Developments in X-Ray Tomography XII最新文献

Developments in X-Ray Tomography XII Pub Date : 2019-11-22 DOI: 10.1117/12.2552433

引用次数: 0

Development of synchrotron pink beam x-ray grating interferometer at the Diamond Light source I13-2 beamline 金刚石光源I13-2光束线上同步加速器粉红束x射线光栅干涉仪的研制

Developments in X-Ray Tomography XII Pub Date : 2019-10-16 DOI: 10.1117/12.2530698

S. Marathe, M. Storm, Venkata Sree Charan Kuppilli, R. Harrison, G. Das, S. Schroeder, S. Schroeder, S. Cipiccia, F. Döring, C. David, C. Rau

{"title":"Development of synchrotron pink beam x-ray grating interferometer at the Diamond Light source I13-2 beamline","authors":"S. Marathe, M. Storm, Venkata Sree Charan Kuppilli, R. Harrison, G. Das, S. Schroeder, S. Schroeder, S. Cipiccia, F. Döring, C. David, C. Rau","doi":"10.1117/12.2530698","DOIUrl":"https://doi.org/10.1117/12.2530698","url":null,"abstract":"X-ray Grating Talbot Interferometer (XGTI) is already routinely used for quantitative phase contrast imaging of soft tissue samples. XGTI can be realized using various measurement techniques, depending on the X-ray source used, the required spatial resolution and the speed of acquisition. The phase-stepping measurement technique, which is commonly used for XGTI data acquisition, needs multiple acquisitions for a single projection. For fast imaging the Moire technique, a single-shot technique, is often preferred. However, it requires two gratings which increases the dose on the sample. We have therefore examined the Spatial Harmonic Imaging (SHI) technique which is low-dose and single-shot, using the I13-2 Diamond-Manchester Beamline at Diamond Light Source (DLS). The DLS I13-2 beamline is equipped with a Double Crystal Monochromator (DCM) and a Multi-Layer Monochromator (MLM) to deliver monochromatic beam, which work at the energy bandwidths (ΔE/E) of 10-4 and 10-2, respectively. However, the disadvantage of using these monochromators, especially for fast imaging, is loss of X-ray flux. It has already been shown that XGTI can work with an energy bandwidth (ΔE/E) of 10-1. Our aim is to develop a single phase grating interferometer with pink beam from an undulator source, with X-ray mirror optics and multiple absorption filters, to obtain maximum possible flux with sufficient coherence and monochromaticity. We demonstrate performance with optimized beamline parameters for a photon energy of 15 keV with some demonstrative image reconstructions.","PeriodicalId":417260,"journal":{"name":"Developments in X-Ray Tomography XII","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129836180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Recent trends in high-resolution hard x-ray tomography 高分辨率硬x射线断层扫描的最新趋势

Developments in X-Ray Tomography XII Pub Date : 2019-10-15 DOI: 10.1117/12.2530085

B. Müller

引用次数: 1

The osteocyte lacuno-canalicular network in bone investigated by synchrotron radiation-based techniques 基于同步辐射技术的骨细胞腔隙-骨管网络研究

Developments in X-Ray Tomography XII Pub Date : 2019-10-09 DOI: 10.1117/12.2531980

