Pathologia最新文献

{"title":"Peculiarities of surgical treatment of atrial macro reentry tachyarrhythmia in elderly patients with implanted pacemaker","authors":"A. V. Yakushev, O. A. Lozovoy","doi":"10.14739/2310-1237.2022.2.257517","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.257517","url":null,"abstract":"Atrial macro reentry tachycardias are the most common tachyarrhythmias in the structure of cardiac arrhythmias in the elderly. Catheter ablations are the gold standard for the treatment of atrial macro reentry arrhythmias, but in the elderly group, the risks of complex ablations often outweigh the benefits.\u0000Aim: to determine the optimal volume of catheter ablation in atrial tachyarrhythmia using an implanted pacemaker in elderly patients.\u0000Materials and methods. The work is based on a retrospective analysis of the results of surgical treatment of (n = 45) elderly patients (75–90 years) with atrial macro reentry tachycardia, who were previously identified as an artificial pacemaker at the National M. Amosov Institute of Cardiovascular Surgery Affiliated to National Academy of Medical Sciences of Ukraine. Patients were divided into 3 groups depending on the response of the reentry tachycardia to electrical pacing (assessed by the difference between postpacing interval (PPI) and tachycardia cycle lens (CL): group І – PPI-CL 20–40 ms; group ІІ – PPI–CL 20–40 ms; group ІІІ – PPI-CL 60 ms and more.\u0000Results. In the group I (n = 20) in 100 % of the patients isthmus-dependent reentry tachyarrhythmia was diagnosed and cava-tricuspid isthmus was ablated. In the group ІІ (n = 12) 4 (33 %) patients were diagnosed with reentry tachycardia around the right pulmonary veins, in 8 (67 %) patients – reentrant tachycardia around the mitral valve. In the group ІІІ (n = 13) in 8 (62 %) patients macro reentry around the mitral valve was found, in 3 (23 %) – reentry around the left pulmonary veins, in another 2 (15 %) of the patients – reentry of the left atrial roof.\u0000Conclusions. Non-invasive electrophysiological study with pacemaker can be an effective way to study atrial macro reentry tachyarrhythmias. Electrophysiological PPI-SI criteria less than 20 ms can be used as an additional diagnostic criterion for the selection of patients for surgical treatment. Catheter ablation is recommended for elderly patients when the reentry circle is located in the right atrium.\u0000 ","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"21 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83489004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of epidermal proliferation and terminal differentiation in various histological types of seborrheic keratosis","authors":"G. Makurina, S. I. Tertyshnyi, L. О. Cherneda","doi":"10.14739/2310-1237.2022.2.253482","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.253482","url":null,"abstract":"Aim of the study is to determine the peculiarities of epidermal proliferation and terminal differentiation in various histological types of seborrheic keratosis (SK).\u0000Materials and methods. Pathomorphological and immunohistochemical analysis was performed on the skin biopsy material of 60 patients with SK, who constituted the study group, and on the material of 30 healthy skin samples, which were considered a control group.\u0000Results. Level of expression of Ki-67 marker in papillomatous and acanthotic types of SK is significantly lower (P < 0.005) compared to healthy skin samples, which indicates a low proliferative potential of tumors. While the expression of the marker of terminal differentiation between these groups of SK and healthy skin is significantly higher (P < 0.005). Comparative characterization of the association of the expression degree of the immunohistochemical marker of proliferation Ki-67 depending on the activity of terminal differentiation processes in acanthotic and papillomatous types of SK indicates a statistically significant inverse correlation of these pathogenetically determined processes. Thus, activation of terminal differentiation with increase of caspase-14 expression level inhibits proliferation in basal epidermal layers that is accompanied by decrease of Ki-67 level.