Modern Health Science最新文献_第2页

Index of Unfairness 不公平指数

Modern Health Science Pub Date : 2019-04-30 DOI: 10.30560/mhs.v2n1p22

Ilija Barukčić

{"title":"Index of Unfairness","authors":"Ilija Barukčić","doi":"10.30560/mhs.v2n1p22","DOIUrl":"https://doi.org/10.30560/mhs.v2n1p22","url":null,"abstract":"Objective. Objective scientific knowledge for many authors more valuable than true subjective belief is determined by research on primary data but a renewed analysis of already recorded or published data is common too. Ever since, an appropriate experimental or study design is an important and often a seriously underappreciated aspect of the informativeness and the scientific value of any (medical) study. The significance of study design for the reliability of the conclusions drawn and the ability to generalize the results from the sample investigated for the whole population cannot be underestimated. In contrast to an inappropriate statistical evaluation of a medical study, it is difficult to correct errors in study design after the study has been completed. Various mathematical aspects of study design are discussed in this article. \u0000Methods. In assessing the significance of a fair study design of a medical study, important measures of publication bias are introduced. Methods of data or publication bias analysis in different types of studies are illustrated through examples with fictive data. Formal mathematical requirements of a fair study design which can and should be fulfilled carefully with regard to the planning or evaluation of medical research are developed. \u0000Results. Various especially mathematical aspects of a fair study design are discussed in this article in detail. Depending on the particular question being asked, mathematical methods are developed which allow us to recognize data which are self-contradictory and to exclude these data from systematic literature reviews and meta-analyses. As a result, different individual studies can be summed up and evaluated with a higher degree of certainty. \u0000Conclusions. This article is intended to give the reader guidance in evaluating the design of studies in medical research even ex post which should enable the reader to categorize medical studies better and to assess their scientific quality more accurately.","PeriodicalId":421866,"journal":{"name":"Modern Health Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129058327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Epstein Barr Virus and Atrial Fibrillation eb病毒与心房颤动

Modern Health Science Pub Date : 2019-01-30 DOI: 10.30560/mhs.v2n1p1

Ilija Barukčić

引用次数: 1

Studies on the Lipid Profiles of Wistar Rat Models Treated with Aqueous and Methanolic Leaf Extracts of Alchornea Cordifolia and Thaumatococcus Daniellii Cordifolia Alchornea Cordifolia和Thaumatococcus Daniellii的水、甲醇叶提取物对Wistar大鼠模型脂质谱的影响

Modern Health Science Pub Date : 2019-01-29 DOI: 10.30560/MHS.V1N2P46

K. Osuocha, E. Ogbonnaya, E. O. Nweke, D. Ejiofor, P. Njoku

{"title":"Studies on the Lipid Profiles of Wistar Rat Models Treated with Aqueous and Methanolic Leaf Extracts of Alchornea Cordifolia and Thaumatococcus Daniellii","authors":"K. Osuocha, E. Ogbonnaya, E. O. Nweke, D. Ejiofor, P. Njoku","doi":"10.30560/MHS.V1N2P46","DOIUrl":"https://doi.org/10.30560/MHS.V1N2P46","url":null,"abstract":"This study aims at establishing the effect of T. daniellii and A. cordifolia leaf extracts on the lipid profile of experimental rat models. A total of twenty five (25) adult male wistar rats were used for the study. The rats were divided into five groups of five rats each. Group I (normal control) was administered with 2ml/kg distilled water p.o. Group II was administered with 200mg/kg aqueous leaf extract of T. daniellii p.o. Group III was administered with 200mg/kg methanolic leaf extract of T. daniellii p.o. Group IV and V were administered with 200mg/kg aqueous and methanolic leaf extracts of A. cordifolia respectively. Administration of extracts lasted for 14 days after which animals were sacrificed and serum developed from blood samples was collected and used for analysis to evaluate the lipid profiles of experimental models using standard methods. Results obtained from the study show that the highest level of Low Density Lippoprotein (LDL) (31.21±0.04 mg/dL) was recorded on Group II and was not significantly different from the control group (33.20±0.10 mg/dL). However, for High Density Lipoprotein (HDL), the highest level was recorded on Group IV (48.14±0.08mg/dL). Similarly, this was not significantly different from the Control group (51.80±0.10mg/dL). Group II presented the highest level of Triacylglyceride (TG) (48.80±0.02mg/dL), which however, was considered not significantly different from the control group (51.17±0.08mg/dL). For Total Cholesterol (TC), highest level (64.64±0.49mg/dL) was recorded on Group II and value was not significantly different from that recorded on the normal control (63.83±0.10mg/dL). In conclusion, it can be deduced from this study that extracts of T. daniellii and A. cordifolia lacks the potential to alter the lipid profile of patients depending on them for one medicinal use or the other and may thus be considered potential candidates for drug development.","PeriodicalId":421866,"journal":{"name":"Modern Health Science","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134290151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hepatotoxicity and Histological Evaluation of Aqueous and Methanolic Leaf Extracts of Thaumatococcus Daniellii and Alchornea Cordifolia in Wistar Rat Models 大鼠Wistar模型中Daniellii和Alchornea Cordifolia叶片水提物和甲醇提物的肝毒性和组织学评价

Modern Health Science Pub Date : 2019-01-04 DOI: 10.30560/MHS.V1N2P42

Service @ Ideasspread.org, Okafor I. J., Nweke E. O., Ewa O.