Jonas Palle, N. K. Wittig, Maja Østergaard, A. B. Jensen, H. Birkedal

{"title":"The osteocyte lacuno-canalicular network in bone investigated by synchrotron radiation-based techniques","authors":"Jonas Palle, N. K. Wittig, Maja Østergaard, A. B. Jensen, H. Birkedal","doi":"10.1117/12.2531980","DOIUrl":"https://doi.org/10.1117/12.2531980","url":null,"abstract":"Bone has a complex hierarchical structure, which is essential for its performance. Bone is typically replete with cells called osteocytes that are embedded in the mineralized bone matrix in osteocyte lacunae, which are interconnected by canaliculi only a few hundred nanometer wide to form a vast cellular network. Our understanding of the osteocyte lacuno-canalicular network has been limited because of difficulties to image the cellular network within the opaque bone matrix in 3D. Synchrotron X-ray computed tomography is ideally suited to study the lacuno-canalicular network in bone because it combines the high penetration power of X rays with sub-micron resolution while retaining a fast acquisition time and thus high throughput. We discuss how synchrotron radiation-based tomography techniques have given insights into the osteocyte network in bone both in the form of regular tomography and, for higher resolution studies, in the form of nanotomography such as holotomography. These studies have provided quantitative measures of osteocyte lacunar properties and their relation to location within bones and bone challenges such as immobilization or lactation. Nanotomography revealed new features of the canalicular network that we term canalicular junctions, which are likely to play an important but hitherto hidden role in fluid flow dynamics within the bone cellular network. The examples illustrate how tomography provides information on complex biological materials like bone and we foresee that these capabilities will continue to improve with future/upgraded synchrotron X-ray sources.","PeriodicalId":417260,"journal":{"name":"Developments in X-Ray Tomography XII","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121901104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Optimization of high-energy microtomography using synchrotron radiation at PETRA III PETRA III同步辐射高能微层析成像优化

Developments in X-Ray Tomography XII Pub Date : 2019-10-08 DOI: 10.1117/12.2530001

F. Beckmann, J. Hammel, J. Moosmann, L. Lottermoser, G. Gunnell, J. Habersetzer

引用次数: 3

Cone-beam computed tomography - magnetic resonance imaging registration in dento-maxillary imaging 锥束计算机断层扫描。牙颌成像中的磁共振成像配准

Developments in X-Ray Tomography XII Pub Date : 2019-10-07 DOI: 10.1117/12.2530643

F. Bornert, C.-I. Gros, J. Lutz, D. Schultz, S. Riehm, P. Choquet, G. Schulz, B. Müller, Jean-Philippe Dillenseger

引用次数: 1

New staining tools and developments for 3D soft tissue CT imaging 三维软组织CT成像的新染色工具和发展

Developments in X-Ray Tomography XII Pub Date : 2019-10-01 DOI: 10.1117/12.2529558

M. Busse, S. Ferstl, Mark Müller, M. Kimm, E. Drecoll, T. Bürkner, S. Allner, Lorenz Hehn, M. Dierolf, K. Achterhold, J. Herzen, D. Pfeiffer, E. Rummeny, W. Weichert, F. Pfeiffer

{"title":"New staining tools and developments for 3D soft tissue CT imaging","authors":"M. Busse, S. Ferstl, Mark Müller, M. Kimm, E. Drecoll, T. Bürkner, S. Allner, Lorenz Hehn, M. Dierolf, K. Achterhold, J. Herzen, D. Pfeiffer, E. Rummeny, W. Weichert, F. Pfeiffer","doi":"10.1117/12.2529558","DOIUrl":"https://doi.org/10.1117/12.2529558","url":null,"abstract":"The application of 3D X-ray imaging for biological samples (e.g. biopsies) to gain a deeper understanding of microscopic structures on a (sub)cellular level is restricted by the weak attenuation contrast of soft tissue. The development of novel staining tools for X-ray soft-tissue imaging will overcome these challenges. Here, we present the application of a recently developed method combining a laboratory-based nanoscopic X-ray CT setup enabling resolutions down to 100 nm with a target-specific X-ray staining protocol. The results clearly show that the X-ray attenuation contrast in the samples is remarkably improved by our staining method and detailed tissue (sub)structures are apparent, which cannot be visualized without the staining. The nanoscopic CT data reproduce the tissue morphology with a similar level of detail as the corresponding histological light microscopy images in 2D and enable pathological characterization of the crucial structures. Beyond that, the applied method allows for visualization of the 3D tissue architecture, offering deeper insights into the 3D microscopic structure of soft-tissue. Moreover, we demonstrate the compatibility of the X-ray stain with standard histological staining methods. Beside medical research, the methodology has the potential to contribute to advances in zoology and developmental biology.","PeriodicalId":417260,"journal":{"name":"Developments in X-Ray Tomography XII","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126960059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fast Multi-scale imaging using the Beamline I13L at the Diamond Light Source 在钻石光源下使用I13L光束线的快速多尺度成像

