Egyptian Journal of Haematology最新文献_第3页

Pattern of HLA types in renal transplant patients in Sohag Governorate: A cross-sectional study 索哈格省肾移植患者HLA分型的横断面研究

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_33_21

E. Yossef, Eman H. Salama, Ahmad M Elsharif

{"title":"Pattern of HLA types in renal transplant patients in Sohag Governorate: A cross-sectional study","authors":"E. Yossef, Eman H. Salama, Ahmad M Elsharif","doi":"10.4103/ejh.ejh_33_21","DOIUrl":"https://doi.org/10.4103/ejh.ejh_33_21","url":null,"abstract":"Objective This study aimed to assess the pattern of HLA types in Egyptian renal transplant patients in the Sohag governorate. Materials and methods A retrospective chart review was conducted on all patients and their donors, who were scheduled to undergo renal transplantation at Sohag University Hospital through the period from January 2010 to December 2019. We retrieved the following data from eligible patients’ files: age of the recipient and donor, gender of the recipient and donor, consanguinity, blood group, cross-matching, HLA classes A and B, and DR alleles. Results Overall, a total of 26 recipients (70.3%) and 25 donors (67.6%) had HLA-A alleles, while 22 recipients (59.5%) and 26 donors (70.3%) had HLA-B alleles. In terms of the pattern of HLA-A distribution among recipients, the most frequent alleles were AFNx0101/02 (8.1%), AFNx0102/23 (5.4%), AFNx0102/32 (5.4%), and AFNx0102 (5.4%). On the other hand, the most frequent HLA-A alleles in the donors’ group were AFNx0101/02 (5.4%), AFNx0102/03 (5.4%), and AFNx0126/68 (5.4%). Regarding HLA-B allele distribution, all recipients had different alleles. While BFNx0141/52 was the most frequent allele in the donors’ group. All recipients, except two patients, had HLA-DR alleles, most commonly DRFNx0111/13 (13.5%) and DRFNx0113/15 (8.1%). Negative cross-matching was present in 59.5% of the cases. Among female recipients, only AFNx0113/15 and BFNx0127/51/53 alleles were detected. Conclusion In conclusion, our findings were very similar to the results from other local and global studies. Different populations and ethnicities are the main dependent variables of the major differences in terms of HLA allele distribution.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"316 - 320"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42580105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interrelationship between G-6-PD-deficiency frequency and accumulated number of coronavirus disease 2019 cases: An observation from provinces in a highly endemic area in Indochina

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_16_22

R. Mungmunpuntipantip, V. Wiwanitkit, P. Sookaromdee

引用次数: 0

Platelet/lymphocyte, neutrophil/lymphocyte, and red-cell distribution width/platelet ratios for assessment of hepatitis-C virus infection severity 血小板/淋巴细胞、中性粒细胞/淋巴细胞和红细胞分布宽度/血小板比值用于评估丙型肝炎病毒感染严重程度

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_32_22

Ghada Abdelsalam, Hossam A. Hodeib, T. Elbedewy, Loai M. Elahwal, M. Aboelnasr

{"title":"Platelet/lymphocyte, neutrophil/lymphocyte, and red-cell distribution width/platelet ratios for assessment of hepatitis-C virus infection severity","authors":"Ghada Abdelsalam, Hossam A. Hodeib, T. Elbedewy, Loai M. Elahwal, M. Aboelnasr","doi":"10.4103/ejh.ejh_32_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_32_22","url":null,"abstract":"Introduction Chronic hepatitis C is a global health problem with high cost, morbidity, and mortality. There is increasing need for noninvasive parameters to assess disease severity. Some parameters obtained from routine full-blood count are used as indicators for systemic inflammation. These include platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and red-cell distribution width-to-platelet ratio (RPR). The aim of the present study was to investigate the utility of these parameters in assessment of hepatitis-C virus disease severity. Patients and methods The study population included 180 participants who were divided into four groups. Group I included 90 healthy participants as control. Group II included 30 patients in sustained virus response after 6 months of treatment with direct-acting antiviral agents. Group III included 30 untreated noncirrhotic patients with chronic hepatitis C. Group IV included 30 untreated cirrhotic patients. All underwent thorough clinical evaluation and investigations, including PLR, NLR, RPR, aspartate aminotransferase to platelet-ratio index, and fibrosis index based on the 4 factors. Results NLR did not express significant difference among the studied groups (P=0.998). When moving from the first to the fourth group, PLR showed a gradual decrease being significantly lower in group IV (P<0.001), while RPR showed a gradual increase being significantly higher in group IV (P<0.001). Conclusion PLR and RPR were closely related to disease severity in patients with hepatitis-C virus-related liver disease. NLR was not correlated to disease severity in the same cohort.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"288 - 293"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46606597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortactin: A novel prognostic marker in chronic myeloid leukemia Cortactin：一种新的慢性粒细胞白血病预后标志物

