{"title":"A hybrid segmentation approach for rapid and reliable liver volumetric analysis in daily clinical practice","authors":"Zygomalas Apollon, Karavias Dionissios, Koutsouris Dimitrios, Maroulis Ioannis, Karavias D. Dimitrios, Giokas Konstantinos, Megalooikonomou Vasileios","doi":"10.1109/BIBE.2015.7367715","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367715","url":null,"abstract":"Preoperative evaluation of liver future remnant volume is essential for liver oncologic and transplantation surgery. Segmentation of liver imaging studies allow for an excellent liver volumetric analysis. We developed a hybrid liver segmentation algorithm which is based on thresholding by pixel intensity value. The algorithm consists of a semiautomatic and an automatic part. The aim of this prospective study was to evaluate the efficacy of preoperative liver volumetric analysis in daily clinical practice using this hybrid approach. Accuracy and speed were validated on a random prospectively selected sample of 20 patients undergoing elective major liver resections at our institution from June 2013 to June 2015. Complete liver volumetric analysis was performed in average in 15.5 min/dataset SD±2.6 (computation and interaction time). Mean similarity index was 95.5% SD±2. The future liver remnant volume calculated by the application showed a correlation of 0.98 to that calculated using manual boundary tracing. The hybrid segmentation approach proved to be fast and accurate for the preoperative planning in oncologic liver surgery.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"124 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121470572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hybrid intelligent methods for microarray data analysis","authors":"P. Ganeshkumar, Ku-Jin Kim","doi":"10.1109/BIBE.2015.7367704","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367704","url":null,"abstract":"Data produced out of microarray experiments are of great use for the physician when it is presented in a meaningful manner. This paper proposes hybrid intelligent methods for addressing the challenges in analyzing the microarray data. The concept of fuzzy and rough set is hybridized with FInformation (FRFI) for gene selection. An optimal fuzzy logic based classifier (FLC) is developed for sample classification using a hybrid Genetic Swarm Algorithm (GSA). Detailed experiments are conducted using microarray data related to Cancer and Rheumatoid Arthritis. From the simulation study, it is found that the proposed FRFI-FLC-GSA produces compact classification system with reasonably good informative genes that can be used for disease diagnosis.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121527920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Axial vibration of an artificial muscle","authors":"L. Cvetićanin, I. Bíró, J. Sárosi, M. Zukovic","doi":"10.1109/BIBE.2015.7367634","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367634","url":null,"abstract":"Significant number of muscles can be assumed to be of longitudinal type where the length is much higher than its cross-section. Usual motion of the longitudinal muscles is axial due to its contraction and dilatation. Our aim is to investigate the axial vibration of such muscles. The artificial muscle is formed whose physical model is a clamped-free beam. Characteristics of the muscle material are obtained experimentally and the data are applied for the rheological model. It is obvious that the stress-strain properties are strong nonlinear. The beam is assumed to be fixed at one end and free for axial motion at the other end. Mathematical model of motion is supposed as a partial truly strong nonlinear differential equation. In the paper an analytical procedure for approximate solving of the equation is developed. Using a suitable transformation the equation is rewritten into two strong nonlinear ordinary second order differential equations. Analyzing the solution, the influence of the geometric properties, but also of material properties and boundary conditions on the motion is considered. Special attention is given to frequency of vibration of the beam. Effect of the order of nonlinearity and of the initial conditions on the frequencies is widely analyzed.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127050665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. G. Kanas, E. Zacharaki, Evangelia Pippa, Vasiliki Tsirka, M. Koutroumanidis, V. Megalooikonomou
{"title":"Classification of epileptic and non-epileptic events using tensor decomposition","authors":"V. G. Kanas, E. Zacharaki, Evangelia Pippa, Vasiliki Tsirka, M. Koutroumanidis, V. Megalooikonomou","doi":"10.1109/BIBE.2015.7367731","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367731","url":null,"abstract":"Misdiagnosis of epilepsy, even by experienced clinicians, can cause exposure of patients to medical procedures and treatments with potential complications. Moreover, diagnostic delays (for 7 to 10 years on average) impose economic burden at individual and population levels. In this paper, a seizure classification framework of epileptic and non-epileptic events from multi-channel EEG data is proposed. In contrast to relevant studies found in the literature, in this study, the non-epileptic class consists of two types of paroxysmal episodes of loss of consciousness, namely the psychogenic non-epileptic seizure (PNES) and the vasovagal syncope (VVS). EEG signals are represented in the spectral-spatial-temporal domain. A tensor-based approach is employed to extract signature features to feed the classification models. TUCKER decomposition is applied to learn the essence of original, high-dimensional domain of feature space and extract a multilinear discriminative subspace. The classification models were evaluated on EEG epochs from 11 subjects in an inter-subject cross-validation setting and achieved an accuracy of 96%.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121331906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Vukicevic, G. Jovicic, N. Jovicic, Z. Milosevic, N. Filipovic
{"title":"Assessment of bone stress intensity factor using artificial neural networks","authors":"A. Vukicevic, G. Jovicic, N. Jovicic, Z. Milosevic, N. Filipovic","doi":"10.1109/BIBE.2015.7367680","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367680","url":null,"abstract":"Assessment of the risks associated with bone injures is nontrivial because fragility of human bones is varying with aging. Since only a limited number of experiments have been performed on the specimens from human donors, there is limited number of fracture resistance curves available in literature. This study proposes a decision support system for the assessment of bone stress intensity factor by using artificial neural networks (ANN). The procedure estimates stress intensity factor according to patient's age and diagnosed crack length. ANN was trained using the experimental data available in literature. The automated training of ANN was performed using evolutionary assembled Artificial Neural Networks. The obtained results showed good correlation with the experimental data, with potential for further improvements and applications.