Egyptian Journal of Haematology最新文献_第2页

The association between hemostatic and genetic parameter variation and the susceptibility to develop vascular complications in Egyptian Bechet’s disease patients 埃及Bechet病患者止血与遗传参数变异及血管并发症易感性之间的关系

Egyptian Journal of Haematology Pub Date : 2023-01-01 DOI: 10.4103/ejh.ejh_35_22

Hanan Raslan, S. El-Jaafary, Aya Hassan, S. Yousry, Maha Hamdi El Sissy

{"title":"The association between hemostatic and genetic parameter variation and the susceptibility to develop vascular complications in Egyptian Bechet’s disease patients","authors":"Hanan Raslan, S. El-Jaafary, Aya Hassan, S. Yousry, Maha Hamdi El Sissy","doi":"10.4103/ejh.ejh_35_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_35_22","url":null,"abstract":"Objectives Bechet’s disease (BD) is a multisystem inflammatory disorder with predominant and frequent vascular complications. The pathogenesis of thrombosis in BD is not clearly known, vasculitis and/or multifactorial procoagulant activities are the cornerstone histopathological features of the disease. Patients and methods In this study, we investigated the role of hypercoagulable state and the hemostatic alteration in BD patients and their susceptibility to develop vascular thrombotic complications using ViennaLab CVD StripAssay for molecular detection of thrombophilia gene mutation by PCR and reverse hybridization to allele-specific oligonucleotide probes immobilized on test strip. Natural anticoagulant levels were also assessed to trace the association between activated coagulation system and increased susceptibility of BD patients to develop vascular complication. Results The study revealed a significant association between human platelet antigen-1 polymorphism and the presence of vascular thrombosis, either arterial or venous, in BD patients. Also, there was a significant relationship between mutant MTHFR genotype and venous thrombosis. But, there was an insignificant association between vascular complications in BD patients from one side and the levels of natural anticoagulants (protein C, protein S, and antithrombin III) and mean platelet volume (MPV) level from the other side. Conclusion Despite the association of some thrombophilic factors with the thrombotic tendency seen in BD, the usage of anticoagulants in BD patients with thrombosis may be unnecessary.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"48 1","pages":"1 - 8"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47006424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the bleeding severity in patients with type I von Willebrand using the International Society on Thrombosis and Hemostasis-Bleeding Assessment Tool (ISTH-BAT) questionnaire 使用国际血栓和止血学会出血评估工具（ISTH-BAT）问卷评估I型von Willebrand患者的出血严重程度

Egyptian Journal of Haematology Pub Date : 2023-01-01 DOI: 10.4103/ejh.ejh_20_23

R. Hafez, Shery Hennes, Azza Abdelaal, Nabawia M. Tawfik, Safinaz Hussein

{"title":"Assessing the bleeding severity in patients with type I von Willebrand using the International Society on Thrombosis and Hemostasis-Bleeding Assessment Tool (ISTH-BAT) questionnaire","authors":"R. Hafez, Shery Hennes, Azza Abdelaal, Nabawia M. Tawfik, Safinaz Hussein","doi":"10.4103/ejh.ejh_20_23","DOIUrl":"https://doi.org/10.4103/ejh.ejh_20_23","url":null,"abstract":"Background In the recent decade, bleeding evaluation methods have evolved to standardize the severity of bleeding symptoms in a uniform manner. In 2010, the International Society on Thrombosis and Hemostasis-Bleeding Assessment Tool (ISTH-BAT) was developed and validated. Aim and objectives The aim of the study was to evaluate bleeding score (BS) in Egyptian patients with von Willebrand disease (VWD) type I and correlate it with laboratory parameters. Patients and methods This cross-sectional cohort study was conducted at Assiut University Hospital. It included 100 participants that were divided into 49 patients with type I VWD and 51 healthy participants with no known problem with bleeding or bruising. The duration of the study was ~12 months. Results Study revealed that there was significant relation between BS severity and laboratory parameters such as level of von Willebrand factor: Ag (P=0.02) while there was no significant relation between BS and sex (P=0.390). By using receiver operating characteristic curve analysis, ISTH-BAT BS can detect type I VWD patients in total with excellent accuracy (98%), area under the curve was 0.989 with sensitivity and specificity of 96 and 100%, respectively (P<0.001). Conclusion The ISTH-BAT BS is designed to reflect the severity of bleeding. Our results demonstrate the inherent variability of this bleeding pattern. We also found that the ISTH-BAT BS has high sensitivity and specificity to detect type I VWD patients in total with excellent accuracy.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"48 1","pages":"82 - 87"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44524165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the morphologic changes in the peripheral blood smear as a predictive tool for the early diagnosis of coronavirus disease 2019 and their relation to the clinical course severity 外周血涂片形态学变化对2019冠状病毒病早期诊断的预测作用及其与临床病程严重程度的关系研究