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_30_22

M. El-Razzaz, Tamer M. Ahmed, D. Eissa, N. Abdalla, Mohammed Shaheen, Haydi S. Mohamed

{"title":"Cortactin: A novel prognostic marker in chronic myeloid leukemia","authors":"M. El-Razzaz, Tamer M. Ahmed, D. Eissa, N. Abdalla, Mohammed Shaheen, Haydi S. Mohamed","doi":"10.4103/ejh.ejh_30_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_30_22","url":null,"abstract":"Background Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease characterized by leukocytosis and an accumulation of granulocytes and their precursors. Cortactin is an actin-binding protein substrate of Src kinase. High cortactin expression in many hematological malignancies has been correlated with adverse prognostic factors. Aim The aim of our study was to measure cortactin levels in patients with CML at diagnosis and correlate such levels with other prognostic factors. Patients and methods This is a case–control study that was executed at hematology unit, Ain-Shams University Hospital during the period between January 2021 and October 2021. The study included 25 newly diagnosed patients with chronic phase CML and 25 healthy controls. Accelerated phase and blast crisis were excluded from the study. Results Cortactin level at diagnosis was higher in the patients group compared with the control group (71.04 ± 20.04 vs. 36.8 ± 11.6%, P<0.001). Cortactin level was significantly higher in patients who did not achieve complete hematological remission (CHR) at 3 months in comparison with those who achieved CHR (88.49 ± 8.02 vs. 61.23 ± 17.98, P<0.001). Patients who failed to attain CHR at 3 months had a significantly worse prognostic score at diagnosis using Sokal, Hasford, and ELTS scores (P=0.016, 0.035, and 0.009, respectively), but this did not apply to EUTOS score (P=0.089). Conclusion Higher cortactin levels are associated with delayed CHR in newly diagnosed patients with chronic phase CML, and it can be used as a prognostic marker for patients with CML at diagnosis.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"249 - 254"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42572810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low leukocyte count in Langya henipavirus and severity of infection: A brief report 狼牙病病毒白细胞计数低与感染严重程度的关系

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_50_22

R. Mungmunpuntipantip, V. Wiwanitkit

引用次数: 0

DNMT3A-448A>G nucleotide polymorphism and susceptibility to acute myeloid leukemia in a cohort of Egyptian patients 埃及患者队列中DNMT3A-448A>G核苷酸多态性与急性粒细胞白血病易感性

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_81_22

Essam H Elnoshokaty, Gamal T A Ebid, M. Fahmy, Tarek Shikhon, Rania M. Gawdat

{"title":"DNMT3A-448A>G nucleotide polymorphism and susceptibility to acute myeloid leukemia in a cohort of Egyptian patients","authors":"Essam H Elnoshokaty, Gamal T A Ebid, M. Fahmy, Tarek Shikhon, Rania M. Gawdat","doi":"10.4103/ejh.ejh_81_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_81_22","url":null,"abstract":"Background DNA-methyltransferase 3 A (DNMT3A) plays an important role in DNA methylation. Its mutation is the commonest mutated epigenetic regulator in acute myeloid leukemia (AML). However, the relation between DNMT3 polymorphism and AML risk in Egyptian patients is still unknown. Objectives To detect the frequency of DNMT3A-448A>G (rs 1550117) single nucleotide polymorphism in a cohort of adult Egyptian patients with AML and normal controls matched by age, sex, and ethnicity and to assess its effect on the susceptibility of AML. Patients and methods PCR-restriction fragment length polymorphism was the genotyping method used to assess DNMT3A polymorphism in the present case–control study. Results The frequency of the wild (GG), mutant heterozygous (AG), and mutant homozygous (AA) genotypes among patients and controls were 47.90 versus 47.70%, 46.50 versus49.20%, and 5.60 versus 3.10%, respectively (P=0.763, 0.505, and 0.462, respectively), whereas the frequency of A allele was 28.87 versus 27.69% P=0.829. The patients with DNMT3A mutant types (AG, AA, and carrier of the variant Allele of the DNMT3A) were not associated with the risk of AML (odds ratio: 0.548, 0.516, and 0.934; 95% confidence interval: 0.094–3.206, 0.088–3.014, and 0.556-1.60, respectively). Conclusion DNMT3A-448A>G (rs 1550117) polymorphism conferred no risk to AML in our studied Egyptian patients.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"294 - 298"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45365186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between anemia and hypovitaminosis D 贫血与维生素D缺乏症之间的关系

