Iranian Journal of Pharmaceutical Research : IJPR最新文献_第9页

Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells 甘草根乙酸乙酯提取物促进人骨髓间充质干细胞增殖和成骨分化

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2246

Arezou Azizsoltani, K. Piri, S. Behzad, M. Soleimani, Mina Nekouei, Z. Mahmoudi, A. Kazemi

{"title":"Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells","authors":"Arezou Azizsoltani, K. Piri, S. Behzad, M. Soleimani, Mina Nekouei, Z. Mahmoudi, A. Kazemi","doi":"10.22037/IJPR.2018.2246","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2246","url":null,"abstract":"Glycyrrhiza glabra (G. glabra) has been used as a flavoring and sweetener agent, in addition to its therapeutic properties. It is rich in phytoestrogen and may prevent osteoporosis caused by estrogen deficiency; however, there is no evidence for its effects on proliferation and osteogenesis in mesenchymal stem cells. So, we were encouraged to investigate whether the ethyl acetate extract of licorice root as a source of phytoestrogen can act similar to estrogen in cell culture. Furthermore, the analysis of the licorice extract (LE) based on HPLC-DAD-ESI-MS indicated that LE comprises phytoestrogen compounds, such as glabridin and glabrene. In this study, the effects of LE on proliferation of human bone-marrow mesenchymal stem cells (hBM-MSCs) were investigated using MTT assay. In addition, its effects on the osteogenesis were evaluated using alkaline phosphatase activity (ALP), calcium deposition, and bone specific gene expression such as ALP, osteocalcin, Runx2, and BMP-2. The quantitative gene expression was studied by real-time RT-PCR. Our results showed a significant increase in proliferation in presence of LE in concentration 10-50 µg/mL. The differentiation of hBM-MSCs increased in doses of LE (10-25 µg/mL) compared to the control group. The effects of LE were similar to those of 17β-estradiol (E2) (10-8 M) and were abolished by ICI 182,780 an antagonist of estrogen receptor (ER) (10-7), indicating that the stimulatory effects of LE occur through estrogen receptor-mediated mechanism . Taking these into account, LE may be a potential candidate for prevention of osteoporosis in menopausal women.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131240595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Intravitreal Injection of Bevacizumab: Review of our previous Experience 贝伐单抗玻璃体内注射:回顾我们以前的经验

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2254

M. Afarid, Ali Sadegi Sarvestani, F. Rahat, Ali Azimi

{"title":"Intravitreal Injection of Bevacizumab: Review of our previous Experience","authors":"M. Afarid, Ali Sadegi Sarvestani, F. Rahat, Ali Azimi","doi":"10.22037/IJPR.2018.2254","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2254","url":null,"abstract":"Several ocular and systemic complications have been reported after the bevacizumab intravitreal injection. This study aims at reporting the main indications for the bevacizumab intravitreal injection in our center, the intravitreal injection method in this study, and the incidence of the post-injection complication, such as endophthalmitis.This study is a retrospective review of the consecutive intravitreal bevacizumab (Avastin®) injections for 359 patients between 2011 and 2013 at a single institute (Poostchi Clinic of Ophthalmology). Before the injection, a drop containing 5 mLCiprofloxacin and 5 mL Betadine 10% was applied 3 times at the intervals of 10 min. The eye lashes, upper and lower eyelids, and caruncle were swabbed with Betadine 10% but the lid speculum, drape, and conjunctival washing were not conducted.The patients were followed up 8 weeks after the injection for the evaluation of any complications.In this study, 1376 intravitreal injection of bevacizumab in 479 eyes of 359 patients were enrolled. Among them, 141patients (39.3%) were men and 218 (60.7%) were women. The mean age ( ± SD) of the patients was 61.48 (± 11.21) years. On average, each patient received 3.83 (the range 1-13) injections. The most common indications for the bevacizumab intravitreal injection were diabetic retinopathy, choroidal neovascularization, and central retinal vein occlusion. None of the patients developed endophthalmitis, retinal detachment, or other adverse effects. This study showed that the above-mentioned method of the intravitreal bevacizumab injection is easy and safe. The future studies involving more participants are required for the evaluation of rare complications.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"71 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115189611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Simultaneous Determination of Ascorbic Acid, Uric Acid and Tryptophan by Novel Carbon Nanotube Paste Electrode 新型碳纳米管膏状电极同时测定抗坏血酸、尿酸和色氨酸