\u0000Conclusions. Level of expression of Ki-67 as a marker of proliferative activity in patients with acanthotic and papillomatous types is significantly lower than in the control group, which may indicate no tendency to malignancy. The expression level of caspase-14 in acanthotic and papillomatous types is increased compared to healthy skin, which may indicate a violation of keratinization, which occurs during the terminal differentiation of epidermocytes. Statistical inverse conjugacy between caspase-14 and Ki-67 indicates inhibition of proliferation against the background of increased terminal differentiation activity and may justify the vectors of therapeutic action of topical agents.","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"47 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77983639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition and cancer: modern aspects of a healthy lifestyle (literature review)","authors":"O. Kolesnik, O. M. Levyk, D. Y. Cherniavskyi, V. O. Kuzmenko, L. Lytvynenko","doi":"10.14739/2310-1237.2022.2.258362","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.258362","url":null,"abstract":"Despite significant improvements in screening, diagnosis and targeted therapy, cancer remains the second leading cause of death in the world. It is becoming increasingly clear that diet and lifestyle play a significant role in the development and progression of cancer. Thus, various dietary combinations can be proposed to reduce the risk of cancer and to improve the impact of basic therapy. Nutrition is closely linked to cancer. Food carcinogens, macronutrients, micronutrients such as vitamins A, C and D, dietary fiber, modulation of metabolism by diet, dietary supplements and anticancer agents in food affect the development of cancer. This article discusses research on the relationship between nutrition and cancer, as well as current dietary guidelines for reducing the risk of cancer.\u0000The aim of the study is to analyze information from the professional literature on the influence of various nutritional regimes in cancer patients.\u0000Conclusions. Proper nutrition can prevent the risk of cancer and improve the impact of treatment on the disease. Ketogenic diet is useful in combination with standard therapy on the basis of its ability to enhance the antitumor effects of classical chemotherapy and radiation therapy, its overall good safety and tolerability, as well as improving the quality of life. Mediterranean diet is a protective factor against cancer, due to the antioxidant and anti-inflammatory properties of the ingredients. Fasting is also a potentially effective strategy for inducing the differential stress resistance of cancer and normal cells as an adjunct to standard treatment. Promising benefits of vitamins in the prevention and treatment of cancer can be achieved through the use of new potent analogues, as well as combinations of vitamins in the early stages of cancer.\u0000 ","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"25 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85517998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Tru-Cut biopsy in differential diagnosis and challenges in breast adenoid cystic carcinoma on a case basis","authors":"İ. Sayar, U. Memiş, S. Bilici, Nurten Arslan Isik","doi":"10.14739/2310-1237.2022.2.245804","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.245804","url":null,"abstract":"Adenoid cystic carcinoma (AdCC) is a very rare low-grade invasive carcinoma primarily in the breast. The fact that similar patterns can be observed in invasive breast carcinomas (IВC) such as AdCC and breast ductal carcinoma in situ (DCIS) in Tru-Cut biopsies creates difficulties in the differential diagnosis.\u0000Case presentation. A 70-year-old female patient was admitted to our outpatient clinic with the complaint of a palpable mass in the left breast subareolar region. In the light microscopy examination of 3 tissue samples with a size of 3 measurements, IBC-like tubular structures, some of which were formed by tiny uniform cells with narrow cytoplasm, and some with eosinophilic material, and solid nest structures suggesting DCIS in focal areas were observed.\u0000Immunohistochemical examination showed continuity of myoepithelial cells with p63 and calponin, and epithelial cells, staining with Cd117 and CK7. No staining was observed with progesterone, estrogen, and Cerbb2. The staining rate of Ki-67 was determined as 2 percent. A diagnosis of AdCC was made with these findings.\u0000Conclusions. It is important to search for different patterns in addition to double cell population and pay attention to the material in the lumens in breast Tru-Cut biopsies that contain AdCC patterns that may cause the diagnosis of IBC and DCIS in error.","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"260 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77143113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of the treatment of combat injuries of the maxillofacial area with titanium implants in the conditions of modern war","authors":"D. V. Ivchenko, S. Varzhapetian, O. Mishchenko, O. Sydor, Y. Petrenko, Yevgeniy Yatsun, T. V. Strohanova","doi":"10.14739/2310-1237.2022.2.260598","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.260598","url":null,"abstract":"The aim. To research some features of a combat injury of the jaw-facial region and possible options of surgical treatment using titanium implants.