Developments in X-Ray Tomography XII Pub Date : 2019-10-01 DOI: 10.1117/12.2543405

C. Rau, M. Storm, S. Marathe, A. Bodey, M. Zdora, S. Cipiccia, D. Batey, Xiaowen Shi, S. Schroeder, G. Das, M. Loveridge, R. Ziesche, B. Connolly

引用次数: 7

Three-dimensional characterization of soft silicone elements for intraoral device 口腔内装置用软硅胶元件的三维表征

Developments in X-Ray Tomography XII Pub Date : 2019-09-30 DOI: 10.1117/12.2529340

J. Jackowski, G. Schulz, Bekim Osmani, Tino Töpper, B. Müller

{"title":"Three-dimensional characterization of soft silicone elements for intraoral device","authors":"J. Jackowski, G. Schulz, Bekim Osmani, Tino Töpper, B. Müller","doi":"10.1117/12.2529340","DOIUrl":"https://doi.org/10.1117/12.2529340","url":null,"abstract":"Hard X-rays tomography enables us to determine the shape and inner microstructure of a wide variety of solid states and their combinations. Biological samples, and in particular soft tissues from animals and humans, can be encapsulated in suitable containers to avoid deformations during the rotation and radiograph acquisition. The quantitative characterization of soft silicone objects, however, is challenging, because their shape depends on the orientation with respect to the gravitation force. Solid supports may help, but have some impact on the more or less complex-shaped silicone part. In medicine, silicone implants and devices play a major role, since the mechanical properties can be easily tailored. Using the nanotom® m (phoenix|x-ray, GE Sensing & Inspection Technologies GmbH, Wunstorf, Germany), we measured the X-ray absorption of silicone with pre-defined softness. The density resolution of the CT-system was insufficient to establish a density-stiffness relationship. In addition, the shape of a silicone part of a soft intraoral device was measured for three angles with respect to the gravitation force, for which the bending was obvious. These successful tomographic measurements will become the basis of finite element modeling to extract the mechanical properties including their local variations.","PeriodicalId":417260,"journal":{"name":"Developments in X-Ray Tomography XII","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127146051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of laboratory-based x-ray phase tomographic microscope 实验室x射线相层析显微镜的研制

Developments in X-Ray Tomography XII Pub Date : 2019-09-27 DOI: 10.1117/12.2525997

H. Takano, Koh Hashimoto, Yukinori Nagatani, Yanlin Wu, A. Momose

{"title":"Development of laboratory-based x-ray phase tomographic microscope","authors":"H. Takano, Koh Hashimoto, Yukinori Nagatani, Yanlin Wu, A. Momose","doi":"10.1117/12.2525997","DOIUrl":"https://doi.org/10.1117/12.2525997","url":null,"abstract":"Quantitative measurements of the phase shift of X-rays passing through a matter allow us to perform X-ray phase tomography for visualization of soft materials. Combination of an X-ray microscope and a grating interferometer is a promising approach to realize quantitative phase measurements with a microscopic spatial resolution. A Lau interferometer consisting of a source grating and a phase grating is available for this purpose with an incoherent laboratory X-ray source. We installed a Lau interferometer into a laboratory-based X-ray microscope adopting a copper rotating anode source and Fresnel zone plates (ZEISS Xradia 800 Ultra). A “twin-phase image”, which consists of positive and negative phase images overlaid with a certain separation, is generated through a fringe-scanning measurement with this microscope. A step for generating a quantitative phase image from the twin phase image should be developed to perform phase tomography. However, conventional deconvolution operations are not suitable because of artifacts and noise remained in resultant phase images. To reduce the artifacts and noise, an iterative calculation algorithm has been developed. The evaluation of the algorithm shows that the artifacts and noise are suppressed and quantitative phase images are obtained. Finally, results of phase tomography obtained for soft materials are demonstrated.","PeriodicalId":417260,"journal":{"name":"Developments in X-Ray Tomography XII","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128340708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3