{"title":"Hepatotoxicity and Histological Evaluation of Aqueous and Methanolic Leaf Extracts of Thaumatococcus Daniellii and Alchornea Cordifolia in Wistar Rat Models","authors":"Service @ Ideasspread.org, Okafor I. J., Nweke E. O., Ewa O.","doi":"10.30560/MHS.V1N2P42","DOIUrl":"https://doi.org/10.30560/MHS.V1N2P42","url":null,"abstract":"This study was carried out to ascertain the hepatotoxic potential of T.daniellii (T.d) and A. cordifolia (A.c). Investigations were conducted using standard methods. Oral administration of 200mg/kg aqueous leaf extracts of T.daniellii caused a non-significant increase in the activity of ALT (5.43±0.60IU/L), AST (16.93±0.26 IU/L) and ALP (160.70±1.04 IU/L) compared to the values recorded on the normal control (group I) ALT (3.84±0.16 IU/L), AST (14.19±0.52 IU/L) and ALP (157.26±0.64 IU/L). Group III administered with 200mg/kg methanolic leaf extract of T. daniellii manifested a significant elevation in the activity of ALT (13.15±0.89 IU/L), AST (22.84±0.38 IU/L) and ALP (170.40±0.44 IU/L) compared to the normal control. Similarly, groups IV and V which were orally administered with 200mg/kg aqueous and methanolic leaf extracts of A. cordifolia showed significant increase in the activity of ALT (6.32±0.33U/L), AST (17.70±0.030U/L) and ALP (161.13±0.09U/L) and ALT (7.55±0.59U/L), AST (19.35±0.26U/L) and ALP (165.38±0.35U/L) respectively compared to the values recorded on the control (group I). In conclusion, drug development protocols involving T. daniellii leaf should preferably use water as an ideal solvent. On the other hand, the hepatotocity associated with both aqueous and methanolic extracts of A. cordifolia could imply the presence of hepatotoxins in the leaf of the said plant.","PeriodicalId":421866,"journal":{"name":"Modern Health Science","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123934952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Infective Endocarditis by Rare Organism Granulicatella Adiacens 由罕见芽胞杆菌引起的感染性心内膜炎

Modern Health Science Pub Date : 2018-12-03 DOI: 10.30560/MHS.V1N2P37

A. Hamoudi, Dana Vais, Vian Taqi

引用次数: 0

Gastric Cancer and Epstein-Barr Virus Infection 胃癌与eb病毒感染

Modern Health Science Pub Date : 2018-08-29 DOI: 10.30560/mhs.v1n2p1

Ilija Barukčić

{"title":"Gastric Cancer and Epstein-Barr Virus Infection","authors":"Ilija Barukčić","doi":"10.30560/mhs.v1n2p1","DOIUrl":"https://doi.org/10.30560/mhs.v1n2p1","url":null,"abstract":"Background: Epstein-Barr virus (EBV) has an important role in the oncogenesis of several malignant diseases. Reports even demonstrated the presence of Epstein-Barr virus in gastric carcinoma (GC). However, the pathogenic role of EBV in GC is uncertain. The present investigation was carried out to investigate a possible causal relationship between GC and EBV. \u0000Statistical Analysis: The method of the conditio sine qua non relationship was used to proof the hypothesis whether gastric cancer is a necessary condition (a conditio sine qua non) of the presence of EBV in human gastric tissues. In other words without GC no EBV in human stomach. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between gastric cancer and EBV. Significance was indicated by a p-value (two sided) of less than 0.05. \u0000Results: In toto 26 ISH based studies with a sample size of N = 11860 were re-analyzed. All the studies analyzed support the null-hypothesis without GC no EBV positivity in human stomach. In other words, gastric cancer itself is a conditio sine qua non of EBV positivity in stomach tissues while the cause effect relationship between gastric cancer and EBV was highly significant. \u0000Conclusions: Epstein-Barr virus is neither a cause, nor the cause of human gastric cancer.","PeriodicalId":421866,"journal":{"name":"Modern Health Science","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123086660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Reviewer Acknowledgements for Modern Health Science, Vol. 1, No. 1 《现代健康科学》第1卷第1期审稿人致谢

Modern Health Science Pub Date : 2018-07-03 DOI: 10.30560/mhs.v1n1p51

Lacy Brown

引用次数: 0

Incidental Follicular Lymphoma in Duodenum After Routine Biopsy 常规活检后十二指肠偶发滤泡性淋巴瘤

Modern Health Science Pub Date : 2018-06-22 DOI: 10.30560/MHS.V1N1P39

Alhareth Alsagban, Hamza Altaie, Marwah Algodi, N. Ahmed

引用次数: 0

Emerging Role of Galectin-3 in Pulmonary Artery Hypertension 半凝集素-3在肺动脉高压中的新作用

Modern Health Science Pub Date : 2018-06-22 DOI: 10.30560/mhs.v1n1p35

A. Berezin