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2268

M. Mazloum‐Ardakani, Mahboobe Abolhasani-Soorki, A. Khoshroo, Fariba Sabaghian, B. Mirjalili

{"title":"Simultaneous Determination of Ascorbic Acid, Uric Acid and Tryptophan by Novel Carbon Nanotube Paste Electrode","authors":"M. Mazloum‐Ardakani, Mahboobe Abolhasani-Soorki, A. Khoshroo, Fariba Sabaghian, B. Mirjalili","doi":"10.22037/IJPR.2018.2268","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2268","url":null,"abstract":"In the present paper, electrochemical methods were used to investigate the behavior of ascorbic acid at a carbon paste electrode modified with 2,2′-((1E)-(1,2 phenylenebis(azanylylidene)) bis(methanylylidene))bis(benzene-1,4-diol) (PBD) and oxidized multiwall carbon nanotubes. The modified carbon paste electrode showed high electrocatalytic activity toward ascorbic acid; the current was enhanced significantly relative to the situation prevailing when an unmodified carbon paste electrode was used. Cyclic voltammetry was used to investigate the redox properties of this modified electrode at various solution pH values and at various scan rates. Using differential pulse voltammetry, the calibration curves for AA were obtained over the range of 1.0–80.0 and 80–4000.0 μM, respectively. The detection limit was 0.3 μM. The present method provides a simple method for selective detection of ascorbic acid. DPV also was used for simultaneous determination of AA, uric acid, and tryptophan at the modified electrode. Finally, the proposed electrochemical sensor was used for determinations of these substances in in biological systems and pharmaceutical samples.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129603836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Reducing Inappropriate Utilization of Albumin: The Value of Pharmacist-led Intervention Model 减少白蛋白不合理使用:药师主导干预模式的价值

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2264

F. Dastan, H. Jamaati, H. Emami, R. Haghgoo, Raha Eskandari, Seyedeh Shadab Hashemifard, Fatemeh Khoddami, Zahra Mirshafiei Langari

{"title":"Reducing Inappropriate Utilization of Albumin: The Value of Pharmacist-led Intervention Model","authors":"F. Dastan, H. Jamaati, H. Emami, R. Haghgoo, Raha Eskandari, Seyedeh Shadab Hashemifard, Fatemeh Khoddami, Zahra Mirshafiei Langari","doi":"10.22037/IJPR.2018.2264","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2264","url":null,"abstract":"Albumin is known as a human blood product, with high cost and limited availability. Several studies have demonstrated the extent in which albumin is being utilized in controversial indications not supported or weakly supported by the available literature. To rationalize the use of albumin and to decrease the inappropriate cost of this expensive drugˏ a two phase study, with equal length of 66-days, comprising an observational drug utilization evaluation and a pharmacist-led audit and feedback interventional study, was conducted in a tertiary referral hospital in Tehran, Iran. The results of the interventional phase including the introduction of evidence-base guideline for albumin via a pharmacist-led audit and feedback intervention was compared to the ones from the observational phase. A total of 90 and 45 patients were included in the phase one and phase two of the study respectively. During the initial phase, 1870 albumin vials were used, of which 1467 (78.4%) vials were prescribed inappropriately. Inappropriate use of albumin was decreased significantly by 79.3% (p < 0.001) through the interventional phase, leading to 38,800 USD reduction in inappropriate costs of albumin. Introduction of evidence based guideline in conjugation with pharmacist-led audit and feedback can significantly decrease the inappropriate use of albumin. These results also demonstrate shifting towards a more evidence-based practice, which can increase patient’s safety and enhance quality of care.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129910137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Novel and Efficient Method for Solid Phase Synthesis of Urea-Containing Peptides Targeting Prostate Specific Membrane Antigen (PSMA) in Comparison with Current Methods 固相合成针对前列腺特异性膜抗原(PSMA)的含尿素肽的新方法与现有方法的比较

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2276

Mona Mosayebnia, S. Rezaeianpour, Pedram Rikhtechi, Z. Hajimahdi, D. Beiki, F. Kobarfard, O. Sabzevari, M. Amini, K. Abdi, S. Shahhosseini