Egyptian Journal of Haematology Pub Date : 2023-01-01 DOI: 10.4103/ejh.ejh_80_22

Hadeel Abdelsalam, Mohamed Rahman, Amr Ibrahim Elsherif, Osama Bakheet, Hadir El-Kady

{"title":"Study of the morphologic changes in the peripheral blood smear as a predictive tool for the early diagnosis of coronavirus disease 2019 and their relation to the clinical course severity","authors":"Hadeel Abdelsalam, Mohamed Rahman, Amr Ibrahim Elsherif, Osama Bakheet, Hadir El-Kady","doi":"10.4103/ejh.ejh_80_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_80_22","url":null,"abstract":"Introduction Coronavirus disease 2019 (COVID-19) infection affects different organs of the human body, and also the blood cells. Since the beginning of the COVID-19 pandemic, many studies have described the quantitative peripheral blood findings seen in COVID-19 patients. However, morphologic changes have been described by only a few studies. Peripheral blood smear (PBS) is a simple and available method to investigate blood cells’ morphologic changes. Aim In this study, we aimed to determine the morphologic changes affecting all blood cells of COVID-19 patients and their relation to the early diagnosis and the patients’ clinical course severity. Patients and methods PBS of 200 COVID-19 patients and 50 non-COVID-19 controls was examined for morphological changes in the period between January 2021 and January 2022, the patients’ clinical course and blood chemistry were reported. Results Significant morphological changes were found. Smudge cells are the most frequent. Other findings were schistocyte, increased large granular lymphocytes, leukoerythroblastic reaction, pseudo Pelger–Huët, abnormal monocytes, and giant platelets. Our results showed significant relationship between PBS findings and the clinical course severity and outcome.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"48 1","pages":"19 - 27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45720051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios in adult and pediatric acute lymphoblastic leukemia patients 成人和儿童急性淋巴细胞白血病患者中性粒细胞与淋巴细胞、淋巴细胞与单核细胞以及血小板与淋巴细胞比值的预测价值

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_19_22

Mariam K. Youssef, R. Radwan, S. Makkeyah, Sara I. Taha

{"title":"Predictive value of neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios in adult and pediatric acute lymphoblastic leukemia patients","authors":"Mariam K. Youssef, R. Radwan, S. Makkeyah, Sara I. Taha","doi":"10.4103/ejh.ejh_19_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_19_22","url":null,"abstract":"Background Methods used for prognostication of acute lymphoblastic leukemia (ALL) are expensive; discovering low-cost prognostic factors is challenging. Objectives This study aimed to explore the prognostic role of baseline neutrophil-to-lymphocyte (NLR), lymphocyte-to-monocyte (LMR), and platelet-to-lymphocyte (PLR) ratios in predicting the response to end of induction chemotherapy in ALL patients. Patients and methods We included 44 adult patients and 47 pediatric patients who were newly diagnosed with ALL. All participants were subjected to a full history taking and a thorough medical examination. Laboratory investigations included complete blood count (CBC) with differential count analysis, with calculation of NLR, LMR, and PLR; bone marrow examination; conventional cytogenetic analysis; and immunophenotyping. Patients were followed until the end of the induction phase, and their response to treatment was assessed. Results Among the adult patients, 63.6% showed complete remission at the end of induction; their baseline CBC showed significantly lower NLR (P=0.001) and higher LMR (P=0.013). On the other hand, 66% of the pediatric patients showed good response to induction chemotherapy; their baseline CBC showed significantly lower NLR (P<0.001), greater LMR (P=0.0134), and lower PLR (P=0.017). NLR more than or equal to 1, LMR less than or equal to 2.846, and PLR more than or equal to 39.1 were able to discriminate adult patients who will respond to induction chemotherapy, similarly NLR more than or equal to 1, LMR less than or equal to 3.286, and PLR more than or equal to 10 among pediatric patients. Conclusion Our research discovered that the rise in NLR and PLR, together with the decline of LMR at ALL diagnosis, could predict future resistance to the routinely used induction protocols, and the need for intensification regimens.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"239 - 248"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48609456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telemedicine in patients with hematological diseases during the coronavirus disease 2019 (Covid-19) pandemic: Beneficial care or waste of time? 2019冠状病毒病（新冠肺炎）大流行期间血液病患者的远程医疗：有益的护理还是浪费时间？