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_7_22

Raed Alharbi

{"title":"The association between anemia and hypovitaminosis D","authors":"Raed Alharbi","doi":"10.4103/ejh.ejh_7_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_7_22","url":null,"abstract":"Background Hypovitaminosis D (deficiency and insufficiency) and anemia are both known as major public health concerns globally. A suboptimal level of vitamin D has been suggested to be a potential trigger player for reduced hemoglobin levels, thus increasing the risk of anemia. Objective The purpose of this study was to determine the prevalence of hypovitaminosis D and anemia, as well as the relationship between the two. Patients and methods Demographic and laboratory data were collected and analyzed (Pearson’s correlation and multivariate logistic regressions) using IBM Statistical Package for SPSS, and graphical data visualization was performed using the R programming language and R-based Rstudio. Results The overall prevalence of vitamin D deficiency was 75% (n=302), whereas insufficiency and sufficiency were 19.7 and 4.5%, respectively. Vitamin D deficiency was most prevalent in the 30–49-year age group (n=155, 81%), whereas it was least prevalent in the 50–69-year age group (n=63, 65%). A significant positive Pearson’s correlation was found between vitamin D concentration and hemoglobin at the 0.05 level (r=0.133 and P=0.05) and between vitamin D concentration and the patient’s age in years at the 0.01 level (r=0.157 and P=0.01). Anemia was found to be prevalent in 36% of the population. Normocytic anemia was the most prevalent type, followed by microcytic anemia. Conclusion The role of hypovitaminosis D as a risk factor for anemia is unknown, and thus multiple longitudinal and interventional studies are recommended to establish an association between vitamin D deficiency and anemia.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"308 - 315"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46976141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractory splenectomized immune thrombocytopenic purpura: Does vincristine have a role after thrombopoietin receptor agonist failure? 难治性脾切除免疫性血小板减少性紫癜:长春新碱在血小板生成素受体激动剂失效后有作用吗?

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_84_22

S. Moeen, A. Thabet, M. Morad

{"title":"Refractory splenectomized immune thrombocytopenic purpura: Does vincristine have a role after thrombopoietin receptor agonist failure?","authors":"S. Moeen, A. Thabet, M. Morad","doi":"10.4103/ejh.ejh_84_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_84_22","url":null,"abstract":"Introduction The treatment options for patients with refractory splenectomized chronic immune thrombocytopenic purpura (ITP) are often unsatisfactory despite different lines of treatment, especially after thrombopoietin receptor agonist (TPO-RA) failure. Objective This study was done to assess the efficacy of vincristine in the treatment of patients with splenectomized chronic ITP who failed TPO-RA therapy as well as their 8-month follow-up following vincristine discontinuation. Patients and methods A total of 12 patients with splenectomized chronic ITP who failed to respond to TPO-RA were treated with vincristine 1–2 mg weekly for 6 weeks. Results The platelet count was evaluated during the treatment, and every 2 months for 8-month follow-up. The mean platelet count was significantly increased at the third, fourth, fifth, and sixth weeks during the treatment and persistently elevated during the second, fourth, and sixth months of follow-up when compared with the baseline platelet count, while decreasing at the 8-month follow-up, with no significant difference at their baseline. Conclusion Vincristine could be an effective treatment in patients with splenectomized ITP who failed to respond to TPO-RAs and in patients requiring a short-term increase in the platelet count.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"299 - 303"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48559169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple prognostic markers in patients with hematological malignancies and coronavirus disease 2019 infection: Single-center experience 2019年血液系统恶性肿瘤和冠状病毒病感染患者的简单预后标志物：单中心经验

