Indonesian Journal of Kidney and Hypertension最新文献

{"title":"Vol 2 No 3 (2019): September - December 2019","authors":"","doi":"10.32867/inakidney.v2i3","DOIUrl":"https://doi.org/10.32867/inakidney.v2i3","url":null,"abstract":"","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130727795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Single Dialysis on Cognitive Function in Chronic Kidney Disease Stage 5 Hemodialysis Patients","authors":"A. R. Hidayat, H. Rasyid, S. Bakri, H. Kasim, S. Syamsuddin, A. Seweng","doi":"10.32867/INAKIDNEY.V2I2.10","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I2.10","url":null,"abstract":"Abstract \u0000Background: The incidence of cognitive impairment (CI) has been widely reported in various studies among chronic kidney disease (CKD) patients. Many factors influence cognitive function including hemodialysis (HD) process itself. There is much evidence that a single HD session brings about changes in the cognitive status of patients, but just a few studies assessing whether cognitive performance varies with dialysis. \u0000Aim: To know the effect of single dialysis session on cognitive function in HD patients. \u0000Method: Sixty medically stable CKD stage 5 patients on HD maintenance at least for three months were enrolled. Cognitive testing performed thrice, 1-2 hour prior dialysis (T1), 3-4 hour into the session (T2) and 24 hour after the session (T3) using a well-validated neuropsychological test battery, Montreal Cognitive Assessment (MoCA) Indonesian version which assess the domain of cognitive function including visuospatial, executive function, naming, memory, attention, language, abstraction, recall, and orientation. \u0000Result: among 60 patients complete testing, mean age 45,45 ± 11,28 years, dialysis vintage 10,12 ± 11,88 months, 44 patients (73,3%) had CI at baseline. Cognitive function decline during dialysis (T2) (MoCA INA score 21,65 to 19,67, p < 0.001) and visuospatial, executive function, attention, language and recall was impaired during dialysis. While cognitive function reached its best 24 hour after dialysis (MoCA INA score 23,65, p < 0.001) and all the domain of cognitive function was improved except naming that didn’t change over the dialysis session. Age and dialysis  adequacy were associated with the decline.      \u0000Conclusion: There is effect of a single HD session on global cognitive function where cognitive function was deteriorated during HD and reached its best 24 hour after HD. \u0000Keywords: cognitive function, chronic kidney disease, hemodialysis","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131251753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Urinary Cyclophilin A and Urinary Albumin Levels on Diabetic Kidney Disease","authors":"Harnavi Harun, Rangga Lunesia, Syaiful Azmi","doi":"10.32867/INAKIDNEY.V2I2.29","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I2.29","url":null,"abstract":"Introduction: Diabetic kidney disease (DKD) is a complication of diabetes mellitus characterized by albuminuria persisting within 3 to 6 months, the earliest clinical evidence is microalbuminuria (30-299 mg/24hours or 20-199 ug/i). Cyclophilin A (Cyp A) is an 18 k-Da 165-amino acid long cytosolic protein also known as peptidylprolyl isomerase A. In DN, hyperglycemia will cause Cyp A secretion by human kidney-2 (HK-2) cells from PTEC and mesangial-13 cells (MES-13) and causes kidney damage. \u0000Material and Methods: This study was an analytic observational, cross sectional study conducted at the clinic and inpatient internal medicine installation at dr. M. Djamil General Hospital Padang  for 6 months. Samples were selected by consecutive sampling, as many as 60 people with post prandial blood glucose > 180 mg/dl and urinary albumin > 30 mg/24 hours and met the inclusion and exclusion criteria. The samples were examined for urinary Cyp A and albumin levels. \u0000Results: The mean level of urinary Cyp A in patients with DKD is 4.96 (2.03) ng/ml. Median urinary albumin levels in DKD patients is 287.89 (30.79-394.57) mg/24 hours. Correlation analysis between urinary Cyp A and albumin levels showed a significant (p < 0.05) with a positive and strong correlation (r = 0.776) in DKD patients. \u0000Conclusion: There was an increase of urinary Cyp A and urinary albumin levels, with a positive and strong correlation between them in DKD patients. \u0000Keywords: Urinary Cyclophilin A, urinary albumin, diabetic kidney disease","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134006528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Rate of Living Related Kidney Transplant Patients in Surabaya","authors":"Decsa Medika, Aditiawardana Aditiawardana, Pranawa Pranawa, D. Santoso, W. Widodo, Chandra Irwanadi Mohani","doi":"10.32867/INAKIDNEY.V2I2.27","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I2.27","url":null,"abstract":"Abstract \u0000Background The survival outcome of transplant patients have improved in the past three decades. The short and long term survival of graft and patients are still being widely studied. Many factors affect the survival rate such as age, gender, diabetes mellitus, and immunosuppressive therapy. \u0000Objective The