ENT Updates最新文献

{"title":"THE INCIDENCE AND SEVERITY OF FREY’S SYNDROME AFTER PAROTIDECTOMY: A RETROSPECTIVE STUDY","authors":"Mustafa Daloğlu, K. Güney","doi":"10.32448/ENTUPDATES.568049","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.568049","url":null,"abstract":"Objective: The aim of this study was to investigate the  incidence and severity of Frey’s syndrome (FS) among  parotidectomy patients and to assess the impact of  parotidectomy sequelae on quality of life (QoL). Methods: In total, 43 patients (21 males, 22 females) who  underwent parotidectomy were included in this study.  Iodine-starch test was applied to identify the presence  and the severity of FS. The results were evaluated using a  previously described grading system. Patients’ perceptions  of parotidectomy sequelae were graded to identify their  impact on QoL and also if there is an association between  the extent of parotidectomy, the time elapsed after  surgery and the severity of symptoms. Results: FS was diagnosed in 18 (41.8%) patients, 10 of  which (23.3%) reported having FS symptoms. Of all  patients who were diagnosed with FS, 11 (61.2%) patients’  symptoms were classified as mild, whereas 7 (38.8%)  were classified as severe. There was no significant correlation  between the incidence of FS and the time between  surgery and diagnosis, or the extent of parotidectomy.  Among all symptoms reported by patients, FS was the sequelae  that caused the most discomfort after parotidectomy. Conclusion: The negative impact of FS on QoL is restricted  to cases with severe symptoms, the incidence of which  is rare and independent of the extent of surgery. To avoid  overtreatment, true incidence of FS remains to be identified  in study samples from different centers. By this  means, clinicians can make more accurate definitions for  indications of preventive procedures as well as treatment  approaches.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48078605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METFORMIN AND DICHOLOROACETATE COMBINATION EXERT A SYNERGISTIC EFFECT ON CELL VIABILITY OF ORAL SQUAMOUS CELL CARCINOMA","authors":"Ş. Inanç, Didem Keleş, G. Eskiizmir, Y. Başbınar, G. Oktay","doi":"10.32448/ENTUPDATES.569464","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.569464","url":null,"abstract":"Objective: To assess the effects of Metformin, Dichloroacetate  (DCA) and their combination on cell viability in oral squamous  cell carcinoma, UPCI-SCC-131 cell line. Methods: UPCI-SCC-131 cells were plated in 96 E-plate (1x104  cells/well) and were treated with Metformin (1-16mM) and/or  DCA (15-120mM) for 24-48-72h. xCELLigence SP system was used  to monitor real time cell viability. In addition, drug combination  index was analyzed with CompuSyn software according to  Chou-Talalay method. Results: Half-maximal inhibitory concentrations (IC50) of Metformin  and DCA were found to be 3mM and 23mM, respectively,  for 72 hours. CI values (0.76-0.80) in all combination groups below  1 indicated that Metformin/DCA combination had a moderate  synergistic effect on cell viability in UPCI-SCC-131 cells. Discussion: Metformin/DCA combination synergistically decreased  the cell viability of UPCI-SCC-131 cells. Therefore, a combined  application of Metformin and DCA may be considered as  a candidate therapy for the “drug repositioning” of the treatment  of oral cavity cancer.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42592940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation of Genetic Polymorphism In The Rs35521 Serotonin Transporter Gene In Allergic Rhinitis","authors":"I. Salcan, S. Salcan, H. Erdem, S. Müderris","doi":"10.32448/ENTUPDATES.595445","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.595445","url":null,"abstract":"Objective: Allergic rhinitis (AR) is one of the most frequently  encountered allergic disorders and has a typical  prevalence of between 18 and 40%.The factors which  underlie allergic disorders may vary since they are linked  to climate, geography, different social conditions and genetic  makeup. The objective of our research was to investigate  any connections between polymorphism in the  serotonin transporter gene and allergic rhinitis.  Methods: This study involved the participation of two groups aged between 15 and 60 years of age who attended the ENT clinic of the Medical Faculty at Erzincan University: 100 individuals with allergic rhinitis plus a control group of 200 individuals who lacked the condition. The AR cases were established on the basis of history, physical examination and skin prick testing. Peripheral blood samples were taken from both groups and subjected to genetic analyses. The analysis utilised a 5-HTT Taqman® primer as genetic probe. The Chi-squared method was utilised for statistical analysis.  