\u0000Materials and methods. We investigated clinical cases of the treatment of high-speed combat injuries of the maxillofacial area in the department of maxillofacial surgery with otolaryngological beds of Municipal Non-Commercial Enterprise “City Hospital of Emergency and Urgent Medical Care of the Zaporizhzhia City Council”.\u0000Results. Postoperative follow-up of the patients affected by high-velocity projectile showed positive treatment outcomes in all observations.\u0000The negative consequences of the trauma revealed in the postoperative period were persistent paralysis of facial muscles, lower jaw dysfunction with limited mouth opening, necrosis of the damaged tissues of the oral cavity, necrosis and suppuration of tissues around the wounds, formation of deforming scars and fistulas, sequestration. The most common functional disorders as a result of injury were paralysis of the facial muscles and mandibular dysfunction which were observed in 100 % of our cases.\u0000Sequestration of the bone fragments was observed in only one case, only one patient showed all the above mentioned negative pathological consequences of high-speed trauma.\u0000Conclusions. Our experience in the treatment of high-velocity gunshot wounds at the face leads to the conclusion that the results of the treatment and the choice of surgical tactics depend primarily on the severity of the wound and the degree of destruction of soft and bone tissues of the face. The great variety of the nature of injuries does not allow determining of a “golden standard” for final surgical treatment.\u0000 ","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"69 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76308369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The level of antimicrobial peptides in different clinical forms of urinary tract infections in children","authors":"H. O. Lezhenko, N. A. Zakharchenko","doi":"10.14739/2310-1237.2022.2.259894","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.259894","url":null,"abstract":"The aim. To study the content of antimicrobial peptides in the serum of children with urinary tract infections depending on the clinical form of the disease and to establish their pathogenetic role in the development of various clinical forms of pathology.\u0000Materials and methods. The study groups consisted of 84 children (mean age – 10.0 ± 1.3 years). The main group was divided into subgroups: the first subgroup – 17 children with acute pyelonephritis, the second subgroup – 21 patients with chronic pyelonephritis, the third subgroup – 16 patients with acute cystitis, the fourth subgroup – 10 patients with unspecified urinary tract infections. The control group consisted of 20 relatively healthy children. The study of the content of cathelicidin, hepcidin and lactoferrin was performed by enzyme-linked immunosorbent assay.\u0000Results. The development of urinary tract infection was accompanied by a statistically significant increase in the content of cathelicidin (P < 0.05). The highest level of serum cathelicidin was registered in children of the first (P <0.05) and third subgroups (P < 0.05). In the other two subgroups, the level of LL-37 had only a trend towards increasing (P > 0.05). The level of hepcidin in the main study group was statistically lower than in the control group (P < 0.05).\u0000The development of chronic pyelonephritis and acute cystitis occurred amid a statistically significant decrease in hepcidin levels by 2.5 and 1.7 times (P < 0.01 and P < 0.05, respectively). The level of lactoferrin in the general group was within the control group figures (P > 0.05), however, there was a statistically significant decrease in serum lactoferrin in a subgroup of children with unspecified urinary tract infections (P < 0.05).\u0000We determined a relationship between hepcidin and lactoferrin levels in the investigated groups and found a clear direct relationship in a subgroup of children diagnosed with chronic pyelonephritis (r = 0.58, P < 0.01).\u0000Conclusions. Each nosological form of urinary tract infection has its own configuration of antimicrobial peptides. The analysis of the relationship between hepcidin and lactoferrin, the antimicrobial peptides that limit the access of the pathogens to serum iron, indicates the synchronization of the body’s defense mechanisms aimed at eliminating the pathogen.","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"4 11","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72397117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the simultaneous course of pulmonary aspergillosis and tuberculosis on the background of type 1 diabetes mellitus (clinical case)","authors":"O. Raznatovska, Yu. V. Myronchuk, O. S. Shalmin, A. V. Fedorets, O. Svitlytska","doi":"10.14739/2310-1237.2022.2.259846","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.259846","url":null,"abstract":"Aim. To analyze the features of the simultaneous course of pulmonary aspergillosis and multidrug-resistant pulmonary tuberculosis (MDR-TB) on the background of type 1 diabetes mellitus, on the example of a clinical case of our practice.