Shiyi Wang, Ryan Baumert, Gabrielle Séjourné, Dhanesh Sivadasan Bindu, Kylie Dimond, Kristina Sakers, Leslie Vazquez, Jessica L Moore, Christabel Xin Tan, Tetsuya Takano, Maria Pia Rodriguez, Nick Brose, Luke Bradley, Reed Lessing, Scott H Soderling, Albert R La Spada, Cagla Eroglu
{"title":"PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation.","authors":"Shiyi Wang, Ryan Baumert, Gabrielle Séjourné, Dhanesh Sivadasan Bindu, Kylie Dimond, Kristina Sakers, Leslie Vazquez, Jessica L Moore, Christabel Xin Tan, Tetsuya Takano, Maria Pia Rodriguez, Nick Brose, Luke Bradley, Reed Lessing, Scott H Soderling, Albert R La Spada, Cagla Eroglu","doi":"10.1101/2023.04.09.536178","DOIUrl":"10.1101/2023.04.09.536178","url":null,"abstract":"<p><p>Astrocytes are highly complex cells that mediate critical roles in synapse formation and maintenance by establishing thousands of direct contacts with synapses through their perisynaptic processes. Here, we found that the most common Parkinsonism gene mutation, LRRK2 G2019S, enhances the phosphorylation of the ERM proteins (Ezrin, Radixin, and Moesin), components of the perisynaptic astrocyte processes in a subset of cortical astrocytes. The ERM hyperphosphorylation was accompanied by decreased astrocyte morphological complexity and reduced excitatory synapse density and function. Dampening ERM phosphorylation levels in LRRK2 G2019S mouse astrocytes restored both their morphology and the excitatory synapse density in the anterior cingulate cortex. To determine how LRRK2 mutation impacts Ezrin interactome, we used an <i>in vivo</i> BioID proteomic approach, and we found that astrocytic Ezrin interacts with Atg7, a master regulator of autophagy. The Ezrin/Atg7 interaction is inhibited by Ezrin phosphorylation, thus diminished in LRRK2 G2019S astrocytes. Importantly, the Atg7 function is required to maintain proper astrocyte morphology. Our data provide a molecular pathway through which the LRRK2 G2019S mutation alters astrocyte morphology and synaptic density in a brain-region-specific manner.</p>","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"32 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11383028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89020817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Geschichte heilen: Urbane Interventionen und ihre Deutung durch den päpstlichen Hofarchitekten Domenico Fontana (1543–1607)","authors":"Fabian Voss","doi":"10.1515/anab-2023-0007","DOIUrl":"https://doi.org/10.1515/anab-2023-0007","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"117 - 146"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67253655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"L’amico, la moneta e l’Imperatore: Petrarca tra politica e restaurazione dell’antichità","authors":"P. Rigo","doi":"10.1515/anab-2023-0004","DOIUrl":"https://doi.org/10.1515/anab-2023-0004","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"58 - 75"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43395637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Die maiestas als Antitugend? Zur Performanz der herrscherlichen persona in Giovanni Pontanos De principe","authors":"Tristan Spillmann","doi":"10.1515/anab-2023-0005","DOIUrl":"https://doi.org/10.1515/anab-2023-0005","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"76 - 99"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43256646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dekolonialisierung und Diversifizierung des Wissens von der Antike: Zur Debatte um ‹Antike und Identität› in den Altertumswissenschaften","authors":"Quintus Immisch, Saskia Schomber","doi":"10.1515/anab-2023-0002","DOIUrl":"https://doi.org/10.1515/anab-2023-0002","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"21 - 43"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47358368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"La Tebe di Stazio come figura della civitas diaboli nella Commedia di Dante","authors":"Maria Maślanka-Soro","doi":"10.1515/anab-2023-0003","DOIUrl":"https://doi.org/10.1515/anab-2023-0003","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"44 - 57"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48782533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ψεύσματα ποικίλα: Lukians Wahre Geschichten und Amerigo Vespuccis Berichte aus der Neuen Welt","authors":"Katharina Wesselmann","doi":"10.1515/anab-2023-0006","DOIUrl":"https://doi.org/10.1515/anab-2023-0006","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"100 - 116"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49574763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"«May our journey be long, filled with agony and torment» – Transformierte mythologische Stoffe und Motive in Louis Leterriers Clash of the Titans (2010)","authors":"Laura Frölich","doi":"10.1515/anab-2023-0009","DOIUrl":"https://doi.org/10.1515/anab-2023-0009","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"170 - 190"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45406443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antike im Plural Deutsche Altertumskonkurrenzen im 19. und frühen 20. Jahrhundert","authors":"Andrea Polaschegg","doi":"10.1515/anab-2023-0001","DOIUrl":"https://doi.org/10.1515/anab-2023-0001","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"69 1","pages":"1 - 20"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46188033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Titelseiten","authors":"","doi":"10.1515/anab-2023-frontmatter1","DOIUrl":"https://doi.org/10.1515/anab-2023-frontmatter1","url":null,"abstract":"","PeriodicalId":42033,"journal":{"name":"ANTIKE UND ABENDLAND","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135716561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}