{"title":"Novel and Efficient Method for Solid Phase Synthesis of Urea-Containing Peptides Targeting Prostate Specific Membrane Antigen (PSMA) in Comparison with Current Methods","authors":"Mona Mosayebnia, S. Rezaeianpour, Pedram Rikhtechi, Z. Hajimahdi, D. Beiki, F. Kobarfard, O. Sabzevari, M. Amini, K. Abdi, S. Shahhosseini","doi":"10.22037/IJPR.2018.2276","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2276","url":null,"abstract":"The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liquid phase or bound to solid phase for urea bond formation. In this study, we developed a new facile method for formation of both isocyanate and urea on solid phase under standard peptide coupling conditions. The solid phase-bound isocyanate served as intermediate to form urea bond. To monitor reaction progress qualitative test (Kaiser Test) and On-Bead FT-IR spectroscopy were used. The structure of Glutamate-Urea-Lysine (EUK) was confirmed using LC-Mass and 1H-NMR. This novel method successfully was applied to synthesize of another urea-based peptide containing a sequence of Glu-Urea-Lys (OMe)-GABA-Tyr-Tyr-GABA and the bifunctional linker hydrazinonicotinamide (HYNIC) as well.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134486946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Combined Unfolded Principal Component Analysis and Artificial Neural Network for Determination of Ibuprofen in Human Serum by Three-Dimensional Excitation–Emission Matrix Fluorescence Spectroscopy 三维激发-发射矩阵荧光光谱法测定人血清中布洛芬的未展开主成分分析与人工神经网络相结合

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2266

G. Bahrami, Hamid Nabiyar, K. Sadrjavadi, M. Shahlaei

引用次数: 2

Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents 作为潜在抗惊厥剂的4-氟酞酰亚胺的设计与合成

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2265

M. Iman, Sina Fakhari, Mohammad Jahanpanah, N. Naderi, A. Davood

引用次数: 7

The Synergistic Effects of Celecoxib and Sodium Valproate on Apoptosis and Invasiveness Behavior of Papillary Thyroid Cancer Cell Line In-vitro 塞来昔布和丙戊酸钠对体外甲状腺乳头状癌细胞凋亡和侵袭行为的协同作用

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2269

M. Fanian, Maedeh Bahmani, M. Mozafari, S. Naderi, Marzieh Alizadeh Zareie, Mohammad Ali Okhovat, Jamileh Saberzadeh, A. Dehshahri, M. Takhshid

{"title":"The Synergistic Effects of Celecoxib and Sodium Valproate on Apoptosis and Invasiveness Behavior of Papillary Thyroid Cancer Cell Line In-vitro","authors":"M. Fanian, Maedeh Bahmani, M. Mozafari, S. Naderi, Marzieh Alizadeh Zareie, Mohammad Ali Okhovat, Jamileh Saberzadeh, A. Dehshahri, M. Takhshid","doi":"10.22037/IJPR.2018.2269","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2269","url":null,"abstract":"Metastasis to lymph nodes and distant organs is the main challenge in the treatment of papillary thyroid cancer. In the current investigation, we aimed to evaluate the synergistic effects of celecoxib (CX) and sodium valproate (VPA) against cell survival, invasiveness properties, and expression of metalloproteinase-2 and -9 (MMP-2 and MMP-9) in papillary thyroid cancer cell line, B-CPAP cells. The effect of CX and VPA on B-CPAP cells viability and apoptosis were investigated using MTT assay and annexin V/7-AAD flowcytometry, respectively. The effects of the drugs on invasiveness properties of B-CPAP cells and expression of MMP-2 and MMP-9 were evaluated using transwell assay and real time PCR, respectively. MTT assay showed that CX and VPA decreased viability of B-CPAP cells dose dependently (IC50 32.4µM and 6.8 mM, respectively). Combination of CX (5 μM) and VPA (2.5 and 5 mM) increased apoptosis, and reduced cell migration and invasion of B-CPAP cell, synergistically. Real time PCR results showed that both CX (5 µM) and VPA (2.5 and 5 mM) reduced MMP-2 expression (P < 0.05) but had no significant effects on the expression of MMP-9. Our findings suggest that CX and VPA synergistically increase apoptosis and suppress migration and invasion of B-CPAP cells through inhibition of MMP-2 expression.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133721629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Response Surface Methodology for Optimization of Genistein Content in Soy Flour and its Effect on the Antioxidant Activity 响应面法优化大豆粉中染料木素含量及其对抗氧化活性的影响