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_90_22

Rasha Rawi, M. Salah, M. Mattar, Noha M. El Husseiny, M. Morad

{"title":"Telemedicine in patients with hematological diseases during the coronavirus disease 2019 (Covid-19) pandemic: Beneficial care or waste of time?","authors":"Rasha Rawi, M. Salah, M. Mattar, Noha M. El Husseiny, M. Morad","doi":"10.4103/ejh.ejh_90_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_90_22","url":null,"abstract":"Introduction Telemedicine (TM) is a method for follow-up of patients experiencing chronic morbidities, such as those with myeloproliferative neoplasms (MPNs) and thalassemia, particularly during the coronavirus disease 2019 (COVID-19) pandemic. Objective To assess medical services administrated to patients with MPNs and thalassemia after 6 months of online follow-up. Patients and methods During the COVID-19 pandemic, of 250 patients who were regularly following up in the hematology clinic, only 45 patients with MPNs and 30 patients with thalassemia were able to connect through the WhatsApp group. Six months later, a questionnaire was given to patients. We asked if COVID-19 affected their routine medical service and receipt of their treatment. Finally, did they attend the clinic despite TM service and why?Results Two patient groups were included. A total of 75 patients were included, comprising 56 (80%) females and 19 (20%) males. The median age was 51.2 (16–73) years in the MPN group and 29.5 (17–50) years in the thalassemia group. All patients with MPNs found the application easy to use, whereas 93.3% of patients with thalassemia found the application to be easy. TM consultations increased since the start of online follow-up for 41 patients, with no change in three and decreased in one patient. Seven patients had suspicious COVID symptoms, and four of them notified the consultant. During the follow-up, about 205 consultations and 300 laboratory results had been medically debated through WhatsApp groups or audio-visual calls. Conclusion Evidence supports that TM is a fast, safe, and effective tool to increase care and decrease morbidity for both patients with MPNs and adult patients with thalassemia during the pandemic time.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"304 - 307"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47597568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augmented Berlin-Frankfurt-Munster versus GRAALL-2003 in young adults with Philadelphia-negative, B-cell acute lymphoblastic leukemia: A single-center experience 增强柏林-法兰克福-明斯特与GRAALL-2003在年轻成人费城阴性，b细胞急性淋巴细胞白血病:单中心经验

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_5_22

F. Ghobrial, H. Elkerdawy, Mostafa Abdelhakiem, S. El-Ashwah

{"title":"Augmented Berlin-Frankfurt-Munster versus GRAALL-2003 in young adults with Philadelphia-negative, B-cell acute lymphoblastic leukemia: A single-center experience","authors":"F. Ghobrial, H. Elkerdawy, Mostafa Abdelhakiem, S. El-Ashwah","doi":"10.4103/ejh.ejh_5_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_5_22","url":null,"abstract":"Background Acute lymphoblastic leukemia (ALL) is a heterogeneous group of diseases characterized by clonal proliferation of lymphoblasts. Improvement in the outcome of ALL in adolescents and young adult (AYA) patients remains one of the challenging problems in ALL treatment. Aim This study was conducted to compare the outcome of polychemotherapy regimens, augmented Berlin-Frankfurt-Munster (ABFM) regimen and GRAALL-2003, in Philadelphia-negative, B-cell ALL in AYA patients. Patients and methods A single-center retrospective study was performed on AYA patients with Philadelphia-negative, B-cell ALL who were diagnosed between 2013 and 2019. Results A total of 37 patients were included (27 males and 10 females) with a mean age of 22.3 years. Complete remission (CR) rate in the ABFM group was 94.1 versus 75% in the GRALL-2003 group (P=0.1). There was no statistically significant difference regarding relapse rate between both regimens (P=0.2). Regarding toxicities, there was no statistically significant difference between the two regimens apart from ICU admission rate, which was statistically significantly higher in the GRAALL-2003 group compared with the ABFM group (P=0.048); however, it had no influence on the overall survival. Conclusion The outcome of both polychemotherapy regimens, ABFM and GRAALL-2003, was comparable regarding CR rate, relapse rate, overall survival, and toxicity profile apart from a noticeable increased rate of ICU admission in GRAALL-2003 regimen, which makes ABFM regimen the more feasible option in treatment.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"281 - 287"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47063179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unwelcome guests in monocytes: Peripheral blood histoplasmosis 单核细胞中不受欢迎的客人：外周血组织胞浆菌病