Results: 129 of the participants were female (64.5%) and 71 (35.5%) male. The average age of those participating was 34.5 ± 14.6 (range: 20-65) years. In reference to the sex distribution of the patients, 79% of the patients were female. There was a significant difference between the groups according to sex (p <0.01). No significant differences were noted between the patient and control groups when compared according to genetic polymorphism or place of residence. In 61% of the allergic rhinitis sufferers, their symptoms were seasonal. The incidence of AR was higher in both females and in those living in an urban rather than rural setting. When the polymorphism is examined in both the patient and control groups, the most common type is the mutant type. In both the cases and controls, when the polymorphism was investigated, the most frequently seen type was the Mutant variety and no significant difference in frequency was noted according to sex or place of residence. Conclusion: In this study, when the cases and controls were compared in terms of the polymorphism in the rs35521 serotonin transporter gene, there was no difference at  the level of statistical significance between the frequency  of occurrence of the mutant or heterozygote form of the  gene.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45600128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age And Sex Matched Data- Two Ears Improved Social Interaction And Quality Of Life","authors":"S. Erkan, B. Tuhanioğlu","doi":"10.32448/ENTUPDATES.595446","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.595446","url":null,"abstract":"Introduction: Hearing aids are electronic devices used by  individuals with hearing loss to improve their quality of  life. It is more useful to use bilateral hearing aids. Thus,  the localization of the sound is better determined and  an additional 6-10 dB increase in sound intensity can be  achieved. In our study, we compared the satisfaction  level of  patients with hearing loss who used unilateral  or bilateral devices. Methods: Patients with bilateral sensorineural hearing loss  and using unilateral or bilateral hearing aids for at least  3 months and whose hearing loss cannot be treated with  medical or surgical treatments were included. International  Outcome Inventory for Hearing Aids Turkish Version (IOI-HA- R) was administered to them. Results: Matched data were used to standardize age  and gender between the groups. In high school bilateral  fitting increased. There was no difference between the  groups in terms of hearing pure tone thresholds and speech discriminations. There was a significant difference  between the groups in terms of the mean score of  question 5 (p=0.047), question 7 (p=0.022) and mean total  scale (p=0.028) in IOI-HA-TR. Conclusion: As a result, we found that the satisfaction  level of bilateral hearing aid users was higher. Bilateral  hearing aid use has a positive effect on the social life of  patients and increases their quality of life.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48058769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-rater and Inter-rater consistency of drug induced sleep endoscopy","authors":"A. Kılavuz, Ali Bayram","doi":"10.32448/ENTUPDATES.596457","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.596457","url":null,"abstract":"Objective: Drug induced sleep endoscopy (DISE) is a valuable  tool which is used in the diagnosis of obstructive  sleep apnea (OUA). The aim of this study is to evaluate  inter-rater and intra-rater consistency of DISE. Methods: 36 OSA patients with Apnea-hypopne index>5  included in this study. DISE was performed and recorded  digitally for all patients, by the first author (OA1). VOTE  scores were noted to procedure report in patients’ charts.  Video records of DISE were blindly evaluated six months  after the last procedure, by observer 1 for the second  time (OA2) and by observer 2 (OB) for the first time. DISE  was evaluated by using VOTE classification. OA1 and OA2  scores were compared to determine intra-rater reliability  and OA2 and OB scores were compared to determine inter- rater reliability. Results: Inter-rater consistency of DISE was poor to good.  Highest consistency rate was found in velum at anteroposterior  configuration, while the lowest was found in  the same level at lateral configuration. Intra-rater consistency  of DISE was moderate to excellent. Highest consistency  rate was found in epiglottis at lateral configuration,  while the lowest was found in oropharynx level. Conclusion: OSA is condition with possible serious complications.  