ANTIKE UND ABENDLAND最新文献

筛选
英文 中文
Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM Phosphorylation. 星形胶质细胞 LRRK2 通过调节 ERM 磷酸化控制突触连接性
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2024-08-28 DOI: 10.1101/2023.04.09.536178
Shiyi Wang, Ryan Baumert, Gabrielle Séjourné, Dhanesh Sivadasan Bindu, Kylie Dimond, Kristina Sakers, Leslie Vazquez, Jessica Moore, Christabel Xin Tan, Tetsuya Takano, Maria Pia Rodriguez, Scott H Soderling, Albert R La Spada, Cagla Eroglu
{"title":"Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM Phosphorylation.","authors":"Shiyi Wang, Ryan Baumert, Gabrielle Séjourné, Dhanesh Sivadasan Bindu, Kylie Dimond, Kristina Sakers, Leslie Vazquez, Jessica Moore, Christabel Xin Tan, Tetsuya Takano, Maria Pia Rodriguez, Scott H Soderling, Albert R La Spada, Cagla Eroglu","doi":"10.1101/2023.04.09.536178","DOIUrl":"10.1101/2023.04.09.536178","url":null,"abstract":"<p><p>Astrocytes, a major glial cell type of the brain, regulate synapse numbers and function. However, whether astrocyte dysfunction can cause synaptic pathologies in neurological disorders such as Parkinson's Disease (PD) is unknown. Here, we investigated the impact of the most common PD-linked mutation in the leucine-rich repeat kinase 2 (<i>LRRK2</i>) gene (G2019S) on the synaptic functions of astrocytes. We found that both in human and mouse cortex, the LRRK2 G2019S mutation causes astrocyte morphology deficits and enhances the phosphorylation of the ERM proteins (Ezrin, Radixin, and Moesin), which are important components of perisynaptic astrocyte processes. Reducing ERM phosphorylation in LRRK2 G2019S mouse astrocytes restored astrocyte morphology and corrected excitatory synaptic deficits. Using an <i>in vivo</i> BioID proteomic approach, we found Ezrin, the most abundant astrocytic ERM protein, interacts with the Autophagy-Related 7 (Atg7), a master regulator of catabolic processes. The Ezrin/Atg7 interaction is inhibited by Ezrin phosphorylation, thus diminished in the LRRK2 G2019S astrocytes. Importantly, Atg7 function is required to maintain proper astrocyte morphology. These studies reveal an astrocytic molecular mechanism that could serve as a therapeutic target in PD.</p>","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11383028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89020817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geschichte heilen: Urbane Interventionen und ihre Deutung durch den päpstlichen Hofarchitekten Domenico Fontana (1543–1607) 修复历史:任教的宫廷建筑师多米尼克·方坦纳(1543—1607)完成了城市干预和故事
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0007
Fabian Voss
{"title":"Geschichte heilen: Urbane Interventionen und ihre Deutung durch den päpstlichen Hofarchitekten Domenico Fontana (1543–1607)","authors":"Fabian Voss","doi":"10.1515/anab-2023-0007","DOIUrl":"https://doi.org/10.1515/anab-2023-0007","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"117 - 146"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67253655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L’amico, la moneta e l’Imperatore: Petrarca tra politica e restaurazione dell’antichità 朋友,货币和皇帝,彼得拉克在政治和恢复古代之间
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0004
P. Rigo
{"title":"L’amico, la moneta e l’Imperatore: Petrarca tra politica e restaurazione dell’antichità","authors":"P. Rigo","doi":"10.1515/anab-2023-0004","DOIUrl":"https://doi.org/10.1515/anab-2023-0004","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"58 - 75"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43395637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Die maiestas als Antitugend? Zur Performanz der herrscherlichen persona in Giovanni Pontanos De principe 作为反美德的迈斯塔?论乔瓦尼·蓬塔诺斯·德·普里普统治人物形象的表现
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0005
Tristan Spillmann
{"title":"Die maiestas als Antitugend? Zur Performanz der herrscherlichen persona in Giovanni Pontanos De principe","authors":"Tristan Spillmann","doi":"10.1515/anab-2023-0005","DOIUrl":"https://doi.org/10.1515/anab-2023-0005","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"76 - 99"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43256646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dekolonialisierung und Diversifizierung des Wissens von der Antike: Zur Debatte um ‹Antike und Identität› in den Altertumswissenschaften 古物知识的非殖民化与多元化——古物学“古物与同一性”之争
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0002
Quintus Immisch, Saskia Schomber
{"title":"Dekolonialisierung und Diversifizierung des Wissens von der Antike: Zur Debatte um ‹Antike und Identität› in den Altertumswissenschaften","authors":"Quintus Immisch, Saskia Schomber","doi":"10.1515/anab-2023-0002","DOIUrl":"https://doi.org/10.1515/anab-2023-0002","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"21 - 43"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47358368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La Tebe di Stazio come figura della civitas diaboli nella Commedia di Dante 斯塔齐奥的底比斯作为但丁喜剧中的迪亚波利市民形象
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0003
Maria Maślanka-Soro
{"title":"La Tebe di Stazio come figura della civitas diaboli nella Commedia di Dante","authors":"Maria Maślanka-Soro","doi":"10.1515/anab-2023-0003","DOIUrl":"https://doi.org/10.1515/anab-2023-0003","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"44 - 57"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48782533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ψεύσματα ποικίλα: Lukians Wahre Geschichten und Amerigo Vespuccis Berichte aus der Neuen Welt 谎言千变万化:鲁的真实故事与维斯普奇的新世界报道
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0006
Katharina Wesselmann
{"title":"Ψεύσματα ποικίλα: Lukians Wahre Geschichten und Amerigo Vespuccis Berichte aus der Neuen Welt","authors":"Katharina Wesselmann","doi":"10.1515/anab-2023-0006","DOIUrl":"https://doi.org/10.1515/anab-2023-0006","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"100 - 116"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49574763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
«May our journey be long, filled with agony and torment» – Transformierte mythologische Stoffe und Motive in Louis Leterriers Clash of the Titans (2010) “愿我们的旅程漫长,充满痛苦和折磨”——路易斯·莱特里的《诸神之战》中的变形者神话中的斯托夫和动机
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0009
Laura Frölich
{"title":"«May our journey be long, filled with agony and torment» – Transformierte mythologische Stoffe und Motive in Louis Leterriers Clash of the Titans (2010)","authors":"Laura Frölich","doi":"10.1515/anab-2023-0009","DOIUrl":"https://doi.org/10.1515/anab-2023-0009","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"170 - 190"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45406443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antike im Plural Deutsche Altertumskonkurrenzen im 19. und frühen 20. Jahrhundert 虽然是老和早期20。世纪
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-0001
Andrea Polaschegg
{"title":"Antike im Plural Deutsche Altertumskonkurrenzen im 19. und frühen 20. Jahrhundert","authors":"Andrea Polaschegg","doi":"10.1515/anab-2023-0001","DOIUrl":"https://doi.org/10.1515/anab-2023-0001","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"1 - 20"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46188033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Titelseiten 头版
4区 历史学
ANTIKE UND ABENDLAND Pub Date : 2023-08-22 DOI: 10.1515/anab-2023-frontmatter1
{"title":"Titelseiten","authors":"","doi":"10.1515/anab-2023-frontmatter1","DOIUrl":"https://doi.org/10.1515/anab-2023-frontmatter1","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135716561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信