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_34_22

A. Rath, G. Vishwanathan

引用次数: 0

Prognostic value of neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, lactate dehydrogenase, and mean platelet volume in the diagnosis of patients with diffuse large B-cell lymphoma 中性粒细胞/淋巴细胞比率、淋巴细胞/单核细胞比率、乳酸脱氢酶和平均血小板体积对弥漫性大B细胞淋巴瘤患者的预后诊断价值

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_14_22

M. Bakırtaş, S. Başcı, B. Candır, B. Ulu, S. Yaman, T. Yiğenoğlu, M. Dal, M. Çakar, F. Altuntaş

{"title":"Prognostic value of neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, lactate dehydrogenase, and mean platelet volume in the diagnosis of patients with diffuse large B-cell lymphoma","authors":"M. Bakırtaş, S. Başcı, B. Candır, B. Ulu, S. Yaman, T. Yiğenoğlu, M. Dal, M. Çakar, F. Altuntaş","doi":"10.4103/ejh.ejh_14_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_14_22","url":null,"abstract":"Background Diffuse large B-cell lymphoma (DLBCL), a heterogeneous type of lymphoma, encompasses various biologic abnormalities and numerous morphologic variants, showing several clinical findings and responses to treatments. Lactate dehydrogenase (LDH) is a well-established diagnostic and prognostic marker for DLBCL, and neutrophil/lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and mean platelet volume (MPV) have been shown to have prognostic values in several malignancies. Objectives In the study, we examined the prognostic value of LMR, NLR, LDH, and MPV in the stage and prognosis of DLBCL by analyzing the data of patients treated with rituximab-based chemotherapies. Patients and methods A total of 188 patients diagnosed as having DLBCL between January 2012 and January 2020 were selected. DLBCL stages were categorized as early and late, international prognostic index was categorized as below and above 4, and the treatment response was categorized as responders and nonresponders. NLR, LMR, LDH, MPV, and other factors predicting these outcomes were analyzed. Results Logistic regression analysis showed that the factors influencing stage of DLBCL were NLR [P=0.009, odds ratio (OR)=1.220, 95% confidence interval (CI): 1.050–1.417] and LDH (P=0.001, OR=0.286, 95% CI: 0.146–0.561). The factor influencing international prognostic index score was LMR (P=0.001, OR=6.226, 95% CI: 2.092–18.533). Factors influencing response were R-CHOP treatment (P=0.001, OR=0.181, 95% CI: 0.068–0.478) and stage (P=0.005, OR=18.306, 95% CI: 2.383–140.607). Conclusion The pretreatment LMR, NLR, LDH, and MPV values may affect the stage and prognosis of DLBCL, which showed influences on the treatment response.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"233 - 238"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46621657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of hematological response to iron and folic acid supplementation among the expectant mothers attending Kakamega County Referral Hospital, Kenya 肯尼亚卡卡梅加县转诊医院孕妇对补充铁和叶酸的血液学反应测定