study aim to provide patients’ survival rates 1, 3, and 5 years after transplant. \u0000Methods The study used descriptive approach on 67 kidney transplant patients undergoing outpatient treatment from 1996 to 2016. The data collected was analyzed using SPSS with the Kaplan-Meier curve to observe the survival rate. \u0000Result The survival rate of patients in 1, 3, and 5 years were 100%, 97%, and 94% respectively. The survival rate in geriatric and non-geriatric patients in the first year post-transplantation was both 100%, the third year post-transplantation survival rate were 100% and 94.7%, and the five year post-transplantation survival rate were 100% and 89.5%. The 1, 3, and 5 year survival rate for male and female patients were both 100%, 96.3% vs 100%, and 92.6% vs 100% respectively. Compared to their non-diabetic counterparts, diabetic patients’ survival rate in 1, 3, and 5 years were both 100%, 96.5% vs 100%, and 93% vs 100% respectively. The survival rate of patients receiving tacrolimus vs cyclosporine were both 100% in the first year, 97.1% vs 97% in the third year, and 97.1% vs 90.9% in the fifth year after transplant. \u0000Conclusion The survival rate of kidney transplant patients in 1, 3, and 5 year after transplant were 100%, 97%, and 94%. Factors linked to higher survival rate were geriatric patients, female gender, diabetes, and the use of cyclosporine in the immunosuppressant therapy regimen. \u0000  \u0000Keyword: kidney transplantation, survival","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132127781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioplasty in CKD patients with immature AV fistula: A Case Report","authors":"Atma Gunawan, Sulih Ngutamani, Achmad Rifai, N. Nursamsu","doi":"10.32867/INAKIDNEY.V2I2.19","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I2.19","url":null,"abstract":"Arteriovenous fistula has been preferred to other vascular access for dialysis due to better patient outcome for morbidity and mortality. However, AVF failure is quite prevalent. One of the cause for AVF failure is due to venous stenosis, diagnosed through Doppler ultrasound and venography. Angioplasty is one of the methods that can be used to repair and salvage an immature AVF. In this report, a 59 year old female patient was diagnosed with CKD with a long history diabetes mellitus type 2 and admitted for routine hemodialysis. An AVF was created on her radiocephalic vein, and upon evaluation was found to not mature properly. Doppler ultrasound examination showed fistula diameter of 3 mm and volume flow of 160 ml/min, whereas venography showed stenosis in radiocephalic fistula. Balloon angioplasty was then performed with balloon diameter of 4 mm and balloon pressure of 10, 15, and 20 atm for three minutes each. After the procedure, the fistula exhibit dilatation with minimum residual stenosis and adequate as vascular access for hemodialysis.","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"75 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123114924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors of Cardio-Cerebrovascular Event, Hospitalization, and Mortality in Patients Undergoing Regular Hemodialysis","authors":"I. Mahendra, Y. Kandarini, I. Widiana","doi":"10.32867/INAKIDNEY.V2I2.18","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I2.18","url":null,"abstract":"Background: CKD patients undergoing regular HD experience high rate of hospitalization and mortality compared with general population. The main contributing factors were cardiovascular event and infection. In Indonesia, there has been no comprehensive and representative data available. This study aims to discover the incidence and risk factors of cardio-cerebrovascular events, hospitalization and mortality, as well as the survival rate among patients undergoing regular HD at Sanglah general hospital Denpasar. \u0000  \u0000Methods: The study was an analytic retrospective cohort study conducted in Sanglah general hospital Denpasar from July 1st to December 31st 2017. Inclusion criteria were patients with CKD stage-5, ≥ 18 years old, and have undergone regular HD for at least 3 months. Patients with malignancy and requiring elective hospitalization were excluded. The Kaplan-Meier method was used to calculate the cumulative survival rate, and the log-rank test was used for extracting the risk factors that influenced the survival rate. Multivariate Cox regression analysis was used to test contributing risk factors towards composite outcomes (cardio-cerebrovascular events, hospitalization and mortality) and mortality outcome. The risk factors contributors were declared with a value of relative risk and odds ratio adjusted with the confidence interval (CI) 95%, the level of significance (α) was specified in the value of p<0.05. \u0000  \u0000Results: The composite outcome incidence of 222 subject within 6 months (184 days) was 18.09% and mortality outcome was 8.11%, with cardiovascular event was a major cause (56%) of mortality outcome. Risk factors significantly contributed on composite outcome related to etiology (p=0.03) as follows: 1) Diabetic nephropathy (OR=1.33; CI 95% 0.16-11.06); 2) Hypertensive nephrosclerosis (OR=0.98; CI 