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128847673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A mathematical model of a novel automated medical device for needle insertions","authors":"Ivan Buzurovic, S. Šalinić","doi":"10.1109/BIBE.2015.7367697","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367697","url":null,"abstract":"In medical procedures, needle insertion is a challenging task highly dependent on the surgeon's manual skills. Implanted needles are used for drug delivery, biopsy, delivery of radiation sources, etc. In the named clinical procedures, the accuracy of the needle placement is crucial for patient treatment outcomes. Therefore, we have proposed an automated medical device for needle implantation to eliminate uncertainties of the standard procedures and to increase the accuracy of the needle placement. In this article, the mathematical model of such a device has been developed. The mathematical model takes into account the needle deflection; therefore, with the adequate development of the control strategy, the deflection could be minimized using predictive or adaptive controllers.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131442344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of ruptured anterior cruciate ligament and medial meniscectomy on stress distribution of human knee joint at full extension","authors":"Aleksandra Vulovic, N. Filipovic, B. Ristic","doi":"10.1109/BIBE.2015.7367650","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367650","url":null,"abstract":"A three dimensional biomechanical model of the human knee joint was developed. The model was created from MRI scans and includes: bones, menisci, articular cartilage and relevant ligaments (posterior cruciate ligament, lateral collateral ligament and medial collateral ligament). The purpose of this study was to compare the stress distribution on the human knee joint in two situations. The first situation includes the rupture of anterior cruciate ligament (ACL) while the second situation includes the ACL rupture and the condition after medial meniscectomy is performed. We have used the finite element model of human knee joint to measure stress when person is standing on one foot. The finite element analysis can provide better insight at the situation in the knee joint when having anterior cruciate ligament and meniscus injury.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123850269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Karanasiou, Dimitrios A. Gatsios, M. Lykissas, K. Stefanou, G. Rigas, I. Lagaris, Ioannis P. Kostas-Agnantis, I. Gkiatas, A. Beris, A. Sakellarios, D. Fotiadis
{"title":"Fluid-structure interaction analysis of anastomosis in patient specific arterial segment","authors":"G. Karanasiou, Dimitrios A. Gatsios, M. Lykissas, K. Stefanou, G. Rigas, I. Lagaris, Ioannis P. Kostas-Agnantis, I. Gkiatas, A. Beris, A. Sakellarios, D. Fotiadis","doi":"10.1109/BIBE.2015.7367679","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367679","url":null,"abstract":"Although micro-anastomosis is the most commonly performed procedure for reconnecting two blood vessels through sutures, thrombus formation and subsequently anastomotic failure remains one of the most serious clinical complications. An important stimulus to thrombus formation is the altered hemodynamics with abnormal Wall Shear Stress (WSS) distribution on endothelial cells generated by the presence of sutures. Computational simulation is a valid tool to examine the local hemodynamics of micro-anastomosed vessels, allowing for the calculation of the WSS, a factor that could otherwise not directly possible to be measured in vivo. The aim of this study is to perform Fluid-Structure Interaction (FSI) analysis of micro-anastomosis in order to examine the effects of the wall compliance on the hemodynamic quantities.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130093835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kaplarevic-Malisic, M. Ivanovic, B. Stojanovic, M. Svicevic, Darko B. Antonijevic
{"title":"Employing phenomenological model in load-balancing optimization of parallel multi-scale muscle simulations","authors":"A. Kaplarevic-Malisic, M. Ivanovic, B. Stojanovic, M. Svicevic, Darko B. Antonijevic","doi":"10.1109/BIBE.2015.7367673","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367673","url":null,"abstract":"Since multi-scale models of muscles rely on the integration of physical and biochemical properties across multiple length and time scales, these models are highly CPU consuming and memory intensive. Therefore, their practical implementation and usage in real-world applications is limited by their high requirements for computational power. There are various reported solutions to the problems of the distributed computation of the complex systems that could also be applied to the multi-scale muscle simulations. In this paper, we present a novel load balancing method for parallel multi-scale muscle simulations on distributed computing resources. The method uses data obtained from simple Hill phenomenological model in order to predict computational weights of the integration points within the multi-scale model. Using obtained weights it is possible to improve domain decomposition prior to multi-scale simulation run and consequently significantly reduce computational time. The method is applied to two-scale muscle model where a finite element (FE) macro model is coupled with Huxley's model of cross-bridge kinetics on the microscopic level. The massive parallel solution is based on decomposition of micro model domain and static scheduling policy. It was verified on real-world example, showing high utilization of all involved CPUs and ensuring high scalability, thanks to the novel scheduling approach. Performance analysis clearly shown that inclusion of complexities prediction in reducing the execution time of parallel run by about 40% compared to the same model with scheduler that assumes equal complexities of all micro models.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134325800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new information-theoretic approach to detect gene-gene interactions in case-control studies","authors":"Xiangdong Zhou, Keith C. C. Chan","doi":"10.1109/BIBE.2015.7367739","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367739","url":null,"abstract":"Gene-gene interaction is an important factor to consider in selecting genes in genotype data or microarray expression data for association with diseases. However current definitions of gene-gene interaction are not very clear and accurate. An inequality is proved in this paper and a new definition of gene-gene interaction: conditional independence and redundancy based definition of gene-gene interaction (CIR), together with a definition of interaction group are proposed according to this inequality. A new algorithm to detect gene-gene interaction with order greater than two is also proposed based on these new definitions and a theorem. Experimental results show the usefulness of these new definitions and the effectiveness and efficiency of this new algorithm.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116189782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}