\u0000Materials and methods. Clinical case of our practice of simultaneous pulmonary aspergillosis and MDR-TB on the background of type 1 diabetes mellitus in a patient, who was treated in Pulmonary tuberculosis department No. 2 of clinical base of Phthisiatry and Pulmonology Department of Zaporizhzhia State Medical University at Communal Non-Commercial Enterprise of the “Zaporizhzhia Regional Clinical and Diagnostic Center of Phthisiatry and Pulmonology” of Zaporizhzhia Regional Council.\u0000Results. In the presented clinical case, the patient had been suffering from diabetes mellitus for 8 years and had been receiving insulin therapy for all these years. One year before the TB disease, he had contact with an index patient, but he categorically refused a course of preventive chemotherapy. Also, the patient did not make a comparison X-ray TCO after 6 months, as a contact person.\u0000MDR-TB and aspergilloma of the left lung of the patient were diagnosed simultaneously on the background of severe condition with decompensated form of type 1 diabetes mellitus, severe intoxication syndrome and inflammatory process, massive hemoptysis. Aspergilloma of the left lung was diagnosed using X-ray TCO and cultural examination of bronchial aspirate for Aspergillus, which was not difficult to diagnose. Diagnosis of MDR-TB was also not difficult, because the patient had MBT, which contributed to the timely and correct appointment of antimycobacterial therapy. Surgery for aspergilloma of the left lung was contraindicated, as the type 1 diabetes was in decompensation. Persistent hyperglycemia remained, despite the fact of antifungal therapy and constant correction of insulin therapy prescribed for the patient. Endocarditis quickly developed in the patient, which was the reason of patient’s death.\u0000Conclusions. The decompensated form of type 1 diabetes mellitus caused persistent hyperglycemia, which was the reason of immune disorders and this made the patient’s body susceptible to bacterial (MDR-TB) and fungal (aspergillosis) infections, which led to the development of the complication of endocarditis and death. A big mistake in his case, was a categorical refusal by the patient to receive a course of preventive chemotherapy, as a contact person with an index patient. In view of this, in the presence of type 1 diabetes, the patient should have not neglected it. And as a result, the patient had a MDR-TB, one year after. At the same time, the patient did not make a comparison X-ray TCO, after 6 months, as a contact person, which was a possible reason for the missing of early diagnosis of pulmonary aspergilloma.\u0000That’s why, a correct treatment of type 1 diabetes mellitus and timely preventive radiological examination of the thoracic cavity organs are","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"57 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76878378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical cases of extrapulmonary manifestations in patients with coronavirus disease (COVID-19)","authors":"O. Riabokon, К. А. Pak, О. О. Furyk, V. V. Cherkaskyi","doi":"10.14739/2310-1237.2022.2.257403","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.257403","url":null,"abstract":"The aim of the work – to provide variants of extrapulmonary manifestations of coronavirus disease (COVID-19) based on the analysis of the relevant course of the disease in adults.\u0000Results. The paper presents two clinical cases of coronavirus disease (COVID-19) with the manifestation of extrapulmonary symptoms, which required some individualization of therapy.\u0000The first clinical observation showed that in a 56-year-old patient with moderate COVID-19, the development of oxygen dependence on the 8th day of the disease was combined with the manifestation of extrapulmonary symptoms in the form of cutaneous manifestations. Individualization of glucocorticosteroid therapy and endothelioprotective therapy has been shown to be effective in regressing both oxygen dependence and cutaneous vasculitis.\u0000The second clinical observation showed that in a 35-year-old patient, moderate COVID-19 without oxygen dependence was accompanied by the development of extrapulmonary manifestations, namely short-lasting diarrheal syndrome, which manifested in the onset of the disease and of the development of orchiepididymitis on the 9th day of illness, which required the appointment of anti-inflammatory therapy.