v01i01.003

U. B., M. C., Uba A, Muhammad A. A

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引用次数: 0

摘要

摘要:本文报道了希夫碱及其由水杨醛和二苯胺衍生的金属(II)配合物(Co, Cu)的抑菌和抑菌活性。利用红外光谱(FTIR)、熔点、溶解度和摩尔电导等分析技术对希夫碱及其金属配合物进行了表征，并对希夫碱及其金属配合物进行了着色。红外光谱分析结果显示，在1614cm-1处有亚甲基(C=N)形成，证实了席夫碱的形成。在664cm-1处的条带表示配合物的形成，该配合物为V(M-N)，支持希夫碱与相应金属的配位。溶解度测试结果表明，希夫碱和配合物均可溶于大多数有机溶剂，不溶于水。希夫碱和配合物的熔点和分解温度都很高。配合物在二甲基亚砜(DMSO)中的摩尔电导数据显示为9和10欧姆-1cm2 mol-1的低值，表明配合物是非电解质。对所有化合物的抗菌和抗真菌活性进行了测试。结果表明，这些化合物对被试生物的生长有抑制作用。

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Study of Antibacterial and Antifungal Activities of Schiff Base Complexes of Co (II) and Cu (II) Derived from Salicyldehyde and Diphenylamine

Abstract: This paper reports antibacterial and antifungal activities of Schiff base and that’s of its metal (II) complexes (Co, Cu) derived from salicyldehyde and diphenylamine. The Schiff base and its metal (II) complexes were characterized using different analytical techniques like FTIR, melting point, solubility, and molar conductance, The Schiff base and its respective metals complexes were colored. The result from IR analysis revealed bands at 1614cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. The band at 664cm-1 indicate the formation of complex which is assign to V(M-N) supporting coordination of Schiff base to respective metals. The solubility test result showed that both the Schiff base and complexes are soluble in most organic solvent and insoluble in water. Both the schiff base and complexes revealed sharp melting point and decomposition temperature. The molar conductance data of the complexes in Dimethylsulphoxide (DMSO) show low value of 9 and 10 Ohm-1cm2 mol-1) indicating the complexes are non-electrolytes. The entire compounds were tested for their antibacterial and antifungal activities. The results indicated that the growth of the tested organism was inhibited by the compounds.

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Middle East Research Journal of Pharmaceutical Sciences

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