DISE is a tool that could change the course of  treatment in OSA. The validity of DISE is quite acceptable  although a golden standard classification tool could enable  us to “speak the exact same language” and will surely  increase the diagnostic success of DISE.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47646813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do you perform your tympanoplasty, endoscopically or microscopically?","authors":"Ali Bayram, D. Marchioni, Kevin Peng, I. Moon, C. Cingi","doi":"10.32448/ENTUPDATES.594625","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.594625","url":null,"abstract":"Since the introduction of endoscopic ear surgery (EES) in the 1990s, endoscopic systems have been utilized in a number  of ear surgeries including myringoplasty and tympanoplasty. Endoscopic tympanoplasty (ET) is described as a minimally  invasive surgery for surgical repair of the tympanic membrane (TM) with comparable graft survival and hearing outcomes  to conventional microscopic surgery (CMT). In the present review, we aimed to outline the surgical benefits and  potential drawbacks of ET with clinical outcomes in order to determine whether ET constitutes a proper alternative to  CMT.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43264298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Chronic Rhinosinusitis and The Vestibular System","authors":"Kadri Ila, Emre Soylemez, N. Yilmaz, A. Eshraghi","doi":"10.32448/ENTUPDATES.587285","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.587285","url":null,"abstract":"Objective: Objective: Chronic rhinosinusitis (CRS) is inflammation  of the nasal mucosa and paranasal sinuses.  Subjective complaint of dizziness can be observed in patients  with CRS. However, a review of the literature did  not reveal any prospective studies that have used videonystagmography  (VNG) to examine the vestibular system  of patients with CRS. The goal of this study is the evaluation  of the vestibular system of CRS patients. Methods: The study comprised 30 patients with CRS and  30 control subjects. The vestibular system was evaluated  through VNG. The association with vestibular function  was evaluated according to the Lund-Mackay score, the  Sino-Nasal Outcome Test-22 (SNOT-22) score, and the existence  of nasal polyps. Results: Abnormal caloric test results were observed in  eight (26.6%) of the 30 CRS patients. The caloric test results  were normal for the control group. The oculomotor  test results with VNG were normal for the CRS and control  groups. The abnormal caloric results were higher for  the CRS with nasal polyp patients than for the CRS without  nasal polyp patients. The VNG showed no correlation  among the SNOT-22 scores and the Lund-Mackay scores  in patients with CRS. Conclusion: Abnormal caloric responses can be observed  in patients with CRS with nasal polyps.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46394166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IRAP-PCR As A Tool For Screening HERV Polymorphisms In Nasal Mucosal Swabs","authors":"A. Kepekçi, Merve Seda Ibisoglu, S. Yılmaz, Cenk Kıg","doi":"10.32448/ENTUPDATES.578602","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.578602","url":null,"abstract":"Objective: Inter-retrotransposon polymorphism Polymerase  Chain Reaction (IRAP-PCR) technique allows for  detecting insertional polymorphisms via amplification  of the DNA fragment between two retrotransposons in  plant genomes. However, this method has not been reported  to be used for analyzing human samples to date.  Recently, Human Endogenous Retrovirus (HERV) polymorphisms  gained interest due to their potential effect  on pathophysiology of certain diseases. Nevertheless, the  association between HERV polymorphisms and the risk  for developing nasal polyposis (NP) has not been studied.  In this study, we aimed to investigate whether or not  IRAP-PCR could be performed in nasal swab samples for  comparing HERV polymorphisms in different nasal mucosal  samples. Methods: Nasal swab samples from 16 patients were used  for DNA isolation. These DNA samples were used as templates  for IRAP PCR of HERV-K6, HERV-K11, HERV-L1 and  HERV-L2 and PCR products were analyzed by agarose gel  electrophoresis. Results: Nasal swab samples yielded enough DNA material  for successfully performing IRAP-PCR. We obtained  specific banding patterns the three out of four HERV  sequences tested in this study. No polymorphisms was  detected between samples from different patients. Similarly,  polymorphic bands was not detected between the  polyps or nasal mucosal swab samples obtained from the  same patient. Conclusion: We have, for the first time, shown that IRAPPCR  can be performed in nasal swabs. Our findings suggest  that this technique can serve as an inexpensive and  effective screening tool for investigating links between  nasal mucosal diseases and HERV polymorphisms such as  nasal polyposis.