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_10_22

Kirui Dennis, Do Marera, T. Were

{"title":"Determination of hematological response to iron and folic acid supplementation among the expectant mothers attending Kakamega County Referral Hospital, Kenya","authors":"Kirui Dennis, Do Marera, T. Were","doi":"10.4103/ejh.ejh_10_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_10_22","url":null,"abstract":"Background Despite iron and folic acid supplementation program among expectant mothers while attending antenatal care clinic at Kakamega County, the rates of maternal and fetal morbidity and mortality due to anemia complications are still high. Aim First, we determined changes in hematological profiles following iron and folic acid supplementation. Second, we determined association between hematological changes with demographic and clinical characteristics in response to iron and folic acid supplementation. Patients and methods Full hemogram and reticulocyte profiles of 127 expectant mothers were determined at baseline and endpoint after 1 month of iron and folic acid supplementation. Full hemogram profiles were measured using a Maxim 3010 fully automated hematology analyzer, whereas reticulocyte profiles were examined microscopically at ×100 magnification. Demographic data were collected using pretested structured questionnaires. Results The end point measures of red blood cells, hemoglobin (Hb), hematocrit, mean cell volume, reticulocyte count, reticulocyte production index, and absolute reticulocyte number among the anemic mothers were significantly higher relative to baseline levels. Among nonanemic mothers, Hb and mean cell volume levels differed significantly between baseline and end point of the study. The change in erythropoietic response and adequate Hb response was significantly associated with adherence to iron and folic acid supplement. Conclusion Hematological profiles significantly changed especially among anemic mothers following iron and folic acid supplementation. Adherence to supplement is associated with positive erythropoietic response and adequate Hb response.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"262 - 269"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45664463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosine kinase inhibitors reduce myeloid-derived suppressor cells in patients with chronic myeloid leukemia with better outcome 酪氨酸激酶抑制剂在慢性髓性白血病患者中减少髓源性抑制细胞，效果更好

Egyptian Journal of Haematology Pub Date : 2022-10-01 DOI: 10.4103/ejh.ejh_37_22

Youmna Refaat, Y. Rahman, Mostafa F Mohammed Saleh, D. Sayed, M. Elzohri

{"title":"Tyrosine kinase inhibitors reduce myeloid-derived suppressor cells in patients with chronic myeloid leukemia with better outcome","authors":"Youmna Refaat, Y. Rahman, Mostafa F Mohammed Saleh, D. Sayed, M. Elzohri","doi":"10.4103/ejh.ejh_37_22","DOIUrl":"https://doi.org/10.4103/ejh.ejh_37_22","url":null,"abstract":"Background and objectives Myeloid-derived suppressor cells (MDSCs) are increased in several hematologic malignancies. We looked at the effect of imatinib and nilotinib (tyrosine kinase inhibitors) on MDSCs in patients with chronic myeloid leukemia (CML) and how those cells could affect prognosis in CML. Patients and methods A randomized controlled trial was conducted that enrolled 103 patients with newly diagnosed chronic phase CML who were randomly subgrouped into group I, which included patients treated with oral imatinib (n=58) 400 mg/day, and group II, which included patients treated with oral nilotinib (n=45) 600 mg/day. Follow-up of BCR/ABL transcript was measured by quantitative PCR every 3 months. Moreover, detection of the percentages of granulocytic-MDSCs and monocytic (M-MDSCs) in the peripheral blood (HLA-DR/CD11b//CD33/CD14) by flow cytometry was done at baseline and during follow-up. Results Both groups had insignificant difference regarding baseline laboratory and clinical data. Both groups showed significant reduction in MDSCs but with insignificant differences between both of them. Patients did not achieve major molecular response (MMR) and had significantly higher M-MDSCs at baseline. Moreover, baseline M-MDSCs were a predictor for MMR (odds ratio=0.78, 95% confidence interval=0.66–0.93) and for loss of MRR (odds ratio=2.17, 95% confidence interval=1.22–3.87). For prediction of MMR, baseline M-MDSCs had 89.2% accuracy at cutoff point less than 8.9% and had 89.5% accuracy for prediction of loss of MMR at a cutoff point more than 8.5%. Conclusion Both imatinib and nilotinib are effective in reducing MDSCs in patients with CML. Baseline M-MDSCs are predictors of MMR and loss of response in patients with CML. The study was registered on clinicaltrials.gov with NCT03214718.","PeriodicalId":42139,"journal":{"name":"Egyptian Journal of Haematology","volume":"47 1","pages":"272 - 280"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46755004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0