95% 0.11 - 8.47); 3) Chronic pyelonephritis (OR=0.36; CI 95% 0.05 – 2.74); 4) Chronic Glomerulonephritis (OR=0.23; CI 95% 0.02 – 2.66) and AV fistula (+) (OR=0.37; CI 95% 0.17 – 0.77; p=0.01). Whereas risk factors significantly contributed on mortality outcome related to AV fistula (+) (OR=0.46; CI 95% 0.23 - 0.92; p=0.028) and age < 52 years old (OR=0.51; CI 95% 0.26 to 0.99; p=0.047). The cumulative survival rate (composite outcome) was 165.83±3.57 days with the cumulative survival rate (mortality outcome) was 177.34±2.00 days. \u0000  \u0000Conclusion: This study concluded that the incidence of mortality outcome was 8.11% within 6 months (184 days), with cardiovascular event was a major cause (56%), risk factors significantly contributed on mortality outcomes were AV fistula and age, whereas the cumulative survival rate (mortality outcome) was 177.34±2.00 days.","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128007557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Glycated Albumin and Glycated Hemoglobin with Glycemic Control in Patients with Diabetic Chronic Kidney Disease on Hemodialysis","authors":"Z. Ali, Rostika Dewi, Alwi Shahab, Irsan Saleh","doi":"10.32867/INAKIDNEY.V2I1.22","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I1.22","url":null,"abstract":"Background and aims. Diabetes mellitus (DM) is the most common cause of end-stage renal disease (ESRD) worldwide and is the primary etiology of ESRD in Indonesia. It is estimated that there are 10 million patients with DM in Indonesia and about 25-40% of diabetics develop diabetic nephropathy (DN) within 25 years. Poor glycemic control is associated with increased mortality in a large observational study among diabetics on hemodialysis. Glycated hemoglobin, or known as HbA1c, was the currently recommended biomarker to monitor long-term glycemic control in diabetes mellitus guideline. However, it becomes underestimated in patients with DN on hemodialysis (DN-HD), because of 20- 50% reduction of erythrocyte lifespan, clinical use of iron therapy, and effects of recombinant human erythropoietin. Glycated albumin (GA), ketoamine formed via a non-enzymatic glycation reaction of serum albumin, is free from interference by erythrocyte lifespan or erythropoietin therapy and subsequently can be used as an alternative biomarker to monitor glycemic control in DN-HD. As albumin has a half-life of only 14-21 days* compared to Hb 60-100 days in well ESKD patients, thus GA may provide a better reflection of recent diabetic control than HbA1c. The aim of this study was to analyze the correlation between GA and HbA1c with glycemic control in DN-HD. \u0000Methods The study was an analytical observational study with a cross-sectional design. The subjects were consecutive patients with DN-HD who visited Hemodialysis Unit at Mohammad Hoesin General Hospital Palembang during August-November 2014. The glycemic control index was determined by the average value of 2 times a week pre-HD random blood glucose for 4 weeks (aRBG). \u0000Results. The subjects were 25 patients with an average age of 56.16±7.49 years old. The average value of GA was 26.94±7.74%. GA was strongly correlated with aRBG with r=0.776; p=0.000. After correcting for age, sex, and BMI, the correlations became significantly very strong (r=0.809, p <0.001). The simple linear regression for the relationship between GA and aRBG was aRBG=4,62×GA+42.74 (R2=0.602, P<0.001), estimating that a 1% increase of GA was associated with 4.62mg/dL increase of aRBG. After correcting for age, sex, & BMI, the correlations between HbA1c and aRBG were significant (r=0.852, p<0.001). \u0000Conclusion. GA was strongly correlated with glycemic control in patients with DN-HD and HbA1c was correlated better.","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130274364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Settings The Role of Low Blood Glucose Level of Mothers with Severe Preeclampsia in Fetal Growth Restriction: a Mini-Study","authors":"A. Prameswari","doi":"10.32867/INAKIDNEY.V2I1.24","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I1.24","url":null,"abstract":"Background. The number of patients with severe preeclampsia continues to increase worldwide. Blood glucose is significantly decreased in severe preeclampsia patients, starting at the sudden onset of high blood pressure. This depicts the state of low placental energy status in preeclampsia patients with intrauterine growth restriction (IUGR), due to either glycolysis or ischemia disorders resulting from decreased maternal placental blood flow. \u0000Aim. To observe the relationship between mother’s random blood glucose level with fetal growth restriction complications during acute onset of severe preeclampsia. \u0000Methods. A cross-sectional study, random sampling involving twenty-one pregnant women with severe preeclampsia who underwent cesarean section at Permata Bunda Hospital, Malang, Indonesia. Data were taken from medical records, which included: mother’s random blood glucose, blood pressure, proteinuria, and complete blood count. Fetal data includes body weight and length. The data were obtained at the subjects’ initial admission in the emergency room during