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49105685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of hearing in patients with rheumatoid arthritis compared with controls","authors":"Zafer Volkan Gökçe, S. Öztürk, Ceki Paltura","doi":"10.32448/ENTUPDATES.574363","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.574363","url":null,"abstract":"Objective: To demonstrate the effects of rheumatoid arthritis (RA) on hearing with audiometric and tympanometric measurements, and to reveal its relationship with the disease in comparison with healthy volunteers. Methods: The study included 30 RA patients and 30 healthy controls. Demographic findings such as age, height, weight, onset of complaint (year), time elapsed since diagnosis, previous surgery, accompanying systemic disease, drugs used, family history, habits of smoking and alcohol use were questioned for both groups. Tympanometry, pure voice audiometry and otoacoustic Emission tests were performed. Results: The hearing thresholds in the airway conduction in RA group were significantly higher in all frequencies (0.25-6 kHz) than in the control group. When bone conduction hearing thresholds were compared, RA group was more affected at only 4 kHz and left ear (p=0.006). When air-bone conduction differences (AB-gap) were examined, the differences in the RA group at 0.5, 1 and 4 kHz were statistically significant. When tympanometry and acoustic reflex measurement results were evaluated, there was no statistically significant difference between groups. In the transient OAE test, 3 (10 %) patients were in the RA and 2 (6.6 %) patients in the control group (p=0.064). Conclusion: Conductive hearing loss was significantly more frequent in patients with RA than in healthy individuals, whereas bone conduction was affected partially at high frequencies; whereas stapes reflex, compliance and pressure values were not significantly affected.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41946270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the factors affecting the success of vestibular rehabilitation therapy in patients with idiopathic unilateral vestibular hypofunction and idiopathic bilateral vestibular hypofunction","authors":"S. Ertugrul, Emre Soylemez","doi":"10.32448/ENTUPDATES.570136","DOIUrl":"https://doi.org/10.32448/ENTUPDATES.570136","url":null,"abstract":"Objective: The aim of this study was to determine the  factors affecting the success of vestibular rehabilitation  therapy (VRT) in patients with idiopathic unilateral vestibular  hypofunction (UVH) and idiopathic bilateral vestibular  hypofunction (BVH). Methods: 30 patients with idiopathic UVH and 30 patients  with idiopathic BVH were included in this prospective  study. Visual analog scale (VAS) was used to evaluate  the severity of the patients’ complaints of dizziness. The  duration of the complaint of dizziness was recorded. All  patients underwent the Dizziness Handicap Inventory  (DHI) before and after VRT. The severity, duration, and  localization (unilateral/bilateral) of the vestibular hypofunction  were compared with the efficacy of VRT. Results: A significant decrease in DHI scores was observed  after VRT for both, UVH and BVH patients, as compared  to their pre-VRT scores (p<0.001). There was no significant  difference in the efficacy of vestibular rehabilitation  therapy in patients with UVH and BVH (p=0.09). As the  VAS scores increased and the duration of the complaint  lengthened, the efficacy of VRT decreased significantly  (p<0.001/r=5.6, p=0.016/r=3.1, respectively). Conclusion : VRT is an effective treatment for the relief  of symptoms in both UVH and BVH patients. Unilateral  or bilateral vestibular hypofunction does not affect the  efficacy of VRT, whereas prolonged or severe symptoms  of dizziness affect the effectiveness of VRT negatively.  In idiopathic vestibular hypofunction patients with  long-standing and/or severe dizziness complaints, VRT  should be initiated immediately and continued longer.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45933083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}