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_31_22

N. Rakha, D. Mohammed, N. Hassan, Nour El Abdalla

{"title":"Simple prognostic markers in patients with hematological malignancies and coronavirus disease 2019 infection: Single-center experience","authors":"N. Rakha, D. Mohammed, N. Hassan, Nour El Abdalla","doi":"10.4103/ejh.ejh_31_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_31_22","url":null,"abstract":"Background Coronavirus disease 2019 (COVID-19) pandemic rapidly spread from China to other countries. The clinical features of patients with COVID-19 have revealed a number of potential biochemical markers associated with in-hospital mortality. Numerous studies have proposed the use of hematological markers that seem to associate with increased severity and mortality in patients with COVID-19. Aim To evaluate the prognostic value of some hematological parameters and inflammatory biomarker effect on overall survival (OS) and mortality on patients with hematological malignancies infected with COVID-19. Patients and methods A cross-sectional study of 50 adult Egyptian patients with different hematological malignancies were recruited from Clinical Hematology Department, Ain Shams University Hospital, over the period from December 2020 to October 2021. Results The mean of neutrophil-to-monocyte ratio (NMR) was 0–110 and median interquartile range 7.40 (3.0–16.67)×103/µl and there is significant correlation between NMR and OS with P value of 0.031, there is significant correlation between OS of those patients and D-dimer, ferritin, hematocrit, and red-blood cell count. Conclusion There are simple, easy, and rapid tests such as the NMR, inflammatory biomarkers (ferritin and D-dimer), and some hematological parameters (hematocrit and red blood cell) that have prognostic value on OS and mortality on patients with hematological malignancies infected with COVID-19.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"255 - 261"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42762119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and prognostic significance of miRNA-511 and miRNA-16 expressions in adult patients with B-acute lymphoblastic leukemia miRNA-511和miRNA-16表达在成年b急性淋巴细胞白血病患者中的诊断及预后意义

Egyptian Journal of Haematology Pub Date : 2022-07-01 DOI: 10.4103/ejh.ejh_41_21

Manal El Sorady, A. Elhadidi, Omar Gallab, Nermeen Eldabah, Mohamed Elbahoty

{"title":"Diagnostic and prognostic significance of miRNA-511 and miRNA-16 expressions in adult patients with B-acute lymphoblastic leukemia","authors":"Manal El Sorady, A. Elhadidi, Omar Gallab, Nermeen Eldabah, Mohamed Elbahoty","doi":"10.4103/ejh.ejh_41_21","DOIUrl":"https://doi.org/10.4103/ejh.ejh_41_21","url":null,"abstract":"Background Acute lymphoblastic leukemia (ALL) is a neoplastic disease that results from multistep somatic mutations in a single lymphoid progenitor cell. MicroRNAs (miRNAs) are critical regulators of gene expression, tumor suppression, and oncogenesis. Aim To evaluate miRNA-511 and miRNA-16 expression in Egyptian adult patients with B-ALL. Patients and methods A total of 37 newly diagnosed adult patients with B-ALL admitted to Alexandria Main University Hospital in 2019 were included. Complete blood count, bone marrow aspiration, immunophenotyping, BCR-ABL testing, karyotyping, miRNA extraction using miRNeasy Mini followed by cDNA synthesis AQ6 (RQ-PCR combines cDNA synthesis from RNA templates using miScript II RT kit), and finally real-time PCR for miRNA-511 and miRNA-16 expression were among the investigations that were conducted. Results Mean age of patients with ALL was 30.65 ± 10.39 years, with male to female ratio of 1.4 : 1. Cytogenetic findings showed that only three patients had favorable risk, and the rest were either intermediate risk (19) or high risk (15). Among the high-risk group, there were 11 patients with Philadelphia chromosome (BCR-ABL 190) positive. Regarding the expression of miRNAs, most patients showed overexpression of both miRNA-16 and miRNA-511. MiRNA-511 was overexpressed in 81.1% (30) patients; among these patients, 43.3% (13) had adverse cytogenetic findings. MiRNA-16 was overexpressed in 70.3% (26) of patients, and half of them (13) had adverse cytogenetic findings. receiver operating characteristic curves showed diagnostic significance in B-ALL for miRNA-16, with sensitivity of 75.7% and specificity of 80%, and for miRNA-511, sensitivity was 89.2% and specificity was 90% (P<0.05). Conclusion MiRNA-16 and miRNA-511 were significantly overexpressed in adult patients with B-ALL. They have a role in diagnosis but a weak role in patient prognosis.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"204 - 209"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47918768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0