the acute phase of the preeclampsia. \u0000Result. Maternal blood glucose had a negative and significant relationship with systolic blood pressure (r = -0.843, p < 0.0001) and with newborn body weight (r = 0.465, p = 0.034) in the acute onset of severe preeclampsia. \u0000Conclusion. The blood glucose level of patients at the acute onset of preeclampsia is inversely correlated with systolic blood pressure. The blood glucose level is also correlated with fetal weight. However, due to the chronic nature of IUGR, future studies should analyze the relationship between blood glucose, blood pressure, and fetal growth through multiple stages of pregnancy","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122896350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does High Ultrafiltration Volume Correlate to Occurrence of Desaturation in Patients Undergoing Hemodialysis?","authors":"L. Sen, N. M. Hustrini","doi":"10.32867/INAKIDNEY.V2I1.21","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I1.21","url":null,"abstract":"Background: Hemodialysis is a metabolically stressful condition for patients that leads to reduced oxygen saturation and tissue perfusion. One of the identified drivers is a high ultrafiltration volume (UFV). Concurrently, central venous oxygen saturation (ScvO2) is a marker for global tissue hypoxia that has been used in cases of sepsis and trauma to guide fluid therapy. In dialysis patients with a central venous catheter (CVC) access ScvO2 is accessible. Here we intend to delineate the relationship of UFV to desaturation during dialysis through the measurement of ScvO2. \u0000Methods: PICO was formulated from a clinical case, and a literature search was conducted in Pubmed, Embase, Scopus, and Cochrane. Selected studies were then critically appraised using harm/etiology worksheet from CEBM1 for validity, importance, and applicability. \u0000Results: Studies by Harrison, et al., Zhang, et al. and Rotondi, et al. were chosen for answering our PICO. Harrison, et al. reported a relation of r: -0.680, p:0.015 between UFV and ScvO2. While, Zhang, et al. utilized retrospective data of Critline Monitor (CLM) reading of dialysis patients and reported a negative 0.3% slope of ScvO2 over corrected UFV (cUFV). Whilst, Rotondi, et al. demonstrated that in 20 patients separated equally to exclusively dialysis or ultrafiltration and both caused lowering of ScvO2, but only the former was statistically significant. \u0000Discussion: The mechanism of relationship may include incapability of plasma refill rate to compensate for the fluid shift during ultrafiltration, resulting in lower cardiac preload and stroke volume which is detrimental in patients who are natively prone to suffer from reflex bradycardia and intradialytic hypotension. Studies have shown that episodes of hypoxemia in dialysis patients translate to worse prognosis. \u0000Conclusion: ScvO2 is inversely proportional to UFV. As such, monitoring for ScvO2 in dialysis patients will be beneficial to prevent end-organ ischemia.","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126542249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Settings The Role of Methylglyoxal Accumulation on Cognitive Function Impairment of Chronic Hemodialysis Patients: an Observational Study","authors":"Harnavi Harun, Roslaini Roslaini, Syaiful Azmi, R. Martini","doi":"10.32867/INAKIDNEY.V2I1.23","DOIUrl":"https://doi.org/10.32867/INAKIDNEY.V2I1.23","url":null,"abstract":"Background: Cognitive function decline is prevalent on routine hemodialysis patients. Many factors contribute to the increased risk of cognitive function impairment, one of them is the accumulation of uremic toxins. Methylglyoxal (MG) has been identified as one of the uremic toxins found in dialysis patients by the European Uremic Toxin Group. It has also been found much higher on CKD patients; over five times higher in non-dialysis CKD and 18-40 times higher in CKD patients on dialysis, and cause impaired cognitive function in rats with diabetes. \u0000Aim: To find the correlation between blood MG levels and cognitive function of patients who underwent routine hemodialysis. \u0000Methods: This study is an observational cross-sectional study done in Hemodialysis Unit of Dr. M Djamil General Hospital, Padang, West Sumatera, Indonesia. Fifty-seven subjects aged 40-60 years old were included in this study, where the blood MG levels were obtained. Cognitive function was measured using the Mini Mental State Examination (MMSE) questionnaire. \u0000Result: Among 57 subjects, 29 (50.8%) were male, and 33 (57.9%) were 50-60 years old. The subjects’ mean methylglyoxal levels were 10.8 (SD ± 3.2) µmol/L. The subjects’ mean MMSE score was 26 (SD ± 1.8), with 35% of the subjects had low ( < 0.001). \u0000Conclusion: High levels of methylglyoxal negatively correlates with cognitive function in chronic hemodialysis patients. Future research should include analysis regarding age, gender, hypertension, and other confounding factors.","PeriodicalId":423107,"journal":{"name":"Indonesian Journal of Kidney and Hypertension","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116047465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}