\u0000Conclusions. The abovementioned clinical observations of COVID-19 cases show relatively rare cases of SARS-CoV-2- associated extrapulmonary manifestations in patients with moderate disease, but their development necessitated individualization of treatment.\u0000 ","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"36 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86640579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vegetative and electrical disorders in women with chronic coronary syndrome depending on the state of bone mineral density","authors":"N. Mykhailovska, I. Stetsiuk","doi":"10.14739/2310-1237.2022.2.254816","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.254816","url":null,"abstract":"Aim: to determine the features of heart rate variability and electrical changes in the myocardium in women with chronic coronary syndrome, depending on the state of the bone mineral density (BMD).\u0000Materials and methods. 121 women with chronic coronary syndrome (CCS): stable exertional angina of II–III functional class (FC) (mean age 68.0 (60.0; 75.0) years) were examined and divided into 3 groups: group 1 − 30 women with ССS and normal BMD; group 2 – 33 women with CCS and osteopenia (OPе); group 3 – 58 women with CCS and osteoporosis (OP). All patients underwent daily ECG monitoring and ultrasound osteodensitometry.\u0000Results. In women with CCS and OP, increase in the frequency (by 2.9 times; P < 0.05) and duration (by 2.3 times; P < 0.05) of tachycardia episodes, the frequency of registration of ventricular and supraventricular extrasystole episodes (by 8.1 time and 1.2 times, respectively; P < 0.05) if compared to patients without BMD disorders was found. In women with СCS and OPе there was a tendency to increase in these indicators, which did not reach the level of statistical significance. The presence of BMD disorders in patients with CCS was accompanied with decrease in total HRV activity (RMSSD and HRVT), the development of the predominance of ANS sympathetic domain activity, as evidenced by an increase in LF by 44.3 % at the daytime and 44.0 % at night, decrease in HF 2.3 times during the day and 2.1 times at night in patients with OPe and OP, respectively. According to the correlation analysis data, the presence of correlations between the state of BMD and indicators of electrical and autonomic activity of the myocardium was established.\u0000Conclusions. In postmenopausal women with CCS, the severity of autonomic and electrical disorders is associated with the degree of bone disorders and is maximal in osteoporosis.\u0000 ","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"33 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77359763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating sST2 and prognosis of cardiovascular events in remission of multiple myeloma","authors":"M. Panasenko, B. Samura, S. Dotsenko","doi":"10.14739/2310-1237.2022.2.259260","DOIUrl":"https://doi.org/10.14739/2310-1237.2022.2.259260","url":null,"abstract":"Aim. We aimed to evaluate the prognostic value of circulating sST2 for cumulative cardiovascular events in patients with multiple myeloma.\u0000Materials and methods. Ninety seven patients with complete or partial remission of multiple myeloma were enrolled in the study. Observation period was up to 1 year. Blood samples for biomarkers measurements were collected. ELISA method for measurements of circulating level of sST2 was used.\u0000Results. During observation period progression of multiple myeloma was proved in 25 patients, 5 persons were excluded for poor follow-up. 67 patients were included into statistical analysis. Thirty six cumulative clinical events occurred in 18 patients (26.9 %) within the follow-up, with their distribution being as follows: 2 deaths due to cardiovascular causes, 16 heart arrhythmias, 3 cardiac ischemic events, 1 stroke, 4 episodes of chronic heart failures and 10 hospital admissions due to cardiovascular events. 2 deaths were not related to cardiovascular pathology. Medians of levels of sST2 in free-events patients and patients with cardiovascular events were 24.17 ng/ml (95 % confidence interval (CI) = 12.87–27.48 ng/ml) and 47.57 ng/ml (95 % CI = 21.36–68.79 ng/ml) (Р < 0.01) respectively. In multivariate logistic regression analysis sST2 independently predicted cardiovascular events (odds ratio (OR) = 1.112; 95 % CI = 1.081–1.154; Р = 0.010) within 1 year of observation period.\u0000Conclusions. Among patients with confirmed multiple myeloma at remission increased level of circulating sST2 associates with increased cumulative cardiovascular events during 1 year.\u0000 ","PeriodicalId":41645,"journal":{"name":"Pathologia","volume":"14 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78694464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}