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2250

A. Abdella, A. E. El baz, E. Mahrous, Alaa A. Abd El Maksoud, I. A. Ibrahim, A. Abdel-Monem, Shangtian Yang

{"title":"Response Surface Methodology for Optimization of Genistein Content in Soy Flour and its Effect on the Antioxidant Activity","authors":"A. Abdella, A. E. El baz, E. Mahrous, Alaa A. Abd El Maksoud, I. A. Ibrahim, A. Abdel-Monem, Shangtian Yang","doi":"10.22037/IJPR.2018.2250","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2250","url":null,"abstract":"Biotransformation of isoflavones glycosides into the aglycone form is essential to attain the maximum bioavailability. The factors affecting deglycosylation of genistin in soy flour using commercial β-glucosidase enzyme were evaluated. The presence of genistin in soy flour was confirmed by isolation through chromatographic fractionation and identification by spectral method. Two-levels Plackett-Burman design was applied and effective variables for genistein production were determined. Agitation rate, enzyme concentration, and reaction time, owing to their significant positive effect, and pH, owing to its significant negative effect, were further evaluated using Box-Behnken model. Accordingly the optimal combination of the major reaction affecting factors was “enzyme concentration, 1 IU; agitation speed, 250 rpm; reaction time, 5 h and pH 4. The concentration of genistein can be increased by 9.91 folds (from 0.8 mg/g in the non biotransformed soy flour to 7.93 mg/g in the biotransformed one) using the determined optimal combination of major reaction affecting factors. The antioxidant activity of the non biotransformed and biotransformed soy flour extracts was determined by DPPH method. It was found that biotransformation increase the antioxidant activity by two folds. The concentration causing a 50% reduction of DPPH absorbance (EC50) were 10 and 5 mg/mL for the non biotransformed and biotransformed soy flour extracts, respectively.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116178884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Impact of Clopidogrel Resistance on Clinical Outcome of Iranian Patients Undergoing Percutaneous Coronary Intervention 氯吡格雷耐药对伊朗经皮冠状动脉介入治疗患者临床预后的影响

Iranian Journal of Pharmaceutical Research : IJPR Pub Date : 2018-07-01 DOI: 10.22037/IJPR.2018.2259

Mohammad Haji Aghajani, F. Kobarfard, Seyedpouzhia Shojaei, F. Ahmadpour, O. Safi, Neda Kazemina, Naeime Zarepishe, Mohammad Sistanizad

{"title":"The Impact of Clopidogrel Resistance on Clinical Outcome of Iranian Patients Undergoing Percutaneous Coronary Intervention","authors":"Mohammad Haji Aghajani, F. Kobarfard, Seyedpouzhia Shojaei, F. Ahmadpour, O. Safi, Neda Kazemina, Naeime Zarepishe, Mohammad Sistanizad","doi":"10.22037/IJPR.2018.2259","DOIUrl":"https://doi.org/10.22037/IJPR.2018.2259","url":null,"abstract":"The aim of current study was evaluating the frequency of clopidogrel resistance and its impact on clinical outcome of patients in Iranian patients. Patients undergoing percutaneous coronary intervention in Imam Hussein Medical center, Tehran, Iran, who received standard dosage of clopidogrel (Plavix®, Sanofi, France, 600 mg loading dose and 75 mg/day afterward) were recruited. Platelet aggregation was measured using light transmission aggregometer. The patients were categorized as responder (platelet aggregation less than 43%) and non-responder (platelet aggregation more than 43%). All patients were evaluated for major adverse cardio vascular events one month and 3 years after the angioplasty based on MACE criteria by phone contact. One hundred and five patients with average age of 60.30 ± 12.2 years entered the study of whom 26 (24.76%) did not respond to clopidogrel. None of patients experienced cardiac events one month after PCI. Three years after PCI, data were collected from 55 (69.62%) and 10 (38.46%) subjects in responder and non-responder groups, respectively. MACE criteria was positive in 4 patients, 3 (5.45%) in responder and 1 (10%) in non-responder group (p = 0.28). We did not find any significant differences between clopidogrel resistance and past medical history. In drug history 1 (1.26%) and 4 (15.38%) patients received omeprazole with clopidogrel in responder and none-responder group, respectively (p = 0.003). This study showed 24.76% resistance to clopidogrel in Iranian population but, we did not find any correlation between clopidogrel resistance and cardiac events in follow up maybe due to study limitations particularly missed follow-up in non-responder patients.","PeriodicalId":416671,"journal":{"name":"Iranian Journal of Pharmaceutical Research : IJPR","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125538236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3